Digital Commons Network^™

Functional Features Of Hyperactive Deg/Enac Channels Involved In Cell Death, Cristina Matthewman

Open Access Dissertations

Ion channels of the DEG/ENaC family can induce neurodegeneration under conditions in which they become hyperactivated. The C. elegans DEG/ENaC channel MEC-4(d) encodes a mutant channel with a substitution in the pore domain that causes swelling and death of the six touch neurons in which it is expressed. Dominant mutations in homolog channel UNC-8 result in uncoordinated movement. Here we show that this unc-8(d) movement defect is correlated with the selective death of cholinergic motor neurons in the ventral nerve cord, a milder toxicity compared with MEC-4(d). UNC-8(G387E), denoted UNC-8(d), and UNC-8(A586T) mutants encode hyperactivated channels that are strongly inhibited …

How Do Teacher Evaluation Ratings On Kentucky's Professional Growth And Effectiveness System Relate To Student Achievement?, Martha Collins Jones, Jennifer R. Allen, Jim Masters

Morehead State Theses and Dissertations

A capstone submitted in partial fulfillment of the Requirements for the degree of Doctor of Education in the College of Education at Morehead State University by Martha Collins Jones, Jennifer R. Allen, and Jim Masters on January 23, 2017.

Chemistry Professor Takita Felder Sumter Named First Provost’S Faculty Fellow, Winthrop University

Winthrop News 2017

• The Provost’s Faculty Fellows Program provides emerging and current faculty leaders with opportunities to develop and demonstrate administrative leadership.
• Provost’s Faculty Fellows represent the Provost on special projects to advance the university’s strategic plan, as well as supporting routine office operations.

New Hampshire’S Changing Climate, Land Cover, And Ecosystems, Ecosystems & Society Project Research Team

New Hampshire EPSCoR

No abstract provided.

Current, January 23, 2017, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

Grand Valley Forum, Volume 041, Number 17, January 23, 2017, Grand Valley State University

2016-2017, Volume 41

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Diet Composition Of Age-0 Fishes In Created Habitats Of The Lower Missouri River, Trevor A. Starks, James M. Long

United States Geological Survey: Staff Publications

Channelization of the Missouri River has greatly reduced the availability of shallow water habitats used by many larval and juvenile fishes and contributed to imperilment of floodplain-dependent biota. Creation of small side channels, or chutes, is being used to restore shallow water habitat and reverse negative environmental effects associated with channelization. In the summer of 2012, the U.S. Army Corps of Engineers collected early life stages of fishes from constructed chutes and nearby unrestored shallow habitats at six sites on the Missouri River between Rulo, Nebraska and St. Louis, Missouri. We compared the diets of two abundant species of fishes …

Anthropology Alum Studies Primatology At Iowa State, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Plant Biology Alum Has Tasty Career Based On Coffee And Chocolate, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Tiger Vol. 111 Issue 2 2017-01-23, Clemson University

Tiger Newspapers 2017

No abstract provided.

The Performance Analysis Of Two Relatively Small Capacity Urban Retrofit Stormwater Controls, James J. Houle, Thomas P. Ballestero, Timothy A. Puls

UNH Stormwater Center

This paper details field investigations that were conducted on the performance of small capacity urban retrofit stormwater control measures. The objective of the two year study (2013–2015) was to provide performance data on stormwater retrofits that could not be fully sized according to conventional standards due to space constraints. In many states performance credits are not granted to stormwater management controls that are not designed to manage regionally derived water quality volumes. In retrofit applications there may exist numerous limitations to conventionally sized systems such as limited rights of way, setback distances or existing utilities. The larger scale objective of …

Passing On The Huntington’S Disease Advocacy Baton To The Next Generation, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Utah Statesman, January 23, 2017, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Two New Genera Of Songbirds Represent Endemic Radiations From The Shola Sky Islands Of The Western Ghats, India, Sushma Reddy, V. V. Robin, C. K. Vishnudas, Pooja Gupta, Frank E. Rheindt, Daniel M. Hooper, Uma Ramakrishnan

Biology: Faculty Publications and Other Works

A long-standing view of Indian biodiversity is that while rich in species, there are few endemics or in-situ radiations within the subcontinent. One exception is the Western Ghats biodiversity hotspot, an isolated mountain range with many endemic species. Understanding the origins of the montane-restricted species is crucial to illuminate both taxonomic and environmental history.

