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Mcb 7410 Seminar A Search For The Ugly Truth About Aging Using The Genome Of The Longest-Lived Rodent The Naked Mole Rat, Jan 31, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Historical Sediment Record And Levels Of Pcbs In Sedimentsand Mangroves Of Jobos Bay, Puerto Rico, Lindsey Hanson

USF St. Petersburg campus Master's Theses (Graduate)

Polychlorinated biphenyls (PCBs) were quantified in 18 surface sediment samples, 1 sediment core, and several mangrove tissue samples collected in Jobos Bay, Puerto Rico in September 2013. Total PCBs in surface sediments ranged from 0.42 to 1232 ng g-1 dw. Generally, higher levels were observed near the shore, close to urban and industrial areas. The levels suggest significant pollution in Jobos Bay with respect to PCBs. Two-thirds of the sites were dominated by lighter PCB congeners (tri- to penta-chlorinated PCBs) while one-third had heavy PCB congeners (hexa- to octa-chlorinated PCBs) dominant. Total PCBs in a sediment core indicated levels fluctuating …

Surface-Enhanced Fast Cars: En Route To Quantum Nano-Biophotonics, Dmitri V. Voronin, Zhenrong Zhang, Alexei V. Sokolov, Marlan O. Scully

Physics Faculty Publications

Quantum nano-biophotonics as the science of nanoscale light-matter interactions in biological systems requires developing new spectroscopic tools for addressing the challenges of detecting and disentangling weak congested optical signals. Nanoscale bio-imaging addresses the challenge of the detection of weak resonant signals from a few target biomolecules in the presence of the nonresonant background from many undesired molecules. In addition, the imaging must be performed rapidly to capture the dynamics of biological processes in living cells and tissues. Label-free non-invasive spectroscopic techniques are required to minimize the external perturbation effects on biological systems. Various approaches were developed to satisfy these requirements …

Fdg Avid Breast Cancer Bone Metastases Silent On Ct And Scintigraphy: A Case Report With Radiologic-Pathologic Correlation, Daniel Jeong, Marilyn Bui, Daniel Peterson, Jaime Montilla-Soler, Kenneth L. Gage

Pathology and Cell Biology Faculty Publications

Bone is the one of the most common distant metastatic sites in breast cancer. Routine initial breast cancer staging evaluation typically includes computed tomography (CT) and skeletal scintigraphy while 18F fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) is reserved for clinically high-risk cases. Since FDG PET-CT is not routinely performed during staging or surveillance evaluations, it is important for radiologists and clinicians to appreciate the limitations of bone metastasis detection on CT and scintigraphy. We present a case of bony metastases of invasive ductal carcinoma of the breast which were not detected on diagnostic CT or skeletal scintigraphy but were …

Alisertib Promotes Apoptosis And Autophagy In Melanoma Through P38 Mapk-Mediated Aurora A Signaling, Yuan-Yuan Shang, Ming Yao, Zhi-Wei Zhou, Jian Cui, Li Xia, Rong-Ying Hu, Ying-Yao Yu, Qiong Gao, Biao Yang, Yu-Xi Liu, Jie Dang, Shu-Feng Zhou, Nan Yu

Pharmacy Faculty Publications

We investigated the efficacy of Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, in melanoma. We found that ALS exerts anti-proliferative, pro-apoptotic, and pro-autophagic effects on A375 and skmel-5 melanoma cells by inhibiting p38 MAPK signaling. SB202190, a p38 MAPK-selective inhibitor, enhanced ALS-induced apoptosis and autophagy in both cell lines. ALS induced cell cycle arrest in melanoma cells through activation of the p53/p21/cyclin B1 pathway. Knockdown of p38 MAPK enhanced ALS-induced apoptosis and reduced ALS-induced autophagy. Inhibition of autophagy sensitized melanoma cells to ALS-induced apoptosis. These data indicate ALS is a potential therapeutic agent for melanoma.

