Digital Commons Network^™

Acute Treatment With Doxorubicin Affects Glutamate Neurotransmission In The Mouse Frontal Cortex And Hippocampus, Theresa Currier Thomas, Joshua A. Beitchman, Francois Pomerleau, Teresa Noel, Paiboon Jungsuwadee, D. Allan Butterfield, Daret K. St. Clair, Mary Vore, Greg A. Gerhardt

Spinal Cord and Brain Injury Research Center Faculty Publications

Doxorubicin (DOX) is a potent chemotherapeutic agent known to cause acute and long-term cognitive impairments in cancer patients. Cognitive function is presumed to be primarily mediated by neuronal circuitry in the frontal cortex (FC) and hippocampus, where glutamate is the primary excitatory neurotransmitter. Mice treated with DOX (25 mg/kg i.p.) were subjected to in vivo recordings under urethane anesthesia at 24h post-DOX injection or 5 consecutive days of cognitive testing (Morris Water Maze; MWM). Using novel glutamate-selective microelectrode arrays, amperometric recordings measured parameters of extracellular glutamate clearance and potassium-evoked release of glutamate within the medial FC and dentate gyrus (DG) …

Targeting Mitochondrial Dysfunction In Cns Injury Using Methylene Blue; Still A Magic Bullet?, Hemendra J. Vekaria, Lora Talley Watts, Ai-Ling Lin, Patrick G. Sullivan

Spinal Cord and Brain Injury Research Center Faculty Publications

Complex, multi-factorial secondary injury cascades are initiated following traumatic brain injury, which makes this a difficult disease to treat. The secondary injury cascades following the primary mechanical tissue damage, are likely where effective therapeutic interventions may be targeted. One promising therapeutic target following brain injury are mitochondria. Mitochondria are complex organelles found within the cell, which act as powerhouses within all cells by supplying ATP. These organelles are also necessary for calcium cycling, redox signaling and play a major role in the initiation of cell death pathways. When mitochondria become dysfunctional, there is a tendency for the cell to loose …

High Trait Shame Undermines The Protective Effects Of Prevalence Knowledge On State Shame Following Hpv/Cin Diagnosis In Women, Sarah Mcqueary Flynn, Tory A. Eisenlohr-Moul, Suzanne C. Segerstrom, Christen T. Logue, Jamie L. Studts

Psychology Faculty Publications

Human papillomavirus (HPV), and the related, cervical intraepithelial neoplasia (CIN), are common yet poorly understood physical conditions. The diagnosis of HPV often elicits shame and guilt, which in turn may undermine psychological and physical health. The current study compared shame and guilt responses to diagnosis among two groups: women diagnosed with HPV/CIN and women diagnosed with Epstein–Barr Virus (EBV/IM). Eighty women recently diagnosed with HPV/CIN or EBV/IM completed measures of shame- and guilt-proneness, shame and guilt following diagnosis, and disease knowledge including prevalence estimates (HPV and EBV, respectively). HPV/CIN (vs. EBV/IM) predicted more diagnosis-related shame and guilt. Estimates of high …

Adipose Tissue As A Site Of Toxin Accumulation, Erin Jackson, Robin C. Shoemaker, Nika Larian, Lisa A. Cassis

Pharmacology and Nutritional Sciences Faculty Publications

We examine the role of adipose tissue, typically considered an energy storage site, as a potential site of toxicant accumulation. Although the production of most persistent organic pollutants (POPs) was banned years ago, these toxicants persist in the environment due to their resistance to biodegradation and widespread distribution in various environmental forms (e.g., vapor, sediment, and water). As a result, human exposure to these toxicants is inevitable. Largely due to their lipophilicity, POPs bioaccumulate in adipose tissue, resulting in greater body burdens of these environmental toxicants with obesity. POPs of major concern include polychlorinated biphenyls (PCBs), polychlorinated dibenzo‐p‐dioxins and furans …

Increased Birth Weight Is Associated With Altered Gene Expression In Neonatal Foreskin, Leryn J. Reynolds, Rebecca I. Pollack, Richard J. Charnigo, Cetewayo S. Rashid, Arnold J. Stromberg, Shu Shen, John O'Brien, Kevin J. Pearson

Pharmacology and Nutritional Sciences Faculty Publications

Elevated birth weight is linked to glucose intolerance and obesity health-related complications later in life. No studies have examined if infant birth weight is associated with gene expression markers of obesity and inflammation in a tissue that comes directly from the infant following birth. We evaluated the association between birth weight and gene expression on fetal programming of obesity. Foreskin samples were collected following circumcision, and gene expression analyzed comparing the 15% greatest birth weight infants (n = 7) v. the remainder of the cohort (n = 40). Multivariate linear regression models were fit to relate expression levels on differentially …

Evaluating The Therapeutic Effect Of Purslane Extract On The Submandibular Salivary Glands Of Cyclosporine-A Treated Rats, Heba Mahmoud, Rabab T. Mubarak, Iman M. Aboushady

Dentistry

Salivary glands are affected by immunosuppressive drugs, like Cyclosporine-A (CsA) which plays a major role in transplant medicine. Thus, this work aimed to study the possible therapeutic effect of purslane on CsA induced salivary gland alterations.

