Digital Commons Network^™

A C3(H20) Recycling Pathway Is A Component Of The Intracellular Complement System, Michelle Elvington, M. Kathryn Liszewski, Paula Bertram, Hrishikesh S. Kulkarni, John P. Atkinson

Open Access Publications

No abstract provided.

Evolution Of The Hypoxia-Sensitive Cells Involved In Amniote Respiratory Reflexes, Charles K. Kaufman, Et Al

Open Access Publications

No abstract provided.

A Phase 1 Dose-Escalation And Expansion Study Of Binimetinib (Mek162), A Potent And Selective Oral Mek1/2 Inhibitor, Benjamin R. Tan, Et Al

Open Access Publications

No abstract provided.

Phospholipase Cγ1 (Plcγ1) Controls Osteoclast Numbers Via Colony-Stimulating Factor 1 (Csf-1)-Dependent Diacylglycerol/Β-Catenin/Cyclind1 Pathway, Zhengfeng Yang, Seokho Kim, Sahil Mahajan, Ali Zamani, Roberta Faccio

Open Access Publications

No abstract provided.

Engineering Of Glcnac-1-Phosphotransferase For Production Of Highly Phosphorylated Lysosomal Enzymes For Enzyme Replacement Therapy, Lin Liu, Wang-Sik Lee, Balraj Doray, Stuart Kornfeld

Open Access Publications

No abstract provided.

Genome Engineering Of Stem Cells For Autonomously Regulated, Closed-Loop Delivery Of Biologic Drugs, Jonathan M. Brunger, Ananya Zutshi, Vincent P. Willard, Charles A. Gersbach, Farshid Guilak

Open Access Publications

No abstract provided.

Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears In A Small Animal Model, Adam Z. Khan, Et Al

Open Access Publications

No abstract provided.

Loss Of Navβ4-Mediated Regulation Of Sodium Currents In Adult Purkinje Neurons Disrupts Firing And Impairs Motor Coordination And Balance, Joseph L. Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L. Donermeyer, Paul M. Allen, Jeanne M. Nerbonne

Open Access Publications

No abstract provided.

Research Priorities In Limb And Task-Specific Dystonias, Sarah Pirio Richardson, Eckart Altenmüller, Katharine Alter, Ron L. Alterman, Robert Chen, Steven Frucht, Shinichi Furuya, Joseph Jankovic, H.A. Jinnah, Teresa J. Kimberley, Codrin Lungu, Joel S. Perlmutter, Cecilia N. Prudente, Mark Hallett

Open Access Publications

No abstract provided.

Inhibitory Control Of Feature Selectivity In An Object Motion Sensitive Circuit Of The Retina, Tahnbee Kim, Daniel Kerschensteiner

Open Access Publications

No abstract provided.

Ebola Virus Vp30 And Nucleoprotein Interactions Modulate Viral Rna Synthesis, Wei Xu, Priya Luthra, Chao Wu, Jyoti Batra, Daisy W. Leung, Christopher F. Basler, Gaya K. Amarasinghe

Open Access Publications

No abstract provided.

Esterase Mutation Is A Mechanism Of Resistance To Antimalarial Compounds, Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg

Open Access Publications

No abstract provided.

Polarity Of Varicosity Initiation In Central Neuron Mechanosensation, Yuanzheng Gu, Peter Jukkola, Qian Wang, Thomas Esparza, Yi Zhao, David Brody, Chen Gu

Open Access Publications

No abstract provided.

Epigallocatechin-3-Gallate, A Prototypic Chemopreventative Agent For Protection Against Cisplatin-Based Ototoxicity, Vikrant Borse, Raheem Fh Al Aameri, Kelly Sheehan, Sandeep Sheth, Tejbeer Kaur, Debashree Mukherjea, Srinivasan Tupal, Michelle Lowy, Sumana Ghosh, Asmita Dhukhwa, Puspanjali Bhatta, Leonard P. Rybak, Vickram Ramkumar

Open Access Publications

No abstract provided.

Captivity Shapes The Gut Microbiota Of Andean Bears: Insights Into Health Surveillance, Andrea Borbon-Garcia, Alejandro Reyes, Martha Vives-Florez, Susana Caballero

Open Access Publications

No abstract provided.

Complementary Network-Based Approaches For Exploring Genetic Structure And Functional Connectivity In Two Vulnerable, Endemic Ground Squirrels, Victoria H. Zero, Adi Barocas, Denim M. Jochimsen, Agnes Pelletier, Xavier Giroux-Bougard, Daryl R. Trumbo, Jessica A. Castillo, Diane Evans Mack, Mark A. Linnell, Rachel M. Pigg, Jessica Hoisington-Lopez, Stephen F. Spear, Melanie A. Murphy, Lisette P. Waits

Open Access Publications

No abstract provided.

