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2017

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The Fundamentals Of The State Policy Of The Russian Federation In The Field Of Naval Operations For The Period Until 2030, Russia Maritime Studies Institute, Anna Davis Jan 2017

The Fundamentals Of The State Policy Of The Russian Federation In The Field Of Naval Operations For The Period Until 2030, Russia Maritime Studies Institute, Anna Davis

RMSI Research

The Fundamentals of the State Policy of the Russian Federation in the Field of Naval Operations for the Period Until 2030 reflects the Russian Federal Navy’s (RFN) improved capabilities, its evolving strategic and operational role, and its future ambitions. Signed on July 20, 2017 by President Vladimir Putin, it provides a series of guideposts for understanding the RFN’s future, as well as broader insight into how Moscow approaches issues of national and international security.

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Sharing Student Research: Student Colloquia At University Of South Florida St. Petersburg, Camielle Crampsie, Kaya Van Beynen Jan 2017

Sharing Student Research: Student Colloquia At University Of South Florida St. Petersburg, Camielle Crampsie, Kaya Van Beynen

USF St. Petersburg Campus Faculty Publications

No abstract provided.

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Towards A High Quality High School Workforce: A Longitudinal, Demographic Analysis Of U.S. Public School Physics Teachers., Gregory T. Rushton, David Rosengrant, Andrew Dewar, Lisa Shah, Herman E. Ray, Keith Sheppard, Lynn Watanabe Jan 2017

Towards A High Quality High School Workforce: A Longitudinal, Demographic Analysis Of U.S. Public School Physics Teachers., Gregory T. Rushton, David Rosengrant, Andrew Dewar, Lisa Shah, Herman E. Ray, Keith Sheppard, Lynn Watanabe

USF St. Petersburg Campus Faculty Publications

Efforts to improve the number and quality of the high school physics teaching workforce have taken several forms, including those sponsored by professional organizations. Using a series of large-scale teacher demographic data sets from the National Center for Education Statistics (NCES), this study sought to investigate trends in teacher quality at the national level in the two and a half decades between 1987 and 2012. Specifically, we investigated (i) details about the degree backgrounds, main teaching assignments, and experience levels of those assigned to teach physics; (ii) whether the proportion of those with certifications in physics as a fraction of …

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The Family's Constitution, Douglas Nejaime Jan 2017

The Family's Constitution, Douglas Nejaime

Constitutional Commentary, Vols 1–36 (1984–2022)

Part of Symposium: The Constitution and the Family

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Florida Adoption Intervention Statute: Balancing The Constitutional Rights Of The Parents With The Best Interest Of The Dependent Child, Taylor Smith Jan 2017

Florida Adoption Intervention Statute: Balancing The Constitutional Rights Of The Parents With The Best Interest Of The Dependent Child, Taylor Smith

Child and Family Law Journal

No abstract provided.

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Virus Taxonomy In The Age Of Metagenomics, Peter Simmonds, Mike Adams, Mária Benkő, Mya Breitbart, J. Rodney Brister, Eric Carstens Jan 2017

Virus Taxonomy In The Age Of Metagenomics, Peter Simmonds, Mike Adams, Mária Benkő, Mya Breitbart, J. Rodney Brister, Eric Carstens

Marine Science Faculty Publications

The number and diversity of viral sequences that are identified in metagenomic data far exceeds that of experimentally characterized virus isolates. In a recent workshop, a panel of experts discussed the proposal that, with appropriate quality control, viruses that are known only from metagenomic data can, and should be, incorporated into the official classification scheme of the International Committee on Taxonomy of Viruses (ICTV). Although a taxonomy that is based on metagenomic sequence data alone represents a substantial departure from the traditional reliance on phenotypic properties, the development of a robust framework for sequence-based virus taxonomy is indispensable for the …

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Interpreting The Role Of Ph On Stable Isotopes In Large Benthic Foraminifera, L. L. Robbins, P. O. Knorr, J. G. Wynn, Pamela Hallock, P. J. Harries Jan 2017

