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2017

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A Presynaptic Role For Nitric Oxide At A Gabaergic Synapse, John Wesley Maddox Jan 2017

A Presynaptic Role For Nitric Oxide At A Gabaergic Synapse, John Wesley Maddox

LSU Doctoral Dissertations

Amacrine cells are a class of retinal interneurons that process the visual signal in the inner retina. Several subtypes of amacrine cells express nitric oxide synthase and produce nitric oxide (NO), making NO a possible regulator of amacrine cell function. My dissertation research tests the hypothesis that NO alters amacrine cell GABAergic synaptic output. To investigate this, I made whole-cell voltage clamp recordings of cultured chick amacrine cells receiving synaptic input from other amacrine cells and Ca2+ imaging of amacrine cell dendrites, which can be presynaptic. I find that NO-dependent increases in GABAergic spontaneous postsynaptic current (sPSC) frequency are …

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Design, Synthesis, Characterization And Evaluation Of Near Infrared Bodipy Dyes For Various Applications, Qianli Meng Jan 2017

Design, Synthesis, Characterization And Evaluation Of Near Infrared Bodipy Dyes For Various Applications, Qianli Meng

LSU Doctoral Dissertations

4,4-Difluoro-4-bora-3a,4a-diaza-5-indacene (BODIPY) have drawn a large number of research attention, for its numerous useful application in the fields of material and biology. Small modification of this well-known fluophore has been shown to optimize its photophysical and chemical properties. This work mainly focuses on functionalization of BODIPY cores with halogenated atoms, particularly iodine, and their subsequent post-functionalization reactions, mainly cross-coupling reaction and substitutions, for various further applications. Chapter 1 of this dissertation gives a general overview of BODIPYs including their synthetic strategies, post-functionalization, and how BODIPYs are utilized in many biological applications. Chapter 2 mainly focuses on the synthesis and characterization …

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Condition Of Birds In Amazonian Rainforest Fragments And Second-Growth Forests, Angelica Maria Hernandez Palma Jan 2017

Condition Of Birds In Amazonian Rainforest Fragments And Second-Growth Forests, Angelica Maria Hernandez Palma

LSU Doctoral Dissertations

Deforestation modifies otherwise intact expanses of forest into small, isolated fragments. In addition to fragmentation, deforestation also creates abrupt forest edges and large areas of regenerating vegetation where land is abandoned after clearing. Understanding how changes in the landscape affect the physical condition of birds is crucial for managing populations in human-modified landscapes. Here I use the biomarkers feather growth rate and feather quality (ptilochronology), fluctuating asymmetry (FA), and stress hormones from feathers (CORT), to estimate the physical condition of Amazonian understory birds living in forest fragments, second-growth forests, and continuous forests. Feather CORT revealed how fragmentation disrupts interspecific interactions; …

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Social Work Practitioners Working In End Of Life Care:Learning To Provide Culturally Appropriate Care To Clients Of Middle Eastern Descent, Laura Shafica Meiki Jan 2017

Social Work Practitioners Working In End Of Life Care:Learning To Provide Culturally Appropriate Care To Clients Of Middle Eastern Descent, Laura Shafica Meiki

LSU Doctoral Dissertations

This study utilized an interpretive qualitative methodological approach to learn about the experiences of individuals with a Master of Social Work degree (MSWs) working in end-of-life (EOL) care with patients of Middle Eastern descent and their families. Specifically, it examined (1) how a sample of social workers obtained the skills necessary to provide culturally appropriate EOL care to clients and families of Middle Eastern descent; (2) the common intervention strategies social workers employ while providing this care; and (3) the recommendations they offer to others who anticipate encountering this population in their own practice. Data collection consisted of in-depth, semi-structured …

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Documentation Of Siderophore Activity, Metal Binding, And Its Effect On Symptomatology Of Cercospora Leaf Blight Caused In Soybean By Cercosporin From Cercospora Cf. Flagellaris, Brian Michael Ward Jan 2017

Documentation Of Siderophore Activity, Metal Binding, And Its Effect On Symptomatology Of Cercospora Leaf Blight Caused In Soybean By Cercosporin From Cercospora Cf. Flagellaris, Brian Michael Ward