The Lncrna Casc15 Regulates Sox4 Expression In Runx1-Rearranged Acute Leukemia, Michael O. Alberti, Et Al

Open Access Publications

No abstract provided.

Avoiding Proteolysis During Protein Purification, Barry J. Ryan, Gary T. Henehan

Books/Book Chapters/ Proceedings

All cells contain proteases which hydrolyze the peptide bonds between amino acids in a protein backbone. Typically, proteases are prevented from nonspecific proteolysis by regulation and by their physical separation into different subcellular compartments; however, this segregation is not retained during cell lysis, which is the initial step in any protein isolation procedure. Prevention of proteolysis during protein purification often takes the form of a two-pronged approach; firstly inhibition of proteolysis in situ, followed by the early separation of the protease from the protein of interest via chromatographical purification. Protease inhibitors are routinely used to limit the effect of the …

Hypoxia Reduces The Pathogenicity Of Pseudomonas Aeruginosa By Decreasing The Expression Of Multiple Virulence Factors, Bettina Schaible, Javier Rodriguez, Amaya Garcia, Alexander Von Kriegsheim, Siobhan Mcclean, Caitríona Hickey, Ciara E. Keogh, Eric Brown, Kirsten Schaffer, Alexis Broquet, Cormac T. Taylor

Articles

Our understanding of how the course of opportunistic bacterial infection is influenced by the microenvironment is limited. We demonstrate that the pathogenicity of Pseudomonas aeruginosa strains derived from acute clinical infections is higher than that of strains derived from chronic infections, where tissues are hypoxic. Exposure to hypoxia attenuated the pathogenicity of strains from acute (but not chronic) infections, implicating a role for hypoxia in regulating bacterial virulence. Mass spectrometric analysis of the secretome of P. aeruginosa derived from an acute infection revealed hypoxia-induced repression of multiple virulence factors independent of altered bacterial growth. Pseudomonas aeruginosa lacking the Pseudomonas prolyl-hydroxylase …

Mrgprs Activation Is Required For Chronic Itch Conditions In Mice, Yuyan Zhu, Claire E. Hanson, Qin Liu, Liang Han

Open Access Publications

No abstract provided.

Evolving Faith: Wanderings Of A Mormon Biologist, Blake T. Ostler

BYU Studies

Steven L. Peck. Evolving Faith: Wanderings of a Mormon Biologist.

Provo, Utah: Neal A. Maxwell Institute, 2015.

The Influence Of Dietary Factors On Child Food Allergies, Jessica A. Shaw

Honors Theses and Capstones

Solid food introduction guidelines were recently amended to suggest that earlier introduction of peanuts is associated with a decreased prevalence of peanut allergies in high-risk children. This study aimed to determine whether there is a relationship between timing of introduction to the eight most common food allergens and the development of a food allergy. A total of 177 biological mothers of school-aged New Hampshire children completed the survey, but some were excluded due to answering <50% of the survey or not consenting to participate in the study. This left data on 101 participants, and the number of participants then varied between the various food allergens. Out of the 22 children with a milk allergy, 10 children were introduced to milk when they were less than 12 months old and 12 children were introduced at or after one year old. Fifty-nine percent of those introduced before 12 months of age developed a milk allergy, while only 17% of those introduced at or past 12 months developed a milk allergy (p = 0.00). Out of the 55 participants that developed a peanut/tree nut allergy, 12 were introduced to peanuts/tree nuts before the age of 12 months, and 43 introduced after. This means that 63% of those introduced before a year developed an allergy, while only 33% introduced later developed an allergy (p = 0.01). Although not significant, the results for egg, wheat, and peanut also demonstrated that earlier introduction may be associated with an increased risk of an allergy to that food. When only one child per family was considered, to exclude genetic confounders, the only significant value was for a milk allergy, in which 64% of children introduced before 12 months developed a food allergy, while only 18% of children introduced at or after 12 months developed one (p = 0.00). Results were similar even after the exclusion of child one and two. The results of this study concur with the recommendation of introducing milk after one year, but do not support earlier introduction to other food allergens in the general population.

Reconstructing The Dedicatory Experience: Flexibility And Limitation In The Ancient Greek Dedicatory Process, Nicole M. Colosimo

Bryn Mawr College Dissertations and Theses

Identifying the factors that affected dedicatory practices has long been an area of consideration in the study of ancient Greek religion. However, this discussion is largely dominated by two concepts, those of divine specialization and appropriateness. Whereas the former assumes that divine beings had responsibilities specific to them and that this specialization limited the range of offerings a deity could receive, the latter assumes that worshippers not only selected gifts in accordance with those divine specializations but also based on preconceived notions of gender roles of worshippers and deities alike. In addition, there is a tendency to deprive worshippers of …

Reverse Passing, Khaled A. Beydoun, Erika K. Wilson

Faculty Publications

No abstract provided.