Interpreting The Role Of Ph On Stable Isotopes In Large Benthic Foraminifera, L. L. Robbins, P. O. Knorr, J. G. Wynn, Pamela Hallock, P. J. Harries

Marine Science Faculty Publications

Large benthic foraminifera (LBF) are prolific producers of calcium carbonate sediments in shallow, tropical environments that are being influenced by ocean acidification (OA). Two LBF species, Amphistegina gibbosa (Order Rotaliida) with low-Mg calcite tests and Archaias angulatus (Order Miliolida) with high-Mg calcite tests, were studied to assess the effects of pH 7.6 on oxygen and carbon isotopic fractionation between test calcite and ambient seawater. The δ 18O and δ 13C values of terminal chambers and of whole adult tests of both species after 6 weeks were not significantly different between pH treatments of 8.0 and 7.6. However, tests of juveniles …

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Diagnostic And Prognostic Relevance Of Cp2c And Yy1 Expression In Hepatocellular Carcinoma, Ji Sook Kim, Seung Han Son, Min Young Kim, Dongho Choi, Ik-Soon Jang, Seung Sam Paik, Ji Hyung Chae, Vladimir N. Uversky, Chul Geun Kim Jan 2017

Diagnostic And Prognostic Relevance Of Cp2c And Yy1 Expression In Hepatocellular Carcinoma, Ji Sook Kim, Seung Han Son, Min Young Kim, Dongho Choi, Ik-Soon Jang, Seung Sam Paik, Ji Hyung Chae, Vladimir N. Uversky, Chul Geun Kim

Molecular Medicine Faculty Publications

Recent studies have demonstrated an oncogenic role of the transcription factor (TF) CP2c in hepatocellular carcinoma (HCC) based on a strong correlation between CP2c expression, tumor grade, and aggressiveness. We recently found that CP2c directly interacts with another TF, YY1, which is also overexpressed in multiple cancers, including HCC. To evaluate if these proteins are co-regulated in carcinogenesis, we analyzed the expression of CP2c and YY1 in HCC (n = 136) tissues and examined the correlation between their expression and clinicopathological characteristics of HCC. Receiver operating characteristic analysis exhibited the validity of CP2c and nuclear YY1 expression as a …

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Sertoli Cells Loaded With Doxorubicin In Lipid Micelles Reduced Tumor Burden And Dox-Induced Toxicity, Mahasweta Das, Mark Howell, Elspeth A. Foran, Rohit Iyre, Shyam S. Mohapatra, Subhra Mohapatra Jan 2017

Sertoli Cells Loaded With Doxorubicin In Lipid Micelles Reduced Tumor Burden And Dox-Induced Toxicity, Mahasweta Das, Mark Howell, Elspeth A. Foran, Rohit Iyre, Shyam S. Mohapatra, Subhra Mohapatra

Molecular Medicine Faculty Publications

The toxic side effects of doxorubicin (Dox) limit its long-term use as a lung cancer chemotherapeutic. Additionally, drug delivery to the deep lung is challenging. To address these challenges, isolated rat Sertoli cells (SCs) were preloaded with Dox conjugated to lipid micelle nanoparticles (SC-DLMNs) and delivered to mouse lungs. These immunocompetent cells, when injected intravenously, travel to the lung, deliver the payload, and get cleared by the system quickly without causing any adverse reaction. We observed that SC-DLMNs effectively treated Lewis lung carcinoma 1-induced lung tumors in mice and the drug efficacy was comparable to SC-Dox treatment. Mice treated with …

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Calreticulin: Challenges Posed By The Intrinsically Disordered Nature Of Calreticulin To The Study Of Its Function, Lilian Varricchio, Mario Falchi, Massimiliano Dall'ora, Benedittis, Caterina De Benedittis, Alessandra Ruggeri, Vladimir N. Uversky, Anna Rita Migliaccio Jan 2017

Calreticulin: Challenges Posed By The Intrinsically Disordered Nature Of Calreticulin To The Study Of Its Function, Lilian Varricchio, Mario Falchi, Massimiliano Dall'ora, Benedittis, Caterina De Benedittis, Alessandra Ruggeri, Vladimir N. Uversky, Anna Rita Migliaccio

