Digital Commons Network^™

The Role Of The Mediator Transcriptional Co-Activator Complex And Promoter Dependence In Ty1 Retrotransposition In Saccharomyces Cerevisiae, Alicia Salinero

Legacy Theses & Dissertations (2009 - 2024)

Retrotransposons are mobile genetic elements that replicate via an RNA intermediary and constitute a significant portion of most eukaryotic genomes. Saccharomyces cerevisiae has been invaluable to retrotransposon research due to the presence of an active retroelement known as Ty1. The mobility of Ty1 is regulated both positively and negatively by numerous host factors, including several subunits of the Mediator transcriptional co-activator complex. The Mediator core complex is organized into genetically and structurally defined head, middle, and tail modules, along with a transiently associated kinase module. We show that with the exception of the kinase module, deletion of non-essential subunits from …

Factors Influencing Quality Of Life Of Persons Living With Human Immunodeficiency Virus Infection In Almaty, Kazakhstan, Bakhytkul Zhakipbayeva Zhakipbayeva

Legacy Theses & Dissertations (2009 - 2024)

Introduction: Health-related Quality of life (HRQoL) is recognized as a significant medical outcome measure for persons living with HIV (PLWH). Identification of potentially modifiable determinants of HRQoL could help target people in need of additional health care and social services in order to improve their HRQoL. The main objective of this study was to determine the factors with the strongest impact on HRQoL in PLWH.

The History Of Forensic Science In The State Of New York, Elke Hof-Kenyon

Legacy Theses & Dissertations (2009 - 2024)

This dissertation delineates the process and advancements in professionalizing the police departments and the development of forensic science in New York. Furthermore, as a preliminary and exploratory study it examines the evolution and changes of forensic science within the growth and expansion of a New York county police department. The relationship between police and forensic science was complex; for example, the impetus for the police to adopt a particular forensic methodology varied. At times, the development of forensic methodologies necessitated a further step in professionalizing the police departments. Other times, law enforcement sought new forensic inventions, or the improvement of …

Mystical Oil : Mapping The Oil Narrative In Fiction, Sara Alotaibi

Legacy Theses & Dissertations (2009 - 2024)

Oil’s representation is shaped by the resource’s biological properties and its material forms of flow, which are features that contribute to its mystification as a commodity bringing instant and laborless wealth. I examine oil’s impact on narrative by charting some of the transnational formal and thematic patterns in literature shaped by the oil fetish and its mystified transformative capacities. Through a comparative reading of Upton Sinclair’s Oil!, Abdelrahman Munif’s Cities of Salt, and Helon Habila’s Waiting for an Angel and Oil on Water, I aim to locate the specific ruptures oil creates on temporal and spatial structures that shape the …

Climate Change, Spruce Root Phenology, And Allocation Of Carbon Below- And Above-Ground, Marie Louise Orton

Legacy Theses & Dissertations (2009 - 2024)

Tree ring analysis has relied on a close relationship between climate and photosynthetically-derived stem enlargement. Lengthening growing seasons associated with climate warming have been predicted to enhance carbon sequestration as wood in trees, but this

Effects Of Antibiotic Treatment On The Expression Of Hepatic And Intestinal Cytochrome P450, Bruno Pereira De Carvalho

Legacy Theses & Dissertations (2009 - 2024)

Expression of metabolic enzymes Cytochrome P450 (CYP) is highly affected by drugs, diseases, age and gender. The Intestinal microflora has been suggested to play a role in regulating CYP expression and antibiotic treatments would lead to changes in level and composition of microbiota in mouse gut. This study aims to analyze CYP expression changes in the liver and small intestine resulted from the reduction of intestinal microflora by antibiotics. Impacts on bile acid signaling were also analyzed for a better comprehension of the mechanisms involved in this modulation. Female C57BL/6J mice (9- to 13-week old) were treated with ampicillin (AMP) …

Hepatitis C Status Awareness And Test Results Confirmation Among People Who Inject Drugs In Ukraine, Olena Iakunchykova

Legacy Theses & Dissertations (2009 - 2024)

Background. Hepatitis C virus (HCV) positivity is frequently found in people who inject drugs (PWID). The prevalence of HCV in this population in Ukraine is estimated at 71%. As treatment for HCV infection becomes more available, it is important to know what modifiable factors are related to testing, linkage to care and treatment.

Protein Aggregation As Hallmark Of Neurodegenerative Diseases, Viktoriia Stroilo

Legacy Theses & Dissertations (2009 - 2024)

Neurodegenerative diseases like Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Prion Diseases tend to have similar cellular and molecular mechanisms of protein aggregation and inclusion body formation. These processes suggest common mechanisms of pathogenesis. Similarities in structure, mechanism of formation and physiological effects of protein aggregates in neurodegenerative diseases may lead to development of common preventative or therapeutic strategies.

