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Imsa360: Winter 2017, Imsa Fund

IMSA Fund Reports

IMSA is nurturing a strong and diverse pipeline of innovative leaders for Illinois and the world, preparing them to solve the most complex social problems of our time.

Innovation is part of IMSA’s legacy. In fact, IMSA alumni have been driving the technology sector over the past decade. Andrew Baptist ‘94, Greg Dhuse ‘99, Dusty Hendrickson ‘01 and Ethan Wozniak ‘99 are responsible for 212 of 350 patents generated by data storage leader, Cleversafe. Sam Yagan ‘95 relocated his tech company, ShopRunner, to Illinois and also co-founded OkCupid, SparkNotes, Techstars Chicago and Corazon Capital. Jessica Droste Yagan ‘95, CEO of …

Presentation, Samira Cheruku '20, Liza Kuzmina '20

Living Green

No abstract provided.

Effect Of Endurance Exercise On Micrornas In Myositis Skeletal Muscle-A Randomized Controlled Study., Jessica F Boehler, Marshall W Hogarth, Matthew D Barberio, James S Novak, Svetlana Ghimbovschi, Kristy J Brown, Li Alemo Munters, Ingela Loell, Yi-Wen Chen, Heather Gordish-Dressman, Helene Alexanderson, Ingrid E Lundberg, Kanneboyina Nagaraju

Genomics and Precision Medicine Faculty Publications

Objective

To identify changes in skeletal muscle microRNA expression after endurance exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis (PM) and dermatomyositis (DM) patients.

Methods

Following a parallel clinical trial design, patients with probable PM or DM, exercising less than once a week, and on stable medication for at least one month were randomized into two groups at Karolinska University Hospital: a 12-week endurance exercise group (n = 12) or a non-exercised control group (n = 11). Using an Affymetrix microarray, microRNA expression was determined in paired muscle biopsies taken before and …

Molecular Signatures Of Differential Responses To Exercise Trainings During Rehabilitation., Yi-Wen Chen, Chris Gregory, Fan Ye, Naoe Harafuji, Donovan Lott, San-Huei Lai, Sunita Mathur, Mark Scarborough, Parker Gibbs, Celine Baligand, Krista Vandenborne

Genomics and Precision Medicine Faculty Publications

The loss and recovery of muscle mass and function following injury and during rehabilitation varies among individuals. While recent expression profiling studies have illustrated transcriptomic responses to muscle disuse and remodeling, how these changes contribute to the physiological responses are not clear. In this study, we quantified the effects of immobilization and subsequent rehabilitation training on muscle size and identified molecular pathways associated with muscle responsiveness in an orthopaedic patient cohort study. The injured leg of 16 individuals with ankle injury was immobilized for a minimum of 4 weeks, followed by a 6-week rehabilitation program. The maximal cross-sectional area (CSA) …

A System To Monitor Segmental Intracellular, Interstitial, And Intravascular Volume And Circulatory Changes During Acute Hemodialysis, Leslie Montgomery, Richard Montgomery, Wayne Gerth, Marty Loughry, Susie Q. Lew, Manuel T. Velasquez

Medicine Faculty Publications

This paper describes a new combined impedance plethysmographic (IPG) and electrical bioimpedance spectroscopic (BIS) instrument and software that allows noninvasive real-time measurement of segmental blood flow and changes in intracellular, interstitial, and intravascular volumes during various fluid management procedures. The impedance device can be operated either as a fixed frequency IPG for the quantification of segmental blood flow and hemodynamics or as a multi-frequency BIS for the recording of intracellular and extracellular resistances at 40 discrete input frequencies. The extracellular volume is then deconvoluted to obtain its intra-vascular and interstitial component volumes as functions of elapsed time. The purpose of …

Review Of Current Immunologic Therapies For Hidradenitis Suppurativa, Victoria K. Shanmugam, Nadia Meher Zaman, Sean Mcnish, Faye Hant

