Digital Commons Network^™

Resolution Agonist 15-Epi-Lipoxin A4 Programs Early Activation Of Resolving Phase In Post-Myocardial Infarction Healing, Vasundhara Kain, Fei Liu, Veronika Kozlovskaya, Kevin A. Ingle, Subhashini Bolisetty, Anupam Agarwal, Santosh Khedkar, Sumanth D. Prabhu, Eugenia Kharlampieva, Ganesh V. Halade

Internal Medicine Faculty Publications

Following myocardial infarction (MI), overactive inflammation remodels the left ventricle (LV) leading to heart failure coinciding with reduced levels of 15-epi-Lipoxin A4 (15-epi LXA4). However, the role of 15-epi LXA4 in post-MI acute inflammatory response and resolving phase is unclear. We hypothesize that liposomal fusion of 15-epi-LXA4 (Lipo-15-epi-LXA4) or free 15-epi-LXA4 will expedite the resolving phase in post-MI inflammation. 8 to 12-week-old male C57BL/6 mice were subjected to permanent coronary artery ligation. Lipo-15-epi-LXA4 or 15-epi-LXA4 (1 μg/kg/day) was injected 3 hours post-MI for (d)1 or continued daily till d5. 15-epi-LXA4 activated formyl peptide receptor (FPR2) and GPR120 on alternative macrophages …

A Miniature Acoustic Device For Tracking Small Marine Animals Or Submerged Drifters, Godi Fischer, Thomas Rossby, Daniel Moonan

Electrical, Computer, and Biomedical Engineering Faculty Publications

This paper presents an acoustic archival tag capable of tracking small marine animals. It is also a technology that can be ported to other platforms, such as the next-generation acoustic and Argo floats as well as gliders. Tracking is achieved by standard RAFOS triangulation using the arrival times of unique sound signals emitted by moored sources. At the core of the tag is a custom microchip that controls all system operations. It incorporates the critical acoustic arrival time detector, a thermal sensor, and a pressure sensor interface. All the electronic components are housed inside a cylindrical hydrophone of 25.4-mm length …

Diatom Community Response To An Acidic, Ambient Temperature, Geothermal Gradient, April Fox

Water Resources Professional Project Reports

Geothermally influenced surface waters are typically linked to high temperatures; however, they can also be associated with ambient temperature and have the distinct solute chemistry that identifies them as geothermal in origin. Few studies have been linked to diatom assemblages in ambient temperature, geothermally influenced waters. This study focused on the Sulphur Creek watershed in the Valles Caldera National Preserve, northern New Mexico. Seven representative sites were sampled monthly between May 2016-September 2016 for physicochemical parameters and diatom community composition. Ambient temperature waters with high conductivities, lower pH values (≤ 4.0), and increased Al+++, Fe++, SO4=, and SiO2 concentrations are …

Cancer Diagnosis And Prognosis With Histopathology Image Analysis And Pattern Recognition, Naiyun Zhou

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The dissertation focuses on the histopathology image analysis for cancer diagnosis and prognosis, based on the innovation of histopathological machine vision techniques. Histopathology images are regarded as the reference standard to identify diseases, and especially as a gold standard on cancer diagnosis. With the recent advance of the electronic scanners, digitized whole slide images (WSI) make it possible to analyze cancer tissues in high resolution and large-scale manner. At the same time, computer aided diagnosis (CAD) algorithms are being developed to detect cancer automatically, both in radiological and pathological field. However, those CAD algorithms are based on object segmentation and …

The Biochemical And Structural Characterization Of Insulin Receptor And Insulin-Like Growth Factor 1 Receptor, Richard Delle Bovi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) are receptor tyrosine kinases (RTKs) involved in the regulation of many important cellular processes. Hyperactivity of IR and IGF1R is associated with cancer, whereas low IR activity and insulin resistance are linked to diabetes. The current proposed models of activation are derived from structural studies using either soluble extracellular domains or cytoplasmic tyrosine kinase domains. Although these structures have provided a wealth of information about the IR, there is still a significant disconnect in our understanding of the transmembrane signaling mechanism. Only studies on intact, membrane-spanning, full-length, holoreceptors can …