LSU Doctoral Dissertations

Cercospora leaf blight of soybean (Glycine max) is a serious problem in the mid-south of the United States and is present in most soybean-growing regions of the world. The causal organisms, Cercospora kikuchii, C. cf. flagellaris and C. cf. sigesbeckiae, utilize the photo-activated toxin cercosporin as the primary pathogenicity factor. The disease has historically been understood to progress from a purpling or bronzing of the leaves to a blight in which tissue dies. Previous literature showed possible binding of cercosporin to metals and previous work in our group showed possible use of minor element nutrition in the plant to reduce …

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Fluorescent Probe Interrogation Of A Cytoprotective Cancer-Linked Oxidoreductase In Two-Dimensional Human Cell Cultures And Solid Tumor Mimics, Bijeta Prasai Jan 2017

Fluorescent Probe Interrogation Of A Cytoprotective Cancer-Linked Oxidoreductase In Two-Dimensional Human Cell Cultures And Solid Tumor Mimics, Bijeta Prasai

LSU Doctoral Dissertations

Fluorescence molecular imaging is an emerging field with potential to aid in optically guided surgery for cancer treatment. To overcome the drawbacks of always-on fluorescent probes, such as indocyanine green, activatable fluorescent probes are being developed that allow high signal-to-background imaging for better discrimination of cancerous cells from normal cells. For activation, turn-on fluorescent probes rely on the presence of biomarkers such as antibodies, cell-surface receptors or enzymes that are highly specific to tumor cells. hNQO1 (human NAD(P)H: quinone oxidoreductase isoenzyme 1) is considered as one of such cancer-associated biomarkers that are present intracellularly in cancers of multiple origins. It …

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Influences Of Perceived Social Network Structure Characteristics On College Student's Perceptions Of Social Capital Value And Career Decision-Making Self-Efficacy, Troy Autin Jan 2017

Influences Of Perceived Social Network Structure Characteristics On College Student's Perceptions Of Social Capital Value And Career Decision-Making Self-Efficacy, Troy Autin

LSU Doctoral Dissertations

The collective group of resources that are accessible to an individual because of people within his/her social network is known as social capital. Social capital becomes more valuable when an individual sees that it can help with goal achievement. This is especially true with college-aged students who are deciding on academic major, career path and if should persist or dropout. The purpose of this study was to determine the influence of social network characteristics on the perceived social capital value (SCV) and career decision-making self-efficacy (CDMSE) among freshman college students enrolled at a research university. This present study examined how …

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Digital Osteology: 3d Surface Scanning The Os Coxa, Victoria Harrington Jan 2017

Digital Osteology: 3d Surface Scanning The Os Coxa, Victoria Harrington

LSU Doctoral Dissertations

ABSTRACT This research was designed to isolate a standard 3D scanning methodology using a popular 3D scanner (NextEngine®) used in biological anthropology to reproduce research-quality human skeletal remains. Settings using NextEngine® hardware were determined through three successive studies. The first study used minimum settings to create a topography of nine postcranial bones excavated from a Maya archaeological site, Moho Cay, Belize. The research was conducted in Louisiana State University’s (LSU) Digital Imaging and Visualization in Archaeology (DIVA) Lab. The resulting 3D scans were visually compared to the original bone specimens for similarities in five categories. The similarity ratings were used …

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Microbial Distributions And Survival In The Troposphere And Stratosphere, Noelle Celeste Bryan Jan 2017

Microbial Distributions And Survival In The Troposphere And Stratosphere, Noelle Celeste Bryan

LSU Doctoral Dissertations

Although bioaerosols in the lower altitudes of the atmosphere have been extensively studied, little is known about the distribution and nature of microorganisms at altitudes above the Earth’s surface. To examine the vertical distribution of microorganisms in the atmosphere, a helium balloon payload system was developed to sample bioaerosols at stratospheric altitudes of up to 38 km, where temperature, air pressure, relative humidity, and ultraviolet-C (UV-C) radiation conditions are similar to the surface of Mars. Bioaerosol concentrations between 3 and 29 km were similar to each other, ~three-fold lower than those in the convective boundary layer (CBL; 0-3 km; 1 …

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A Graph-Based Taxonomic Intelligent Tutoring System Utilizingbloom’S Taxonomy And Item-Response Theoretic Assessment, Dennis Gordon Castleberry Ii Jan 2017

A Graph-Based Taxonomic Intelligent Tutoring System Utilizingbloom’S Taxonomy And Item-Response Theoretic Assessment, Dennis Gordon Castleberry Ii

