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Dsrna Sensing In Fish Cells: Using Chse-214 As A Model For The Study Of Class A Scavenger Receptors, Andrea Monjo

Theses and Dissertations (Comprehensive)

When infecting cells, most viruses produce dsRNA molecules at some point in their replicative cycle. When an infection results in cell lysis, these molecules are released into the extracellular space. Class A scavenger receptors (SR-As) on the surface of animal cells bind extracellular dsRNA and bring it into the cell where dsRNA triggers an innate immune response, enabling the cell to protect itself from an impending virus infection. Very few cells are unable to bind and respond to extracellular dsRNA, thus cell-based assays for studying extracellular dsRNA sensing via SR-As have been limited. CHSE-214 cells are a promising model for …

Size And Shape Control In Metal Nanoparticles And Nanocomposites, Tomendro Subedi

Theses and Dissertations (Comprehensive)

This thesis describes major findings on the shape transformation of the precursor silver decahedral nanoparticles (AgDeNPs) with pentagonal symmetry and twin defects into silver pentagonal prism nanoparticles (AgPPNPs) using Br¯ as a shape selective reagent. Silica-encapsulation of the gold-plated AgDeNPs was also carried out forming ordered arrays of silica encapsulated gold-plated AgDeNPs (SiO₂@Au@AgDeNPs) of different sizes. At first, synthetic procedures for AgDeNPs (pentagonal bipyramids), silver pentagonal rod nanoparticles (AgPRNPs) and gold-plating of AgDeNPs (Au@AgDeNPs) were optimized. Gold plating enhances the chemical stability of AgDeNPs and preserves the superior plasmonic properties of silver. This thesis deals with the transformation …

Exclusion From Rights Through Extra-Territoriality At Home: The Case Of Paris Roissy-Charles De Gaulle Airport's Waiting Zone, Pauline Gj Maillet

Theses and Dissertations (Comprehensive)

In this dissertation I argue that, since the 1980s, French airports have been designed to exclude people from legal, human and refugee rights. The particular space where this happens has been successively called “international zone”, “transit zone” and “waiting zone” and its scope has been significantly extended overtime. I contend that French authorities have used the concept of extra-territoriality in concert with the material design of the airport to sustain exclusion. While this research focuses on France, findings bear relevance to the global governance of migrants and refugees. The French case epitomizes how states creatively use the law (or absence …

A Comprehensive Study Of Personal And Social Information Use In Female Brown-Headed Cowbirds, Molothrus Ater, Hayden Davies, David J. White

Theses and Dissertations (Comprehensive)

Brood parasites face considerable cognitive challenges when locating and selecting host nests for their young. One aspect of this challenge is determining how to use different sources of information to make decisions regarding the quality of a prospective nest. Here we investigate how female-brown-headed cowbirds, Molothrus ater, use information when prospecting for nests, and then expand upon this to investigate decisions related to foraging. In chapter 1, we demonstrated female could use social information acquired from observing the nest prospecting patterns of conspecifics to influence their own patterns of nest selection. Furthermore, we found a negative relationship between a …

Students' Experiences Of The Scent-Free Initiative At The Faculty Of Social Work, Tanya Marie Smith

Theses and Dissertations (Comprehensive)

This research project sought to explore how students experienced the introduction of a scent-free initiative within the Faculty of Social Work at Wilfrid Laurier University. An intersectional, critical disability approach is used to understand participants' experiences and to identify gaps in implementation, as well as recommendations for future policy development. Working from a transformative paradigm, this study used a mixed methods design, including an online survey and in-person focus groups. Findings indicate that social work students felt well-informed about the initiative, however they did not feel adequately knowledgeable about how to embody the initiative via scent-free practices. Participants expressed stigmatizing …

Natural Organic Matter Characterization And Lead Speciation As Indicators Of Potential Lead Bioavailability In Aquatic Environments, Giselle Cimprich

Theses and Dissertations (Comprehensive)

Trace metals and natural organic matter (NOM) are ubiquitous in aquatic environments. Some trace metals are essential for aquatic life, while other non-essential metals (like lead) can be toxic if present in great enough concentrations. Natural waters contain a combination of inorganic, and organic ligands capable of binding metals. While the chemistry of inorganic Pb species is well understood, and National Institute of Standards and Technology (NIST) certified K values are readily available, the interactions between metals and organic matter is not so clearly defined. It is important to understand how NOM interacts with metals in the environment, as the …

The Experiences Of Athletes, Parents, And Coaches With The Long-Term Athlete Development Model (Ltad) In Youth Soccer Academies, Kody Watson

Theses and Dissertations (Comprehensive)

