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Developmental Biology, The Stem Cell Of Biological Disciplines, Scott F. Gilbert

Biology Faculty Works

Developmental biology (including embryology) is proposed as "the stem cell of biological disciplines.” Genetics, cell biology, oncology, immunology, evolutionary mechanisms, neurobiology, and systems biology each has its ancestry in developmental biology. Moreover, developmental biology continues to roll on, budding off more disciplines, while retaining its own identity. While its descendant disciplines differentiate into sciences with a restricted set of paradigms, examples, and techniques, developmental biology remains vigorous, pluripotent, and relatively undifferentiated. In many disciplines, especially in evolutionary biology and oncology, the developmental perspective is being reasserted as an important research program.

Review Article: Uric Acid Homeostasis And Disturbances, Ferry Fredy Karwur, Dwi Rahayu Pujiastuti

Folia Medica Indonesiana

This review examined the homeostasis of uric acid in human body and analyzed recent studies of the affecting major variables. Normal uric acid concentration in male is 3.5-7.2 mg/dL and in female is 2.6-6 mg/dL. Daily turnover of normal uric acid ranges from 498-1392 mg/day, miscible pool is 767-1650 mg, reabsorption is 8064 mg/day, renal excretion is 262-620 mg/day and intestine 186-313 mg/day. The dynamics of uric acid is influenced by factors of food, drink, age, history of disease, and genetic. High purine dietary consumption increases blood uric acid by 1-2 mg/dL, 213-290 g/day fructose drinks increases 0.52-1.7 mg/dL, 1.5 …

Investigating The Role Of Small Noncoding Rnas In Vertebrate Anoxia Tolerance, Claire Louise Riggs

Dissertations and Theses

Very few vertebrates survive extended periods of time without oxygen. Entry into metabolic depression is central to surviving anoxia, which is supported by overall suppression of protein synthesis, yet requires increased expression of specific proteins. Studying the rapid and complex regulation of gene expression associated with survival of anoxia may uncover new mechanisms of cellular biology and transform our understanding of cells, as well as inform prevention and treatment of heart attack and stroke in humans. Small non-coding RNAs (sncRNAs) have emerged as regulators of gene expression that can be rapidly employed, can target individual genes or suites of genes, …

Alumni News | Plant Biology's Robert Specker Passes Away, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Provitamin A Biofortification Of Cassava Enhances Shelf Life But Reduces Dry Matter Content Of Storage Roots Due To Altered Carbon Partitioning Into Starch, Getu Beyene, Felix R. Solomon, Raj D. Chauhan, Eliana Gaitán-Solis, Narayanan Narayanan, Jackson Gehan, Dimuth Siritunga, Robin L. Stevens, John Jifon, Joyce Van Eck, Edward Linsler, Malia Gehan, Muhammad Ilyas, Martin Fregene, Richard T. Sayre, Paul Anderson, Nigel Taylor, Edgar B. Cahoon

Center for Plant Science Innovation: Faculty Publications

Storage roots of cassava (Manihot esculenta Crantz), a major subsistence crop of sub-Saharan Africa, are calorie rich but deficient in essential micronutrients, including provitamin A β-carotene. In this study, β-carotene concentrations in cassava storage roots were enhanced by coexpression of transgenes for deoxy-d-xylulose-5-phosphate synthase (DXS) and bacterial phytoene synthase (crtB), mediated by the patatin-type 1 promoter. Storage roots harvested from field-grown plants accumulated carotenoids to ≤50 lg/g DW, 15- to 20-fold increases relative to roots from nontransgenic plants. Approximately 85%–90% of these carotenoids accumulated as all-trans-β-carotene, the most nutritionally efficacious carotenoid. β-Carotene-accumulating storage roots displayed delayed onset of postharvest …

Nuclear Spindles Pave The Way To Metastasis, Patrick J. Hensley, Natasha Kyprianou

Urology Faculty Publications

No abstract provided.

