Digital Commons Network^™

Reproducibility And Reuse Of Adaptive Immune Receptor Repertoire Data, Felix Breden, Eline T. Luning Prak, Bjoern Peters, Florian Rubelt, Chaim A. Schramm, Christian E. Busse, Jason A. Vander Heiden, Scott Christley, Syed Ahmad Chan Bukhari, Adrian Thorogood, Tania M. Bubela

Office of the Provost

High-throughput sequencing (HTS) of immunoglobulin (B-cell receptor, antibody) and T-cell receptor repertoires has increased dramatically since the technique was introduced in 2009 (1-3). This experimental approach explores the maturation of the adaptive immune system and its response to antigens, pathogens, and disease conditions in exquisite detail. It holds significant promise for diagnostic and therapy-guiding applications. New technology often spreads rapidly, sometimes more rapidly than the understanding of how to make the products of that technology reliable, reproducible, or usable by others. As complex technologies have developed, scientific communities have come together to adopt common standards, protocols, and policies for generating …

Paving The Road To Personalized Medicine: Recommendations On Regulatory, Intellectual Property And Reimbursement Challenges, Lori Knowles, Westerly Luth, Tania M. Bubela

Office of the Provost

Personalized medicine (PM) aims to harness a wave of 'omics' discoveries to facilitate research and discovery of targeted diagnostics and therapies and increase the efficiency of healthcare systems by predicting and treating individual predispositions to diseases or conditions. Despite significant investment, limited progress has been made bringing PM to market. We describe the major perceived regulatory, intellectual property, and reimbursement challenges to the development, translation, adoption, and implementation of PM products into clinical care. We conducted a scoping review to identify (i) primary challenges for the development and implementation of PM identified in the academic literature; (ii) solutions proposed in …

Efficacy And Safety Of Pembrolizumab In Patients Enrolled In Keynote-030 In The United States: An Expanded Access Program., Tara C Gangadhar, Wen-Jen Hwu, Michael A Postow, Omid Hamid, Adil Daud, Roxana Dronca, Richard Joseph, Steven J O'Day, F S Hodi, Anna C Pavlick, Harriet Kluger, Romina P Oxborough, Aiming Yang, Mihaela Gazdoiu, Debra A Kush, Scot Ebbinghaus, April K S Salama

Articles, Abstracts, and Reports

KEYNOTE-030 (ClinicalTrials.gov ID, NCT02083484) was a global expanded access program that allowed access to pembrolizumab, an antiprogrammed death 1 antibody, for patients with advanced melanoma before its regulatory approval. Patients with unresectable stage III/IV melanoma that progressed after standard-of-care therapy, including ipilimumab and, if BRAF mutant, a BRAF inhibitor, were eligible to receive pembrolizumab 2 mg/kg every 3 weeks. Response was assessed by immune-related response criteria by investigator review. Adverse events (AEs) were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0. In the United States, 979 patients enrolled between April and September 2014. …

Ms4 Resource: Opti-Tool Training, University Of New Hampshire Stormwater Center (Unhsc), New England Environmental Finance Center

UNH Stormwater Center

UNHSC has been assisting the New England Environmental Finance Center in the development and delivery of training sessions to promote the new BMP Performance Curves and the EPA Region 1 Opti-Tool.

Crossflow Ultrafiltration For Removing Direct-15 Dye From Wastewater Of Textile Industry, Ahmad A.L., Puasa S.W., Abiding S.

ASEAN Journal on Science and Technology for Development

Ultrafiltration membrane was used to treat the effluent from textile industries. Crossflow ultrafiltration using GN polymeric membrane was used to remove the dye from textile effluent. A synthetic textile effluent of Direct-15 dye was used. The study focused through the effect of feed concentration, transmembrane pressure and solution’s pH on the permeate flux and percentage of dye removal were investigated. Dye concentration had significant effects on flux values. Under the fixed pressures and pH, the flux decreased while the dye rejection increased with increasing feed concentration. Transmembrane pressure also had significant effect on flux values. Under the fixed feed concentration …

Dataset For: Toxicity And Mutagenicity Of The Gulf Of Mexico Waters During And After The Deepwater Horizon Oil Spill, July 2010-August 2013, Lauren Mcdaniel

C-IMAGE data

The dataset is representative of 20 research cruises spanning from July 2010 to August 2013 in the North and West Florida Shelf regions of the Gulf of Mexico. This dataset reports microtoxicity data from each site and is an extension and revision of C-IMAGE I dataset R1.x135.119:0005. The North Florida Self data also contains PAH measurements for three cruises (12/6/2010, 12/15/2011, 8/6/2013).