The Long-Term Athlete Development Model (LTAD) has been developed to allow children the best chance of engaging in lifelong sport and physical activity. The LTAD focuses on long-term development, not short-term success, which allows for the best opportunity of sport participation and optimal sport potential throughout life (Balyi, Way, & Higgs, 2013). Research surrounding the LTAD model has stated that there is a lack of empirical evidence of the model being utilized within sport, as some researchers believe that it is more theoretical than practical (Lloyd & Oliver, 2012). However, even with this criticism of the LTAD model, Canadian sport …

The Effect Of Twist On The Mechanical Properties Of The Intervertebral Disc, Maxine Harvey-Burgess

Theses and Dissertations (Comprehensive)

Introduction: Intervertebral disc (IVD) herniation is a common injury to the IVD and a frequent source of low back pain. IVD herniation occurs when the nucleus pulposus migrates through both the inter- and intralamellar matrices of the annulus fibrosus (AF). There are a number of mechanical risk factors associated with herniation, including repetitive flexion and twist. In vivo, twist combined with repetitive flexion has been associated with increased experience of low back pain and herniation. Additionally, in vitro, when repetitive flexion is combined with twist, IVD herniation occurs more easily than repetitive flexion alone. However, the mechanisms behind …

"The Outside Of The Inside;" Experiences Of Discovering Home And Community Within Waterloo Region, Nicole Greig

Theses and Dissertations (Comprehensive)

Abstract: The primary purpose of this research study is to explore the narratives of individuals experiencing homelessness within Waterloo Region as well as the practices of those working with the homeless population. The experience of homelessness is often met with an intersection of complex issues including mental health, substance abuse, deteriorating physical health, trauma, etc. Within this study, the concept of “home” and “community” are explored through the lens of homeless men living with these complicated challenges within the context of Waterloo Region. This qualitative study consisted of semi-structured interviews with six service providers and twelve men who were currently …

Experiences Of Racialized Service Providers Who Work With Racialized Clients: Functions And Constraints Of Master And Counter-Narratives Of Helping, Racism, And Vicarious Racism, Prapti Giri

Theses and Dissertations (Comprehensive)

What are the experiences of racialized frontline workers? How do they experience vicarious racism? I interviewed 8 frontline workers who were involved in counseling racialized individuals. The narrative paradigm, constructivist self-development theory (CSDT), and critical race theory (CRT) were the theoretical frames that guided the interviews and data analysis in order to answer these questions. I conducted a structural narrative analysis, which revealed how participants utilized assumptions from master narratives and at other times countered them. Interviewees occasionally stepped outside of the master narrative entirely, for example, by rejecting the categorization of race. According to CSDT, our meanings are determined …

Uncovering The Protological Hermeneutics Of George Mccready Price And Benjamin Warfield, Sergio L. Silva

Dissertations

Problem

The problem this dissertation addresses is the protological hermeneutical impasse between George McCready Price and Benjamin Warfield over whether biblical protology should be interpreted literally or symbolically in response to the evolutionary theory.

Method

To identify, compare, and contrast the protological hermeneutics of George McCready Price and Benjamin Warfield, this dissertation adopts an interdisciplinary methodology that seeks to integrate historical theology, systematic theology, and exegetical-biblical theology.

Conclusions

The protological hermeneutical impasse between George McCready Price and Benjamin Warfield over the interpretation of biblical protology was caused by how they applied their views on epistemology. On the hermeneutical level (where …

Critique Of A Dual-System Model Of Category Learning, C E R Edmunds

School of Psychology Theses

Some researchers have argued that the category learning literature is conclusive: people learn to generalise from past experiences to novel ones using multiple learning systems (Ashby & Maddox, 2011). To the extent that this claim is true, it is due in no small part to work investigating the predictions of the dual-system model COVIS (COmpetition between Verbal and Implicit Systems; Ashby, Alfonso-Reese, Turken, & Waldron, 1998). The work presented here investigates the evidence for this model. In Chapter 1, I describe the main features of the COVIS model and briefly review some of the evidence that supports this model. This …

A Sense Of The Cycling Environment: Felt Experiences Of Infrastructure And Atmospheres, Paul Simpson

School of Geography, Earth and Environmental Sciences

This paper explores how cyclists gain a sense of the environments they move through by considering their felt experiences of the affective atmospheres that emerge in and through their movements. More specifically, the focus falls upon how various forms of transport infrastructure choreograph bodies in their movements through the city and so contributes towards the co-production of various affective atmospheres between differently mobile bodies. Drawing on video interviews with 24 commuter cyclists in Plymouth, UK, the roles that such infrastructures and atmospheres play in shaping the experience of cycling through shared forms of transport space are considered. Based on this, …

The Effect Of Wastewater Effluent Derived Ligands On Copper And Zinc Complexation, C. Constantino, S. D.W. Comber, M. D. Scrimshaw

School of Geography, Earth and Environmental Sciences

No abstract provided.