Molecular Medicine Faculty Publications

Calreticulin is a Ca2+-binding chaperone protein, which resides mainly in the endoplasmic reticulum but also found in other cellular compartments including the plasma membrane. In addition to Ca2+, calreticulin binds and regulates almost all proteins and most of the mRNAs deciding their intracellular fate. The potential functions of calreticulin are so numerous that identification of all of them is becoming a nightmare. Still the recent discovery that patients affected by the Philadelphia-negative myeloproliferative disorders essential thrombocytemia or primary myelofibrosis not harboring JAK2 mutations carry instead calreticulin mutations disrupting its C-terminal domain has highlighted the clinical need …

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Data On Evolution Of Intrinsically Disordered Regions Of The Human Kinome And Contribution Of Fak1 Idrs To Cytoskeletal Remodeling, Jaymin J. Kathiriya, Ravi Ramesh Pathak, Alexandr Bezginov, Bin Xue, Vladimir N. Uversky, Elisabeth R.M. Tillier, Vrushank Davé Jan 2017

Data On Evolution Of Intrinsically Disordered Regions Of The Human Kinome And Contribution Of Fak1 Idrs To Cytoskeletal Remodeling, Jaymin J. Kathiriya, Ravi Ramesh Pathak, Alexandr Bezginov, Bin Xue, Vladimir N. Uversky, Elisabeth R.M. Tillier, Vrushank Davé

Molecular Medicine Faculty Publications

We present data on the evolution of intrinsically disordered regions (IDRs) taking into account the entire human protein kinome. The evolutionary data of the IDRs with respect to the kinase domains (KDs) and kinases as a whole protein (WP) are reported. Further, we have reported its post translational modifications of FAK1 IDRs and their contribution to the cytoskeletal remodeling. We also report the data to build a protein-protein interaction (PPI) network of primary and secondary FAK1-interacting hybrid proteins. Detailed analysis of the data and its effect on FAK1-related functions have been described in “Structural pliability adjacent to the kinase domain …

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Electronegativity And Intrinsic Disorder Of Preeclampsia-Related Proteins, Carlos Polanco, Jorge Alberto Castañón-González, Vladimir N. Uversky, Thomas Buhse, José Lino Mendoza, Juan J. Calva Jan 2017

Electronegativity And Intrinsic Disorder Of Preeclampsia-Related Proteins, Carlos Polanco, Jorge Alberto Castañón-González, Vladimir N. Uversky, Thomas Buhse, José Lino Mendoza, Juan J. Calva

Molecular Medicine Faculty Publications

Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study in which evaluated the commonness and potential functionality of intrinsic disorder in these proteins and also made an attempt to characterize their origin. To this end, we used a several supervised techniques, as a Polarity Index Method (PIM), which evaluates the electronegativity of proteins from their sequence alone. Peculiarities of resulting polar profile of the group of preeclampsia-related proteins were then compared with profiles of a group of lipoproteins, antimicrobial peptides, angiogenesis-related proteins, …

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Real Time Monitoring Of Children, And Adults With Mental Disabilities Using A Low-Cost Non-Invasive Electronic Device, Carlos Polanco, Ignacio Islas Vazquez, Adrian Martinez-Rivas, Miguel Arias-Estrada, Thomas Buhse, Juan J. Calva, Carlos Aguilar Salinas, Claudia Pimentel Instituto Nacional De Pediatría, Vladimir N. Uversky Jan 2017

Real Time Monitoring Of Children, And Adults With Mental Disabilities Using A Low-Cost Non-Invasive Electronic Device, Carlos Polanco, Ignacio Islas Vazquez, Adrian Martinez-Rivas, Miguel Arias-Estrada, Thomas Buhse, Juan J. Calva, Carlos Aguilar Salinas, Claudia Pimentel Instituto Nacional De Pediatría, Vladimir N. Uversky