Further Development Of Raman Spectroscopy For Body Fluid Investigation : Forensic Identification, Limit Of Detection, And Donor Characterization, Claire K. Muro

Legacy Theses & Dissertations (2009 - 2024)

The challenges to forensic body fluid analysis have placed limitations on the type of information that investigators can acquire and how that information can be collected. In recent years, Raman spectroscopy has proven itself useful for characterizing body fluids. In 2008, a large-scale investigation was undertaken to explore the use of Raman spectroscopy as a means of identifying body fluids. This work resulted in multidimensional Raman spectroscopic signatures for the five main body fluids: semen, peripheral blood, saliva, vaginal fluid, and sweat. These studies were incredibly successful and created the foundation for years of continued research. Accordingly, the studies included …

Grazing And The Coupling Of Vascular Plant And Soil Microbial Diversity In Agricultural Landscapes Of Eastern New York, Caroline Belle Girard-Cartier

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

Structural Characterization Of The Interactions Of Nicotinamide And Analogs With Human Sirt6 By Saturation Transfer Difference (Std) Nmr And Site Directed Mutagenesis, Beatriz Elena Bolivar-Vega

Legacy Theses & Dissertations (2009 - 2024)

The allosteric regulation of SIRT6 by nicotinamide (NAM), along with the growing evidence of this enzyme's key role in the immune response, prompted the mechanistic study of SIRT6 inhibition by pyrazinamide (PZA) and analogs. In our current study, PZA, an analog of NAM, was revealed to have a modest modulatory effect on SIRT6, an enzyme that regulates the NF-κB signaling pathway at the transcriptional level (a relevant pathway to inflammation). Similarly, the analogs of PZA, 5-Cl PZA, 5-MeO PZA, and POA exhibited a modulatory effect against SIRT6 in our in vitro studies, enabling identification of a potential new target for …

Improving Hiv Outcomes In Pakistan : The Interaction Between Politics, Power And Implementation, Hina Khalid

Legacy Theses & Dissertations (2009 - 2024)

HIV contributes to the highest number of deaths from infectious diseases in low-income countries. In this three-paper dissertation, using the case of Pakistan, I focus on understanding how the exercise of power by actors at three different levels of the health system, individual, program and societal, influences policy implementation and shapes HIV program outcomes. The objective is to improve HIV service provision thereby achieving improved health policy outcomes. I adopt a mixed-methods approach and use quantitative (logit regression) and qualitative techniques (content analysis of newspapers and semi-structured interviews). One paper tests the role played by network operators in influencing condom …

Sources, Pathways, And Distribution Of Bisphenol A Diglycidyl Ether (Badge) And Its Derivatives In The Environment, Jingchuan Xue

Legacy Theses & Dissertations (2009 - 2024)

BADGE (bisphenol A diglycidyl ether) based epoxy resins have been used in a variety of applications since the 1940s. However, limited studies are available about the occurrence of BADGE and its derivatives (BADGEs) in the environment. The aims of this thesis were to determine the concentrations of BADGE and its derivatives in dental sealants and textile products from the U.S. to characterize the sources of these substances. Furthermore, concentrations of BADGEs in samples from various stages of waste water treatment plants (WWTPs) in the U.S. were also determined to investigate the environmental pathway and fate of these substances. BADGEs were …

Multigenic Dna Vaccine Induces Protective Cross-Reactive T Cell Responses Against Heterologous Influenza Virus In Nonhuman Primates, Merika T. Koday, Jolie A. Leonard, Paul Munson, Adriana Forero, Michael Koday, Debra L. Bratt, Karen Duus

College of Osteopathic Medicine (TUN) Publications and Research

Recent avian and swine-origin influenza virus outbreaks illustrate the ongoing threat of influenza pandemics. We investigated immunogenicity and protective efficacy of a multi-antigen (MA) universal influenza DNA vaccine consisting of HA, M2, and NP antigens in cynomolgus macaques. Following challenge with a heterologous pandemic H1N1 strain, vaccinated animals exhibited significantly lower viral loads and more rapid viral clearance when compared to unvaccinated controls. The MA DNA vaccine induced robust serum and mucosal antibody responses but these high antibody titers were not broadly neutralizing. In contrast, the vaccine induced broadly-reactive NP specific T cell responses that cross-reacted with the challenge virus …

Benzylideneoxymorphone: A New Lead For Development Of Bifunctional Mu/Delta Opioid Receptor Ligands, Jason R. Healy, Padmavani Bezawada, Nicholas W. Griggs, Andrea L. Devereaux, Rae Reiko Matsumoto, John R. Traynor, Christopher W. Cunningham

Faculty Publications & Research of the TUC College of Pharmacy

Opioid analgesic tolerance remains a considerable drawback to chronic pain management. The finding that concomitant administration of delta opioid receptor (DOR) antagonists attenuates the development of tolerance to mu opioid receptor (MOR) agonists has led to interest in producing bifunctional MOR agonist/DOR antagonist ligands. Herein, we present 7-benzylideneoxymorphone (6, UMB 246) displaying MOR partial agonist/DOR antagonist activity, representing a new lead for designing bifunctional MOR/DOR ligands.