LSU Doctoral Dissertations

This dissertation details an intelligent tutoring system which aims to raise student trait abilities across concepts and levels of Blooms taxonomy within an educational program. The system utilizes Item Response Theory, a probabilistic theory of assessment which accounts for item discrimination, difficulty, and probability of guessing in its assessment of student trait ability. A modification to Item Response Theory which accounts for question dependencies is used to assess the probability that a student will answer a given question correctly given prior responses on the dependency questions. It also draws from theories of memory and forgetting present in the ACT-R model …

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Termite Gut Microbes As Tools And Targets For Termite Control, Chinmay Vijay Tikhe Jan 2017

Termite Gut Microbes As Tools And Targets For Termite Control, Chinmay Vijay Tikhe

LSU Doctoral Dissertations

The Formosan subterranean termite (FST), Coptotermes formosanus, is an invasive urban pest in the United States. Colonies of the FST are dependent on the symbiotic gut protozoa for cellulose digestion in the workers’ guts, and the gut bacterial community is known to provide essential nutrients to the termite. The objectives of this PhD research were to develop and evaluate paratransgenesis and phage therapy for termite control. During this study, a termite gut bacterium: Trabulsiella odontotermitis was genetically engineered and was evaluated as a ‘Trojan horse’ for paratransgenesis. We proved that T. odontotermitis can tolerate 50 times more concentration of ligand-Hecate …

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Microscopic Evaluations Of Bone In Equine And Muroid Models, Heather Ashley Richbourg Jan 2017

Microscopic Evaluations Of Bone In Equine And Muroid Models, Heather Ashley Richbourg

LSU Doctoral Dissertations

The use of advanced imaging techniques has greatly improved orthopedic research and education. Histology of bone is a method of evaluating bone morphology, bony cells, and bone remodeling in two-dimensions, while micro-computed tomography (microCT) is a three-dimensional analysis of bone morphology. Combined, these methods assist in providing a comprehensive analysis of bone. In this dissertation, these techniques were utilized to answer questions currently outstanding in veterinary medicine: the effect of bisphosphonates on equine bone, and variation in murine tarsal anatomy. Bisphosphonates are drugs that reduce osteoclast-mediated bone resorption and have recently been approved for the use in horses. Despite prolific …

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Branch And Stem Growth As Affected By Loss Of Leaf Area On Selected Branches In Loblolly Pine, Shannon Dumo Kidombo Jan 2017

Branch And Stem Growth As Affected By Loss Of Leaf Area On Selected Branches In Loblolly Pine, Shannon Dumo Kidombo

LSU Doctoral Dissertations

Leaf area and crown dynamics control how trees grow through their supply of carbohydrates and growth regulators, and their influence on tree mechanical stability. The influence of leaf area and crown dynamics to tree growth was investigated by testing the interdependence between leaf area, branch, and stem growth on young loblolly pine trees. The objectives were to (1) determine the influence of current and previous year’s leaf area on elongation of branches; (2) describe and test a unique way of quantitatively measuring the effect of neighbor branches on net growth of a target branch; (3) quantify the growth impact of …

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Performance Evaluation And Characterization Of Encapsulated Calcium Nitrate For Self-Healing Concrete Applications, Jose Eduardo Milla Jan 2017

Performance Evaluation And Characterization Of Encapsulated Calcium Nitrate For Self-Healing Concrete Applications, Jose Eduardo Milla

LSU Doctoral Dissertations

Self-healing concrete through microencapsulated calcium nitrate is a novel approach to enhance durability and decrease the costs associated with maintenance and repairs. However, to fully assess the potential of this technology, there are many questions to be answered, ranging from identifying the microcapsule properties that are successfully carry the healing agent, to the effect of the microcapsule size, concentration (by weight of cement), and morphology have on the intrinsic concrete material properties and self-healing potential. Hence, the objectives of this study were to: (a) Develop a microencapsulation procedure for calcium nitrate as the healing agent; (b) Measure the short-term healing …

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Evaluation Of Control Tactics For Management Of Sweetpotato Weevil (Coleoptera: Curculionidae), Jie Chen Jan 2017

Evaluation Of Control Tactics For Management Of Sweetpotato Weevil (Coleoptera: Curculionidae), Jie Chen