Molecular Medicine Faculty Publications

There are a growing number of small children—as well as adults—with mental disabilities (including elderly citizens with Alzheimer’s disease or other forms of age-related dementia) that are getting lost in rural and urban areas for various reasons. Establishing their location within the first 72 h is crucial because lost people are exposed to all kinds of adverse conditions and in the case of the elderly, this is further aggravated if prescribed medication is needed. Herein we describe a non-invasive, low-cost electronic device that operates constantly, keeping track of time, the geographical location and the identification of the subject using it. …

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Identification And Initial Characterization Of The Effectors Of An Anther Smut Fungus And Potential Host Target Proteins, Venkata S. Kuppireddy, Vladimir N. Uversky, Su San Toh, Ming-Chang Tsai, William C. Beckerson, Catarina Cahill, Brittany Carman, Michael H. Perlin Jan 2017

Identification And Initial Characterization Of The Effectors Of An Anther Smut Fungus And Potential Host Target Proteins, Venkata S. Kuppireddy, Vladimir N. Uversky, Su San Toh, Ming-Chang Tsai, William C. Beckerson, Catarina Cahill, Brittany Carman, Michael H. Perlin

Molecular Medicine Faculty Publications

(1) Background: Plant pathogenic fungi often display high levels of host specificity and biotrophic fungi; in particular, they must manipulate their hosts to avoid detection and to complete their obligate pathogenic lifecycles. One important strategy of such fungi is the secretion of small proteins that serve as effectors in this process. Microbotryum violaceum is a species complex whose members infect members of the Caryophyllaceae; M. lychnidis-dioicae, a parasite on Silene latifolia, is one of the best studied interactions. We are interested in identifying and characterizing effectors of the fungus and possible corresponding host targets; (2) Methods: In silico analysis of …

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Structure And Conformational Properties Of D-Glucose/D-Galactose-Binding Protein In Crowded Milieu, Alexander V. Fonin, Sergey A. Silonov, Asiia K. Sitdikova, Irina M. Kuznetsova, Vladimir N. Uversky Jan 2017

Structure And Conformational Properties Of D-Glucose/D-Galactose-Binding Protein In Crowded Milieu, Alexander V. Fonin, Sergey A. Silonov, Asiia K. Sitdikova, Irina M. Kuznetsova, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Conformational changes of d-glucose/d-galactose-binding protein (GGBP) were studied under molecular crowding conditions modeled by concentrated solutions of polyethylene glycols (PEG-12000, PEG-4000, and PEG-600), Ficoll-70, and Dextran-70, addition of which induced noticeable structural changes in the GGBP molecule. All PEGs promoted compaction of GGBP and lead to the increase in ordering of its structure. Concentrated solutions of PEG-12000 and PEG-4000 caused GGBP aggregation. Although Ficoll-70 and Dextran-70 also promoted increase in the GGBP ordering, the structural outputs were different for different crowders. For example, in comparison with the GGBP in buffer, the intrinsic fluorescence spectrum of this protein was shifted to …

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Intrinsic Disorder In Proteins With Pathogenic Repeat Expansions, April L. Darling, Vladimir N. Uversky Jan 2017

Intrinsic Disorder In Proteins With Pathogenic Repeat Expansions, April L. Darling, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Intrinsically disordered proteins and proteins with intrinsically disordered regions have been shown to be highly prevalent in disease. Furthermore, disease-causing expansions of the regions containing tandem amino acid repeats often push repetitive proteins towards formation of irreversible aggregates. In fact, in disease-relevant proteins, the increased repeat length often positively correlates with the increased aggregation efficiency and the increased disease severity and penetrance, being negatively correlated with the age of disease onset. The major categories of repeat extensions involved in disease include poly-glutamine and poly-alanine homorepeats, which are often times located in the intrinsically disordered regions, as well as repeats in …

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Osmolyte-Like Stabilizing Effects Of Low Gdnhcl Concentrations On D-Glucose/D-Galactose-Binding Protein, Alexander V. Fonin, Alexandra D. Golikova, Irina A. Zvereva, Sabato D’Auria, Maria Staiano, Vladimir N. Uversky, Irina M. Kuznetsova, Konstantin K. Turoverov Jan 2017