Functional Characterization Of A Novel Transcript Of Ercc1 In Chemotherapy Resistance Of Ovarian Cancer, Jia Liu, Lin Zhang, Ping Mao, Guoqiang Jiang, Likun Liu, Jing Wang, Wei Yang, Lawrence Owusu, Weiling Li

Pharmacy Faculty Publications

Approximately 15-20% of ovarian cancer patients receiving platinum-based chemotherapy are primary platinum-resistant. Identification of these patients and transfer to other more effective therapy could reduce the morbidity of ovarian cancer. ERCC1 is a DNA repair gene which can complex with XPF to repair cisplatin-induced DNA damage and cause chemotherapy resistance. In this study, we found a novel ERCC1 transcript initiated upstream of the normal transcription initiation site. The expression of this larger ERCC1 transcript dramatically increased following cisplatin treatment in ovarian cancer cells and was regulated by the MAPK pathway. This phenomenon conferred enhanced cisplatin resistance on ovarian cancer cells, …

Relations Between The Dynamics Of Network Systems And Their Subnetworks, Yunjiao Wang, Kiran Chilakamarri, Demetrios Kazakos, Maria C. Leite

Mathematics and Statistics Faculty Publications

Statistical analysis of the connectivity of real world networks have revealed interesting features such as community structure, network motif and as on. Such discoveries tempt us to understand the dynamics of a complex network system by studying those of its subnetworks. This approach is feasible only if the dynamics of the subnetwork systems can somehow be preserved or partially preserved in the whole system. Most works studied the connectivity structures of networks while very few considered the possibility of translating the dynamics of a subnetwork system to the whole system. In this paper, we address this issue by focusing on …

Out Of Asia: Mitochondrial Evolutionary History Of The Globally Introduced Supralittoral Isopod Ligia Exotica, Luis A. Hurtado​, Mariana Mateos, Chang Wang, Carlos A. Santamaria, Jongwoo Jung, Valiallah Khalaji-Pirbalouty, Won Kim

Mathematics and Statistics Faculty Publications

The native ranges and invasion histories of many marine species remain elusive due to a dynamic dispersal process via marine vessels. Molecular markers can aid in identification of native ranges and elucidation of the introduction and establishment process. The supralittoral isopod Ligia exotica has a wide tropical and subtropical distribution, frequently found in harbors and ports around the globe. This isopod is hypothesized to have an Old World origin, from where it was unintentionally introduced to other regions via wooden ships and solid ballast. Its native range, however, remains uncertain. Recent molecular studies uncovered the presence of two highly divergent …

Phylogeography And Cryptic Diversity Of Intertidal Ligia Isopods (Crustacea, Isopoda, Ligiidae) Across The Southern Africa Coastline, Taylor M. Greenan, Charles L. Griffiths​, Carlos A. Santamaria

Mathematics and Statistics Faculty Publications

The extensive coastlines of South Africa and Namibia extends from the Atlantic to the Indian Ocean and encompass several major biogeographic provinces, each characterized by unique faunal and floral assemblages. Recent biogeographic studies have led to competing biogeographic models of the southern African coastline. This has stimulated phylogeographic work to determine whether the distribution of genetic diversity within coastal invertebrate species match the proposed biogeographic regions. The lack of congruence between studies and the discovery of cryptic diversity indicating the possible existence of cryptic species in coastal isopods in the region underscore the need for additional phylogeographic research in southern …

Full Issue, Ontario Birds

Ontario Birds

No abstract provided.

Hippocampal Cholinergic Neurostimulating Peptide As A Possible Modulating Factor Against Glutamatergic Neuronal Disability By Amyloid Oligomers, Toyohiro Sato, Yoshiaki Ohi, Daisuke Kato, Masayuki Mizuno, Hiroshi Takase, Tetsuko Kanamori, Cesar V. Borlongan, Akira Haji, Noriyuki Matsukawa

Neurosurgery and Brain Repair Faculty Publications

Despite having pathological changes in the brain associated with Alzheimer's disease (AD), some patients have preserved cognitive function. A recent epidemiological study has shown that diet, exercise, cognitive training, and vascular risk monitoring interventions may reduce cognitive decline in at-risk elderly people in the general population. However, the details of molecular mechanisms underlying this cognitive function preservation are still unknown. Previous reports have demonstrated that enriched environments prevent the impairment of hippocampal long-term potentiation (LTP) through β2-adrenergic signals, when LTP is incompletely suppressed by synthetic amyloid-β (Aβ) oligomers. The cholinergic network from the medial septal nucleus (MSN) is also a …

Genetic And Histological Alterations Reveal Key Role Of Prostaglandin Synthase And Cyclooxygenase 1 And 2 In Traumatic Brain Injury–Induced Neuroinflammation In The Cerebral Cortex Of Rats Exposed To Moderate Fluid Percussion Injury, Hideki Shojo, Cesar V. Borlongan, Tadashi Mabuchi

