Digital Commons Network^™

Strategies For Reducing Employee Stress And Increasing Employee Engagement, Kumar G. Subramaniam

Walden Dissertations and Doctoral Studies

Stress inside and outside of work affects employee productivity. In 2013, the estimated impact of employee absenteeism on U.S. businesses was $225 billion per year through reduced efficiency, overtime wages, fixed fringe benefits, and the cost of replacement employees. Based on the social exchange theory and the theory of planned behavior, the purpose of this qualitative single case study was to explore the strategies that HR leaders in a single organization used to reduce employee disengagement caused by stress. Using semistructured interviews, data were collected from 12 HR leaders and line managers within a single healthcare organization in eastern Tennessee. …

Marine Science Summer Enrichment Camp's Impact Ocean Literacy For Middle School Students, Victoria Jewel Young

Walden Dissertations and Doctoral Studies

Although careers in science, technology, engineering, and mathematics have expanded in the United States, science literacy skills for K-12 students have declined from 2001 to 2011. Limited research has been conducted on the impact of science enrichment programs on the science literacy skills of K-12 students, particularly in marine science. The purpose of this study was to describe the impact of a marine science summer enrichment camp located in the eastern region of the United States on the ocean literacy skills of middle school students who participated in this camp. Weimar's learner centered teaching approach and the definition and principles …

Educational Module Toolkit To Assist Adult Patients With Type Ii Diabetes Mellitus, Dometrives Armstrong

Walden Dissertations and Doctoral Studies

Diabetes is a challenging chronic disease for adult patients to manage effectively. Poor adherence to prescribed medications treatment is one of the main reasons for poor blood sugar control. Despite healthcare providers' efforts to emphasize the importance of taking medications, adult patients with Type II diabetes frequently present with complications related to persistent failure to adhere to prescribed medication regimen. These patients should thoroughly understand why adhering to a strict medication regimen to maintain control of their blood sugar is so important. The purpose of this project, guided by Orem's self-care deficit nursing theory, was to develop an educational module …

Characterization Of Staphylococcal Nuclease And Tudor Domain Containing Protein 1 (Snd1) As A Molecular Target In Hepatocellular Carcinoma And Non-Alcoholic Steatohepatitis, Nidhi H. Jariwala

Theses and Dissertations

CHARACTERIZATION OF STAPHYLOCOCCAL NUCLEASE AND TUDOR DOMAIN CONTAINING PROTEIN 1 (SND1) AS A MOLECULAR TARGET IN HEPATOCELLULAR CARCINOMA AND NON-ALCOHOLIC STEATOHEPATITIS

Nidhi Jariwala, PhD

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Integrative Life Sciences

Virginia Commonwealth University, 2017

Devanand Sarkar, M.B.B.S., PhD.

Associate Professor, Department of Human and Molecular Genetics

Virginia Commonwealth University

Richmond, Virginia

SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcinoma (HCC). Oncoprotein SND1 regulates gene expression at a post-transcriptional level in multiple cancers including hepatocellular carcinoma (HCC). …

Women's Quest To Occupy Executive Positions In Corporate America, Erica Charles-Lynch

Walden Dissertations and Doctoral Studies

Women comprise 50.8% of the United States population and 47% of the workforce, and over the past few decades, many women have been promoted to midmanagement positions in Fortune 500 and other major corporations, but few run companies at the executive levels. The research problem addressed the underrepresentation of women in top leadership positions in the executive suite. The purpose of this study was to explore the perceptions of women in upper level management in large corporations on rising to the C-suite. A basic qualitative naturalistic inquiry was used employing interviews in collecting and analyzing the data. The targeted population …

Strategies To Secure Sustainable Funding For Nonprofit Organizations, Jasmine Y. Hardy

Walden Dissertations and Doctoral Studies

There are 1.4 million active nonprofit organizations in the United States; however, funding sustainability often forces nonprofit senior leaders into closure, which can lead to increased unemployment and decreased services provided to local communities. Nonprofit senior leaders seek help from scholars, at times, to identify strategies to secure sustainable funding sources, improve the sustainability of funding, or prevent or reverse losses of funding to their organizations. Through the conceptual lens of the general systems theory, the 2015-2016 Baldrige Excellence Framework and Criteria, and single- and double-loop learning, this single-case study explored strategies used to secure sustainable funding for nonprofit organizations …

Development Of An Electrospun And 3d Printed Cellular Delivery Device For Dermal Wound Healing, Ryan M. Clohessy