Uab Undergraduate Student A Finalist For Prestigious Gates Cambridge Scholarship, Tyler Greer

Browse All News

No abstract provided.

Collaborative Inquiry And The Shared Workspace Of Professional Learning Communities, Daniel Carpenter

CUP Faculty Research

An exploration of an educator collaborative inquiry in the shared workspace of professional learning communities reveals that the educator collaborative inquiry enables the leaders to focus on increasing student achievement scores.

Academics: The Newsletter Of The Swosu College Of Arts And Sciences, Peter Grant

aCAdemicS: The Newsletter of the SWOSU College of Arts & Sciences

No abstract provided.

Uab Involved In Critical Nih Study That Identifies Genomic Features Of Cervical Cancer, Staff

Browse All News

No abstract provided.

Effect Of Phytosanitary Irradiation On The Quality Of Two Varieties Of Pummelos (Citrus Maxima (Burm.) Merr.), A. Jain, J. Ornelas-Paz, D. Obenland, K. Rodriguez (Friscia), Anuradha Prakash

Food Science Faculty Articles and Research

Phytosanitary treatments prevent the introduction of pests such as fruit flies into pest free zones, and are often required for international trade. Irradiation is increasingly being considered as an alternative to cold and chemical phytosanitary treatments, such as methyl bromide. In this study, the effect of low dose gamma irradiation on the post-harvest quality of two varieties of pummelos (Citrus maxima (Burm.) Merr.), an emerging crop of interest in the US was evaluated. Two varieties of pummelos grown in California were irradiated at the phytosanitary target dose of 150 Gy and a higher dose of 1000 Gy to exaggerate …

Applying Population And Community Ecology Theory To Advance Understanding Of Belowground Biogeochemistry, Robert W. Buchkowski, Mark A. Bradford, A. Stuart Grandy, Oswald J. Schmitz, William R. Wieder

Faculty Publications

Approaches to quantifying and predicting soil biogeochemical cycles mostly consider microbial biomass and community composition as products of the abiotic environment. Current numerical approaches then primarily emphasise the importance of microbe–environment interactions and physiology as controls on biogeochemical cycles. Decidedly less attention has been paid to understanding control exerted by community dynamics and biotic interactions. Yet a rich literature of theoretical and empirical contributions highlights the importance of considering how variation in microbial population ecology, especially biotic interactions, is related to variation in key biogeochemical processes like soil carbon formation. We demonstrate how a population and community ecology perspective can …

Daily Eastern News: January 23, 2017, Eastern Illinois University

January

No abstract provided.

Students’ Independent Use Of Screencasts And Simulations To Construct Understanding Of Solubility Concepts, Deborah Herrington, Ryan D. Sweeder, Jessica Vandenplas

Peer Reviewed Articles

As students increasingly use online chemistry animations and simulations, it is becoming more important to understand how students independently engage with such materials and to develop a set of best practices for students’ use of these resources outside of the classroom. Most of the literature examining students’ use of animations and simulations has focused on classroom use with some studies suggesting that better outcomes are obtained when students use simulations with minimal guidance while others indicate the need for appropriate scaffolding. This study examined differences with respect to (1) student understanding of the concept of dissolution of ionic and covalent …

One Ion To Rule Them All: Combined Antibacterial, Osteoinductive And Anticancer Properties Of Selenite-Incorporated Hydroxyapatite, Vuk Uskoković, Maheshwar Adiraj Iyer, Victoria M. Wu

Pharmacy Faculty Articles and Research

Although hydroxyapatite (HAp) has been doped with dozens of different ions, the quest for an ion imparting a combination of properties conducive to bone healing is still ongoing. Because of its protean potency and the similarity in size and shape to the phosphate tetrahedron, the selenite ion presents a natural ionic substitute in HAp. The incorporation of selenite into synthetic HAp using two different methods – co-precipitation and ion-exchange sorption – was studied for its effect on crystal properties and on a triad of biological responses: antibacterial, anticancer and osteoinductive. Co-precipitation yielded HAp with a higher selenite content than sorption …

Mcsa Forum Minutes 01/23/2017, Morris Campus Student Association

Morris Campus Student Association

No abstract provided.