Materials & Methods: 30 adult male albino rats were equally divided into 3 groups: control group ] received a vehicle, CsA group received 20 mg/kg/day of CsA, and combination group received CsA and 400mg/kg/day of purslane. Three weeks later rats were sacrified then the submandibular salivary glands were prepared for histological andKi67 immunohistochemical analysis, then the studied groups were statistically evaluated.

Results: Histological examination …

A Social-Ecological Framework Of Theory, Assessment, And Prevention Of Suicide, Robert J. Cramer, Nester D, Kapusta

Community & Environmental Health Faculty Publications

The juxtaposition of increasing suicide rates with continued calls for suicide prevention efforts begs for new approaches. Grounded in the Centers for Disease Control and Prevention (CDC) framework for tackling health issues, this personal views work integrates relevant suicide risk/protective factor, assessment, and intervention/prevention literatures. Based on these components of suicide risk, we articulate a Social-Ecological Suicide Prevention Model (SESPM) which provides an integration of general and population-specific risk and protective factors. We also use this multi-level perspective to provide a structured approach to understanding current theories and intervention/prevention efforts concerning suicide. Following similar multi-level prevention efforts in interpersonal violence …

Lived Experiences Of Men With Dissociative Identity Disorder, Melissa Zeligman, Jennifer H. Greene, Gulnora Hundley, Joseph M. Graham Jr., Sarah Spann, Erin Bickley, Zachary Bloom

Adultspan Journal

No abstract provided.

Neurocounseling: Promoting Human Growth And Development Throughout The Life Span, Sonya Lorelle, Rebecca Michel

Adultspan Journal

No abstract provided.

Llusd Articulator - Volume 28, Number 2, Loma Linda University School Of Dentistry

Articulator (Dentistry)

Contents:

4 | The dean's brown bag
9 | Handysides appointed 6th LLUSD dean
10 | Tory Silvetrin runs life's marathon at a sprint
16 | Jess Hayden family donates his 50,000 prosection slides
20 | LLUSD's 61st Commencement
32 | Bonding & zirconia: a literature review
44 | Falling in L-O-V-E with dentistry
46 | Postgraduate Endo celebrates 50 years
48 | LLUSD News

Local Implementation Effectiveness Of A Multi-Tier System Of Support In Elementary School Settings, Terry P. Houlton

Student Work

Ensuring all students learn at high levels is demanding. Multi-tier systems of supports (MTSS) has shown promise as a way to promote high levels of learning for all students while catching students who are struggling to learn. However, implementing MTSS models in school districts and schools has seen its challenges. The context of an individual school impacts efforts related to implementation especially related to implementing a system such as MTSS. During the 2016-2017 school year, using program theory-driven evaluation methods a program theory for MTSS was developed with input from members of the research school district. Then a questionnaire was …

The Banner - V. 152, No. 9 - (October 2017), Christian Reformed Church In North America

The Banner

No abstract provided.

Fish And Wildlife Management On Federal Lands: Debunking State Supremacy, Sandra B. Zellmer, Martin Nie, Christopher Barnes, Jonathan Haber, Julie Joly, Kenneth Pitt

Faculty Law Review Articles

This Article reviews the authority of federal and state governments to manage wildlife on federal lands. It first describes the most common assertions made by state governments regarding state powers over wildlife and then analyzes the relevant powers and limitations of the United States Constitution and federal land laws, regulations, and polices. Wildlife-specific provisions applicable within the National Park System, National Wildlife Refuge System, National Forest System, Bureau of Land Management, the special case of Alaska, and the National Wilderness Preservation System are covered, as is the Endangered Species Act. We reviewed an extensive collection of cases of conflict between …

Elution Tailing Of Nonaqueous Phase Liquids In Porous Media, Louisa Orr

Civil and Environmental Engineering Undergraduate Honors Theses

A variety of porous media were studied to characterize contaminant dispersion over time. This work looked at a compilation of previously published studies to investigate the dependence of long term elution tailing trends on particular soil characteristics. Recession curve analysis was conducted on existing dispersed contaminant literature, to yield the low-concentration recession constant (K). The R² values correlating the soil properties to contaminant concentration ranged from 0.12494 to 0.95429. The low-concentration recession constant (K) values ranged from 0.9745407 0.9999988. The relationship between K and the soil properties porosity, organic carbon, and fines fraction is increasing. Bulk density and the …

Microbiology For Allied Health Students: Lab Manual, Molly Smith, Sara Selby

Biological Sciences Open Textbooks

This open lab manual is a remix of Openstax Microbiology, CC-BY 4.0, and created through an Affordable Learning Georgia Round Six Textbook Transformation Grant.