LSU Doctoral Dissertations

Sweetpotato weevil (SPW), Cylas formicarius elegantulus (Summer), is the most damaging root-feeding insect of sweetpotato, Ipomoea batatas L. (Lam), worldwide. The efficacy and compatibility of host plant resistance and insecticide control were evaluated in this dissertation. cv. Beauregard is the most susceptible cultivar for oviposition and offspring performance of SPW compared to cvs. Evangeline and Murasaki. The oviposition preference was shaped by the larval experience of SPW, providing evidence in support of the Hopkins’ Host-Plant Selection Principle. Although oviposition on cv. Murasaki was reduced, the egg capacity of SPW developed on cv. Murasaki was not decreased, indicating an adaptive behavior …

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Maternal Fatty Acid And Inflammatory Status During Pregnancy Are Related To Infant Heart Rate And Heart Rate Variability, Merritt Leanne Drewery Jan 2017

Maternal Fatty Acid And Inflammatory Status During Pregnancy Are Related To Infant Heart Rate And Heart Rate Variability, Merritt Leanne Drewery

LSU Doctoral Dissertations

Early life heart rate (HR) and heart rate variability (HRV) reflect autonomic maturation. Intervention with n-3 long chain polyunsaturated fatty acids (LCPUFAs) during pregnancy favorably affects fetal HR and HRV; similar observations have been reported with infant n-3 LCPUFA intake. Infant HR and HRV have not been assessed in relation to maternal fatty acid status during pregnancy. Further, exposure to intrauterine inflammation may underlie these observations, although this hypothesis has not been tested. The aim of this observational study was to explore associations between maternal fatty acid and inflammatory status during pregnancy and infant HR and HRV. Simple linear and …

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Brazilian Surface And Upper-Level Wind Characteristics Based On Ground And Model Observations From 1980–2014, Joshua M. Gilliland Jan 2017

Brazilian Surface And Upper-Level Wind Characteristics Based On Ground And Model Observations From 1980–2014, Joshua M. Gilliland

LSU Doctoral Dissertations

The examination of temporal changes in surface winds has been analyzed by scientists for a variety of physical, biological, climatological, and socioeconomic reasons. This research uses surface and upper-level wind data from historical in-situ and climate models to examine the geographical and climatological characteristics of wind across Brazil during 1980–2014. Overall linear and quantile regression shows that surface wind speed trends are changing regionally across Brazil. Wind speeds across northeastern Brazil are increasing, while a decreasing trend is documented for interior and southeastern Brazil. The spatial and temporal trends found are possibly related to alterations in the physical landscape (urbanization …

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Pre-College Credit And Examination Programs: One Size Fits All?, Guadalupe M. Lamadrid Jan 2017

Pre-College Credit And Examination Programs: One Size Fits All?, Guadalupe M. Lamadrid

LSU Doctoral Dissertations

The purpose of this mixed methods study was to utilize a comprehensive 9-16 dataset to quantitatively examine which pre-college credit programs are the most significant predictors of college achievement as defined by college GPA, first to second year retention, time to degree and graduation date. A qualitative analysis was conducted, which via the use of a survey allowed students to share their perceptions and feeling regarding their pre-college credit experiences. Data for this study was obtained from institutional sources and consisted of 9-16 detail high school record, admissions, financial aid, scholarship and enrolled student information. Univariate and Multi-variate statistical analyses …

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Osteogenic Potential Of Poly (L-Lactic Acid) Scaffolds Prepared By Thermally Controlled Methods On Human Adipose Derived Stem Cells, Harish Chinnasami Shanmugam Jan 2017

Osteogenic Potential Of Poly (L-Lactic Acid) Scaffolds Prepared By Thermally Controlled Methods On Human Adipose Derived Stem Cells, Harish Chinnasami Shanmugam

LSU Doctoral Dissertations

Thermally Induced Phase Separation (TIPS) method was used to make porous three-dimensional PLLA scaffolds. The effect of imposed thermal profile during freezing of the PLLA in dioxane solution on the scaffold was characterized by their micro-structure, porosity (%), pore-sizes distribution and mechanical strength. The porosity (%) decreased considerably with increasing concentrations of PLLA in the solution, while a decreasing trend was observed with increasing cooling rates. The mechanical strength increases with increase in PLLA concentration and also with increase in the cooling rate for both types of solvents. Therefore, mechanical strength was increased by higher cooling rates while the porosity …

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Private Vs. Public: Lesbian, Gay, Bisexual, And Transgender Student Experiences And The Influence Of Anti-Discrimination Policies With Respect To Religion, Shalonda Michelle Skidmore Jan 2017

Private Vs. Public: Lesbian, Gay, Bisexual, And Transgender Student Experiences And The Influence Of Anti-Discrimination Policies With Respect To Religion, Shalonda Michelle Skidmore

