Digital Commons Network^™

Targeting A Microrna Shows Potential To Enhance Effectiveness Of Diabetes Drugs, Jeff Hansen

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No abstract provided.

Uab Establishes Obesity Health Disparities Research Center, Staff

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No abstract provided.

Editorial: Modeling The Plankton-Enhancing The Integration Of Biological Knowledge And Mechanistic Understanding, Christian Lindemann, Dag L. Aksnes, Kevin J. Flynn, Susanne Menden-Deuer

Graduate School of Oceanography Faculty Publications

No abstract provided.

Scholastic Minutes 11/07/2017, Scholastic Committee

Scholastic Committee

No abstract provided.

Arresting Narratives: Incommensurability, Policing, And Settler Security, Darcy H. Brazen

American Studies ETDs

Settler colonialism is interrogated through the practice of arrest. Case studies of arrests at Standing Rock validate the historical salience of settler colonialism as a structure enabling Indigenous elimination and settler replacement that is dependent upon arrest to maintain and enhance settler lives and the settler project through unfettered access to Native land and resources for capital accumulation. Arrest is analyzed in relationship to statehood initiatives, the procuring of settler security, frontier feminism, and road signage in the masculine zones of travel in 1930s North Dakota. Contemporaneous reports from Standing Rock, the memoirs of Elaine Goodale Eastman and newspaper articles …

Targeting A Microrna Shows Potential To Enhance Effectiveness Of Diabetes Drugs, Jeff Hansen

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No abstract provided.

Interview With John Lyda, Cherice Bock, Ralph Beebe

War & Conscientious Objection in Northwest Yearly Meeting of Friends, 1940-1975

John Lyda talks about his religious and familial influences that persuaded him to register as a conscientious objector during the Vietnam War. He also discusses how his two sons serve in the military and how their experience in the Quaker church differs from his own.

The Control Of Water Contaminants Assisted By Natural Materials, Wen Zhao

USF Tampa Graduate Theses and Dissertations

Natural materials can be used to remove water contaminants by applying proper physical, chemical, and biological water treatment processes. This study involves using natural materials, as they are considered to be more environmentally benign and cost-effective than synthetic materials. This dissertation concentrates on monitoring five major water quality parameters—ammonia, fluoride, turbidity, pH, and fecal indicator bacteria (FIB) —in two major applications where clean water is needed. The focus is on meeting the water quality requirements for each contaminant. The overall objective of this study is to control the levels of ammonia in aquaculture wastewater, and adjust fluoride, turbidity, pH, and …

Ventricular Depolarisation Vectors In Exercise Induced Myocardial Ischaemia, Cameruddin W. Vellani, Mohammad Yusuf, Sadia Mahmud, Satwat Hashmi

Section of Cardiology

Ischaemia reduces membrane excitability and conduction of myocardial depolarisation. This would alter the synergy of electromotive forces that contribute to a resultant force at any instant. Changes in magnitude and direction of resultant forces are reflected in electrocardiographic signals. Here we show a method for obtaining the coordinates of resultant electrical forces during exercise derived from a bipolar orthogonal lead system for calculation of electrical vectors in three planes. In a trial, analysis of changes in vectors indicated that the extent of reduction in magnitude with exercise was significantly greater in groups of patients categorized by impaired effort tolerance and …

Pharmaceutical Compounds And Use Of Same In Cancer And Tauopathies, Jason E. Gestwicki, Chad Dickey

USF Patents

Disclosed are compounds of formula (l)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease (AD). The presence of abnormal tau correlates with neuron loss and memory deficits in patients with AD and other neurodegenerative disorders that involve tau accumulation.

Method Of Treatment Of Cancer Using Guanosine 3', 5' Cyclic Monophosphate (Cyclic Gmp), David L. Vesely

USF Patents

A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 .mu.M), 84% (1 mM), 31% (1 .mu.M), and 30% (1 .mu.M), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 .mu.M concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic …

Polarity Sorting Of Axonal Microtubules: A Computational Study, Erin M. Craig, Howard T. Yeung, Anand N. Rao, Peter W. Baas

All Faculty Scholarship for the College of the Sciences

We present a computational model to test a “polarity sorting” mechanism for microtubule (MT) organization in developing axons. We simulate the motor-based axonal transport of short MTs to test the hypothesis that immobilized cytoplasmic dynein motors transport short MTs with their plus ends leading, so “mal-oriented” MTs with minus-end-out are transported toward the cell body while “correctly” oriented MTs are transported in the anterograde direction away from the soma. We find that dynein-based transport of short MTs can explain the predominately plus-end-out polarity pattern of axonal MTs but that transient attachments of plus-end-directed motor proteins and nonmotile cross-linker proteins are …

