Digital Commons Network^™

American Universities And The Birth Of Modern Mormonism, 1867-1940, Heather M. Seferovich

BYU Studies

Thomas W. Simpson. American Universities and the Birth of Modern Mormonism, 1867-1940.

Chapel Hill: University of North Carolina Press, 2016.

The Uncharted Waters Of Competition And Innovation In Biological Medicines, Erika Lietzan

Faculty Publications

In 2010, Congress fundamentally changed how federal law encourages the discovery and development of certain new medicines and for the first time authorized less expensive “duplicates” of these medicines to be approved and compete in the marketplace. The medicines at issue are biological medicines, generally made from, or grown in, living systems. Many of the world’s most important and most expensive medicines for serious and life–threatening diseases are biological medicines.

We have a profound interest in understanding and evaluating the impact of this legislation on innovation and competition. Scholars and courts considering this question may be tempted to reason from, …

From The Director: Conservation In Action, Gail Garber

Hawks Aloft

No abstract provided.

Wildlife And The Border Wall, Maggie Grimason

Hawks Aloft

No abstract provided.

Living On The Edge: Monitoring Raptors On The Upper Rio Grande Gorge And San Antonio Gorge, Amanda Schluter

Hawks Aloft

No abstract provided.

Raptor Monitoring In The Middle Rio Grande Bosque 2004-2017, Everett Ogilvie, Gail Garber

Hawks Aloft

No abstract provided.

Meet The Cassia Crossbill - Before It's Gone, Trevor Fetz

Hawks Aloft

No abstract provided.

Mew Mexico Birder: Mary Bruesch, Maggie Grimason

Hawks Aloft

No abstract provided.

Hawks Aloft Quilt Retreat - Food, Friends, And Fun!, Cynthia Figueroa-Mcinteer

Hawks Aloft

No abstract provided.

2004-2016, A Brief Summary Of Annual Avian Abundance And Avian Use Of Drain Habitat In The Corrales Bosque, Hawks Aloft, Inc.

Multi-Species Reports (Hawks Aloft)

No abstract provided.

A Comprehensive Molecular Phylogeny Of Holocephalans And Identification Of Sex-Specific Genetic Markers In Chondrichthyan Fishes, Jenny Marie Kemper

MUSC Theses and Dissertations

Holocephalan fishes occupy an important phylogenetic position as members of the basal clade of jawed vertebrates, as well as the sister group to bony vertebrates. Thus, they can be used to provide an important reference for comparative studies aimed at understanding early gnathostome genome evolution. However, despite this importance, holocephalans have been understudied, and no comprehensive phylogeny for their inter-relationships has been estimated. A phylogeny will provide information about ancestor-descendant relationships, forming a framework that can be used to test future hypotheses by mapping characters, identifying patterns, and estimating ancestral states. A cross-species hybridization capture method was used to sequence …

Can I Play Too? Transgender Student Athletes’ Inclusion In “Because Of Sex”, Paul Jones

UC Law SF Communications and Entertainment Journal

This article seeks to explore what remedies may be available to transgender student athletes in today's changing legal field. The law is scant as to whether transgender student athletes must be allowed to play on the sex-segregated teams which correspond with their gender identity. New legislation may not be needed. Title VII and Title IX may offer protections for transgender student athletes. The legislative and judicial tools already exist.

Several federal courts have included gender identity under Title VII, yet Title VII currently only protects people who are considered to be employees. There is now a movement across college campuses …

[N′-(4-Decyloxy-2-Oxidobenzylidene)-3-Hydroxy-2-Naphthohydrazidato-Κ3n,O,O′]Dimethyltin(Iv): Crystal Structure And Hirshfeld Surface Analysis, S.N.M. Rosely, R.S.D. Hussen, S.M. Lee, N.R. Halcovitch, M.M. Jotani, E.R.T. Tiekink

Research Publications (2016 to 2020)