Theses and Dissertations

The goal of this research was to develop a system of individualized medicine that could be applied to dermal wounds serving as a wound dressing and synthetic extracellular matrix while delivering stem cells to the wound bed. First, fabrication parameters for electrospinning polymer fibers were determined. This involved evaluating fiber morphology with respect to polymer selection and solution concentration. Next, construct fabrication was examined to produce an integrated void space, or cargo area, suitable to maintain stem cells. In vitro studies to ensure stem cell viability and phenotype were conducted, and results supported the notion that cells could be administered …

Property Law For The Anthropocene Era, John G. Sprankling

McGeorge School of Law Scholarly Articles

Human activity has replaced nature as the principal force shaping our planet. As a result, we stand at the dawn of a new geological epoch: the Anthropocene. Fundamental changes in American law will be required to mitigate and adapt to the negative environmental impacts produced in this new era. These changes will go far beyond the traditional scope of environmental law to encompass property law and other subjects.This Article analyzes how American property law should respond to the Anthropocene challenge. It demonstrates the need to transition from a property law system based on stability to a more dynamic system that …

Length Of Stay And Reimbursement Rates For Medicare Patients, Wandella Ezell

Walden Dissertations and Doctoral Studies

Medicare reimbursement rates across the United States have varied by as much as 49-130% across healthcare facilities. Geographic adjustments and severity of medical diagnoses attribute to some dissimilarity; however, the source of longer hospitalization and higher re-admission rates among Medicare patients requires financial consistency. The research encompassed (N = 3000) patients with hypertension as the focus for the study because this is a critical group of Medicare patients with a chronic disease that has been identified as a silent killer. The principal goal that drove this research study was to explain the variations in length of stay for Medicare patients …

A Meta-Analytic Review Of Play Therapy With Emphasis On Outcomes Measures, Scott A. Jensen, Judith N. Biesen, Elizabeth R. Graham

College of the Pacific Faculty Articles

A meta-analysis of 100 studies of outcomes of play therapy interventions was conducted to determine overall effect of intervention. Different from the Bratton, Ray, Rhine, and Jones (2005), but more consistent with the Lin and Bratton (2015), findings, there was a significant moderate effect for play therapy interventions across all outcomes (d = .44). When 4 studies with aberrantly large effects were removed, this effect was d = .36. These moderate effects are consistent with other meta-analyses that find lower effect sizes for nonbehavioral interventions. Overall study quality was poor with no studies meeting the criteria of randomized control trials. …

Modulation Of H-Reflex Depression With Paired-Pulse Stimulation In Healthy Active Humans, Preeti Deshpande Oza, Shauna Dudley-Javoroski, Richard K. Shields

School of Pharmacy Faculty Articles

Depression of the Hoffman reflex (H-reflex) is used to examine spinal control mechanisms during exercise, fatigue, and vibration and in response to training. H-reflex depression protocols frequently use trains of stimuli; this is time-consuming and prevents instantaneous assessment of motor neuronal excitability. The purpose of this study was to determine if paired-pulse H-reflex depression is reproducible and whether paired-pulse stimulation adequately estimates the depression induced by the more traditional ten-pulse train. H-reflexes were elicited via ten-pulse trains at 0.1, 0.2, 1, 2, and 5 Hz in ten neurologically intact individuals on two separate days. We measured the depression elicited by …

The Anatomy Of Cbpr: A Case Study Of Cbpr Implementation For Health Promotion With The Peer Community, Cory R. Cummings

Theses and Dissertations

This case study is a qualitative examination of a health promotion project conducted in collaboration with members of the mental health peer community. More specifically, it explores the community based participatory research (CBPR) implementation process used to conduct this health promotion project to gain a deeper understanding of the mechanisms at work in the implementation process. While there has been considerable attention to the principles that guide CBPR (Braun et al., 2012; Israel et al., 2008; LaVeaux & Christopher, 2009), there remains important work to be done in bridging these principles to implementation; what processes or mechanisms translate these principles …

Study Of Molecular Interactions Of Glycosaminoglycans And Glycosaminoglycan Mimetics With Their Protein Targets, Daniel K. Afosah

Theses and Dissertations

Glycosaminoglycans (GAGs) are complex linear chain carbohydrate molecules found on virtually all animal cell surfaces. Owing to their negatively charged nature, GAGs interact with a number of different proteins. Thus, although they have great potential as therapeutic agents, their apparent promiscuous interactions increase their side effect risk. GAG mimetics, including GAG oligosaccharides and non-saccharide GAG mimetics (NSGMs) are viable approaches to address this. This work discusses sulfated benzofuran thrombin inhibitors with submaximal protease inhibition, sulfated diflavonoid inhibitors of plasmin and GAG oligosaccharides with selectivity for human neutrophil elastase (HNE).