Tox Regulates Growth, Dna Repair, And Genomic Instability In T-Cell Acute Lymphoblastic Leukemia, Riadh Lobbardi, Jordan Pinder, Barbara Martinez-Pastor, Marina Theodorou, Jessica S. Blackburn, Brian J. Abraham, Yuka Namiki, Marc Mansour, Nouran S. Abdelfattah, Aleksey Molodtsov, Gabriela Alexe, Debra Toiber, Manon De Waard, Esha Jain, Myriam Boukhali, Mattia Lion, Deepak Bhere, Khalid Shah, Alejandro Gutierrez, Kimberly Stegmaier, Lewis B. Silverman, Ruslan I. Sadreyev, John M. Asara, Marjorie A. Oettinger, Wilhelm Haas, A. Thomas Look, Richard A. Young, Raul Mostoslavsky, Graham Dellaire, David M. Langenau

Molecular and Cellular Biochemistry Faculty Publications

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. Using a transgenic screen in zebrafish, thymocyte selection–associated high mobility group box protein (TOX) was uncovered as a collaborating oncogenic driver that accelerated T-ALL onset by expanding the initiating pool of transformed clones and elevating genomic instability. TOX is highly expressed in a majority of human T-ALL and is required for proliferation and continued xenograft growth in mice. Using a wide array of functional analyses, we uncovered that TOX binds directly to KU70/80 and suppresses recruitment of this complex to DNA breaks to inhibit nonhomologous end joining (NHEJ) repair. …

Regenerative Therapy By Replacement Of Stem Cells In Females, Saara Ahmad, Rehana Rehman, Fatima Ahmad

Department of Biological & Biomedical Sciences

No abstract provided.

Association Of Vitamin D Deficiency And Vdbp Gene Polymorphism With The Risk Of Ami In A Pakistani Population, Mujtaba Mubashir, Shaheena Anwar, Asal Khan Tareen, Naseema Mehboobali, Khalida Iqbal, Mohammad Iqbal

Department of Biological & Biomedical Sciences

OBJECTIVE: To investigate the relationship of vitamin D deficiency and risk of AMI in a Pakistani population, and to find out any associationbetween vitamin D binding protein (VDBP) genotypes and risk of AMI in this population.
METHODS: In a comparative cross-sectional study, 246 patients (age: 20-70 years; 171 males and 75 females) with first AMI were enrolled with informed consent. Similarly, 345 healthy adults (230 males and 115 females) were enrolled as controls. Their fasting serum samples were analyzed for 25 (OH) vitamin D, lipids and other biomarkers using kit methods, while DNA was analyzed for VDBP genotypes using PCR-RFLP …

Inclusion Of An Autistic Child In Kindergarten Facility: A Case Study, Ibrahim Al-Qaryouti, Ghazwa Nachabe, Tamara Leeder

Journal of Educational and Psychological Studies

This study aimed to investigate the effects of inclusion of an autistic child, at entrance age of four years and seven months, into the Child Care Center of the Sultan Qaboos University. The study was designed to specifically answer: (1) Which domains of the ASDA scale did „Ahmad‟ show notable improvement? (2) Which areas of the academic program did „Ahmad‟ show notable improvement? The program at the Center is a bilingual mainstream program in Arabic and English. It is a highly structured and individualized program which covers all of the developmental domains. It caters for two groups of mixed age …

Full Issue, Number 46, Fall 2017

Intersections

No abstract provided.

Reforming Our Visions Of City Nature, Lea F. Schweitz

Intersections

No abstract provided.

Celebrating The Reformation: The Lutheran Foundation Of A Called Life, Mark D. Tranvik

Intersections

No abstract provided.

Early Stage Small Cell Lung Cancer: Very Rare, But A Surgical Disease!, Eric Vallières

Articles, Abstracts, and Reports

No abstract provided.

Muna Omar Honors Portfolio, Muna M. Omar

Honors Capstone Portfolios

Muna Omar's honors portfolio captured in November 2017.

Growing Up Fast: Implications For Foster Youth When Independence And Early Adulthood Collide, Brenda M. Morton

Faculty Publications - College of Education

Foster care alumni face overwhelming challenges as they transition from care to independence. Torn between their desire to be independent, yet acknowledging they need support, they struggle to find their footing. Adopting a survivor self-reliance mind-set, they set out to earn a bachelor's degree on their own. As they struggle, they compare themselves to non-foster peers who, by enlarge, have a support system enabling them a prolonged entrance to adulthood, which provides a safety net. Without a safety net, and with a focus on independence, decisions youth from foster care make, result in few alumni earning a bachelor's degree.