Osmolyte-Like Stabilizing Effects Of Low Gdnhcl Concentrations On D-Glucose/D-Galactose-Binding Protein, Alexander V. Fonin, Alexandra D. Golikova, Irina A. Zvereva, Sabato D’Auria, Maria Staiano, Vladimir N. Uversky, Irina M. Kuznetsova, Konstantin K. Turoverov

Molecular Medicine Faculty Publications

The ability of d-glucose/d-galactose-binding protein (GGBP) to reversibly interact with its ligands, glucose and galactose, makes this protein an attractive candidate for sensing elements of glucose biosensors. This potential is largely responsible for attracting researchers to study the conformational properties of this protein. Previously, we showed that an increase in the fluorescence intensity of the fluorescent dye 6-bromoacetyl-2-dimetylaminonaphtalene (BADAN) is linked to the holo-form of the GGBP/H152C mutant in solutions containing sub-denaturing concentrations of guanidine hydrochloride (GdnHCl). It was hypothesized that low GdnHCl concentrations might lead to compaction of the protein, thereby facilitating ligand binding. In this work, we utilize …

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Structural Homologies Between Phenformin, Lipitor And Gleevec Aim The Same Metabolic Oncotarget In Leukemia And Melanoma, Gábor Somlyai, T. Que Collins, Emmanuelle J. Meuillet, Patel Hitendra, Dominic P. D’Agostino, László G. Boros Jan 2017

Structural Homologies Between Phenformin, Lipitor And Gleevec Aim The Same Metabolic Oncotarget In Leukemia And Melanoma, Gábor Somlyai, T. Que Collins, Emmanuelle J. Meuillet, Patel Hitendra, Dominic P. D’Agostino, László G. Boros

Molecular Pharmacology & Physiology Faculty Publications

Phenformin’s recently demonstrated efficacy in melanoma and Gleevec’s demonstrated anti-proliferative action in chronic myeloid leukemia may lie within these drugs’ significant pharmacokinetics, pharmacodynamics and structural homologies, which are reviewed herein. Gleevec’s success in turning a fatal leukemia into a manageable chronic disease has been trumpeted in medical, economic, political and social circles because it is considered the first successful targeted therapy. Investments have been immense in omics analyses and while in some cases they greatly helped the management of patients, in others targeted therapies failed to achieve clinically stable recurrence-free disease course or to substantially extend survival. Nevertheless protein kinase …

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Cloud And Sun-Glint Statistics Derived From Goes And Modis Observations Over The Intra-Americas Sea For Geo-Cape Mission Planning, Lian Feng, Chuanmin Hu, Brian B. Barnes, Antonio Mannino, Andrew K. Heidinger, Kathleen Strabala, Laura T. Iraci Jan 2017

Cloud And Sun-Glint Statistics Derived From Goes And Modis Observations Over The Intra-Americas Sea For Geo-Cape Mission Planning, Lian Feng, Chuanmin Hu, Brian B. Barnes, Antonio Mannino, Andrew K. Heidinger, Kathleen Strabala, Laura T. Iraci

Marine Science Faculty Publications

Knowledge of cloud cover, frequency, and duration is not only important to study cloud dynamics, but also critical in determining when and where to take ocean measurements from geostationary orbits such as the Geostationary Coastal and Air Pollution Events (GEO-CAPE) mission due to the challenges in achieving complete hemispheric coverage of coastal oceans, estuaries, and inland waters at hourly frequency. Using GOES hourly measurements at 4 km nadir resolution between 2006 and 2011, the number of cloud-free hourly observations per day (Ncf) for solar zenith angle θo < 80° was estimated for each 0.1° location of the Intra-Americas Sea. The number of Sun-glint-affected hourly observations per day (Nsg) was also calculated based on the …