Coupled Changes Between The H-Print Biomarker And Delta N-15 Indicates A Variable Sea Ice Carbon Contribution To The Diet Of Cumberland Sound Beluga Whales, T. A. Brown, E. Chrystal, S. H. Ferguson, D. J. Yurkowski, C. Watt, N. E. Hussey, T. C. Kelley, S. T. Belt

School of Geography, Earth and Environmental Sciences

No abstract provided.

Resolving Discrepancies Between Field And Modelled Relative Sea-Level Data: Lessons From Western Ireland, Robin Edwards, W. Roland Gehrels, Anthony Brooks, Ralph Fyfe, Katie Pullen, Joseph Kuchar, Kieran Craven

School of Geography, Earth and Environmental Sciences

No abstract provided.

A Singles' Ministry Project At The Mt. Rubidoux Seventh-Day Adventist Church In Riverside, California, Ekele Nwankwo

Doctor of Ministry Projects

Problem

The purpose of this study was to discover, develop, evaluate, and implement a supportive singles’ ministry at the Mt. Rubidoux Seventh-day Adventist church by way of planned activities and educative programs designed to serve the needs of singles in that congregation. The study was designed to determine the impact the singles’ ministry has on the church and how to shape the ministry in the future. Although society has viewed singles in different ways, depending on time and place, in traditional societies, women and men who did not marry were viewed as imperfect and lacking. Singles battle with strong expectations …

Novel Use Of Field-Portable-Xrf For The Direct Analysis Of Trace Elements In Marine Macroalgae., Annie Bull, Murray T. Brown, Andrew Turner

School of Geography, Earth and Environmental Sciences

Samples of dried marine macroalgae (Fucus serratus, Palmaria palmata and Ulva lactuca) have been analysed for trace elements by a novel, non-destructive approach involving a Niton field-portable-X-ray fluorescence (FP-XRF) spectrometer configured in a low density plastics mode with thickness correction. Detection limits for a 200-s counting time ranged from <5 μg g(-1) for As and Pb in F. serratus and As in P. palmata to several tens of μg g(-1) for Cd, Sb and Sn in all species tested. Arsenic, Cu, Pb and Zn were detected by the XRF in samples collected from a protected beach (n = 18) and in samples therefrom that had been exposed to additional aqueous elements in combination (n = 72) with concentrations returned (in μg g(-1)) ranging from 3.9 to 39.7 for As, 13.0 to 307 for Cu, 6.1 to 14.7 for Pb and 12.5 to 522 for Zn. Independent measurements of trace elements in the macroalgae by ICP-MS following nitric acid digestion revealed a direct and significant proportionality with concentrations returned by the XRF, with slopes of the XRF-ICP relationships (As = 1.0; Cu = 2.3; Pb = 2.4; Zn = 1.7) that can be used to calibrate the instrument for direct measurements. The approach shows potential for the in situ monitoring of macroalgae in coastal regions that is currently being investigated.

Tracking Reveals Limited Interactions Between Campbell Albatross And Fisheries During The Breeding Season, La Sztukowski, Toor Ml Van, H Weimerskirch, Dr Thompson, Lg Torres, Pm Sagar, Pa Cotton, Sc Votier

School of Biological and Marine Sciences

No abstract provided.

Nutrient Pumping By Submesoscale Circulations In The Mauritanian Upwelling System, P. J. Hosegood, P. D. Nightingale, A. P. Rees, C. E. Widdicombe, E. M.S. Woodward, D. R. Clark, R. J. Torres

School of Biological and Marine Sciences

No abstract provided.

Biocompatible Copper Oxide Nanoparticle Composites From Cellulose And Chitosan: Facile Synthesis, Unique Structure, And Antimicrobial Activity, Chieu D. Tran, James Makuvaza, Erik Munson, Brian Bennett

Chemistry Faculty Research and Publications

Copper in various forms has been known to have bactericidal activity. Challenges to its application include preventing mobilization of the copper, to both extend activity and avoid toxicity, and bioincompatibility of many candidate substrates for copper immobilization. Using a simple ionic liquid, butylmethylimmidazolium chloride as the solvent, we developed a facile and green method to synthesize biocompatible composites containing copper oxide nanoparticles (CuONPs) from cellulose (CEL) and chitosan (CS) or CEL and keratin (KER). Spectroscopy and imaging results indicate that CEL, CS, and KER remained chemically intact and were homogeneously distributed in the composites with CuONPs with size of 22 …