Inclusive Education For Preschool Learners With Autism: A Program Evaluation, Rachel C. Morgan

Dissertations

This is an exploration of the perceptions and perspectives of early childhood leaders and practitioners with regards to preschool learners with autism engaged in inclusive educational settings. At a time when inclusive education is acknowledged as best practice, there is still a concern that many preschool learners with disabilities are receiving most of their supports in a segregated setting. Additional concerns noted in the current research relate directly to the beliefs, values, and attitudes towards inclusive education for learners with disabilities. No distinct study has been done with regards to this age group, nor to pinpoint the perceptions and perspectives …

Without Warning? What Occupational Challenges Cause Suicide Among Minority Young Adults? A Literature Review

OCCUPATION: A Medium of Inquiry about Health through Occupation

Suicide is a major public health concern within the United States. Suicide is the tenth leading cause of death for all age groups and the second leading cause of death among young adults aged 15-35. This literature review examines the increase of suicide death rates in young adults age 15-35, specifically young adult minority groups. African American, American Indian, Asian American and Hispanic American have unique occupational challenges that led to the act of suicide. In this review various protective and risk factors are examined to determine the best intervention and prevention measures required to address the epidemic of young …

Center For Teaching & Learning + Scott Memorial Library: Academic Year 2016/2017, Liz Mikita

Annual Reports & Administrative Documents

Contents:

• About Us
• Staff Highlights
• Milestones
• Metrics
• Programs & Exhibits

Ordinal Convolutional Neural Networks For Predicting Rdoc Positive Valence Psychiatric Symptom Severity Scores, Anthony Rios, Ramakanth Kavuluru

Computer Science Faculty Publications

Background—The CEGS N-GRID 2016 Shared Task in Clinical Natural Language Processing (NLP) provided a set of 1000 neuropsychiatric notes to participants as part of a competition to predict psychiatric symptom severity scores. This paper summarizes our methods, results, and experiences based on our participation in the second track of the shared task.

Objective—Classical methods of text classification usually fall into one of three problem types: binary, multi-class, and multi-label classification. In this effort, we study ordinal regression problems with text data where misclassifications are penalized differently based on how far apart the ground truth and model predictions are …

Risk Factors Of Cardiovascular Disease And Its Recommendations In Pakistani Context., Rubina Barolia, Amber Hussain Sayani

School of Nursing & Midwifery

Cardiovascular diseases possess a major cause for fatality and disability the world over. Since last several decades, the rates of cardiovascular diseases-related deaths have decreased in a number of high-income countries but increased in low- and middle-income countries with around 80% of the burden. Despite the seriousness of cardiovascular diseases in low- and middle-income countries, minimal attention is given to the prevention of cardiovascular diseases risk factors in South Asia, particularly in Pakistan. In addition, economic and political instability is accelerating the rates of cardiovascular diseases in the country. Practical efforts are required to enhance the understanding of cardiovascular diseases …

Flipped Classroom Instructional Approach In Undergraduate Medical Education, Syeda Sadia Fatima, Fazal Manzoor Arain, Ather Enam

Department of Biological & Biomedical Sciences

Objective: In this study we implemented the “flipped classroom” model to enhance active learning in medical students taking neurosciences module at Aga Khan University, Karachi.
Methods: Ninety eight undergraduate medical students participated in this study. The study was conducted from January till March 2017. Study material was provided to students in form of video lecture and reading material for the non-face to face sitting, while face to face time was spent on activities such as case solving, group discussions, and quizzes to consolidate learning under the supervision of faculty. To ensure deeper learning, we used pre- and post-class …

Second Primary Malignant Neoplasms And Survival In Adolescent And Young Adult Cancer Survivors., Theresa H M Keegan, Archie Bleyer, Aaron S Rosenberg, Qian Li, Melanie Goldfarb

Articles, Abstracts, and Reports

Importance: Although the increased incidence of second primary malignant neoplasms (SPMs) is a well-known late effect after cancer, few studies have compared survival after an SPM to survival of the same cancer occurring as first primary malignant neoplasm (PM) by age.

Objective: To assess the survival impact of SPMs in adolescents and young adults (AYAs) (15-39 years) compared with that of pediatric (<15 >years) and older adult (≥40 years) patients with the same SPMs.

Design, Setting, and Participants: This was a population-based, retrospective cohort study of patients with cancer in 13 Surveillance, Epidemiology and End Results regions in the United …

The Oversimplification Of Deregulation: A Case Study On Clinical Decision Support Software, Deeva V. Shah

Michigan Telecommunications & Technology Law Review

Until the December 2016 passage of the Cures Act, the FDA had regulatory power over clinical decision support (CDS) software; however, the Act removed a large group of CDS software from the FDA’s statutory authority. Congressional intent was to increase innovation by removing regulatory blockades—such as device testing and certification—from the FDA’s purview. This note argues that the enactment of this specific provision of the Act will instead stymie innovation and overlook the unfortunate safety consequences inherent in its deregulation. CDS software is a burgeoning field ripe for innovation; however, rapid innovation can often lead to a slew of mistakes—mistakes …

M-U-N-I: Evidencing The Inadequacies Of The Municipal Securities Regulatory Framework, John Carriel