Anticoagulants are very important for the treatment of thrombotic diseases. The …

Assessment Of Canopy Chlorophyll Content Retrieval In Maize And Soybean: Implications Of Hysteresis On The Development Of Generic Algorithms, Yi Peng, Anthony L. Nguy-Robertson, Timothy J. Arkebauer, Anatoly A. Gitelson

Department of Agronomy and Horticulture: Faculty Publications

Canopy chlorophyll content (Chl) closely relates to plant photosynthetic capacity, nitrogen status and productivity. The goal of this study is to develop remote sensing techniques for accurate estimation of canopy Chl during the entire growing season without re-parameterization of algorithms for two contrasting crop species, maize and soybean. These two crops represent different biochemical mechanisms of photosynthesis, leaf structure and canopy architecture. The relationships between canopy Chl and reflectance, collected at close range and resampled to bands of the Multi Spectral Instrument (MSI) aboard Sentinel-2, were analyzed in samples taken across the entirety of the growing seasons in three irrigated …

The Hypercapnic Ventilatory Response And Behavior In Ca2+-Activated K+ (Bk) Channel Knock Out Mice And T-Cell Death-Associated Gene 8 (Tdag8) Receptor Knock Out Mice, Christine Annette Ratliff-Rang

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Some acid sensing areas in the brain control the expression of breathing and anxiety/fear including the locus coeruleus (LC) (Redmond & Huang, 1979) and the nucleus tractus solitarius (NTS). It has been found that knocking out T-cell death-associated gene 8 (TDAG8), a chemosensor, attenuates CO2 induced fear phenotypes in mice. However their hypercapnic ventilatory response (HCVR) has not yet been looked at. Also, BK channels are large-conductance, calcium-activated potassium channels that are activated by increases in concentration of intracellular calcium ions. It has been found that BK KO rats have an increase in their HCVR (Patrone et al., 2014) however …

Enhanced Neurogenesis In Subventricular Zone Of Rats That Voluntarily Ingest Fluoxetine And Simavastatin Combination Treatment, Tiffany L. Flannery

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Stroke is one of the leading causes of deaths as the risk factors, both controllable and uncontrollable, are many. We first concentrated on a stress-free way to deliver the drugs. Our preference was to have the animals ingest the drugs, which led us to a reliable method for orally administering medication to the animal models. Using three different drug combinations, we tested the effects on neurogenesis without stroke. We found the drug combination of Fluoxetine/Statin/Ascorbic acid increases neurogenesis 19 fold when compared with control. Lastly, we looked at the gene changes in the cortex of the animal models that had …

Thermal Burn Injury Induced Microvesicle Particle Release, Katherine Erin Fahy

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Microvesicle particles (MVP) are found to be important for cellular communication because they contain many bioactive proteins, lipids, cytokines, and nucleic acids. We have previously found that ultraviolet B radiation (UVB) and a Platelet-activating factor agonist (CPAF) can stimulate the release of MVP in keratinocytes. We hypothesized that there may also be an increase in MVP released after thermal burn and that could be involved in pathogenesis of the systemic effects found in some patients. In this thesis various keratinocyte cell lines, mice and human ex vivo skin were used as model systems to test our hypotheses. It was determined …

Toward The Synthesis Of Functionalized Poly (Ether Ether Ketone): Monitoring The Meta-Fluorine Displacement In 3,5,4’-Trifluorobenzophenone, Giovanni Covarrubias

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The synthesis of functionalized, linear poly (ether ether ketone), tailored to be semi-crystalline and soluble in a variety of organic-solvents was explored. Nucleophilic aromatic substitution was a chemical reaction method used to condense 3,5,4’-trifluorobenzophenone (TFK) with four different phenols at its para-positioned carbon-fluorine site: 4-methoxyphenol, 3-aminophenol, 4-bromophenol, and m-cresol. Further poly-condensation of functionalized TFK occurred at the meta-positioned carbon-fluorine sites with 4,4’-Bis[4-hydroxyphenoxy] benzophenone (Big A2) and 4,4’-difluorobenzophenone at molar equivalents of 1 to 0.5, respectively. The reaction afforded products that became insoluble in solvents needed for nuclear magnetic resonance spectroscopic (e.g. DMSO-d6) analysis. The lack of desirable compounds compelled the …