Neurosurgery and Brain Repair Faculty Publications

After the initial insult in traumatic brain injury (TBI), secondary neurodegeneration occurs that is intimately associated with neuroinflammation. Prostaglandin (PG) synthases and cyclooxygenase (COX) 1 and 2 may contribute to inflammation in the brain. Temporal and spatial expression features of PG and COX1 and 2 following trauma may guide the development of antineuroinflammation strategies. Here, we examined PG synthase signaling and COX1 and 2 gene expression levels and COX-1- and 2-positive cell types and their temporal localization in TBI-induced brain in an effort to reveal their participation in the disease’s evolving neuroinflammation. Using brain samples from the cerebral cortex of …

Racial‐Ethnic Disparities In Acute Stroke Care In The Florida‐Puerto Rico Collaboration To Reduce Stroke Disparities Study, Ralph L. Sacco, Hannah Gardener, Kefeng Wang, Chuanhui Dong, Maria A. Ciliberti-Vargas, Carolina M. Gutierrez, Negar Asdaghi, W. Scott Burgin, Olveen Carrasquillo, Enid J. Garcia-Rivera, Ulises Nobo, Sofia Oluwole, David Z. Rose, Michael F. Waters, Juan Carlos Zevallos, Mary Robichaux, Salina P. Waddy, Jose G. Romano, Tatjana Rundek

Neurology Faculty Publications

Background: Racial‐ethnic disparities in acute stroke care can contribute to inequality in stroke outcomes. We examined race‐ethnic disparities in acute stroke performance metrics in a voluntary stroke registry among Florida and Puerto Rico Get With the Guidelines‐Stroke hospitals.

Methods and Results: Seventy‐five sites in the Florida Puerto Rico Stroke Registry (66 Florida and 9 Puerto Rico) recorded 58 864 ischemic stroke cases (2010–2014). Logistic regression models examined racial‐ethnic differences in acute stroke performance measures and defect‐free care (intravenous tissue plasminogen activator treatment, in‐hospital antithrombotic therapy, deep vein thrombosis prophylaxis, discharge antithrombotic therapy, appropriate anticoagulation therapy, statin use, smoking cessation counseling) …

Positive Association Between Toxoplasma Gondii Igg Serointensity And Current Dysphoria/Hopelessness Scores In The Old Order Amish: A Preliminary Study, Abhishek Wadhawan, Aline Dagdag, Allyson Duffy, Maureen Groer, Melanie L. Daue, Braxton D. Mitchell, Kathy A. Ryan, Toni I. Pollin, Lisa A. Brenner, John W. Stiller, Xuemei Huang, Christopher A. Lowry

Nursing Faculty Publications

Toxoplasma gondii (T. gondii) IgG seropositivity and serointensity have been previously associated with suicidal self-directed violence (SSDV). Although associations with unipolar depression have also been investigated, the results have been inconsistent, possibly as a consequence of high heterogeneity. We have now studied this association in a more homogeneous population, [that is (i.e.) Old Order Amish (OOA)] with previously reported high T. gondii seroprevalence. In 306 OOA with a mean age of 46.1±16.7 years, including 191 (62.4%) women in the Amish Wellness Study, we obtained both T. gondii IgG titers (by enzyme-linked immunosorbent assay [ELISA]), and depression screening questionnaires …

Geospatial Analysis And Geography, 2017-2018, University Of South Florida St. Petersburg

Academic Learning Compacts

The Academic Learning Compact for 2017-2018 for the Bachelor's of Arts in Geospatial Analysis and Geography.

Progressive Multifocal Leukoencephalopathy And Monoclonal Antibodies: A Review, Chandrashekar Bohra, Lubomir Sokol, Samir Dalia

Internal Medicine Faculty Publications

Progressive multifocal leukoencephalopathy (PML) is a viral infection predominantly seen in patients with HIV infection. However, with the increased use of monoclonal antibodies (MAB) for various lymphoproliferative disorders, we are now seeing this infection in non-HIV patients on drugs such as natalizumab, rituximab, and so on. The aim of this article is to review the relationship between the occurrence of PML and MAB used in the treatment of hematological malignancies and autoimmune diseases. Review of articles from PubMed-indexed journals which study PML in relation to the use of MAB. Relevant literature demonstrated an increased risk of reactivation of latent John …