The title diorganotin compound, [Sn(CH3)2(C28H32N2O4)], features a distorted SnC2NO2 coordination geometry almost inter-mediate between ideal trigonal-bipyramidal and square-pyramidal. The dianionic Schiff base ligand coordinates in a tridentate fashion via two alkoxide O and hydrazinyl N atoms; an intra-molecular hy-droxy-O - H...N(hydrazin-yl) hydrogen bond is noted. The alk-oxy chain has an all-trans conformation, and to the first approximation, the mol-ecule has local mirror symmetry relating the two Sn-bound methyl groups. Supra-molecular layers sustained by imine-C - H...O(hy-droxy), π-π [between dec-yloxy-substituted benzene rings with an inter-centroid separation of 3.7724 (13) Å], C - H...π(arene) and C - H...π(chelate ring) inter-actions are formed …

A Novel In Vitro Potency Assay Of Antisera Against Thai Naja Kaouthia Based On Nicotinic Acetylcholine Receptor Binding, K. Ratanabanangkoon, P. Simsiriwong, K. Pruksaphon, K.Y. Tan, S. Eursakun, C.H. Tan, B. Chantrathonkul, W. Wongwadhunyoo, S. Youngchim, N.H. Tan

Research Publications (2016 to 2020)

Snake envenomation is an important medical problem. One of the hurdles in antivenom development is the in vivo assay of antivenom potency which is expensive, gives variable results and kills many animals. We report a novel in vitro assay involving the specific binding of the postsynaptic neurotoxins (PSNTs) of elapid snakes with purified Torpedo californica nicotinic acetylcholine receptor (nAChR). The potency of an antivenom is determined by its antibody ability to bind and neutralize the PSNT, thus preventing it from binding to nAChR. The PSNT of Naja kaouthia (NK3) was immobilized on microtiter wells and nAChR was added to bind …

An Investigation Into A Gear-Based Knee Joint Designed For Lower Limb Prosthesis, M.S.H. Bhuiyan, I.A. Choudhury, M. Dahari, Y. Nukman, S.Z. Dawal

Research Publications (2016 to 2020)

A gear-based knee joint is designed to improve the performance of mechanical-type above-knee prostheses. The gear set with the help of some bracing, and bracket arrangement, is used to enable the prosthesis to follow the residual limb movement. The motion analysis and finite-element analysis (FEA) of knee joint components are carried out to assess the feasibility of the design. The maximum stress of 29.74 MPa and maximum strain of 2.393e−004 are obtained in the gear, whereas the maximum displacement of 7.975 mm occurred in the stopper of the knee arrangement. The factor of safety of 3.5 obtained from the FE …

Analyses Of Antioxidant Status And Nucleotide Alterations In Genes Encoding Antioxidant Enzymes In Patients With Benign And Malignant Thyroid Disorders, Nur Siti Fatimah Ramli, Sarni Mat Junit, Khoon Leong Ng, Nurhanani Razali, Jaime Jacqueline Jayapalan, Azlina Abdul Aziz

Research Publications (2016 to 2020)

Background: Synthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this study was to measure the antioxidant activities and biomarkers of oxidative stress in serum and red blood cells (RBC) of patients with benign and malignant thyroid disorders and to investigate if changes in the antioxidant activities in these patients were linked to alterations in genes encoding the antioxidant enzymes. Methods: Forty-one patients with thyroid disorders from University of Malaya Medical …

Antimicrobial Susceptibility Of Leptospira Spp. Isolated From Environmental, Human And Animal Sources In Malaysia, D. Benacer, S.N. Mohd Zain, P.T. Ooi, Kwai Lin Thong

Research Publications (2016 to 2020)

Leptospirosis is a zoonosis with worldwide distribution caused by pathogenic spirochetes of the genus Leptospira. The aim of this study was to evaluate the susceptibility of isolates obtained from different hosts. A total of 65 Leptospira isolates from humans (n = 1), zoonoses (rat, n = 60; dog, n = 1; swine, n = 1) and environment (n = 2) were tested against six antibiotics. All the isolates were resistant to trimethoprim and sulphamethoxazole and had high MIC toward chloramphenicol (MIC90: 6.25 μg/ml). All except one environment isolate were sensitive to ampicillin, doxycycline and penicillin G.