Investigation Of Adenovirus Early Protein E4orf3 Defense Against Host Cell Responses, Coryn Marie Cange

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Viruses have evolved many tactics to ensure robust infection and proliferation. Similarly, human adenovirus employs such techniques that include direct sequestration of cellular antiviral proteins and modulation of host cellular pathways. The viral protein E4ORF3 plays a critical role in carrying out these functions during infection. This protein is unique in its ability to form a nuclear scaffold during infection, which then serves as an interface for cellular protein binding. It has been previously shown that E4ORF3 is responsible for the reorganization of critical antiviral cellular proteins including MRN and TRIM family proteins. Also, it has been established that the …

Defining The Rules Of Substrate Recognition For A Mitochondrial Aaa+ Protease, Anthony John Rampello

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The i-AAA protease is a membrane-anchored ATP-dependent protease that contributes to proteostasis of the mitochondrial inner membrane and intermembrane space. The protease is required to select specific substrates for degradation from among the diverse complement of proteins present in mitochondria, yet the molecular mechanisms of substrate recognition have yet to be fully described. Importantly, dysfunction of the mitochondrial AAA proteases has been implicated in the development of numerous neurodegenerative diseases. Detailed solution studies of these enzymes have been hampered by the requirement for an insoluble transmembrane span to drive hexamerization and thus form the ATPase active sites. By replacing the …

Glycan Type Specificity In N-Linked Glycosylation: Implications For Highly Glycosylated Viral Surface Proteins, Artem Krantesvich

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Virtually every living cell is covered with glycoproteins. Most mammalian glycoproteins primarily bear N-linked glycans of complex type, having only a small fraction of hybrid glycans and barely any high-mannose glycans. However, some highly glycosylated proteins translated in mammalian cells have an unusually high fraction of high-mannose glycans. The goal of this thesis is to investigate the nature of the mechanisms behind this unusual distribution of glycan types and glycan type specificity for glycosylation sites. A well-studied example of the abnormally glycosylated protein is HIV envelope glycoprotein gp120, which usually has about 24 glycans, approximately half of them being of …

Topics-Based Teaching Of Applied Physics In Undergraduate Medical Education, Shang-Lung Dong, Yeu-Sheng Tyan

Journal of Medical Education

Background: In recent years, the academic credit system of undergraduate medical education at some universities has simplified in Taiwan. Therefore, the course contents and teaching methods of physics courses must be readjusted to meet the needs of medical schools. This study examined the application of topics-based teaching of applied physics in undergraduate medical education at Chung Shan Medical University. Methods: The 18-week course offered 2 required credits, involving a total of 126 enrolled first-year medical students and 6 representative topics in physics. The course first introduced physics principles under each topic and then used medical applications as examples. These were …

Interfacing A Hirudo Medicinalis Retzius Cell With Insulated Gate Of Mosfet, Rachel M. Smith

Master's Theses

Much work has been done to study the external stimulation of nervous tissue as well as the transmission of neural signals to electronics. Peter Fromherz was one of the pioneers in this area of electrophysiology, with a series of experiments in the 1990s that aimed to characterize and optimize the interface between neural tissue and transistors. In this thesis, Kurt Sjoberg and I interfaced a Retzius cell isolated from a Hirudo medicinalis ganglion with the insulated gate of a MOSFET. The goal was to see change in membrane potential that could be related Fromherz’s original 1991 work. Our experimental setup …

Repeated Observations Of Northern Goshawks Foraging As Terrestrial Predators, Robert A. Miller