LSU Doctoral Dissertations

For a vast majority of Americans, religion is an integral part of life. In fact, 10:30am on Sundays is considered the most holy time in the United States as most persons have just left, are currently attending, or are on their way to their various places of worship. Believing in organized religion comes with challenges, as religion has often been the basis and justification for discriminatory practices. These challenges can cause emotional tension, especially to those who identify with teachings that religions have traditionally condemned. This document sought to determine if religion matters to lesbian, gay, bisexual, and transgender (LGBT) …

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Evolutionary Interactions Of Feather Molt In Birds, Ryan Scott Terrill Jan 2017

Evolutionary Interactions Of Feather Molt In Birds, Ryan Scott Terrill

LSU Doctoral Dissertations

The evolution of feathers was a key innovation for birds. The many functions that feathers provide have allowed birds to diversify into myriad habitats and styles of life. However, feathers are lightweight and break down, and must be replaced regularly in a process known as molt. The patterns and timing with which birds molt varies within and between species, and these different strategies are likely a product of the different ways birds use their feathers and the uneven distribution of resources available for molt in time and space. So far, no studies have attempted to place these strategies into an …

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Oxygen Transport In Carotid And Stented Coronary Arteries, Eoin A. Murphy Jan 2017

Oxygen Transport In Carotid And Stented Coronary Arteries, Eoin A. Murphy

Doctoral

Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation can have significant effects on the oxygen transport into the arterial wall. Helical flow has been theorised to improve the local haemodynamics and the oxygen transport within stented arteries. In this study an advanced oxygen transport model was developed to assess different stent designs. This advanced oxygen transport model incorporates both the free and bound oxygen contained in blood and includes a shear-dependent dispersion coefficient for red blood cells. In two test cases …

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Discursos Contrasexuales: Subversiones Queer, Stephanie Colin Jan 2017

Discursos Contrasexuales: Subversiones Queer, Stephanie Colin

LSU Master's Theses

Judith Butler argues that gender is a performative cultural construction; this analysis is taken to further means of discussion in reference to the revelation of sex and gender as both cultural and social constructions. Sex and gender appear as a result of heteornormative regulations imposed onto social actors, arguing that these constructions are essences naturally attached to the human body. The constructions of the sex/gender system are inflicted by a regulative discourse. In the heterocentric society this discursive control is implemented through social norms which enforce male with masculinity and female with femininity. Through various analyses of contra-hegemonic cultural and …

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Development And Application Of A Modis Inorganic Sediment Model During The 2016 Mississippi River Diversion In Lake Pontchartrain, Louisiana, Robert Lee Iles Iv Jan 2017

Development And Application Of A Modis Inorganic Sediment Model During The 2016 Mississippi River Diversion In Lake Pontchartrain, Louisiana, Robert Lee Iles Iv

LSU Master's Theses

The Bonnet Carré Spillway (BCS) is a Mississippi River diversion located on the southwestern coastline of Lake Pontchartrain in Louisiana. The discharge of potentially high amounts of Mississippi River nutrients and sediments during BCS diversion events has a noted ecological impact on the Lake Pontchartrain estuary. Projected river flooding prompted the opening of the Spillway from 10 January to 1 February 2016. MODIS satellite images were aerosol-corrected and then compared to in-situ measurements of inorganic sediment concentration (ISC) to derive a predictive algorithm for estimating ISC (in mg L^-1) in Lake Pontchartrain for satellite images in January and February. The …

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Sediment Infilling Of Louisiana Continental-Shelf Dredge Pits: A Record Of Sedimentary Processes In The Northern Gulf Of Mexico, Meg Cathlin O'Connor Jan 2017

Sediment Infilling Of Louisiana Continental-Shelf Dredge Pits: A Record Of Sedimentary Processes In The Northern Gulf Of Mexico, Meg Cathlin O'Connor

LSU Master's Theses

Sediment cores were collected at continental-shelf sites of the Northern Gulf of Mexico off the coast of Louisiana to develop a better understanding of post-dredging evolution of mud-capped dredge pits. The two pits studied were Sandy Point (SP) and Raccoon Island (RI) (both with water depths of ~10m and dredged to ~ 15-20 m below water surface), which were dredged in 2012 and 2013 respectively. Vibracores and multicores were collected in 2015. Preliminary radiochemistry analyses identified Beryllium-7 distribution in multicore samples from both sites. SP1, the northwestern site in the Sandy Point dredge pit, showed 26 cm of 7Be penetration. …