Medicine Faculty Publications

Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of apocrine gland-bearing skin which affects approximately 1–4% of the population. The disease is more common in women and patients of African American descent and approximately one-third of patients report a family history. Obesity and smoking are known risk factors, but associations with other immune disorders, especially inflammatory bowel disease, are also recognized. The pathogenesis of HS is poorly understood and host innate or adaptive immune response, defective keratinocyte function, and the microbial environment in the hair follicle and apocrine gland have all been postulated to play a role in disease …

Predictors Of High On-Aspirin Platelet Reactivity In Elderly Patients With Coronary Artery Disease., J W Zhang, W W Liu, Timothy A Mccaffrey, X Q He, W Y Liang, X H Chen, X R Feng, Sidney W Fu, M L Liu

Medicine Faculty Publications

Objectives

Previous studies have illustrated the link between high on-aspirin platelet reactivity (HAPR) with increasing thrombotic risks. The aim of our study was to investigate relative risk factors of HAPR in elderly patients with coronary artery disease.

Methods

Elderly, hospitalized coronary artery disease patients on regular aspirin treatment were enrolled from January 2014 to September 2016. Medical records of each patient were collected, including demographic information, cardiovascular risk factors, concomitant drugs and routine biological parameters. Arachidonic acid (AA, 0.5 mg/mL) and adenosine diphosphate (ADP, 5 µmol/L) induced platelet aggregation were measured via light transmission assay (LTA) to evaluate antiplatelet responses, …

Plasmablastic Lymphoma: Case Report Of Prolonged Survival Of An Advanced Human Immunodeficiency Patient And Literature Review, Hind Rafei, Ehab El-Bahesh, Antoine Finianos, Min-Ling Liu, Geraldine Schechter

Medicine Faculty Publications

Clinical Practice Points. Plasmablastic lymphoma (PBL) is a rare and highly aggressive variant of diffuse large B cell lymphoma with median survival of advanced stage patients varying between 6 and 15 months in previous reports. We report here a human immunodeficiency virus-infected patient surviving over 12 years following treatment for advanced PBL with EPOCH chemotherapy and intrathecal therapy. This case highlights the potential for improved survival in PBL with intensive chemotherapy. Further, literature review suggests promising prospects utilizing novel targeted therapies to increase the rate of prolonged responses.

Ptpro Represses Erbb2-Driven Breast Oncogenesis By Dephosphorylation And Endosomal Internalization Of Erbb2., H Dong, L Ma, J Gan, W Lin, Rakesh Kumar, +9 Additional Authors

Biochemistry and Molecular Medicine Faculty Publications

The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro inMMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor latency and accelerated tumor growth due to loss of Ptpro within the breast cancer cells but not in surrounding tissue as confirmed by hetero-transplantation studies. Both in vitro and in vivo data demonstrated that the phosphatase activity was required for the inactivation of ERBB2 and its downstream signaling. PTPRO regulated the phosphorylation status of ERBB2 at Y1248. Co-immunoprecipitation and proximity ligation assay (Duolink) indicated that …

Medical Genetics And Genomic Medicine In The United States. Part 2: Reproductive Genetics, Newborn Screening, Genetic Counseling, Training, And Registries, Debra S. Regier, Carlos Ferreira, Suzanne Hart, Donald Hadley, Maximilian Muenke

Pediatrics Faculty Publications

eview of genetics in the United States with emphasis on the prenatal, metabolic, genetic counseling, and training aspects of the field.

Urban Pooling, Christian Iaione, Elena De Nictolis

Fordham Urban Law Journal

No abstract provided.

Confusion In Montgomery’S Wake: State Responses, The Mandates Of Montgomery, And Why A Complete Categorical Ban On Life Without Parole For Juveniles Is The Only Constitutional Option, Alice Reichman Hoesterey

Fordham Urban Law Journal

No abstract provided.