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Remote-Sensing Estimation Of Phytoplankton Size Classes From Goci Satellite Measurements In Bohai Sea And Yellow Sea, Deyong Sun, Yu Huan, Zhongfeng Qiu, Chuanmin Hu, Shengqiang Wang, Yijun He Jan 2017

Remote-Sensing Estimation Of Phytoplankton Size Classes From Goci Satellite Measurements In Bohai Sea And Yellow Sea, Deyong Sun, Yu Huan, Zhongfeng Qiu, Chuanmin Hu, Shengqiang Wang, Yijun He

Marine Science Faculty Publications

Phytoplankton size class (PSC), a measure of different phytoplankton functional and structural groups, is a key parameter to the understanding of many marine ecological and biogeochemical processes. In turbid waters where optical properties may be influenced by terrigenous discharge and nonphytoplankton water constituents, remote estimation of PSC is still a challenging task. Here based on measurements of phytoplankton diagnostic pigments, total chlorophyll a, and spectral reflectance in turbid waters of Bohai Sea and Yellow Sea during summer 2015, a customized model is developed and validated to estimate PSC in the two semienclosed seas. Five diagnostic pigments determined through high-performance …

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Estimating Particulate Inorganic Carbon Concentrations Of The Global Ocean From Ocean Color Measurements Using A Reflectance Difference Approach, C. Mitchell, C. Hu, B. Bowler, D. Drapeau, W. M. Balch Jan 2017

Estimating Particulate Inorganic Carbon Concentrations Of The Global Ocean From Ocean Color Measurements Using A Reflectance Difference Approach, C. Mitchell, C. Hu, B. Bowler, D. Drapeau, W. M. Balch

Marine Science Faculty Publications

A new algorithm for estimating particulate inorganic carbon (PIC) concentrations from ocean color measurements is presented. PIC plays an important role in the global carbon cycle through the oceanic carbonate pump, therefore accurate estimations of PIC concentrations from satellite remote sensing are crucial for observing changes on a global scale. An extensive global data set was created from field and satellite observations for investigating the relationship between PIC concentrations and differences in the remote sensing reflectance (Rrs) at green, red, and near-infrared (NIR) wavebands. Three color indices were defined: two as the relative height of Rrs …

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What Are The Most Commonly Used Tools To Screen Depression In Hiv-Infected Gay And Bisexual Men?, Michael Isner Jan 2017

What Are The Most Commonly Used Tools To Screen Depression In Hiv-Infected Gay And Bisexual Men?, Michael Isner

Honors Undergraduate Theses

Gay and bisexual men infected with human immunodeficiency virus (HIV) comprise a sizable, medically vulnerable population. Depression is the most commonly experienced mental health disorder affecting this group of people, lending itself to a host of risks associated with depression. As screening of depression in this population can be challenging, it is vital that clinicians have the best available tools and guidelines to detect depressive symptomology. This focused, comprehensive review of the literature examined current data describing the clinical instruments used to detect depressive symptoms in HIV-infected gay and bisexual men. The aim of this analysis was to seek out …

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Crops In Silico: Generating Virtual Crops Using An Integrative And Multi-Scale Modeling Platform, Amy Marshall-Colon, Stephen P Long, Douglas K Allen, Gabrielle Allen, Daniel A Beard, Bedrich Benes, Susanne Von Caemmerer, A J Christensen, Donna J Cox, John C Hart, Peter M Hirst, Kavya Kannan, Daniel S Katz, Jonathan P Lynch, Andrew J Millar, Balaji Panneerselvam, Nathan D Price, Przemyslaw Prusinkiewicz, David Raila, Rachel G Shekar, Stuti Shrivastava, Diwakar Shukla, Venkatraman Srinivasan, Mark Stitt, Matthew J Turk, Eberhard O Voit, Yu Wang, Xinyou Yin, Xin-Guang Zhu Jan 2017