Northern Eurasia Future Initiative (Nefi): Facing The Challenges And Pathways Of Global Change In The Twenty-First Century, Pavel Ya. Groisman, Herman Shugart, David Kicklighter, Geoffrey Henebry, Nadezhda Tchebakova, Shamil Maksyutov, Erwan Monier, Garik Gutman, Sergey Gulev, Jiaguo Qi, Alexander Prishchepov, Elena Kukavskaya, Boris Porfiriev, Alexander I. Shiklomanov, Tatiana Loboda, Nikolay Shiklomanov, Son Nghiem, Kathleen Bergen, Jana Albrechtova, Jiquan Chen, Maria Shahgedanova, Anatoly Shvidenko, Nina Speranskaya, Amber Soja

Faculty Publications

During the past several decades, the Earth system has changed significantly, especially across Northern Eurasia. Changes in the socio-economic conditions of the larger countries in the region have also resulted in a variety of regional environmental changes that can have global consequences. The Northern Eurasia Future Initiative (NEFI) has been designed as an essential continuation of the Northern Eurasia Earth Science Partnership Initiative (NEESPI), which was launched in 2004. NEESPI sought to elucidate all aspects of ongoing environmental change, to inform societies and, thus, to better prepare societies for future developments. A key principle of NEFI is that these developments …

Home-Based Pre-Exposure Prophylaxis (Prep) Services For Gay And Bisexual Men: An Opportunity To Address Barriers To Prep Uptake And Persistence, Steven A. John, H Jonathon Rendina, Christina Grov, Jeffrey T. Parsons

Publications and Research

Gay, bisexual, and other men who have sex with men (GBM) are disproportionately affected by the HIV epidemic. Despite the promise of pre-exposure prophylaxis (PrEP) in reducing HIV transmission risk, barriers for uptake and persistence exist. We sought to identify whether GBM in a nationwide cohort who have not yet initiated PrEP (n = 906) would prefer to get PrEP-related care from a primary care provider (PCP) compared to a specialist clinic or provider. We then sought to identify their level of interest and factors associated with preference for using home-based PrEP services (i.e., HB-PrEP), defined to participants as conducting …

Antimicrobial Activity Of Vaginal Lactobacillus Against Urogenital Pathogens, Suhad Faisal Hatem Al-Mugdadi, Ishraq Hasan Elew

Muthanna Medical Journal

Lactobacillus is one of the most important genera of Lactic Acid Bacteria (LAB). Lactobacilli present in a healthy vagina are part of normal bacterial microbiota and protect the host from urogenital infections by maintaining a low pH. Important features of probiotic lactobacilli are to achieve antagonistic activity against bacterial pathogens because of their capacity to produce lactic acid and other organic acids, H2O2 and bacteriocin. This study aimed to studying the effect of Lactobacillus spp. isolated from healthy vagina as aprobiotic against many clinical bacterial isolates from urogenital tract infection. Susceptibility to Five antibiotics, such as amikacin (AK), Tobramycin (TOB), …

Genetic Diversity Of Introduced (Pomacea Canaliculata) And Native (Pila) Apple Snails In Thailand Revealed By Randomly Amplified Polymorphic Dna (Rapd) Analysis, Thaewnon-Ngiw B., Klinbunga S., Phanwichien K., Sangduen N., Lauhachinda N., Menasveta P.

ASEAN Journal on Science and Technology for Development

Genetic diversity of the introduced golden apple snail, Pomacea canaliculata (Lamarck, 1822) and four native apple snails; Pila ampullacea (Linneaus, 1758), P. angelica (Annandale, 1920), P. pesmei (Morelet, 1889) and P. polita (Deshayes, 1830) in Thailand were studied by RAPD analysis. Two hundred and two polymorphic fragments (180-1500 bp in length) were generated across overall investigated samples (N = 254) using three informative primers (OPA07, OPB10 and UBC122). The percentages of polymorphic bands were 98.86%, 94.56%, 90.91%, 96.94% and 95.51% for Pomacea canaliculata, P. ampullacea, P. angelica, P. pesmei and P. polita, respectively. This indicated high genetic polymorphism of these …

Microfluidic Pore Model Study On Physical And Geomechanical Factors Influencing Fluid Flow Behavior In Porous Media, Shuang Cao

LSU Doctoral Dissertations

Fluid flow in porous media is a subject of fundamental importance and relevant to numerous engineering applications. The comprehensive description of fluid interaction parameters containing wetting properties, fluid-fluid displacement ratio, and capillary pressure, are inevitably needed. Moreover, the fine-grained sediments’ response to various pore fluids and migration in porous media influences reservoir geomechanical properties and pore clogging is essential to a better understanding of fluids flow behavior.