Active Site Structures Of Cyp11a1 In The Presence Of Its Physiological Substrates And Alterations Upon Binding Of Adrenodoxin, Qianhong Zhu, Piotr J. Mak, Robert C. Tuckey, James R. Kincaid

Chemistry Faculty Research and Publications

The rate-limiting step in the steroid synthesis pathway is catalyzed by CYP11A1 through three sequential reactions. The first two steps involve hydroxylations at positions 22 and 20, generating 20(R),22(R)-dihydroxycholesterol (20R,22R-DiOHCH), with the third stage leading to a C20–C22 bond cleavage, forming pregnenolone. This work provides detailed information about the active site structure of CYP11A1 in the resting state and substrate-bound ferric forms as well as the CO-ligated adducts. In addition, high-quality resonance Raman spectra are reported for the dioxygen complexes, providing new insight into the status of Fe–O–O fragments encountered during the …

User-Friendly Taxpaying, Kathleen Delaney Thomas

Faculty Publications

No abstract provided.

Dna Exonerations And The Elusive Promise Of Criminal Justice Reform, Carissa Byrne Hessick

Faculty Publications

Review of Wrongful Convictions and the DNA Revolution: Twenty-Five Years of Freeing the Innocent (Daniel S. Medwed ed., Cambridge University Press 2017).

Disparities In Infant Mortality: Are Sociocultural Risk Factors Shaped By Institutionalized Racism?, Madison Grimm

Honors Program Theses

The infant mortality rate (IMR) is an incredibly important indicator of the overall health of a nation. Because the IMR is so closely related with factors such as quality and accessibility of healthcare and socioeconomic conditions, it is helpful in evaluating a nation’s success. The United States (US) has one of the highest infant mortality rates among countries with a similar degree of economic development (those belonging to the OECD). In 2013, the IMR was 5.96 deaths per 1,000 live births, according to the Centers for Disease Control and Prevention, or CDC (Mathews, MacDorman, & Thoma, 2015). Furthermore, this rate …

Anolis Equestris (Cuban Knight Anole), Christopher J. Thawley, Andrew C. Battles, Sozos N. Michaelides, Jason J. Kolbe

Biological Sciences Faculty Publications

No abstract provided.

Controlled Manipulation Of Floating Objects On Deformed Fluid Interfaces And Conditions For Stable Equilibria, Jose M. Carballo, Qi Ni, Jose Vasquez, Nathan B. Crane

Faculty Publications

At the millimeter scale, interactions between floating and semi-immersed objects are significant. The local curvature of the interface is modified by the weight/buoyancy forces of floating objects, and by the surface properties of semi-immersed objects. The curvature changes generate attractive (or repulsive) interactions between floating parts, and semi-immersed objects. This work demonstrates how electrowetting can manipulate these interactions in order to position, align, assemble and transport parts attached to the fluid interface. This demonstrates one way in which fluid interfaces can provide an alternative to standard pick and place technology for part positioning/assembly. Typically, the part/rod forces are purely attractive …

Fundamental Principles Of Tremor Propagation In The Upper Limb, Andrew D. Davidson, Steven Knight Charles

Faculty Publications

Although tremor is the most common movement disorder, there exist few effective tremor-suppressing devices, in part because the characteristics of tremor throughout the upper limb are unknown. To clarify, optimally suppressing tremor requires a knowledge of the mechanical origin, propagation, and distribution of tremor throughout the upper limb. Here we present the first systematic investigation of how tremor propagates between the shoulder, elbow, forearm, and wrist. We simulated tremor propagation using a linear, time-invariant, lumped-parameter model relating joint torques and the resulting joint displacements. The model focused on the seven main degrees of freedom from the shoulder to the wrist …

Jewish Families In The United States, Trevan Hatch, Loren Marks, David C. Dollahite

Faculty Publications

As mentioned in chapter 8, the rich context of religious minority families offers the chance to highlight issues like identity formation in youth and emerging adults, the importance of social support from their religious community, and the unique challenges religious minorities face as they strive to live their religion. In this chapter we feature Judaism and the 30 Jewish families from the American Families of Faith project.

Let The Machines Out. Towards Hybrid Social Systems, M Straeubig

School of Art, Design and Architecture

INTRODUCTION When Alan Turing proposed the imitation game as a method to investigate the question if machines can think, he described a social system. However, the various disciplines that have pursued this seminal enquiry rarely touch base with sociological concepts. Cybernetics developed into various interdisciplinary fields, yet it was mainly rooted in physiological models. In the meantime, the mainstream of AI focused on cognitive problem solving, predominately from a topdown approach. Traditional cognitive science rests on the concept of organisms as information processing systems - so does Artificial Life, but from a biological simulation perspective. The recently revitalised branch of …