Intermountain Bird Observatory Publications and Presentations

The Northern Goshawk (Accipiter gentilis; hereafter goshawk) is a generalist predator occupying boreal and temperate forests of the Holarctic (Squires and Reynolds 1997). The diet of goshawks has been studied in many areas and varies substantially among study sites, but some avian and mammalian genera are consistently represented (Squires and Reynolds 1997, Squires and Kennedy 2006). Within the northern Great Basin of North America, the breeding-season diet of goshawks is often dominated by Belding's ground squirrels (Urocitellus beldingi, also known as Spermophilus beldingi; Younk and Bechard 1994, Miller et al. 2014). The local reliance upon …

Physical Aggressiveness And Gray Matter Deficits In Ventromedial Prefrontal Cortex, David S. Chester, Donald R. Lynam, Richard Milich, C. Nathan Dewall

Psychology Faculty Publications

What causes individuals to hurt others? Since the famous case of Phineas Gage, lesions of the ventromedial prefrontal cortex (VMPFC) have been reliably linked to physically aggressive behavior. However, it is unclear whether naturally-occurring deficits in VMPFC, among normal individuals, might have widespread consequences for aggression. Using voxel based morphometry, we regressed gray matter density from the brains of 138 normal female and male adults onto their dispositional levels of physical aggression, verbal aggression, and sex, simultaneously. Physical, but not verbal, aggression was associated with reduced gray matter volume in the VMPFC and to a lesser extent, frontopolar cortex. Participants …

Human-Bear Interactions Among Black Bears In Bryce Canyon National Park, Utah, And Polar Bears On Alaska's North Slope, Wesley G. Larson

Theses and Dissertations

Human-bear interactions are an important consideration of bear biology, as interactions can lead to destruction of property as well as injury or death for both human and bear. Successful analysis of why these interactions occur can lead to appropriate preventative measures and mitigation of further conflict. Bryce Canyon National Park (BRCA) is comprised of relatively poor bear habitat, but a black bear population exists on the Paunsaugunt Plateau, on which the park occupies the eastern edge. Park managers expressed interest in learning more about bear movements and, specifically, bear use of anthropogenic features following a number of human-bear incidents located …

Vibronically Coherent Ultrafast Triplet-Pair Formation And Subsequent Thermally Activated Dissociation Control Efficient Endothermic Singlet Fission, Hannah L. Stern, Alexandre Cheminal, Shane R. Yost, Katharina Broch, Sam L. Bayliss, Kai Chen, Maxim Tabachnyk, Karl J. Thorley, Neil Greenham, Justin Hodgkiss, John E. Anthony, Martin Head-Gordon, Andrew J. Musser, Akshay Rao, Richard H. Friend

Chemistry Faculty Publications

Singlet exciton fission (SF), the conversion of one spin-singlet exciton (S₁) into two spin-triplet excitons (T₁), could provide a means to overcome the Shockley–Queisser limit in photovoltaics. SF as measured by the decay of S₁ has been shown to occur efficiently and independently of temperature, even when the energy of S₁ is as much as 200 meV less than that of 2T₁. Here we study films of triisopropylsilyltetracene using transient optical spectroscopy and show that the triplet pair state (TT), which has been proposed to mediate singlet fission, forms on ultrafast timescales …

Species Are Not Most Abundant In The Centre Of Their Geographic Range Or Climatic Niche, Tad Dallas, Robin R. Decker, Alan Hastings

Faculty Publications

© 2017 John Wiley & Sons Ltd/CNRS The pervasive idea that species should be most abundant in the centre of their geographic range or centre of their climatic niche is a key assumption in many existing ecological hypotheses and has been declared a general macroecological rule. However, empirical support for decreasing population abundance with increasing distance from geographic range or climatic niche centre (distance–abundance relationships) remains fairly weak. We examine over 1400 bird, mammal, fish and tree species to provide a thorough test of distance–abundance relationships, and their associations with species traits and phylogenetic relationships. We failed to detect consistent …

Editorial: Special Thematic Issue On Inland Aquatic Ecosystems, Hongchen Jiang, Yongqin Liu, Gary King

Faculty Publications

No abstract provided.