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A Comparative Study Of The Effects Of River Flow Rates On Decomposition, Maddisen Paige Neuman Jan 2017

A Comparative Study Of The Effects Of River Flow Rates On Decomposition, Maddisen Paige Neuman

LSU Master's Theses

While the general biological processes of decomposition are known to forensic anthropologists, data on aquatic decomposition is in need of refinement. Water composition varies in mineral content, temperature, flow rate, and scavengers; each of these elements can have an effect on the rate of decomposition. This study specifically focuses on the effects of river flow rates on decomposition by comparing the rate of decay of three feral pigs (Sus scrofa) on land (control specimen), in faster flowing water, and in slower flowing water. The hypothesis states that the pig placed in the faster section of the river will decompose more …

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Effects Of Timing Of Local Anesthesia On Physiological Responses In Calves After Dehorning, Amanda Jane Mathias Jan 2017

Effects Of Timing Of Local Anesthesia On Physiological Responses In Calves After Dehorning, Amanda Jane Mathias

LSU Master's Theses

The American Veterinary Medical Association has stated the importance of minimizing pain associated with dehorning to limit the amount of distress and changes in the animal’s behavior and physiological states (AVMA, 2014b). The following studies aim to determine the effect of timing of lidocaine administration on physiological responses in calves after dehorning. The first study compared cortisol and substance P levels in calves dehorned immediately after administration of lidocaine and meloxicam, calves dehorned 10 minutes after the administration of lidocaine and meloxicam, and calves that were administered lidocaine and meloxicam and not dehorned. It was concluded waiting 10 minutes after …

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Molecular Genetics Of Cold Tolerance At Germination And Seedling Stages In Rice, Anna Hissahe Borjas Artica Jan 2017

Molecular Genetics Of Cold Tolerance At Germination And Seedling Stages In Rice, Anna Hissahe Borjas Artica

LSU Master's Theses

Low temperature stress is a major constraint for rice production in temperate and high altitude areas of the world. Delayed germination coupled with reduced seedling vigor hinders crop establishment and crop growth resulting in reduced rice productivity. Mapping of chromosomal regions controlling cold tolerance will accelerate marker-assisted breeding of cold tolerant rice varieties. A recombinant inbred line (RIL) mapping population involving a rice cultivar ‘Bengal’ and a US weedy rice accession ‘PSRR-1’ was evaluated for cold tolerance at both germination and seedling stages. Observations on germinating ability and seedling vigor were recorded under both low temperature (13oC) and optimum temperature …

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Vertebral Pathologies And Implications For Economic Lifestyle Changes In Two Prehistoric Skeletal Populations, Alyxandra Leigh Stanco Jan 2017

Vertebral Pathologies And Implications For Economic Lifestyle Changes In Two Prehistoric Skeletal Populations, Alyxandra Leigh Stanco

LSU Master's Theses

Little research considers the vertebral column in relation to inter-populational variation and changes in economic lifestyle. Numerous studies have been conducted regarding the influence of activity-related stress on post-cranial elements such as the knees, hips and shoulders, but few studies have considered the vertebral column. This study examined the vertebral columns of two prehistoric skeletal populations. The Indian Knoll site, home to a population of early hunter-gatherers, is located in Ohio County, Kentucky along the Green River. Indian Knoll was first excavated in 1915 by C.B. Moore. The Moundville site, a chiefdom of early agriculturalists, is located in the Black …

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Evaluation Of Broad Anti-Herpesviral Activity With Α-Hydroxytropolones, Shannon David Dehghanpir Jan 2017

Evaluation Of Broad Anti-Herpesviral Activity With Α-Hydroxytropolones, Shannon David Dehghanpir

LSU Master's Theses

Herpesviruses are ubiquitous in animals and cause economic losses concomitant with many diseases, including upper respiratory disease, keratitis, abortion, neonatal death, and neurologic disease. The majority of the domestic animal herpesviruses are within the subfamily Alphaherpesvirinae, along with the prototypical human herpes simplex virus 1 (HSV-1). Suppression of HSV-1 replication has been reported with α-hydroxytropolones (αHTs), which are aromatic ring compounds that have broad bioactivity due to potent chelating activity. It is postulated that αHTs inhibit enzymes within the nucleotidyltransferase superfamily (NTS), similarly structured enzymes that require divalent cations for nucleic acid cleavage activity. One potential herpesviral target includes the …

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