Valuing Identity, Osamudia James

Faculty Publications

No abstract provided.

Progesterone Receptor And Prostaglandins Mediate Luteinizing Hormone-Induced Changes In Messenger Rnas For Adamts Proteases In Theca Cells Of Bovine Periovulatory Follicles, Erin L. Willis, Phillip J. Bridges, Joanne E. Fortune

Animal and Food Sciences Faculty Publications

Little is known about the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of extracellular proteases in ovarian follicles of non‐rodent species, particularly in theca cells. In the present study, temporal changes in the abundance of mRNA encoding four ADAMTS subtypes and hormonal regulation of mRNA encoding two subtypes were investigated in theca interna cells during the periovulatory period in cattle. Gonadotropin‐releasing hormone (GnRH) was injected into animals to induce a luteinizing hormone (LH)/follicle‐stimulating hormone (FSH) surge, and follicles were obtained at 0 hr post‐GnRH (preovulatory) or at 6, 12, 18, or 24 hr (periovulatory). ADAMTS1, ‐2, …

Assessing In-Service Teachers’ Chemistry Content Knowledge And Self-Efficacy In Teaching The K To 12 Science Curriculum, Yna Camille A. Mongcal, Queena N. Lee-Chua, Armando M. Guidote Jr

Chemistry Faculty Publications

As the K to 12 Science program was formally implemented, interventions to enhance competence and confidence of teachers in teaching science in a spiral progression approach are main concerns. This study aims to assess the chemistry content knowledge and self-efficacy of 38 in-service teachers enrolled in a graduate program from a teacher education institution using a content knowledge test (CKT) and a self-efficacy beliefs scale (SeS) using a mixed-method approach. Quantitative findings reveal that the least mastered topics in chemistry of the teacher-respondents include solutions, chemical bonding, the mole concept, gas laws, and chemical reactions. The science teachers say they …

Power, Deviance, Stigma, And Control: A Sociological Reconceptualization Of Sexuality Within Social Work Services, Richard A. Brandon-Friedman

The Journal of Sociology & Social Welfare

Despite shared societal and historical origins, sociology and social work have had a contentious relationship, leading some to suggest the two disciplines are inherently incompatible. This article challenges that assertion by examining how sociological conceptions of deviance, power, stigma, and control can contribute to more just social work services, particularly in the contentious area of adolescent sexuality. As respected social agents, social workers can play a role in counteracting the forces that alienate outsiders. By understanding how sociological theories contribute to their ability to contest the social discourse regarding sexuality, social workers can challenge social norms and work with clients …

Freeze-Drying As A Novel Biofabrication Method For Achieving A Controlled Microarchitecture Within Large, Complex Natural Biomaterial Scaffolds, Claire Brougham, Tanya J. Levingstone, Nian Shen, Gerard M. Cooney, Thomas C. Flanagan, Stefan Jockenhoevel, Fergal J. O’Brien

Articles

The biofabrication of large scaffolds from natural biomaterials into complex 3D shapes with controllable microarchitecture remains a major challenge. Freeze-drying (or lyophilization) is a technique used to create bioactive scaffolds with a porous architecture and is typically only used to generate scaffolds in planar 3D geometries. Here we report the development of a new biofabrication process to form a collagen-based scaffold into a large, complex geometry which has a large height to width ratio, and a controlled porous microarchitecture. This biofabrication process was validated through the successful development of a heart valve shaped scaffold, fabricated from a collagen-glycosaminoglycan co-polymer. Notably, …

Study Of Phenolic Extractability In Grape Seeds By Means Of Atr-Ftir And Raman Spectroscopy, Julio Nogales-Bueno, Berta Baca-Bocanegra, Abigail Rooney, José Miguel Hernández-Hierro, Hugh Byrne, Francisco José Heredia

Articles

Near infrared hyperspectral imaging has been applied to grape seeds in order to select a representative subset of samples according to their spectral features in the 900-1700nm range. Afterwards, selected grape seeds have been classified according to their total phenol and flavanol extractabilities. In this way, samples were sorted in three different groups identified as low, medium and high extractability levels. In order to establish the chemical structures which can be responsible for the different extractabilities, vibrational spectroscopy has been applied to the non-extracted material after seed extractions. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) and Raman spectra of non-extracted …