Impact Of Dietary Resistant Starch On The Human Gut Microbiome, Metaproteome, And Metabolome, Tanja V. Maier, Marianna Lucio, Lang Ho Lee, Nathan C. Verberkmoes, Colin J. Brislawn, Jörg Bernhardt, Nathalie Bergeron

Faculty Publications & Research of the TUC College of Pharmacy

Diet can influence the composition of the human microbiome, and yet relatively few dietary ingredients have been systematically investigated with respect to their impact on the functional potential of the microbiome. Dietary resistant starch (RS) has been shown to have health benefits, but we lack a mechanistic understanding of the metabolic processes that occur in the gut during digestion of RS. Here, we collected samples during a dietary crossover study with diets containing large or small amounts of RS. We determined the impact of RS on the gut microbiome and metabolic pathways in the gut, using a combination of “omics” …

Undressing The Locker Room Issue: Applying Title Ix To The Legal Battle Over Locker Room Equality For Transgender Student-Athletes, Meghan M. Pirics

Marquette Sports Law Review

None

2007-2017 Cfw Scholarship Winners, Illinois Wesleyan University

Related Documents

No abstract provided.

Legal And Ethical Implications Of Athletes' Biometric Data Collection In Professional Sport, Barbara Osborne, Jennie L. Cunningham

Marquette Sports Law Review

None

Risk Parameters And Assessment Of Dietary Dsrna Exposure In Folsomia Candida, Jeffrey Edward Noland

Theses and Dissertations--Entomology

Assessing the risk of transgenic crop products is essential when determining the safety of a crop for deregulation and commercialization. The Organization of Economic and Cooperative Development (OECD), International Standards Organization (ISO), and governmental regulatory agencies require a battery of tests to demonstrate the safety of a GM product against several surrogate species of organisms that perform various ecosystem services. Assays are performed using toxicology methods established for pesticides. These methods have been applied to testing the safety, specificity and fate of Bacillus thuringiensis (Bt) Cry protein toxins engineered into crop plants and information exists on the effects on non-target …

Ecological, Molecular, And Morphological Data: A Synergistic Approach To Resolve Species Limits Of Lytopylus From The Area De Conservación Guanacaste, Costa Rica (Hymenoptera: Braconidae: Agathidinae), Ilgoo Kang

Theses and Dissertations--Entomology

Lytopylus is species-rich genus of Agathidinae (Hymenoptera: Braconidae: Agathidinae), but limited information of the genus has been published. Morphological, molecular, and ecological data were compared to resolve the species limits of Lytopylus reared from caterpillars collected the Area de Conservación Guanacaste (ACG) in Costa Rica. Molecular data were initially used to hypothesize species limits, and morphological and host use data were employed to make a final decision when molecular data was indecisive, e.g., when the genetic difference between species was slight. Thirty-two new species are described with image plates of each species. Phylogenetic analyses of the barcode region of the …

The Philosophy And Physics Of Time Travel: The Possibility Of Time Travel, Ramitha Rupasinghe

Honors Capstone Projects

Time travel to the past is an alluring subject for many science fiction writers but is it really science fiction or is there a way to make it happen, possibly in the distant future? In the world of physics, time travel to the future has already been accomplished but time travel to the past seems to be a subject of controversy. Similarly, both philosophers and physicists cannot completely agree on one fundamental question about time: what is it? In this interdisciplinary project, I will explore the fundamental nature of time as a building block to help me understand time travel. …

Peirce’S Sign Theory As An Open-Source R Package, Alon Friedman, Erin Feichtinger

School of Information Faculty Publications

Throughout Peirce’s writing, we witness his developing vision of a machine that scientists will eventually be able to create. Nadin (2010) raised the question: Why do computer scientists continue to ignore Peirce’s sign theory? A review of the literature on Peirce’s theory and the semiotics machine reveals that many authors discussed the machine; however, they do not differentiate between a physical computer machine and its software. This paper discusses the problematic issues involved in converting Peirce’s theory into a programming language, machine and software application. We demonstrate this challenge by introducing Peirce’s sign theory as a software application that runs …

Issf 2017 Reflections, Nabeel Rasheed '18

ISSF 2018 Documents

My weeklong journey in Busan came with disbelief: five-star service, global networking, and a warm, fun-loving tour guide I’ll never forget, Kiwook Hwang. On the night I arrived, I was missing a towel, a poster, and a warm meal, but the Korean Science Academy took care of me and assured I had everything I needed and more (e.g. snacks, cold water bottles, Wi Fi) to live comfortably for the next-week.