The lab manual was made to be used with the remixed textbook Microbiology for Allied Health Students, and the textbook has a set of Instructional Materials.

Authors' Description:

This lab manual was created to support a microbiology course for allied health students.

The first section of the manual was adapted from the OpenStax Microbiology textbook, of which a remixed version, Microbiology for Allied Health Students, is used as the text for the …

Microbiology For Allied Health Students, Molly Smith, Sara Selby

Biological Sciences Open Textbooks

This open textbook is a remix of Openstax Microbiology, CC-BY 4.0, and created through an Affordable Learning Georgia Round Six Textbook Transformation Grant.

The textbook has the following supplemental materials within this repository:

This is a collection of instructional materials for the following open textbook and lab manual:

• Microbiology for Allied Health Students Lab Manual
• Microbiology for Allied Health Students Instructional Materials

Authors' Description:

Microbiology for Allied Health Students is designed to cover the scope and sequence requirements for the single semester Microbiology course for non-majors and allied health students. The book presents the core concepts of microbiology …

Report, Collection Assessment: Sustainability Studies, October 2017, Patricia C. Pettijohn

All-Library Assessments Reports, Summaries & Misc Reports

A report assessing library collections that support the Sustainability Studies program.

Multifractality, Interactivity, And The Adaptive Capacity Of The Human Movement System: A Perspective For Advancing The Conceptual Basis Of Neurologic Physical Therapy, Jon Cavanaugh, Damian G. Kelty-Stephen, Nicholas Stergiou

Journal Articles

Background and Purpose:

Physical therapists seek to optimize movement as a means of reducing disability and improving health. The short-term effects of interventions designed to optimize movement ultimately are intended to be adapted for use across various future patterns of behavior, in potentially unpredictable ways, with varying frequency, and in the context of multiple tasks and environmental conditions. In this perspective article, we review and discuss the implications of recent evidence that optimal movement variability, which previously had been associated with adaptable motor behavior, contains a specific complex nonlinear feature known as “multifractality.”

Summary of Key Points:

Multifractal movement fluctuation …

The Pioneer, Vol. 22, No. 2, Fall 2017, Illinois State University, College Of Education

The Pioneer (alumni newsletter)

Alumni Newsletter for University High School, College of Education

Signs & Symbols, Vol. 17, Fall 2017, Illinois State University, Department Of Sociology And Anthropology

Signs & Symbols

Newsletter of the Illinois State University Department of Sociology and Anthropology

Equality And The Defence Of Provocation: Irreconcilable Differences, Isabel Grant, Debra Parkes

Dalhousie Law Journal

Recent amendments to the defence of provocation have limited access to the defence to those who are provoked by conduct that, if prosecuted, would have been an indictable offence punishable by at least five years imprisonment. The paper argues that these amendments are both over- and under-inclusive and fail to confront the central problem surrounding provocation which is that it privileges loss-of-control rage often in the context of male violence against women or in response to same-sex advances. The paper supports the abolition of the defence of provocation but only if mandatory minimum sentences for murder are abolished providing trial …

Employing Older Prisoner Empirical Data To Test A Novel S. 7 Charter Claim, Adelina Iftene

Dalhousie Law Journal

This article builds the case for expanding s. 7 of the Charter of Canadian Rights and Freedoms to apply to prison regulations and decisions in the specific context of an aging prison population. As original empirical data shows, prisons are highly insensitive to age-related problems, and inappropriate or insufficient medical treatment receives official sanction from a wide range of correctional documents. The stark inadequacies of the current system endanger older prisoners' security of the person, and sometimes their lives, in ways that violate their rights under s. 7, since the deprivations they suffer result from legislative policies and state conduct …

Premedical Programs Newsletter, October 2017, University Of Dayton

Pre-Health Resource Center Campus Communications

Newsletter for students, staff, and faculty in the premedical and predental programs.