Autologous Serum Supplement Favours In Vitro Regenerative Paracrine Factors Synthesis, N. Haque, N.H. Abu Kasim, N.L. Abu Kassim, M.T. Rahman

Research Publications (2016 to 2020)

Objectives: Foetal bovine serum (FBS) is often the serum supplement of choice for in vitro human cell culture. This study compares the effect of FBS and autologous human serum (AuHS) supplement in human peripheral blood mononuclear cell (PBMC) culture to prepare secretome. Materials and methods: The PBMC (n = 7) were cultured either in RPMI-1640 containing L-glutamine and 50 units/ml Penicillin-Streptomycin (BM) or in BM with either AuHS or FBS. Viability, proliferation and differentiation of PBMC were evaluated. Paracrine factors present in the secretomes (n = 6) were analysed using ProcartaPlex Human Cytokine panel (17 plex). Ingenuity Pathway Analysis (IPA) …

Assessment Of Food Safety Knowledge, Attitude, Self-Reported Practices, And Microbiological Hand Hygiene Of Food Handlers, H.K. Lee, H. Abdul Halim, Kwai Lin Thong, L.C. Chai

Research Publications (2016 to 2020)

Institutional foodborne illness outbreaks continue to hit the headlines in the country, indicating the failure of food handlers to adhere to safe practices during food preparation. Thus, this study aimed to compare the knowledge, attitude, and self-reported practices (KAP) of food safety assessment and microbiological assessment of food handlers’ hands as an indicator of hygiene practices in food premises. This study involved 85 food handlers working in a university located in Kuala Lumpur, Malaysia. The food safety KAP among food handlers (n = 67) was assessed using a questionnaire; while the hand swabs (n = 85) were tested for the …

Brucea Javanica Seeds As Source Of Potential Natural Antioxidants To Improve Biodiesel Thermal And Oxidative Stability, Khalil Hasni, Zul Ilham, Jamaludin Mohamad, Mahendra Varman

Research Publications (2016 to 2020)

Biodiesel is one of the most promising renewable energy derived from biological sources. Biodiesel is clean and renewable biofuel but its oxidative stability is low. To increase oxidative stability of biodiesel, natural antioxidants are considered as potential compounds to be used. The purpose of the work was to investigate and determine the antioxidation potential of Brucea javanica seeds by applying different antioxidant assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), metal chelating and ferric reducing antioxidant power (FRAP). Furthermore, Total phenolic content (TPC) and Total flavonoid content (TFC) tests were done. Among the three extracts of Brucea javanica seeds, ethyl acetate extract showed …

Cigarette Smoke Extract Profoundly Suppresses Tnfα-Mediated Proinflammatory Gene Expression Through Upregulation Of Atf3 In Human Coronary Artery Endothelial Cells, J.E. Teasdale, G.G.J. Hazell, A.M.G. Peachey, G.B. Sala-Newby, C.C.T. Hindmarch, T.R. Mckay, M. Bond, A.C. Newby, S.J. White

Research Publications (2016 to 2020)

Endothelial dysfunction caused by the combined action of disturbed flow, inflammatory mediators and oxidants derived from cigarette smoke is known to promote coronary atherosclerosis and increase the likelihood of myocardial infarctions and strokes. Conversely, laminar flow protects against endothelial dysfunction, at least in the initial phases of atherogenesis. We studied the effects of TNFα and cigarette smoke extract on human coronary artery endothelial cells under oscillatory, normal laminar and elevated laminar shear stress for a period of 72 hours. We found, firstly, that laminar flow fails to overcome the inflammatory effects of TNFα under these conditions but that cigarette smoke …