Gota A Gota, No. 14, 2017, Toni Pérez Fernández

KIP Articles

Portada de GOTA A GOTA nº 14 -- Editorial y datos de la publicación -- Breve crónica XVII Congreso Internacional de Espeleología de la UIS en Penrith "Cuevas en la Tierra Antigua" (Australia) -- Contribución al conocimiento de la biología subterránea de Andalucía (sur de España) V: nuevas aportaciones de Lucas von Heyden y Charles Piochard de la Brûlerie -- Neotectónica y patrones de cavernamiento en Punta Guanos, Matanzas, Cuba (III). El desarrollo del karst -- Serra de Na Burguesa. Zona de Puig de Vilarrassa y alrededores (Calvià, Mallorca) (2ªparte) -- La Cueva de la Raíz, mayor cavidad de la …

Cave Research Foundation Annual Report 2016-2017, Ed Klausner

KIP Articles

Contents: Operations Areas and Managers -- Directors and Officers -- CRF 60th Anniversary Remarks -- Cave Research Foundation Awards -- Eastern Operations Area Summary Report -- Lesser Caves of Mammoth Cave National Park Report -- Status of Crystal Cave Mapping and Cartography -- 412 Miles in 60 Years -- Cave Hollow: Arbogast Cave Survey -- Hamilton Valley Operation Report -- Lava Beds Operations -- Mapping of Craig Cave -- Cave Loop Survey Projects -- Modoc National Forest Project Report -- Ice Level Measurements in Selected Caves -- Photo-Monitoring of Selected Caves -- Castle Flows Project -- Cultural Resource Assessment of …

Environmental Dna In Subterranean Biology: Range Extension And Taxonomic Implications For Proteus, Špela Gorički, David Stanković, Aleš Snoj

KIP Articles

Europe’s obligate cave-dwelling amphibian Proteus anguinus inhabits subterranean waters of the north-western Balkan Peninsula. Because only fragments of its habitat are accessible to humans, this endangered salamander’s exact distribution has been difficult to establish. Here we introduce a quantitative real time polymerase chain reaction-based environmental DNA (eDNA) approach to detect the presence of Proteus using water samples collected from karst springs, wells or caves. In a survey conducted along the southern limit of its known range, we established a likely presence of Proteus at seven new sites, extending its range to Montenegro. Next, using specific molecular probes to discriminate the …

A Pilot Study To Measure Dynamic Elasticity Of The Bladder During Urodynamics, Andrew F. Colhoun, Adam P. Klausner, Anna S. Nagle, Ashley W. Carroll, Robert W. Barbee, Paul H. Ratz, John E. Speich

Surgery Publications

AIMS: Previous studies using isolated strips of human detrusor muscle identified adjustable preload tension, a novel mechanism that acutely regulates detrusor wall tension. The purpose of this investigation was to develop a method to identify a correlate measure of adjustable preload tension during urodynamics.

METHODS: Patients reporting urgency most or all of the time based on ICIq-OAB survey scores were prospectively enrolled in an extended repeat fill-and-empty urodynamics study designed to identify a correlate of adjustable preload tension which we now call dynamic elasticity. Cystometric capacity was determined during initial fill. Repeat fills to defined percentages of capacity with passive …

Intertemporal Choice And Delayed Gratification, Jeffrey R. Stevens

Jeffrey Stevens Publications

A parasitoid wasp has deposited half of her eggs in a host. She now faces the choice between depositing her remaining eggs in the same host or searching for another. Continuing to deposit in the current host provides the immediate payoff of completing her reproductive duties, allowing her to move on to other activities such as foraging or searching for another mate. Searching for another host, in contrast, delays the payoffs of reproducing until a suitable host is found. This wasp faces an intertemporal choice—that is, a choice between options that involve payoffs available at different times (Read, 2004; Stevens, …

Beyond Beyond Conjugality, Brenda Cossman, Bruce Ryder

Canadian Journal of Family Law

No abstract provided.

Addressing Controversies About Experts In Disputes Over Children, Nicholas Bala, Rachel Birnbaum, Carly Watt

Canadian Journal of Family Law

There is significant controversy about the use of experts in child-related disputes in family and child protection proceedings in Canada. The 2015 Lang Review of the Motherisk Laboratory at Toronto's Hospital for Sick Children concluded that experts retained by child protection agencies were introducing unreliable expert testimony about parental drug and alcohol use. The recent decision of Ontario Court of Appeal in M. v. F. suggested that evidence from a party-retained expert critiquing the opinion of a court-appointed psychologist is "rarely" helpful or admissible. This paper addresses these and related controversies about the use of experts in child-related cases. It …

Book Review: Autonomous Motherhood? A Socio-Legal Study Of Choice And Constraint By Susan B. Boyd, Dorothy E. Chunn, Fiona Kelly, And Wanda Wiegers, Brenda Cossman

Canadian Journal of Family Law

No abstract provided.