Ursinus Magazine, Fall 2017, Brock Blomberg, Ed Moorhouse, Mark Schneider, Ellen Labrecque, Jack Croft, Geoff Gehman, Matthew Mizenko, Cory Straub

Ursinus Magazine, 1995–Present

Introducing the student commons • Heroic couplet • A mark of pride • Prestigious honors for alumni • Meet the new Dean • Teaching and learning • A commitment to arts • Grant to fund Christian studies pilot program • Lost and found: Centennial Homecoming celebration • Out of this world • Serving the underserved: At home and around the world • A passion for service • The write stuff: Ursinus alumni pen books that level life's playing field • The mission of admission • Burning question: Could internment camps for American citizens be established again? • Anatomy of the …

Justice Blackmun And Individual Rights, Diane P. Wood

Dickinson Law Review (2017-Present)

Of the many contributions Justice Blackmun has made to American jurisprudence, surely his record in the area of individual rights stands out for its importance. Throughout his career on the Supreme Court, he has displayed concern for a wide variety of individual and civil rights. He has rendered decisions on matters ranging from the most personal interests in autonomy and freedom from interference from government in life’s private realms, to the increasingly complex problems posed by discrimination based upon race, sex, national origin, alienage, illegitimacy, sexual orientation, and other characteristics. As his views have become well known to the public, …

Wright State University Magazine, Fall 2017, Office Of Marketing, Wright State University

Wright State University Magazine

Thirty-six page issue of the Wright State University Magazine. This magazine is published twice a year and focuses on news related to Wright State alumni, faculty, staff, and friends of the university.

Nuclear Gene 33/Mig6 Regulates The Dna Damage Response Through An Atm-Dependent Mechanism, C Li, S Park, X Zhang, Leonard Eisenberg, Hong Zhao, Zbigniew Darzynkiewicz, Dazhong Xu

NYMC Faculty Publications

Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions. We recently linked Gene 33 to the DNA damage response (DDR) induced by hexavalent chromium [Cr(VI)], but the molecular mechanism remains unknown. Here we show that ectopic expression of Gene 33 triggers DDR in an ATM serine/threonine kinase-dependent fashion and through pathways dependent or not dependent on ABL proto-oncogene 1 non-receptor tyrosine kinase (c-Abl). We observe clear presence of Gene 33 in the nucleus and chromatin fractions of the cell. We also found that the nuclear localization of Gene 33 is regulated by its 14-3-3 binding motif (14-3-3BD) …

Peptidyl-Prolyl Isomerase 1 Regulates Ca(2+) Handling By Modulating Sarco(Endo)Plasmic Reticulum Calcium Atpase And Na(2+)/Ca(2+) Exchanger 1 Protein Levels And Function, V Sacchi, B Wang, D Kubli, A Martinez, J Jin, R Alvarez, N Hariharan, C Glembotski, T Uchida, J Malter, Y Yang, P Gross, C Zhang, S Houser, Marcello Rota, M Sussman

NYMC Faculty Publications

BACKGROUND: Aberrant Ca(2+) handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca(2+) handling is essential for the development of strategies to blunt pathological changes in calcium dynamics. The peptidyl-prolyl cis-trans isomerase peptidyl-prolyl isomerase 1 (Pin1) is a critical mediator of myocardial hypertrophy development and cardiac progenitor cell cycle. However, the influence of Pin1 on calcium cycling regulation has not been explored. On the basis of these findings, the aim of this study is to define Pin1 as a novel modulator of Ca(2+) handling, with implications for improving myocardial contractility and potential for …

Complete Genome Sequence Of A Colistin-Resistant Escherichia Coli Strain Harboring Mcr-1 On An Inchi2 Plasmid In The United States, V Gilrane, S Lobo, Weihua Huang, J Zhuge, Changhong Yin, Donald Chen, K Alvarez, Alexandra Budhai, I Nadelman, Nevenka Dimitrova, John Fallon, Guiqing Wang

NYMC Faculty Publications

We report here the incidental detection and complete genome sequence of a urinary Escherichia coli strain harboring mcr-1 and resistant to colistin in a New York patient returning from Portugal in 2016. This strain, with sequence type 1485 (ST1485), was a non-extended-spectrum beta-lactamase (ESBL) and non-carbapenemase producer and carried the mcr-1 gene on an IncHI2 plasmid.

Subcutaneous Rituximab For The Treatment Of B-Cell Hematologic Malignancies: A Review Of The Scientific Rationale And Clinical Development, A Davies, C Berge, A Boehnke, A Dadabhoy, Et Al

Peninsula Medical School

UNLABELLED: Rituximab (MabThera®/Rituxan®), a chimeric murine/human monoclonal antibody that binds specifically to the transmembrane antigen CD20, was the first therapeutic antibody to enter clinical practice for the treatment of cancer. As monotherapy and in combination with chemotherapy, rituximab has been shown to prolong progression-free survival and, in some indications overall survival, in patients with various B-cell malignancies, while having a well-established and manageable safety profile and a wide therapeutic window. As a result, rituximab is considered to have revolutionized treatment practices for patients with B-cell malignancies. A subcutaneous (SC) formulation of rituximab has been developed, comprising the same monoclonal antibody …