Digital Commons Network^™

The Source, Yolanda Carr, C.J. Smith

The Source

No abstract provided.

Endonucleolytic Cleavage In The Expansion Segment 7 Of 25s Rrna Is An Early Marker Of Low-Level Oxidative Stress In Yeast, Daniel Shedlovskiy, Jessica A Zinskie, Ethan Gardner, Dimitri G Pestov, Natalia Shcherbik

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The ability to detect and respond to oxidative stress is crucial to the survival of living organisms. In cells, sensing of increased levels of reactive oxygen species (ROS) activates many defensive mechanisms that limit or repair damage to cell components. The ROS-signaling responses necessary for cell survival under oxidative stress conditions remain incompletely understood, especially for the translational machinery. Here, we found that drug treatments or a genetic deficiency in the thioredoxin system that increase levels of endogenous hydrogen peroxide in the yeast Saccharomyces cerevisiae promote site-specific endonucleolytic cleavage in 25S ribosomal RNA (rRNA) adjacent to the c loop of …

Interactions Between Amyloid-Beta And Microglial Cells, Lisa Gouwens

Dissertations

Alzheimer’s disease (AD), the most common cause of dementia, is a neurodegenerative condition characterized by loss of memory and intellectual abilities. Intracellular plaques of aggregated amyloid-beta (Ab) protein are a well-known pathology associated with AD. Although symptoms usually appear late in life, the accumulation of Ab begins decades earlier and causes activation of microglia, the brain’s immune cells. The ensuing inflammation contributes significantly to neurodegeneration. Determination of the particular form of Ab that causes the most damage in the brain is one of the major questions in the AD field. My research focused on the interactions of microglia with monomers, …

The Possibility Of Naturalistic Jurisprudence: Legal Positivism And Natural Law Theory Revisited, Dan Priel

Articles & Book Chapters

Contemporary legal philosophy is predominantly anti-naturalistic. This is true of natural law theory, but also, more surprisingly, of legal positivism. Several prominent legal philosophers have in fact argued that the kind of questions that legal philosophers are interested in cannot be naturalized, such that a naturalistic legal philosophy is something of a contradiction in terms. Against the dominant view I argue that there are arguable naturalistic versions of both legal positivism and natural law. Much of the essay is dedicated to showing that such views are possible: I identify naturalistic versions of a “natural law” view, a “positivist” view, as …

Ecohouse Hosts Sustainable Thanksgiving Dinner With Veggies From Learning Garden, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Clinical Potential Of An Enzyme-Based Novel Therapy For Cocaine Overdose, Ting Zhang, Xirong Zheng, Ziyuan Zhou, Xiabin Chen, Zhenyu Jin, Jing Deng, Chang-Guo Zhan, Fang Zheng

Molecular Modeling and Biopharmaceutical Center Faculty Publications

It is a grand challenge to develop a truly effective medication for treatment of cocaine overdose. The current available, practical emergence treatment for cocaine overdose includes administration of a benzodiazepine anticonvulsant agent (e.g. diazepam) and/or physical cooling with an aim to relieve the symptoms. The inherent difficulties of antagonizing physiological effects of drugs in the central nervous system have led to exploring protein-based pharmacokinetic approaches using biologics like vaccines, monoclonal antibodies, and enzymes. However, none of the pharmacokinetic agents has demonstrated convincing preclinical evidence of clinical potential for drug overdose treatment without a question mark on the timing …

Integrating The Effects Of Salinity On The Physiology Of The Eastern Oyster, Crassostrea Virginica, In The Northern Gulf Of Mexico Through A Dynamic Energy Budget Model, Romain Lavaud, Megan K. La Peyre, Sandra M. Casas, Cédric Bacher, Jérôme F. La Peyre

Faculty Publications

© 2017 We present a Dynamic Energy Budget (DEB) model for the eastern oyster, Crassostrea virginica, which enables the inclusion of salinity as a third environmental variable, on top of the standard foodr and temperature variables. Salinity changes have various effects on the physiology of oysters, potentially altering filtration and respiration rates, and ultimately impacting growth, reproduction and mortality. We tested different hypotheses as to how to include these effects in a DEB model for C. virginica. Specifically, we tested two potential mechanisms to explain changes in oyster shell growth (cm), tissue dry weight (g) and gonad dry weight (g) …

Integrating Item Accuracy And Reaction Time To Improve The Measurement Of Inhibitory Control Abilities In Early Childhood, Brooke E. Magnus, Michael T. Willoughby, Clancy B. Blair, Laura J. Kuhn

Psychology Faculty Research and Publications

Efforts to improve children’s executive function are often hampered by the lack of measures that are optimized for use during the transition from preschool to elementary school. Whereas preschool-based measures often emphasize response accuracy, elementary school-based measures emphasize reaction time (RT)—especially for measures inhibitory control (IC) tasks that typically have a speeded component. The primary objective of this study was to test in a preschool-aged sample whether the joint use of item-level accuracy and RT data resulted in improved scoring for three IC tasks relative to scores derived from accuracy data alone. Generally, the joint use of item-level accuracy and …