This dissertation provides a detailed study of physical and geomechanical factors influencing fluids flow behavior in porous media. The two-dimensional micromodel tests have been conducted under a wide selection of fluids flow conditions. …

A Decline In Primary Production In The North Sea Over 25 Years, Associated With Reductions In Zooplankton Abundance And Fish Stock Recruitment, Elisa Capuzzo, Christopher P. Lynam, Jon Barry, David Stephens, Rodney M. Forster, Naomi Greenwood, Abigail Mcquatters-Gollop, Tiago Silva, Leeuwen Sm Van, Georg H. Engelhard

School of Biological and Marine Sciences

No abstract provided.

Tfpiα Interacts With Fva And Fxa To Inhibit Prothrombinase During The Initiation Of Coagulation, Jeremy P. Wood, Helle H. Petersen, Bingke Yu, Xiaoai Wu, Ida Hilden, Alan E. Mast

Gill Heart & Vascular Institute Faculty Publications

Tissue factor pathway inhibitor α (TFPIα) inhibits prothrombinase, the thrombin-generating complex of factor Xa (FXa) and factor Va (FVa), during the initiation of coagulation. This inhibition requires binding of a conserved basic region within TFPIα to a conserved acidic region in FXa-activated and platelet-released FVa. In this study, the contribution of interactions between TFPIα and the FXa active site and FVa heavy chain to prothrombinase inhibition were examined to further define the inhibitory biochemistry. Removal of FXa active site binding by mutation or by deletion of the second Kunitz domain (K2) of TFPIα produced 17- or 34-fold weaker prothrombinase inhibition, …

Do Mothers Affect Daughter’S Behaviors? Diet, Physical Activity, And Sedentary Behaviors In Kuwaiti Mother–Daughter Dyads, Lemia H. Shaban, Joan A. Vaccaro, Shiryn D. Sukhram, Fatma G. Huffman

Publications and Research

The objective of the study was to evaluate 169 Kuwaiti mother– daughter dyads and their associations with health behaviors for eating healthy, engaging in physical activity, daughters perceived body weight, time spent with computer/video, and time viewing television. Female students aged 10–14 years were selected from private and public schools in the State of Kuwait. Results demonstrated that daughters exhibited similar behaviors to their mothers in their perceived eating behavior, physical activity, computer/ video game use, and TV screen time. Future research is essential to determine the role of mothers in effective health behavior intervention strategies for female Kuwaiti adolescents.

Methods And Compositions For X-Ray Induced Release From Ph Sensitive Liposomes, Daniel Fologea, Ralph Henry, Greg J. Salamo, Yuriy Mazur, Michael J. Borrelli

Patents Granted

Compositions including pH sensitive lipid vesicles comprised of a lipid layer, an agent, and an organic halogen such that the agent is released from the vesicles after exposure to ionizing radiation. Methods of delivering the agent to a target in a subject using the compositions provided herein are also described. The methods allow for controlled release of the agent. The timing of release of the agent from the lipid vesicle may be controlled as well as the location of release by timing and localizing the exposure to ionizing radiation exposure.