Collective Behavior Quantification On Human Odor Effects Against Female Aedes Aegypti Mosquitoes—Open Source Development, A.H. Poh, Mahmoud Moghavvemi, C.S. Leong, Yee Ling Lau, A.S. Ghandari, A. Apau, Faisal Rafiq Mahamd Adikan

Research Publications (2016 to 2020)

Classifying and quantifying mosquito activity includes a plethora of categories, ranging from measuring flight speeds, repellency, feeding rates, and specific behaviors such as home entry, swooping and resting, among others. Entomologists have been progressing more toward using machine vision for efficiency for this endeavor. Digital methods have been used to study the behavior of insects in labs, for instance via three-dimensional tracking with specialized cameras to observe the reaction of mosquitoes towards human odor, heat and CO2, although virtually none was reported for several important fields, such as repellency studies which have a significant need for a proper response quantification. …

Comparison Of Nonsurgical Periodontal Therapy With Oral Hygiene Instruction Alone For Chronic Periodontitis, M. Asad, A.W.A. Aziz, R.P.C. Raman, W.H. Himratul-Aznita, T.B.T. Ali, K. Chinna, R.D. Vaithilingam

Research Publications (2016 to 2020)

We evaluated changes in clinical variables and microbiological profiles of periodontopathogens among 56 patients with moderate to severe CP who were randomly assigned to oral hygiene instruction (OHI; n = 28) or nonsurgical periodontal treatment (NSPT; n = 28). Periodontal variables were assessed and subgingival plaque samples were obtained from deep pockets (>5 mm) at baseline and 3 months after treatment. Real-time polymerase chain reaction was used to quantify Actinobacillus actinomycetemcornitans, Tannerella forsythia, Porphyrotnonas gingivalis, and Prevotella intermedia. All clinical variables significantly improved in both groups. Improvements in gingival bleeding index (GBI), probing pocket depth (PPD), and periodontal attachment …

Concentration And Time Dependent Cytotoxic Effect Of Methanolic Crude Extracts Of Pseuduvaria Macrophylla On The Human Cancer Cell Line, A. Aziz, A.B. Zulkiflee, F.Z.M. Yusof

Research Publications (2016 to 2020)

The previous study demonstrated promising anti-cancer potential in methanolic crude extracts using single concentration, especially on breast cancer cells under 24 hours treatment. The present study investigates the effective concentration of bark and leaf methanolic extract on MCF-7 breast cancer cell line under 48 and 72 hours of treatment. The method employed was MTT assay to determine the half maximal inhibitory concentration (IC50) of both extracts at different concentration under 48 & 72 hours of treatment. The IC50 was obtained by plotting the concentration (μg/mL) versus the percentage of inhibition of each extract. The MCF7 cell line had decreased response …

Correlation Between Numbers Of Cells In Human Dental Pulp And Age: Implications For Age Estimation, Mohammad Zakir Hossain, S. Daud, Phrabhakaran Nambiar, Fathilah Abdul Razak, N. Ab-Murat, R. Saub, Marina Mohd Bakri

Research Publications (2016 to 2020)

Objective: The aim of this study was to investigate correlations between dental pulp cell count of odontoblasts, subodontoblasts and fibroblasts and age, within different age groups. Formulation of regression equations using the dental pulp cell count for predicting age was attempted. Design: Eighty-one extracted teeth were grouped into two age groups (6-25 years, 26-80 years). The teeth were demineralized and histological sections were prepared for cell count. Regression equations were generated from regression analysis of cell count and tested for age estimation. Results: The number of dental pulp cells were found to increase until around the third decade of life …

Development Of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor, A. Termehyousefi, K. Tateno, S. Bagheri, H. Tanaka

Research Publications (2016 to 2020)