Polynomial Regression Analyses Of Parental Desirable Responding, Megan Elizabeth Lilly

LSU Doctoral Dissertations

Child assessments have consistently yielded poor agreement between parent-child self-report measures and considerable research has failed to isolate the underlying source of the discrepancies. Validity testing has successfully been used to differentiate credible from non-credible performance, recognize feigned symptoms, and detect underestimates of ability in adults for decades (Sherman, 2015). Despite these potential benefits, attention to the importance of validity testing in the child assessment literature has been largely neglected. Many psychologists believe children are not capable of feigning or exaggerating their symptoms and lack the underlying motivations and incentives for deception found in adult assessments. Whereas, more research is …

The Cosm Aggregate, Georgia Southern University

College of Science & Mathematics: News & Publications (2012-2022)

No abstract provided.

2017 November 10 - Board Of Trustees Academic And Student Affairs Committee, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

The Effect Of Concentration Of Co2 On The Average Rate Of Photosynthesis In Spinach Leaf Disks, Amelia Robinson-Brown

Journal of the South Carolina Academy of Science

The purpose of this experiment was to determine the effect of carbon dioxide concentration on the rate of photosynthesis in spinach leaves. Small circular disks were cut out of the spinach leaves using a standard hole puncher. Then solutions of differing concentrations of carbon dioxide, 0.2%, 0.4%, 0.6%, 0.8%, and 1.0%, were all prepared, and each solution was spread equally among five cups. There was also a control solution that contained only water. Any gases within the leaves were then sucked with a syringe, using a specific technique to create a vacuum. For each solution of differing carbon dioxide concentration, …

The Echo: November 10, 2017, Taylor University

2017-2018 (Volume 105)

Taylor purchases a church for $1 – Thinking ahead, with your stomach – Circling like sharks – Townies and Trojans series: Hometown relations – Freedom fast to fight human trafficking – Bree’s Beat International News – Corrections – More than just CrossFit: A way to give life – Meet the Dominiques – Taylor University Survival Guide – New Column – Getting in the Sunday swing of things – Coming to your aid – Financial Terms to Know – Bi-weekly comic – Shop (up)lifting – Echograms #TaylorU -- #TaylorU’s Top Tweets – The Beatles are back – The music of millennials …

What's It To Me? Self-Interest And Evaluations Of Financial Conflicts Of Interest, Samuel Bruton, Donald Sacco

Faculty Publications

Disclosure has become the preferred way of addressing the threat to researcher objectivity arising from financial conflicts of interest (FCOIs). This article argues that the effectiveness of disclosure at protecting science from the corrupting effects of FCOIs—particularly the kind of disclosure mandated by US federal granting agencies—is more limited than is generally acknowledged. Current NIH and NSF regulations require disclosed FCOIs to be reviewed, evaluated, and managed by officials at researchers’ home institutions. However, these reviewers are likely to have institutional and personal interests of their own that may undermine the integrity of their evaluations. This paper presents experimental findings …

Teachers' Experience Of A Flood In Their School Community: Their Beliefs, Perceptions, And Thoughts About Practice, Caroline Tolentino

LSU Master's Theses

The increasing number of flooding incidences in Louisiana exposes a significant number of children to the possible traumatic effects of this natural disaster. Flooding takes a toll not only on families and children, but on teachers as well. While the effects of other types of disasters on children have been considered in previous studies, research has not thoroughly addressed the effects of flooding on children and on early childhood teachers. Teachers can be very instrumental in helping young children cope and making sure their needs are met after the experience of a traumatic event (Perry & Szalavitz, 2008; Le Brocque, …

The Parthenon, November 10, 2017, Jared Casto

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2016 Fall semester, the newspaper is only published two days a week. Physical issues are printed on Tuesdays and Fridays. The editorial staff is responsible for the news and the editorial content.

Gender Gaps In Math Performance, Perceived Mathematical Ability And College Stem Education: The Role Of Parental Occupation, Lina Anaya, Frank P. Stafford, Gema Zamarro

Education Reform Faculty and Graduate Students Publications

Employment opportunities in occupations related to Science, Technology, Engineering, and Mathematics, the so-called STEM fields, are predicted to continue growing through time. In addition, STEM occupations also enjoy higher wages on average. Despite these advantages, women remain under-represented in STEM college degree completion and occupations. Encouraging women into the STEM fields has become an important policy concern. We use longitudinal data from the Panel Study of Income Dynamics to study gender differences in math achievement and self-perceived math ability and how they may differ by parental occupation type, specifically science related versus non-science related parental occupations. We then study their …

Proposed Method For Measuring The Let Of Radiotherapeutic Particle Beams, Stephen D. Bello