A Review Of The Occurrence Of Pharmaceuticals And Personal Care Products In Indian Water Bodies, Keshava Balakrishna, Amlan Rath, Yerabham Praveenkumarreddy, Keerthi Siri Guruge, Bikram Subedi

Faculty & Staff Research and Creative Activity

Little information exists on the occurrence and the ultimate fate of pharmaceuticals in the water bodies in India despite being one of the world leaders in pharmaceutical production and consumption. This paper has reviewed 19 published reports of pharmaceutical occurrence in the aquatic environment in India [conventional activated sludge wastewater treatment plants (WTPs), hospital WTPs, rivers, and groundwater]. Carbamazepine (antipsychoactive), atenolol (antihypertensive), triclocarban and triclosan (antimicrobials), trimethoprim and sulfamethoxazole (antibacterials), ibuprofen and acetaminophen (analgesics), and caffeine (stimulant) are the most commonly detected at higher concentrations in Indian WTPs that treat predominantly the domestic sewage. The concentration of ciprofloxacin, sulfamethoxazole, amoxicillin, …

Stimulated Hyposalivary Flow Rates In Healthcare Students In An Interprofessional Awareness Educational Program Curriculum, R Constance Wiener

Faculty & Staff Scholarship

Purpose. Hyposalivation influences quality of life and medication compliance. However, oral health knowledge (in general) and knowledge about hyposalivation (in particular) are often lacking in nondental healthcare professional’s curricula. Additionally, hyposalivation has not been adequately studied in young adults. The purpose for this study is twofold: to use an interprofessional educational curriculum to increase nondental healthcare students’ knowledge about oral health and salivary testing and determine whether hyposalivation is different between sexes in young adults. Method. First-year medical and pharmacy students () learned the process of saliva collection and provided samples in an interprofessional program. Results. There were 14.4% of …

Himmelfarb Library Annual Report 2017, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Annual Report

No abstract provided.

Probabilistic And More General Uncertainty-Based (E.G., Fuzzy) Approaches To Crisp Clustering Explain The Empirical Success Of The K-Sets Algorithm, Vladik Kreinovich, Olga Kosheleva, Shahnaz Shahbazova, Songsak Sriboonchitta

Departmental Technical Reports (CS)

Recently, a new empirically successful algorithm was proposed for crisp clustering: the K-sets algorithm. In this paper, we show that a natural uncertainty-based formalization of what is clustering automatically leads to the mathematical ideas and definitions behind this algorithm. Thus, we provide an explanation for this algorithm's empirical success.

Local To Global: Developing Solutions And Creating Impacts. Annual Report Fy 2017, Robert B. Daugherty Water For Food Global Institute

Daugherty Water for Food Global Institute: Administrative Materials

FOREWORD - Hank M. Bounds, President, University of Nebraska

PREFACE - Peter G. McCornick, Executive Director

Focus Areas: Where we are headed We are committed to helping the world efficiently use its limited freshwater resources to ensure food security for current and future generations. The diversity of projects and activities in this report reflects the complexity of the challenges we face in achieving this goal through technical and policy research, education and communication. Our research and policy development efforts are focused within five areas to maximize the expertise of DWFI staff, our colleagues at the National Drought Mitigation Center (NDMC) …

A Radial Basis Function (Rbf) Compact Finite Difference (Fd) Scheme For Reaction-Diffusion Equations On Surfaces, Erik Lehto, Varun Shankar, Grady B. Wright

Mathematics Faculty Publications and Presentations

We present a new high-order, local meshfree method for numerically solving reaction diffusion equations on smooth surfaces of codimension 1 embedded in ℝ^d. The novelty of the method is in the approximation of the Laplace-Beltrami operator for a given surface using Hermite radial basis function (RBF) interpolation over local node sets on the surface. This leads to compact (or implicit) RBF generated finite difference (RBF-FD) formulas for the Laplace-Beltrami operator, which gives rise to sparse differentiation matrices. The method only requires a set of (scattered) nodes on the surface and an approximation to the surface normal vectors at …

The Law And Big Data, Caryn Devins, Teppo Felin, Stuart Kauffman, Roger Koppl

Cornell Journal of Law and Public Policy

In this Article we critically examine the use of Big Data in the legal system. Big Data is driving a trend towards behavioral optimization and "personalized law," in which legal decisions and rules are optimized for best outcomes and where law is tailored to individual consumers based on analysis of past data. Big Data, however, has serious limitations and dangers when applied in the legal context. Advocates of Big Data make theoretically problematic assumptions about the objectivity of data and scientific observation. Law is always theory-laden. Although Big Data strives to be objective, law and data have multiple possible meanings …