Crops In Silico: Generating Virtual Crops Using An Integrative And Multi-Scale Modeling Platform, Amy Marshall-Colon, Stephen P Long, Douglas K Allen, Gabrielle Allen, Daniel A Beard, Bedrich Benes, Susanne Von Caemmerer, A J Christensen, Donna J Cox, John C Hart, Peter M Hirst, Kavya Kannan, Daniel S Katz, Jonathan P Lynch, Andrew J Millar, Balaji Panneerselvam, Nathan D Price, Przemyslaw Prusinkiewicz, David Raila, Rachel G Shekar, Stuti Shrivastava, Diwakar Shukla, Venkatraman Srinivasan, Mark Stitt, Matthew J Turk, Eberhard O Voit, Yu Wang, Xinyou Yin, Xin-Guang Zhu

Articles, Abstracts, and Reports

Multi-scale models can facilitate whole plant simulations by linking gene networks, protein synthesis, metabolic pathways, physiology, and growth. Whole plant models can be further integrated with ecosystem, weather, and climate models to predict how various interactions respond to environmental perturbations. These models have the potential to fill in missing mechanistic details and generate new hypotheses to prioritize directed engineering efforts. Outcomes will potentially accelerate improvement of crop yield, sustainability, and increase future food security. It is time for a paradigm shift in plant modeling, from largely isolated efforts to a connected community that takes advantage of advances in high performance …

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The Promise Of Systems Biology Approaches For Revealing Host Pathogen Interactions In Malaria., Meghan Zuck, Laura S Austin, Samuel A Danziger, John D Aitchison, Alexis Kaushansky Jan 2017

The Promise Of Systems Biology Approaches For Revealing Host Pathogen Interactions In Malaria., Meghan Zuck, Laura S Austin, Samuel A Danziger, John D Aitchison, Alexis Kaushansky

Articles, Abstracts, and Reports

Despite global eradication efforts over the past century, malaria remains a devastating public health burden, causing almost half a million deaths annually (WHO, 2016). A detailed understanding of the mechanisms that control malaria infection has been hindered by technical challenges of studying a complex parasite life cycle in multiple hosts. While many interventions targeting the parasite have been implemented, the complex biology of

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Framework For The Future: Annual Report 2016, Population Council Jan 2017

Framework For The Future: Annual Report 2016, Population Council

Annual Reports

No abstract provided.

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The Role Of Tre6p And Snrk1 In Maize Early Kernel Development And Events Leading To Stress-Induced Kernel Abortion, Samuel W. Bledsoe, Clémence Henry, Cara A. Griffiths, Matthew J. Paul, Regina Feil, John E. Lunn, Mark Stitt, L. Mark Lagrimini Jan 2017

The Role Of Tre6p And Snrk1 In Maize Early Kernel Development And Events Leading To Stress-Induced Kernel Abortion, Samuel W. Bledsoe, Clémence Henry, Cara A. Griffiths, Matthew J. Paul, Regina Feil, John E. Lunn, Mark Stitt, L. Mark Lagrimini

Department of Agronomy and Horticulture: Faculty Publications

Background: Drought stress during flowering is a major contributor to yield loss in maize. Genetic and biotechnological improvement in yield sustainability requires an understanding of the mechanisms underpinning yield loss. Sucrose starvation has been proposed as the cause for kernel abortion; however, potential targets for genetic improvement have not been identified. Field and greenhouse drought studies with maize are expensive and it can be difficult to reproduce results; therefore, an in vitro kernel culture method is presented as a proxy for drought stress occurring at the time of flowering in maize (3 days after pollination). This method is used to …

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Changes In Soil Microbial Communities After 10 Years Of Winter Wheat Cultivation Versus Fallow In An Organic-Poor Soil In The Loess Plateau Of China, Hui Tian, Hui Wang, Xiaoli Hui, Zhaohui Wang, Rhae A. Drijber, Jinshan Liu Jan 2017

Changes In Soil Microbial Communities After 10 Years Of Winter Wheat Cultivation Versus Fallow In An Organic-Poor Soil In The Loess Plateau Of China, Hui Tian, Hui Wang, Xiaoli Hui, Zhaohui Wang, Rhae A. Drijber, Jinshan Liu