Processing Global Properties In Scene Categorization, Hanshu Zhang

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The current research examined the role of global properties in human observers' scene perception. In Experiment 1, comparisons of four global properties ("natural", "manmade", "open", and "closed") were collected online from a wide range of subjective choices. These answers were analyzed in a pairwise comparison model to generate four standardized reference ranking scales describing the extent to which characteristics can describe scene global properties. In Experiment 2, scene images selected from the reference scales were used to test human's performance in processing global properties conjunctively. Cognitive modeling indicated that human observers were more efficient in categorizing scene images as "natural …

Extracellular Microvesicles As A Novel Biomarker For Wound Healing, Walid Omran Mari

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Introduction: Wound healing is a sophisticated dynamic process that involves complex coordination among a variety of resident cells in a suitable extracellular environment. Chronic wounds are defined as wounds that fail to heal within a period of 3 months. Negative pressure wound therapy (NPWT) is a closed suction drainage system is used to enable mass transport of fluid from the body as an adjunct to surgical procedures. (Oasis-ultra) is a triple layer extracellular matrix containing different types of glycosaminoglycans (GAGs) like heparin sulfate, hyaluronic acid and chondroitin sulfate. In addition, it has adhesion molecule such as fibronectin and laminin along …

Identification Of Novel Ligands And Structural Requirements For Heterodimerization Of The Liver X Receptor Alpha, Shimpi Bedi

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LXRs, LXRa (NR1H3) and LXRß (NR1H2), are ligand-activated transcription factors that are members of the nuclear receptor superfamily. Oxysterols and nonsteroidal synthetic compounds bind directly to LXRs and influence the expression of LXR dependent genes. The use of murine models and LXR-selective agonists have established the important role of LXRs as sterol sensors that govern the absorption, transport, and catabolism of cholesterol. Upon activation, these receptors have been shown to increase reverse cholesterol transport from the macrophage back to the liver to aid in the removal of excess cholesterol. Not surprisingly, LXR dysregulation is a feature of several human diseases, …

Sched-Its: An Interactive Tutoring System To Teach Cpu Scheduling Concepts In An Operating Systems Course, Bharath Kumar Koya

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Operating systems is an essential course in computer science curriculum, which helps students to develop a mental model of how computer operating systems work. The internal mechanisms and processes of an operating system (OS) are often complex, non-deterministic and intangible which makes them difficult for students to understand. One such concept is central processing unit (CPU) scheduling. CPU scheduling forms the basis of the multiprogramming in an OS. In practice, OS courses involve classroom lectures describing high-level abstractions of the concepts, and students complete programming assignments to apply the material in a more concrete way. Depending on the programming assignments, …

Is Mitochondrial Development Impaired In Hyperoxic Rats And Does This Underpin The Blunting Of The Acute Hypoxic Ventilatory Response?, Tariq Hasan Fayyad

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Carotid body (CB) responses to hypoxia are low at birth and increase over time to mature responses. Using an in vitro rat CB-carotid sinus nerve (CSN) preparation, Kholwadwala and Donnelly (1992) demonstrated that the CSN activity in response to hypoxia increased from low levels to robust adult responses after two weeks. This time course of maturation was paralleled by an increase in TASK channel sensitivity to hypoxia in the O2-sensing Type I cells (Kim et al, 2011). Previous studies have indicated that a fall in Type I cell mitochondrial volume and an increase in the rate of oxidative phosphorylation may …

A Novel System For Detection Of Dna Double Strand Breaks And Repair In Human Cells, Todd Warren Lewis

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Imperative to genomic stability is the ability of the cell to repair damaged DNA which can occur from numerous endogenous byproducts of metabolism or exogenous components from the environment. The Fanconi anemia pathway is a DNA repair mechanism used by human cells to resolve multiple forms of DNA damage including interstrand crosslinks (ICL). Fanconi anemia (FA) is an autosomal recessive inherited disorder characterized by genome instability, developmental abnormalities, cancer predisposition and bone marrow failure. FA is attributed to a mutations in at least 18 genes (FANCA-FANCT) that play a concerted role in DNA repair. FANCT is the latest discovery in …

The Role Of Peripheral Vision In Configural Spatial Knowledge Acquisition, Lisa J. Douglas

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This study investigated the importance of the peripheral visual field for acquiring configural spatial knowledge, especially knowledge about structural components like doorways, corners, and walls, but also information about objects. Although peripheral vision helps us orient our bodies in space, navigate successfully through an environment, and physically interact with objects in near physical space (Kesner & Creem-Regehr, 2012; Burgess, Jeffrey, & O’Keefe, 1999), previous research has not investigated the role of the peripheral visual field for the acquisition of spatial knowledge during navigation. All participants in this experiment viewed a virtual navigation tour through a four-room environment with objects located …