Transcendent Mind, Emergent Universe In The Thought Of Michael Polanyi, Vincent Smiles

Theology Faculty Publications

This essay vindicates two major aspects of the science-based philosophy of Michael Polanyi: 1. His concept of tacit knowing, and 2. His concept of the multi-levelled character of reality. These two notions relate closely with one another, and together support the thesis to be argued here, that when it comes to understanding human beings, and most especially the human mind, science and religion have to meet on the common ground of the transcendent capacities of human beings, which are pointers to the transcendent character of the universe. The mind is an emergent of the universe, as are all of its …

Minnesota Fish Taxonomic Key 2017 Edition, Warren Lamb

Journal of Earth and Life Science

Minnesota’s landscape is maze of lakes and river that are home to a recorded total of 163 species of fish. This document is a complete and current dichotomous taxonomic key of the Minnesota fishes. This key was based on the 1972 “Northern Fishes” key (Eddy 1972), and updated based on Dr. Jay Hatch’s article “Minnesota Fishes: Just How Many Are There?” (Hatch 2016). Any new species or family additions were also referenced to the 7th edition of the American Fisheries society “Names of North American Fishes” (Page et al. 2013) to assess whether a fish species is currently recognized by …

Design, Modeling, Fabrication, And Testing Of A Multistage Micro Gas Compressor With Piezoelectric Unimorph Diaphragm And Passive Microvalves For Microcooling Applications, Shawn Thanhson Le

Doctoral Dissertations

This dissertation investigates the development of a multistage micro gas compressor utilizing multiple pump stages cascaded in series to increase the pressure rise with passive microvalves and piezoelectric unimorph diaphragms. This research was conducted through modeling, simulation, design, and fabrication of the microcompressor and its components. A single-stage and a two-stage microcompressor were developed to demonstrate and compare the performance and effectiveness of using a cascaded multistage design.

Steady fluid flow through static microvalves structure was studied to gain insight on its gas flow dynamics and characteristics. Transient analysis combined with the structure's interaction was investigated with an analytical model …

Expanding The Applications Of Poly(Dimethylsiloxane) In Biomicrofluidics, Sawyer D. Stone

Doctoral Dissertations

This work aims to create novel applications for poly(dimethylsiloxane) (PDMS) in the field of biomicrofluidics through oxidative stress detection, doping of the polymer for intentional leaching into microdevices, and the development of low-cost implements for fabricating PDMS microfluidic devices. PDMS has become the polymer of choice for research in microfluidics due to its optical clarity, ease of fabrication, flexibility in design, good mechanical properties, and the ability to chemically modify the surface.

Biomicrofluidics enables the rapid throughput and analysis of small biological samples requiring less time investment and reagent use than traditional macroscale laboratory techniques. Polymer devices are inexpensive, easily …

Amgen Material Handling, Kevin Paiva, Matt Perry, Brandon Fleet

Mechanical Engineering Capstone Design Projects

Amgen is a world leading pharmaceutical company that specializes in biotechnology which develops intravenous or injectable biologic medicines. With an outstanding reputation in the field of safety, quality assurance, superior scientific innovation, and continuous improvement in all aspects, Amgen’s goal is to serve patients cutting edge medications available in today’s market. With this outlook on innovation, Amgen is currently looking into a material handling solution for movement of material between its storage facilities to an IOS9 cleanliness standard laboratory. Such movement includes passing through an airlock which requires the drums containing necessary chemicals for biotechnological production to be cleaned and …

Enhancing Information Literacy Using Bernard Lonergan's Generalized Empirical Method: A Three-Year Case Study In A First Year Biology Course, Lisa Madeleine Rose-Wiles, Marian Glenn, Doreen Stiskal

Library Publications

This paper describes a three-year long collaborative project between a science librarian, a biology professor and a physical therapy professor to improve information literacy in an undergraduate biology laboratory course. The authors used Bernard J. Lonergan’s Generalized Empirical Method (GEM) as a cognitional framework, emphasizing the role of experience, understanding, judgement and action in conducting research. They focused on the selection, integration and citation of scholarly articles in formal laboratory reports. The science librarian became embedded in the course, delivering information literacy instruction sessions, grading and providing feedback on the use of information sources in the lab reports. Overall the …