The Business, Entrepreneurship & Tax Law Review

This article argues that the current regulation of the minicipal securities market is inadequate, and that regulatory reform is not only necessary but also permissible as the Securities and Exchange Commission has the legal authority under the current statutory framework to substantially remedy such inadequacy. In making this argument, this article focuses on the legislative history of the Securities Reform Act of 1975, analyses of statutory text, the current regulatory framework surrounding the municipal securities market, prior attempts to effect regulatory reform, and one of the principal issues with the current regulatory framework - the lack of uniform accounting principles …

Psikopatlar, Frengililer, Veremliler, Ve Mâderzâd Caniler: Osmanli’Dan Cumhuriyet Türkiye’Sine Dejenerasyon Korkusu, Yucel Yanikdag

History Faculty Publications

19I9'da İfham gazetesinde çıkan bir yazısımda, Ömer Seyfettin kendi­sine eski Dahiliye Nazırı Adil Bey tarafindan gönderilen bir mektuptan alımtı yapar. Mektubun burada bizi ilgilendiren kısmı "Türkiye'dc dört milyon Türk vardıf, diyorlar. Bu dört milyondan iki buçuk milyonu geçen muharebede öldü. Geriye kala kala bir buçuk milyon kaldı. Bu bir buçuk milyonunun da dejenere olduğunu muhterem alim, Filozof Rıza Tevfik'le Selim Sırrı Bey müşterek bir makalelerinde vazıhan ispat ettiler," der. Verilen toplam rakamdaki sorun bir yana, nüfusun deje­nere veya tereddi olma konusu ilk defa gündeme gelmiyordu. Ağustos 1915'de psikiyatr Mazhar Osman "Türklerin" mütereddi olup olma­dığına yanıt vermeye çalıştı. O tarihte Osmanlı …

Headwaters To Oceans: Ecological And Biogeochemical Contrasts Across The Aquatic Continuum, Marguerite A. Xenopoulos, John A. Downing, M. Dileep Kumar, Susanne Menden-Deuer, Maren Voss

Graduate School of Oceanography Faculty Publications

While the disciplines of oceanography and limnology often operate in isolate, freshwater, estuarine, and marine ecosystems are intricately linked. The emphasis of this special issue for Limnology and Oceanography is on the aquatic continuum and the connectivity between aquatic ecosystems from headwater streams and inland waters, to coastal and marine systems. Changes in the transport and transformation of elements as well as ecological functions occur along this aquatic continuum. Assemblages of organisms change in a way that reflects the ecological and biogeochemical conditions of the aquatic gradient. Here, we highlight research progress in limnology and oceanography across the aquatic continuum …

Alectryon Vitiensis: A New Species Of Sapindaceae Endemic To Fiji, Sven Buerki, Porter P. Lowry Ii, Jérôme Munzinger, Marika Tuiwawa, Alivereti Naikatini, Martin W. Callmander

Biology Faculty Publications and Presentations

A new species of Alectryon Gaertn. (Sapindaceae) endemic to the Fijian archipelago is described as A. vitiensis Buerki, Lowry, Munzinger & Callm. based on morphological and molecular evidence. It can easily be distinguished from the two congeners currently known from Fiji by its smaller leaves, subsessile leaflets, apetalous flowers, and crested fruits. A phylogenetic analysis using ITS sequence data shows that the new species is closely related to two Australian endemics, A. diversifolius (F. Muell.) S. T. Reynolds and A. oleifolius (Desf.) S. T. Reynolds, but differs in having compound leaves covered with a golden indument. Moreover, the Australian taxa …

Organic Solvent Exposure And Depressive Symptoms Among Licensed Pesticide Applicators In The Agricultural Health Study, Miriam Siegel, Sarah E. Starks, Wayne T. Sanderson, Freya Kamel, Jane A. Hoppin, Fred Gerr

Epidemiology and Environmental Health Faculty Publications

Purpose

Although organic solvents are often used in agricultural operations, neurotoxic effects of solvent exposure have not been extensively studied among farmers. The current analysis examined associations between questionnaire-based metrics of organic solvent exposure and depressive symptoms among farmers.

Methods

Results from 692 male Agricultural Health Study participants were analyzed. Solvent type and exposure duration were assessed by questionnaire. An “ever-use” variable and years of use categories were constructed for exposure to gasoline, paint/lacquer thinner, petroleum distillates, and any solvent. Depressive symptoms were ascertained with the Center for Epidemiologic Studies Depression Scale (CES-D); scores were analyzed separately as continuous (0–60) …

Hexapod Herald - Vol. 29, No. 5, November 2017

Hexapod Herald and Other Entomology Department Newsletters

Contents: Welcome - Congratulations - ESA National Annual Meeting News, November 5-8. 2017, Denver, CO - Student News - Faculty News - Publications - Blast from the Past - Meet an Online Student - Grants - BugFest 2017