Physics & Astronomy ETDs

The Bragg peak geometry of the depth dose distributions for hadrons allows for precise and effective dose delivery to tumors while sparing neighboring healthy tissue. Further, compared against other forms of radiotherapeutic treatments, such as electron beam therapy (EBT) or photons (x and \(\gamma\)-rays), hadrons create denser ionization events along the particle track, which induces irreparable damage to DNA, and thus are more effective at inactivating cancerous cells. The measurement of radiation's ability to inactivate cellular reproduction is the relative biological effectiveness (RBE). A quality related to the RBE that is a measurable physical property is the linear energy transfer …

Education And Health Impacts Of An Affirmative Action Policy On Minorities In India, Robin Dhakal

USF Tampa Graduate Theses and Dissertations

Article 334 of the Constitution of India (1950) stipulates that certain electoral districts in each state should be reserved for minority groups, namely the “Scheduled Caste”(SC) and the Scheduled Tribe”(ST), through the reservation of seats in the states' legislative assemblies. Even though the original article stated that the reservation policy would be in place for just twenty years, it has been amended several times and is still in effect. This dissertation examines the impact of the policy on the education and health outcomes of the SC population. Variations in seat quotas are generated by the timing of elections in different …

Antimicrobial Study Of Azo-Imidazole (Five Cycles) Compounds, Samah Ahmed Kadhum, Aseel Fadhil Kareem

Muthanna Medical Journal

Azo-imidazole compounds are class of important organic compounds that are containing ( azo group with imine group, hetero cycles with hetero atoms ) which considered to be the previously derivatives that have pharmacological and biological activities toward many types of pathogenic organisms due to their content of nitrogen and chlorine atoms in their structures. We prepared four types of azo- imidazole derivatives (C15, C16, C17 and C18) at three different concentrations (5, 10 & 20 mg/ml-1) to study their antimicrobial activity against two types of bacteria (E. coli and P. vulgaris) and two types of fungi (A. niger & P. …

November Agenda, Wku Graduate Council

Graduate School

Meeting agenda.

Biographical Sketches Of The 2013 Agora Writers`, Editor Editor

Agora

No abstract provided.

A Philosophical Journey Through Miracles, The Metaphysics, And The Summa Contra Gentiles, David Bayless

Agora

No abstract provided.

Moving Beyond Discomfort: Race Relations Expert Discusses How To Talk About Race, Edward Fitzpatrick

Featured News Story

Beverly Daniel Tatum shares strategies on building diversity and inclusion in RWU’s “Talking about Race, Gender and Power” series.

Cardiovascular Health Is Associated With Physical Function Among Older Community Dwelling Men And Women., Yichen Jin, Toshiko Tanaka, Yan Ma, Stefania Bandinelli, Luigi Ferrucci, Sameera A Talegawkar

Exercise and Nutrition Sciences Faculty Publications

Background

Age related decline in physical function is a significant concern affecting the quality of life of older individuals.

Methods

We examined the associations between baseline overall cardiovascular health (CVH), its components, and physical function in 906 men and women from the InCHIANTI cohort. Physical function was assessed using the Short Performance Physical Battery and poor physical function was defined as an Short Performance Physical Battery score less than 10. Overall CVH score, ranging from 0 to 12 in the cohort, was operationalized using adherence to ideal levels for health behaviors including smoking status, physical activity, body mass index, and …

Rhoa Gtpase Controls Yap-Mediated Ereg Signaling In Small Intestinal Stem Cell Maintenance, Ming Liu, Zheng Zhang, Leesa Sampson, Xuan Zhou, Kodandaramireddy Nalapareddy, Benjamin Feng, Shailaja Akunuru, Jaime Melendez, Ashley Kuenzi Davis, Feng Bi, Hartmut Geiger, Mei Xin, Yi Zheng

Peer Reviewed Articles

RHOA, a founding member of the Rho GTPase family, is critical for actomyosin dynamics, polarity, and morphogenesis in response to developmental cues, mechanical stress, and inflammation. In murine small intestinal epithelium, inducible RHOA deletion causes a loss of epithelial polarity, with disrupted villi and crypt organization. In the intestinal crypts, RHOA deficiency results in reduced cell proliferation, increased apoptosis, and a loss of intestinal stem cells (ISCs) that mimic effects of radiation damage. Mechanistically, RHOA loss reduces YAP signaling of the Hippo pathway and affects YAP effector epiregulin (EREG) expression in the crypts. Expression of an active YAP (S112A) mutant …

Faculty Council Minutes November 9, 2017, Bronx Community College Faculty Council

BCC Governance Archives

Minutes for the meeting of the Faculty Council on November 9, 2017.

Student Movement - Issue 9, Andrews University

Student Movement v. 102 (2017-2018)

Student Movement, Issue 9, 2017

November 9, 2017, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Biology Of Sharks And Their Relatives Bio 422x, Michael Cerbo

Library Impact Statements

No abstract provided.