The Impact Of Globalization On The Perceptions And Practices Of Menstruation Among Indigenous Women In Peru, Meghan Wallace

Honors Program Theses

The existing perceptions and practices of menstruation on the island of Taquile in Lake Titicaca, Peru provide insights into the manners in which globalization can challenge and shape perspectives in indigenous communities. Through the framework of globalization as polarization, hybridization, and homogenization, this study explores the impacts that changes in menstrual practices and perceptions can have on female health outcomes, agency in the community, and education efforts. Viewpoints of menstruation distinctly differ according to gender and age, yet ultimately point toward the concept that all three lenses of globalization provide explanations for menstruation in the community of Taquile.

Variability In Objective And Subjective Measures Affects Baseline Values In Studies Of Patients With Copd, Wayne H. Anderson, Jae Wook Ha, David J. Couper, Wanda K. O'Neal, R. Graham Barr, Eugene R. Bleecker, Elizabeth E. Carretta, Christopher B. Cooper, Claire M. Doerschuk, M. Bradley Drummond, Meilan K. Han, Nadia N. Hansel, Victor Kim, Eric C. Kleerup, Fernando J. Martinez, Stephen I. Rennard, Donald Tashkin, Prescott G. Woodruff, Robert Paine, Jeffrey L. Curtis, Richard W. Kanner, Spiromics Research Group

Journal Articles: Pulmonary & Critical Care Med

RATIONALE: Understanding the reliability and repeatability of clinical measurements used in the diagnosis, treatment and monitoring of disease progression is of critical importance across all disciplines of clinical practice and in clinical trials to assess therapeutic efficacy and safety.

OBJECTIVES: Our goal is to understand normal variability for assessing true changes in health status and to more accurately utilize this data to differentiate disease characteristics and outcomes.

METHODS: Our study is the first study designed entirely to establish the repeatability of a large number of instruments utilized for the clinical assessment of COPD in the same subjects over the same …

Where You End And I Begin : Notes On Subjectivity And Ethics In The Translation Of Poetry, Andrea Lingenfelter

Journal of Modern Literature in Chinese 現代中文文學學報

What can translation teach us about poetry and poetics? To what extent is a lyric constellation portable, and to what extent is it embedded in a particular culture or language? How much of a foreign syntax can be replicated before things break down? What is the role of sound in a translation? By discussing poems by three poets whose work I have translated—the Taiwanese poet Yang Mu and the mainland-Chinese poets Zhai Yongming and Wang Yin—this paper explores issues such as the above. It connects these issues with the question of “where you end and I begin” and vice versa, …

Intersectionality And Feminist Pedagogy: Lessons From Teaching About Racism And Economic Inequity, Lisa Cunningham, Pao Lee Vue, Virginia B. Maier

English Faculty/Staff Publications

This paper utilizes Rochester, NY, as a case study to argue that approaching race intersectionally and across disciplines creates a stronger model of feminist pedagogy. It is based on our work in the classroom and on the Fisher Race Initiatives—a series of three interactive workshops we created on our campus to create change in the aftermath of the Michael Brown shooting in Ferguson, MO, and in the subsequent rise of the #BlackLivesMatter movement. Our goals were to promote dialogue on race, to expose participants to factual information on race, and to emphasize the intersectional causes of poverty in the Rochester …

Embryonic Exposure Of Chicken Chicks (Gallus Gallus Domesticus) Leads To Heightened Sensitivities Towards The Exposed Scent, Ryan Hughes, Gregory B. Cunningham

Biology Faculty/Staff Publications

In chickens, food consumption can be altered by exposing the chicks to scents as embryos. We exposed eggs to an orange-scented food additive in the final days of incubation. Following hatching, we tested these exposed chicks’ ability to detect this scent at a variety of concentrations. We found that orange-exposed chicks responded to an orange-scented solution at lower concentrations than control chicks. This sensitization may allow chicks to be more effective at locating acceptable food items but requires further testing to determine its significance. Orange-exposed and control chicks were also tested with the scent of raspberry. Orange-exposed chicks responded to …