Evolutionary Adaptations Of Biofilms Infecting Cystic Fibrosis Lungs Promote Mechanical Toughness By Adjusting Polysaccharide Production, Kristin Kovach, Megan Davis-Fields, Yasuhiko Irie, Kanishk Jain, Shashvat Doorwar, Katherine Vuong, Numa Dhamani, Kishore Mohanty, Ahmed Touhami, Vernita D. Gordon

Biology Faculty Publications

Biofilms are communities of microbes embedded in a matrix of extracellular polymeric substances, largely polysaccharides. Multiple types of extracellular polymeric substances can be produced by a single bacterial strain. The distinct polymer components of biofilms are known to provide chemical protection, but little is known about how distinct extracellular polysaccharides may also protect biofilms against mechanical stresses such as shear or phagocytic engulfment. Decades-long infections of Pseudomonas. aeruginosa biofilms in the lungs of cystic fibrosis patients are natural models for studies of biofilm fitness under pressure from antibiotics and the immune system. In cystic fibrosis infections, production of the extracellular …

An Analysis Of Stable Isotopes From N-Alkanes Derived From Leaf Waxes In North America, Katherine T. Truong Ms.

Master's Theses

Leaf wax biomarkers are increasingly becoming a fundamental aspect of paleoclimate research. The strength of the relationship between their molecular and isotopic properties and environmental conditions is critical to their effectiveness in reconstructing past environments. To address the current lack of data pertaining to arid and semi-arid environments, soil and modern plant samples (grasses, trees, forbs, and shrubs) from sites in the western United States were analyzed to assess relationships between normal alkane molecular distribution, δD and δ¹³C and seasonal/annual climatic conditions in semi-arid ecosystems. The data show a stronger relationship between δD of leaf waxes (δD_{wax …}

The Fatty Acid Regulator Fadr Influences The Expression Of The Virulence Cascade In The El Tor Biotype Of Vibrio Cholerae By Modulating The Levels Of Toxt Via Two Different Mechanisms, Gabriela Kovacikova, Wei Lin, Ronald K. Taylor, Karen Skorupski

Dartmouth Scholarship

FadR is a master regulator of fatty acid (FA) metabolism that coordinates the pathways of FA degradation and biosynthesis in enteric bacteria. We show here that a ΔfadR mutation in the El Tor biotype of Vibrio cholerae prevents the expression of the virulence cascade by influencing both the transcription and the posttranslational regulation of the master virulence regulator ToxT. FadR is a transcriptional regulator that represses the expression of genes involved in FA degradation, activates the expression of genes involved in unsaturated FA (UFA) biosynthesis, and also activates the expression of two operons involved in saturated FA (SFA) biosynthesis. …

Fsd-C10, A Fasudil Derivative, Promotes Neuroregeneration Through Indirect And Direct Mechanisms., Yan-Hua Li, Chong Xie, Yuan Zhang, Xing Li, Hai-Fei Zhang, Qing Wang, Zhi Chai, Bao-Guo Xiao, Rodolfo Thome, Guang-Xian Zhang, Cun-Gen Ma

Department of Neurology Faculty Papers

FSD-C10, a Fasudil derivative, was shown to reduce severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through the modulation of the immune response and induction of neuroprotective molecules in the central nervous system (CNS). However, whether FSD-C10 can promote neuroregeneration remains unknown. In this study, we further analyzed the effect of FSD-C10 on neuroprotection and remyelination. FSD-C10-treated mice showed a longer, thicker and more intense MAP2 and synaptophysin positive signal in the CNS, with significantly fewer CD4(+) T cells, macrophages and microglia. Importantly, the CNS of FSD-C10-treated mice showed a shift of activated macrophages/microglia from …

Faculty Senate Bill Fsb-2017-01-23-01: University Curriculum Committee, Armstrong State University

Armstrong Faculty Senate: Bills, Motions & Resolutions (Archived)

Faculty Senate Bill FSB-2017-01-23-01: University Curriculum Committee

Engineering A Fluorescent Protease Sensor For In Vivo Protein Detection, Thomas C. Kinard

Honors Scholar Theses

This report details the results of an ongoing project to engineer a mutant form of Red Fluorescent Protein (RFP) variant mCherry that acts as a real-time in vivo protease sensor. The sought-after mutant only becomes fluorescent when exposed to Tobacco Etch Virus (TEV) Protease, this system’s model protease. This will be accomplished via the insertion of the TEV Protease Recognition Site (TEV-PRS) in such a position that, before cleavage, will prevent the protein from folding to fluorescent conformation, but upon cleavage, will allow for fluorescent conformation to occur. The cylindrical structure of the protein, composed of beta-pleated sheets, contains “loops” …