Prostate-Specific Antigen As A Risk Factor For Skeletal Metastasis In Native Ethnic African Men With Prostate Cancer: A Case-Control Study, Mahmood Qureshi, Khalid Makhdomi, William Stones

Imaging & Diagnostic Radiology, East Africa

Prostate cancer is the most common noncutaneous cancer in males. Men of African origin are at a significantly higher risk as reflected in the higher incidence and mortality rates in this racial group. Metastases incidence increases parallel to serum levels of prostate-specific antigen (PSA), contributing significantly to morbidity and mortality. Staging of the disease involves bone scans, which are sensitive in detecting skeletal metastases. Suggestions that these scans may be omitted in some situations in patients with low prostate specific antigen levels have drawn attention to the matter. In this case-control study, using radiology and pathology records, a registry of …

Implementing Pharmacy-Based Travel Health Services: Insight And Guidance From Frontline Practitioners, Tania Gregorian, Albert Bach, Karl Hess, Keri Hurley, Edith Mirzaian, Jeff Goad

Pharmacy Faculty Articles and Research

PURPOSE In California, the passage of SB493 in July of 2013 was a milestone in advancing pharmacy practice. Among other things, the new legislation allows pharmacists to provide routine immunizations without a protocol and furnish medications for international travelers for conditions not requiring a diagnosis. When developing a pharmacist-run travel health service, consideration must be given to multiple important factors, including pharmacist training, physician partnership, logistics, from scheduling to documentation, and the resources necessary to provide a travel health service.5 This article sets out to provide guidance and insight to pharmacists seeking to implement a travel health service.

SUMMARY Travel …

Development Of Bioinformatics Tools And Algorithms For Identifying Pathway Regulators, Inferring Gene Regulatory Relationships And Visualizing Gene Expression Data, Chathura J. Gunasekara

Dissertations, Master's Theses and Master's Reports

In the era of genetics and genomics, the advent of big data is transforming the field of biology into a data-intensive discipline. Novel computational algorithms and software tools are in demand to address the data analysis challenges in this growing field. This dissertation comprises the development of a novel algorithm, web-based data analysis tools, and a data visualization platform. Triple Gene Mutual Interaction (TGMI) algorithm, presented in Chapter 2 is an innovative approach to identify key regulatory transcription factors (TFs) that govern a particular biological pathway or a process through interaction among three genes in a triple gene block, which …

Performance Comparison Of Binarized Neural Network With Convolutional Neural Network, Lopamudra Baruah

Dissertations, Master's Theses and Master's Reports

Deep learning is a trending topic widely studied by researchers due to increase in the abundance of data and getting meaningful results with them. Convolutional Neural Networks (CNN) is one of the most popular architectures used in deep learning. Binarized Neural Network (BNN) is also a neural network which consists of binary weights and activations. Neural Networks has large number of parameters and overfitting is a common problem to these networks. To overcome the overfitting problem, dropout is a solution. Randomly dropping some neurons along with its connections helps to prevent co-adaptations which finally help in reducing overfitting. Many researchers …

Impact Of Pretreatment Methods On Fast Pyrolysis Of Biomass, Yash Donepudi

Dissertations, Master's Theses and Master's Reports

Biomass is considered a renewable source of energy with minimum carbon foot print if managed sustainably. The majority of the worlds energy is spend on transportation, and fast pyrolysis of biomass could be a potential route for production of a sustainable liquid transportation fuel. However, there are several hurdles in the conversion process. This work addresses these hurdles by investigating the impact of several pretreatment methods on fast pyrolysis including thermal pretreatment (torrefaction), comminution/grinding, mineral reduction. The impact of important parameters like heat transfer medium, conversion temperature and particle size were also investigated.

A mild thermal pretreatment of biomass (~10-15% …

Associations Between Invasive Eurasian Watermilfoil And Littoral Fish And Invertebrate Communities In The Keweenaw Waterway Of Lake Superior, Carmen Leguizamon

Dissertations, Master's Theses and Master's Reports

The invasion of Eurasian watermilfoil (Myriophyllum spicatum) can influence littoral zone communities within lakes. Its formation of dense mats at the water surface can suppress native macrophyte growth and impact fish diets and community structure, as well as invertebrate assemblages. However, in the colder waters of the upper Great Lakes region, Eurasian watermilfoil is patchily distributed and integrates more with the native macrophyte community. In order to identify the associations of invasive Eurasian watermilfoil and the littoral communities of the Keweenaw Waterway of Michigan’s Upper Peninsula, we sampled invertebrates, fish, and macrophytes at sites that represented a gradient of Eurasian …