Department of Agronomy and Horticulture: Faculty Publications

Agricultural management methods, such as cultivation or fallowing, have led to significant changes in soil fertility and hence, crop yield. Such changes may have stemmed from changes in soil microbial communities and associated biogeochemical processes. This phenomenon is particularly true in organic-poor soil in the Loess Plateau of China. In this study, we examined three existing soil management regimes as part of a 10-year field experiment and evaluated their effects on fungal and bacterial community structures by performing high-throughput 454 pyrosequencing. These management regimes were (i) fertilized winter wheat (Triticum aestivum L.) (FW), (ii) continuous natural fallow with weeds …

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Mapping And Characterization Of The Fefe Gene That Controls Iron Uptake In Melon (Cucumis Melo L.), Raghuprakash Kastoori Ramamurthy, Brian M. Waters Jan 2017

Mapping And Characterization Of The Fefe Gene That Controls Iron Uptake In Melon (Cucumis Melo L.), Raghuprakash Kastoori Ramamurthy, Brian M. Waters

Department of Agronomy and Horticulture: Faculty Publications

Iron (Fe) deficiency in plants limits crop growth and productivity. Molecular mechanisms that plants use to sense and respond to Fe deficiency by coordinated expression of Feuptake genes are not fully understood. The C940-fe chlorotic melon (Cucumis melo) mutant known as fefe is unable to upregulate Fe-uptake genes, however, the FeFe gene had not been identified. In this study, we used two F2 mapping populations to map and identify the FeFe gene as bHLH38, a homolog of subgroup Ib bHLH genes from Arabidopsis thaliana that are involved in transcriptional regulation of Feuptake genes in partnership with the …

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Population Structure And Genetic Diversity Of Bromus Tectorum Within The Small Grain Production Region Of The Pacific Northwest, Nevin C. Lawrence, Amber L. Hauvermale, Amit Dhingra, Ian C. Burke Jan 2017

Population Structure And Genetic Diversity Of Bromus Tectorum Within The Small Grain Production Region Of The Pacific Northwest, Nevin C. Lawrence, Amber L. Hauvermale, Amit Dhingra, Ian C. Burke

Department of Agronomy and Horticulture: Faculty Publications

Bromus tectorum L. is an invasive winter annual grass naturalized across the United States. Numerous studies have investigated B. tectorum population structure and genetics in the context of B. tectorum as an ecological invader of natural areas and rangeland. Despite the wealth of information regarding B. tectorum, previous studies have not focused on, or made comparisons to, B. tectorum as it persists in individual agroecosystems. The objectives of this study were to assess the genetic diversity and structure, the occurrence of generalist and specialist genotypes, and the influence of climate on distribution of B. tectorum sourced exclusively from within …

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A Transcriptome‑Snp‑Derived Linkage Map Of Apios Americana (Potato Bean) Provides Insights About Genome Re‑Organization And Synteny Conservation In The Phaseoloid Legumes, Jugpreet Singh, Scott R. Kalberer, Vikas Belamkar, Teshale Assefa, Matthew N. Nelson, Andrew D. Farmer, William J. Blackmon, Steven B. Cannon Jan 2017

A Transcriptome‑Snp‑Derived Linkage Map Of Apios Americana (Potato Bean) Provides Insights About Genome Re‑Organization And Synteny Conservation In The Phaseoloid Legumes, Jugpreet Singh, Scott R. Kalberer, Vikas Belamkar, Teshale Assefa, Matthew N. Nelson, Andrew D. Farmer, William J. Blackmon, Steven B. Cannon

Department of Agronomy and Horticulture: Faculty Publications

Apios (Apios americana; “apios”), a tuberous perennial legume in the Phaseoleae tribe, was widely used as a food by Native Americans. Work in the last 40 years has led to several improved breeding lines. Aspects of the pollination biology (complex floral structure and tripping mechanism) have made controlled crosses difficult, and the previous reports indicated that the plant is likely primarily an outcrosser. We used a pseudo-testcross strategy to construct a genetic map specific to the maternal parent. The map was built using single-nucleotide polymorphism markers identified by comparing the expressed sequences of individuals in the mapping population …

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