A method to fabricate a bioinspired nanobiosensor using electronic-based artificial taste receptors for glucose diagnosis is presented. Fabricated bioinspired glucose nanobiosensor designated based on an artificial taste bud including an amperometric glucose biosensor and taste bud-inspired circuits. In fact, the design of the taste bud-inspired circuits was inspired by the signal-processing mechanism of taste nerves which involves two layers. The first, known as a type II cell, detects the glucose by glucose oxidase and transduces the current signal obtained for the pulse pattern is conducted to the second layer, called type III cell, to induce synchronisation of the neural spiking …

Differential Analysis Of Genetic, Epigenetic, And Cytogenetic Abnormalities In Aml, M. Islam, Z. Mohamed, Y. Assenov

Research Publications (2016 to 2020)

Acute myeloid leukemia (AML) is a haematological malignancy characterized by the excessive proliferation of immature myeloid cells coupled with impaired differentiation. Many AML cases have been reported without any known cytogenetic abnormalities and carry no mutation in known AML-associated driver genes. In this study, 200 AML cases were selected from a publicly available cohort and differentially analyzed for genetic, epigenetic, and cytogenetic abnormalities. Three genes (FLT3, DNMT3A, and NPMc) are found to be predominantly mutated. We identified several aberrations to be associated with genome-wide methylation changes. These include Del (5q), T (15; 17), and NPMc mutations. Four aberrations—Del (5q), T …

Distinct Biological Potential Of Streptococcus Gordonii And Streptococcus Sanguinis Revealed By Comparative Genome Analysis, W. Zheng, M.F. Tan, L.A. Old, I.C. Paterson, N.S. Jakubovics, S.W. Choo

Research Publications (2016 to 2020)

Streptococcus gordonii and Streptococcus sanguinis are pioneer colonizers of dental plaque and important agents of bacterial infective endocarditis (IE). To gain a greater understanding of these two closely related species, we performed comparative analyses on 14 new S. gordonii and 5 S. sanguinis strains using various bioinformatics approaches. We revealed S. gordonii and S. sanguinis harbor open pan-genomes and share generally high sequence homology and number of core genes including virulence genes. However, we observed subtle differences in genomic islands and prophages between the species. Comparative pathogenomics analysis identified S. sanguinis strains have genes encoding IgA proteases, mitogenic factor deoxyribonucleases, …

Distinct Biological Potential Of Streptococcus Gordonii And Streptococcus Sanguinis Revealed By Comparative Genome Analysis, W. Zheng, M.F. Tan, L.A. Old, I.C. Paterson, N.S. Jakubovics, S.W. Choo

Research Publications (2016 to 2020)

Streptococcus gordonii and Streptococcus sanguinis are pioneer colonizers of dental plaque and important agents of bacterial infective endocarditis (IE). To gain a greater understanding of these two closely related species, we performed comparative analyses on 14 new S. gordonii and 5 S. sanguinis strains using various bioinformatics approaches. We revealed S. gordonii and S. sanguinis harbor open pan-genomes and share generally high sequence homology and number of core genes including virulence genes. However, we observed subtle differences in genomic islands and prophages between the species. Comparative pathogenomics analysis identified S. sanguinis strains have genes encoding IgA proteases, mitogenic factor deoxyribonucleases, …

Dystrophin Gene Expression And Intracellular Calcium Changes In The Giant Freshwater Prawn, Macrobrachium Rosenbergii , In Response To White Spot Symptom Disease Infection, A.F. Noor, T.C.C. Soo, F.M. Ghani, Z.H. Goh, L.T. Khoo, S. Bhassu

Research Publications (2016 to 2020)

Background Dystrophin, an essential protein functional in the maintenance of muscle structural integrity is known to be responsible for muscle deterioration during white spot syndrome virus (WSSV) infection among prawn species. Previous studies have shown the upregulation of dystrophin protein in Macrobrachium rosenbergii (the giant freshwater prawn) upon white spot syndrome virus (WSSV) infection. The literature has also suggested the important role of calcium ion alterations in causing such muscle diseases. Thus, the interest of this study lies within the linkage between dystrophin functioning, intracellular calcium and white spot syndrome virus (WSSV) infection condition. Methods In this study, the dystrophin …