Serine-Dependent Sphingolipid Synthesis Is A Metabolic Liability Of Aneuploid Cells, Sunyoung Hwang, H. Tobias Gustafsson, Ciara O’Sullivan, Gianna Bisceglia, Xinhe Huang, Christian Klose, Andrej Schevchenko, Robert C. Dickson, Paola Cavaliere, Noah Dephoure, Eduardo M. Torres

Molecular and Cellular Biochemistry Faculty Publications

Aneuploidy disrupts cellular homeostasis. However, the molecular mechanisms underlying the physiological responses and adaptation to aneuploidy are not well understood. Deciphering these mechanisms is important because aneuploidy is associated with diseases, including intellectual disability and cancer. Although tumors and mammalian aneuploid cells, including several cancer cell lines, show altered levels of sphingolipids, the role of sphingolipids in aneuploidy remains unknown. Here, we show that ceramides and long-chain bases, sphingolipid molecules that slow proliferation and promote survival, are increased by aneuploidy. Sphingolipid levels are tightly linked to serine synthesis, and inhibiting either serine or sphingolipid synthesis can specifically impair the fitness …

Limd1 Is Induced By And Required For Lmp1 Signaling, And Protects Ebv-Transformed Cells From Dna Damage-Induced Cell Death, Ling Wang, Mary E. A. Howell, Brooke Mcpeak, Katrina Riggs, Carissa Kohne, Jether Uel Yohanon, Daniel E. Foxler, Tyson V. Sharp, Jonathon P. Moorman, Zhi Q. Yao, Shunbin Ning

ETSU Faculty Works

LIMD1 (LIM domain-containing protein 1) is considered as a tumor suppressor, being deregulated in many cancers to include hematological malignancies; however, very little is known about the underlying mechanisms of its deregulation and its roles in carcinogenesis. Epstein-Barr Virus (EBV) is associated with a panel of malignancies of lymphocytic and epithelial origin. Using high throughput expression profiling, we have previously identified LIMD1 as a common marker associated with the oncogenic transcription factor IRF4 in EBV-related lymphomas and other hematological malignancies. In this study, we have identified potential conserved IRF4- and NFκB-binding motifs in the LIMD1 gene promoter, and both are …

Comparative Genome Analysis Of Multiple Vancomycin-Resistant Enterococcus Faecium Isolated From Two Fatal Cases, S.Y. Lim, K.P. Yap, C.S.J. Teh, K.A. Jabar, Kwai Lin Thong

Research Publications (2016 to 2020)

Enterococcus faecium is both a commensal of the human intestinal tract and an opportunistic pathogen. The increasing incidence of enterococcal infections is mainly due to the ability of this organism to develop resistance to multiple antibiotics, including vancomycin. The aim of this study was to perform comparative genome analyses on four vancomycin-resistant Enterococcus faecium (VREfm) strains isolated from two fatal cases in a tertiary hospital in Malaysia. Two sequence types, ST80 and ST203, were identified which belong to the clinically important clonal complex (CC) 17. This is the first report on the emergence of ST80 strains in Malaysia. Three of …

Evaluating Behavioral Responses Of Nesting Lesser Snow Geese To Unmanned Aircraft Surveys, Andrew Barnas, Robert Newman, Christopher J. Felege, Michael P. Corcoran, Samuel D. Hervey, Tanner J. Stechmann, Robert F. Rockwell, Susan N. Ellis-Felege

Publications and Research

Unmanned aircraft systems (UAS) are relatively new technologies gaining popularity among wildlife biologists. As with any new tool in wildlife science, operating protocols must be developed through rigorous protocol testing. Few studies have been conducted that quantify the impacts UAS may have on unhabituated individuals in the wild using standard aerial survey protocols. We evaluated impacts of unmanned surveys by measuring UAS-induced behavioral responses during the nesting phase of lesser snow geese (Anser caerulescens caerulescens) in Wapusk National Park, Manitoba, Canada. We conducted surveys with a fixed-wing Trimble UX5 and monitored behavioral changes via discreet surveillance cameras at 25 nests. …

Cultural Competency In A Post-Model Rule 8.4(G) World, Latonia Haney Keith

Duke Journal of Gender Law & Policy

No abstract provided.

A Call To Arms: The Department Of Defense’S Egg Freezing Benefit Summons Increased Reporting Regulations, Gloria Y. Liu

Duke Journal of Gender Law & Policy

No abstract provided.