Lmp1 Signaling Pathway Activates Irf4 In Latent Ebv Infection And A Positive Circuit Between Pi3k And Src Is Required, Ling Wang, Junping Ren, Guang Li, Jonathan P. Moorman, Zhi Q. Yao, Shunbin Ning

ETSU Faculty Works

Interferon (IFN) regulatory factors (IRFs) have crucial roles in immune regulation and oncogenesis. We have recently shown that IRF4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells. However, the intracellular signaling pathway triggering Src activation of IRF4 remains unknown. In this study, we provide evidence that Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) promotes IRF4 phosphorylation and markedly stimulates IRF4 transcriptional activity, and that Src mediates LMP1 activation of IRF4. As to more precise mechanism, we show that LMP1 physically interacts with c-Src, and the phosphatidylinositol 3 kinase (PI3K) subunit P85 mediates their interaction. Depletion of P85 by …

Influence Of Smoking On Lipid Profile In Iraqi Men, Safa W. Azize

Muthanna Medical Journal

Cigarette smoking is generally considered as associated with increased risk of a variety of medical disorders. Several studies provide the evidences that a smoking is strongly associated with change the normal status of the lipid profile. The present study aimed to compare the lipid profile between smokers and non-smokers and to determine the influence smoking on the lipid profile in our community. Forty smoking males and thirty non-smoking males from different areas of Babylon governorate were included in this study. Their age was ranged between 20 and 40 years. Fasting blood was withdrawn from all groups and used for determination …

Efficacy Of An Adenoviral Vectored Multivalent Centralized Influenza Vaccine, Amy Lingel, Brianna L. Bullard, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

Mice were immunized with Adenovirus expressing the H1-con, H2-con, H3-con and H5-con HA consensus genes in combination (multivalent) and compared to mice immunized with the traditional 2010–2011 FluZone and FluMist seasonal vaccines. Immunized mice were challenged with 10–100 MLD50 of H1N1, H3N1, H3N2 and H5N1 influenza viruses. The traditional vaccines induced robust levels of HA inhibition (HI) titers, but failed to protect against five different heterologous lethal influenza challenges. Conversely, the multivalent consensus vaccine (1 × 1010 virus particles (vp)/mouse) induced protective HI titers of ≥40 against 8 of 10 influenza viruses that represent a wide degree of divergence within …

Julia Ballenger, Oral History Index, Juila Ballenger, Anne Poulos

All Oral Histories

This is an index of an oral history interview with Dr. Julia Ballenger. It was conducted on November 7, 2017. The interviewer is Anne Poulous.

In this interview, Dr. Julia Ballenger discusses her experiences growing up in East Texas, and what it was like when public school began to desegregate in 1967, which was her senior year in high school. Upon graduation from high school, she attended East Texas State University from 1967 to 1973. She earned a bachelor's and a master's degree from ETSU.

Julia Ballenger grew up in Tyler, Texas, and graduated from Jackson High School in 1967, …

The George-Anne, Georgia Southern University

The George-Anne

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The Ecology Of Antibiotic Resistance: Sources And Persistence Of Vancomycin-Resistant Enterococci And Antibiotic Resistant Genes In Aquatic Environments, Suzanne M. Young

USF Tampa Graduate Theses and Dissertations

The growing crisis of antibiotic resistance is a major threat to ecosystems and human health. Infections caused by known and emerging antibiotic resistant pathogens are on the rise globally, with approximately 700,000 deaths per year caused by antibiotic resistant bacteria (1). In the United States, infections from antibiotic resistant bacteria cause more than 2 million illnesses and 23,000 deaths (2). Antibiotic resistant bacteria and antibiotic resistance genes are released into aquatic ecosystems through hospital waste, residential sewer lines and animal agricultural waste streams. Animal agriculture accounts for approximately 70% of antibiotic use in the United States (3). In agricultural ecosystems, …

Ros Control Mitochondrial Motility Through P38 And The Motor Adaptor Miro/Trak., Valentina Debattisti, Akos A. Gerencser, Masao Saotome, Sudipto Das, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mitochondrial distribution and motility are recognized as central to many cellular functions, but their regulation by signaling mechanisms remains to be elucidated. Here, we report that reactive oxygen species (ROS), either derived from an extracellular source or intracellularly generated, control mitochondrial distribution and function by dose-dependently, specifically, and reversibly decreasing mitochondrial motility in both rat hippocampal primary cultured neurons and cell lines. ROS decrease motility independently of cytoplasmic [Ca2+], mitochondrial membrane potential, or permeability transition pore opening, known effectors of oxidative stress. However, multiple lines of genetic and pharmacological evidence support that a ROS-activated mitogen-activated protein kinase (MAPK), p38α, is …