Is It Time To Tell? Abolishing Donor Anonymity In Canada, Fiona Kelly

Canadian Journal of Family Law

Over the past two decades, a growing number of donor conceived people have spoken out about the impact of donor anonymity on their health and wellbeing. A significant number of legislatures have responded to these concerns by introducing laws that prospectively (and in one case, retrospectively) abolish donor anonymity. This article considers the increasing pressure on Canadian provinces to end anonymity and introduce registers which enable donor conceived people to access their donor’s identifying information. While the article does not endorse the genetic essentialism that is often a feature of advocacy in the field, it does argue that there are …

Book Review: A Parent-Partner Status For American Family Law By Merle H. Weiner, Frances E. Chapman

Canadian Journal of Family Law

No abstract provided.

2017 The Lindenwood Review, Lindenwood University

State of the University Address (Formerly Annual Reports or President's Reports/)

The 2017 annual report of Lindenwood University. This issue includes a donor report.

Preferential Lineage-Specific Differentiation Of Osteoblast-Derived Induced Pluripotent Stem Cells Into Osteoprogenitors, Casey L. Roberts, Silvia S. Chen, Angela C. Murchison, Rebecca A. Ogle, Michael P. Francis, Roy C. Ogle, Patrick C. Sachs

School of Medical Diagnostics & Translational Sciences Publications

While induced pluripotent stem cells (iPSCs) hold great clinical promise, one hurdle that remains is the existence of a parental germ-layer memory in reprogrammed cells leading to preferential differentiation fates. While it is problematic for generating cells vastly different from the reprogrammed cells' origins, it could be advantageous for the reliable generation of germ-layer specific cell types for future therapeutic use. Here we use human osteoblast-derived iPSCs (hOB-iPSCs) to generate induced osteoprogenitors (iOPs). Osteoblasts were successfully reprogrammed and demonstrated by endogenous upregulation of Oct4, Sox2, Nanog, TRA-1-81, TRA-16-1, SSEA3, and confirmatory hPSC Scorecard Algorithmic Assessment. The hOB-iPSCs formed embryoid bodies …

A Neighborhood-Wide Association Study (Nwas): Example Of Prostate Cancer Aggressiveness, Shannon M. Lynch, Nandita Mitra, Michelle Ross, Craig Newcomb, Karl Dailey, Tara Jackson, Charnita M. Zeigler-Johnson, Harold Riethman

School of Medical Diagnostics & Translational Sciences Publications

Purpose

Cancer results from complex interactions of multiple variables at the biologic, individual, and social levels. Compared to other levels, social effects that occur geospatially in neighborhoods are not as well-studied, and empiric methods to assess these effects are limited. We propose a novel Neighborhood-Wide Association Study(NWAS), analogous to genome-wide association studies(GWAS), that utilizes high-dimensional computing approaches from biology to comprehensively and empirically identify neighborhood factors associated with disease.

Methods

Pennsylvania Cancer Registry data were linked to U.S. Census data. In a successively more stringent multiphase approach, we evaluated the association between neighborhood (n = 14,663 census variables) and prostate …

Distribution, Habitat, And Life History Aspects Of The Shrimp Crayfish, Faxonius Lancifer (Hagen) (Decapoda: Cambaridae) In Arkansas, Henry W. Robison, Chris T. Mcallister, Renn Tumlison

Journal of the Arkansas Academy of Science

The Shrimp Crayfish, Faxonius (formerly Orconectes) lancifer (Hagen) is an uncommon, although widespread, crayfish in Arkansas. This species is herein documented from 19 counties of the Gulf Coastal Plain physiographic region. Between 1974 and 2017, we made 344 collections throughout the 75 counties of Arkansas, of which 22 (6%) yielded 163 specimens of F. lancifer. Thus, from these collections, plus 10 unpublished collections of Reimer (1963), and one collection from G.L. Harp, a total of 34 collections of F. lancifer are now known from the state. Faxonius lancifer ranged from uncommon (1 specimen) to locally abundant …