Vitamin D3 And Suppressor Of Cytokine Signaling Proteins Reduces Pro-Inflammatory Cytokines In An Alzheimer’S Disease Like-Model Consisting Of Microglial And Neuronal Co-Cultures, Alexander Evdokiou

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This study examined the inflammatory effects of amyloid-ß (Aß42) in a microglial-neuronal co-culture system and determined whether 1a, 25-dihydroxyvitamin D3 (1,25-(OH)2D3) along with suppressor of cytokine signaling (SOCS)1 and SOCS 3 mimetics would attenuate the inflammatory response to Aß42. This culture system, when seeded with Aß42, serves as an in vitro model for Alzheimer’s disease (AD). In a neuronal-microglia co-culture, Aß42 stimulated microglia to secrete TNF-a, but with the addition of 1,25-(OH)2D3, TNF-a levels dropped by nearly eight-fold and to near zero values in the presence of both 1,25-(OH)2D3 and SOCS1 and SOCS 3 mimetics. The reduction of the inflammatory …

Role Of Erk3 In Regulating Rhogdi1-Paks Signaling Axis, Hitham Abdulrahman Aldharee

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Extracellular signal-regulated kinase 3 (ERK3) is an atypical protein kinase of the mitogen-activated protein kinase (MAPK) family. In comparison to well-investigated ERK1/2 (classical) MAPKs, much less has been discovered about ERK3 signaling and its cellular functions. Recent studies have shown that ERK3 is overexpressed in various types of cancers such as lung cancer and breast cancer and that ERK3 promotes cancer cell migration and invasion. How ERK3 regulates cancer cell motility and invasiveness, however, is still largely unknown. RhoGTPases, including Rho, Cdc42 and Rac1, play critical roles in regulating cell motility and invasiveness through activating downstream effectors such as p21-activated …

The Effect Of Gram-Positive Staphylococcus Aureus Cell Wall Components Lipoteichoic Acid And Peptidoglycan On Cytokine Production, Cytoskeletal Arrangement, And Cell Viability On Raw 264.7 Murine Macrophages, Gabrielle String

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In this study, gram positive Staphylococcus aureus cell wall components such as lipoteichoic acid (LTA) and peptidoglycan (PGN) were used to study the potential inflammatory and anti-inflammatory cytokine response, cytoskeletal arrangement and cell viability on RAW264.7 murine macrophages over 24 hours. The effect of S.aureus LTA and PGN (5 [mu]g/mL) on RAW 264.7 macrophages was evaluated every six hours for twenty-four hours. Inflammatory cytokine (TNF-a) production peaked at 6 hours before decreasing over time. Anti-inflammatory cytokine (IL-10) production peaked between 12 and 18 hours. During the first twenty-four hours, cytotoxicity of treated macrophages, as defined as the release of lactate …

Identifying The Impact Of Noise On Anomaly Detection Through Functional Near-Infrared Spectroscopy (Fnirs) And Eye-Tracking, Ryan Dwight Gabbard

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Occupational noise frequently occurs in the work environment in military intelligence, surveillance, and reconnaissance (ISR) operations. This impacts cognitive performance by acting as a stressor, potentially interfering with the analysts' decision making process. In this study the effects of different noise stimuli on analysts' performance and workload in anomaly detection were investigated by simulating a noisy work environment. Functional near infrared spectroscopy (fNIRS) was utilized to quantify oxy-hemoglobin (HbO) and deoxy-hemoglobin (HbD) concentration changes in the prefrontal cortex (PFC), as well as behavioral measures which include eye-tracking, reaction time, and accuracy rate. It was found that HbO for some of …

Analysis Of Well Log Data And A 2d Seismic Reflection Survey In The Vicinity Of London, Ohio, Mohammad Mohshin

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During the summer of 2015 a 2D seismic line (WSU-2015), ~2.3km long, was collected by Wright State University along Watson Road, south of London, Ohio. This seismic line is parallel to and approximately 1/4 km south of `Line 6' of Mayhew (1969), which is one of six analog, single-fold seismic lines within the area that he studied. The focus of this research is to interpret the stratigraphy revealed by the new seismic line, especially to evaluate the existence or otherwise of a fault that Mayhew (1969) inferred in his interpretation. An important step in this new interpretation was to construct …