Open Access Publishing In Developed Countries: A Comparative Study Between United States Of America And United Kingdom, Irfan Ul Haq Akhoon

Library Philosophy and Practice (e-journal)

The present study measured quantitatively the current position and growth of Open Access archives, at the first stage it gives a quantitative overview of Open Access archives established and published from different developing and developed countries. Further it focuses on a comparative study between United States of America (USA) and United Kingdom (UK) the two developed nations. Open access journals indexed in Scopus database are being surveyed for this study. As the study is based on the data collected from the Scopus database upto July 2017, which shows that the total number of journals indexed are 36377 in which 63% …

Patient Experience Of Taking Adjuvant Endocrine Therapy For Breast Cancer: A Tough Pill To Swallow, Kuang-Yi Wen, Rita Smith, Aruna Padmanabhan, Lori Goldstein

Patient Experience Journal

Adjuvant endocrine therapy (AET) has substantially improved the mortality rate among breast cancer survivors. Despite the proven efficacy, the non-adherence rate to therapy is still high. This study is aimed to examine women’s challenges related to AET adherence and management. Semi-structured interviews were conducted with six Caucasian and six African American breast cancer survivors who were prescribed for AET. The transcripts of audio-taped interviews were qualitatively analyzed. Key themes were: 1) positive beliefs in AET, 2) uncertainty about long-term adherence, 3) experiences with side effects, 4) forgetting and remembering, 5) other concerns and information needs, 6) potential intervention format, and …

Healthcare Providers Versus Patients' Understanding Of Health Beliefs And Values, Betty M. Kennedy, Matloob Rehman, William D. Johnson, Michelle B. Magee, Robert Leonard, Peter T. Katzmarzyk

Patient Experience Journal

This study examined how well healthcare providers perceive and understand their patients’ health beliefs and values compared to patients’ actual beliefs, and to determine if communication relationships maybe improved as a result of healthcare providers’ understanding of their patients’ illness from their perspective. A total of 61 participants (7 healthcare providers and 54 patients) were enrolled in the study. Healthcare providers and patients individually completed survey instruments and each participated in a structured focus group. Healthcare provider and patient differences revealed that patients perceived greater meaning of their illness (p = 0.038), and a greater preference for partnership (p = …

In Place: November 6, 2017, Place

PLACE Historical Documents

In PLACE is a newsletter designed to keep the Linfield College community apprised of information related to PLACE activities, as well as ways to bring the program into classes. Included in this issue:

• Spotlight On: PLACE Sponsored Events
• Upcoming Events
• PLACE in the News

11-06-2017 Winners Announced For Swosu Homecoming Activities, Southwestern Oklahoma State University

THE BARK ARCHIVE 2017

Southwestern Oklahoma State University in Weatherford celebrated Homecoming on November 4, and winners of the various competitions have been announced.

11-06-2017 Noble Research Institute Professor To Speak Wednesday At Swosu, Southwestern Oklahoma State University

THE BARK ARCHIVE 2017

Dr. Carolyn Young, associate professor of molecular mycology in the Forage Improvements Division at the Samuel Roberts Noble Research Institute, will be guest speaker at the Southwestern Oklahoma State University Department of Biological Sciences J.D. Maness Seminar Series this Wednesday, November 8.

Grand Valley Forum, Volume 042, Number 06, November 6, 2017, Grand Valley State University

2017-2018, Volume 42

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Gc Minutes 2017-11-06, Northern Illinois University

Graduate Council Archives

No abstract provided.

The Statesman, V. 61, I. 11, Stony Brook University

Stony Brook Statesman-Sucolian

v. 61, i. 11;

Ada News - 11/06/2017, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Emergence Of The L Phenotype In Group B Streptococci In The South Of Ireland, Katherine Hayes, Lesley Cotter, L. Barry, Fiona O'Halloran

Department of Biological Sciences Publications

Group B Streptococcal isolates (n = 235) from the South of Ireland were characterised by serotyping, antimicrobial susceptibility and determination of the phenotypic and genotypic mechanisms of resistance. Resistance to erythromycin and clindamycin was observed in 21·3% and 20·4% of the total population, respectively. The c-MLSB phenotype was the most common phenotype detected (62%), with ermB being the predominant genetic determinant, present in 84% of resistant isolates. The rare L phenotype was observed in 2·9% (n = 7) of isolates, four of which harboured the lsaC gene responsible for clindamycin resistance. Serotypes Ia, III and II were the most common …