Impact Of English Language Training On Linguistic And Cultural Identity Of Call Center Employees, Mitima Jean-Paul Zagabe

The Qualitative Report

The Call Center Industry in the Philippines has been attracting employees from different cultural and linguistic backgrounds. Such industry requires employees to have a strong command of the English language. More specifically, American English serves as the model for English language requirements. The problem is that these requirements may have a negative impact on linguistic and cultural identity of Filipino employees. This study explored the Filipino English language trainers’ integration with the American culture and language and whether this has any influence on the way they teach the language. It also investigated whether the Call Center Industry training has any …

The Power Of Multimodal Feedback, Breanne S. Campbell, Ann Feldmann

Journal of Curriculum, Teaching, Learning and Leadership in Education

Abstract: Feedback to students is most effective when it is timely, relevant and meaningful. English teachers spend many hours providing feedback on student writing and are disheartened as students disregard it. An English teacher and a technology specialist, while using available technology, set out to find a way to make the feedback process more streamlined, efficient, and something students would actually employ in the writing process. We discovered that utilizing technology tools available to provide on demand and archivable audio and visual feedback transforms the writing process and student responses are favorable.

The Treadmill And The Contract: A Classcrits Guide To The Anthropocene, Angela Harris

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.

Advent 4 Series B 2017, Phillip L. Brandt

Sunday's Sermon

This PDF comments on the Propers for the Fourth Sunday of Advent, Series B and offers ideas for proclamation and preaching.

Sentencing Pregnant Drug Addicts: Why The Child Endangerment Enhancement Is Not Appropriate, Monica Carusello

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.

Cks1 Expression In Melanocytic Nevi And Melanoma, Anna A. Brożyna, Andrew Aplin, Cynthia Cohen, Grant Carlson, Andrew Joseph Page, Michael Murphy, Andrzej T. Slominski, J. Andrew Carlson

Department of Cancer Biology Faculty Papers

Cyclin-dependent kinase subunit 1 (Cks1) regulates the degradation of p27, an important G1-S inhibitor, which is up regulated by MAPK pathway activation. In this study, we sought to determine whether Cks1 expression is increased in melanocytic tumors and correlates with outcome and/or other clinicopathologic prognostic markers. Cks1 expression was assessed by immunohistochemistry in 298 melanocytic lesions. The frequency and intensity of cytoplasmic and nuclear expression was scored as a labeling index and correlated with clinico-pathological data. Nuclear Cks1 protein was found in 63% of melanocytic nevi, 89% primary and 90% metastatic melanomas with mean labeling index of 7 ± 16, …

How Innovative Companies Gain From A Cap And Trade Agreement, Lucian Montgomery

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

The purpose of both a cap and trade agreement and a carbon tax is to reduce emissions by setting a price on carbon. However, that is where the similarities end.

A cap and trade agreement gives a certain amount of allowances to each company that adds up to an emissions cap, allows companies to trade them. Companies only pay for carbon emissions if they produce more than the amount of allowances they are given, either by paying penalties to the government, or by buying more allowances from other companies. This creates a market for allowances, and based on demand, sets …

Chemistry And Biochemistry News, Georgia Southern University

Biochemistry, Chemistry & Physics: News & Publications (2012-2023)

• SERMACS 2017
• Simpo Akech Defends her Master's Thesis

Computational Fluid Dynamics Analysis Of Blalock-Taussig Shunt, Thomas Hess, Ramesh K. Agarwal

Mechanical Engineering and Materials Science Independent Study

Blalock-Taussig or BT shunts are a surgical procedure performed on infants suffering from cyanosis or “Blue Baby Syndrome.” Cyanosis refers the purple or blue color of the skin resulting from low blood oxygen saturation. A BT shunt is an artificial vessel placed between the right ventricle and the pulmonary artery to increase lung blood flow and blood oxygen saturation levels.During this independent study, the flow of blood through several different BT shunt configurations was analyzed using ANSYS Fluent, a Computational Fluid Dynamics (CFD) software analysis tool.Data from each shunt analysis was when compared to help determine the shunt parameters and …