Pyruvate Dehydrogenase Complex (Pdc) Subunits Moonlight As Interaction Partners Of Phosphorylated Stat5 In Adipocytes And Adipose Tissue, Allison J. Richard, Hardy Hang, Jacqueline M. Stephens

Faculty Publications

© 2017 by The American Society for Biochemistry and Molecular Biology, Inc. STAT5 proteins play a role in adipocyte development and function, but their specific functions are largely unknown. To this end, we used an unbiased MS-based approach to identify novel STAT5-interacting proteins. We observed that STAT5A bound the E1 and E2 subunits of the pyruvate dehydrogenase complex (PDC). Whereas STAT5A typically localizes to the cytosol or nucleus, PDC normally resides within the mitochondrial matrix where it converts pyruvate to acetyl-CoA. We employed affinity purification and immunoblotting to validate the interaction between STAT5A and PDC subunits in murine and human …

Swim Bladder Morphology Changes With Female Reproductive State In The Mouth-Brooding African Cichlid Astatotilapia Burtoni, Julie M. Butler, Sarah M. Whitlow, Anwei P. Gwan, Prosanta Chakrabarty, Karen P. Maruska

Faculty Publications

© 2017. Published by The Company of Biologists Ltd. Journal of Experimental Biology. Mouth brooding is an extreme form of parental care in which the brooding parent carries the developing young in their buccal cavity for the duration of development. Brooding fish need to compensate for the brood weight on the anterior portion of their body. For fishes with a compartmentalized swim bladder, gas distribution between the chambers may aid in regulating buoyancy during brooding. To test this hypothesis, we took radiographs of Astatotilapia burtoni to compare the swim bladder morphology of gravid, mouth-brooding and recovering females. Following spawning, females …

Intramyocellular Lipid Droplet Size Rather Than Total Lipid Content Is Related To Insulin Sensitivity After 8 Weeks Of Overfeeding, Jeffrey D. Covington, Darcy L. Johannsen, Paul M. Coen, David H. Burk, Diana N. Obanda, Philip J. Ebenezer, Charmaine S. Tam, Bret H. Goodpaster, Eric Ravussin, Sudip Bajpeyi

Faculty Publications

© 2017 The Obesity Society Objective: Intramyocellular lipid (IMCL) is inversely related to insulin sensitivity in sedentary populations, yet no prospective studies in humans have examined IMCL accumulation with overfeeding. Methods: Twenty-nine males were overfed a high-fat diet (140% caloric intake, 44% from fat) for 8 weeks. Measures of IMCL, whole-body fat oxidation from a 24-hour metabolic chamber, muscle protein extracts, and muscle ceramide measures were obtained before and after the intervention. Results: Eight weeks of overfeeding did not increase overall IMCL. The content of smaller lipid droplets peripherally located in the myofiber decreased, while increases in larger droplets correlated …

Understanding And Developing Estimates Based On Practical Foundation Methods For Alaska's Discontinuous Permafrost Region, Paul P. Dennison

Theses and Dissertations

This research uses a quantitative analysis to develop a family of curves and a calculator for potential foundation thresholds in the discontinuous permafrost region of Alaska. The United States Pacific Command (PACAF) is bolstering the region by advocating for the F-35, KC-46, and the newly proposed long-range bomber to be stationed in Alaska. These next generation aircrafts and warfighters will need new facilities and beddown plans to efficiently and effectively carry out their mission. The biggest obstacle in the region is permafrost; this unique polar phenomenon is found throughout the northern half of Alaska. Fairbanks in particular has multiple military …

Customizable Textured Tablet Case And Magnetic Prompting System To Improve Communication For Children With Autism Spectrum Disorder, Christina Maragioglio

Theses

As Autism Spectrum Disorder diagnoses increase in prevalence, there is a growing need for assistive devices to help meet the communication needs of each person and their own unique set of challenges. Autism is a neurological disorder which most prominently impacts communication and social skills but can impact each person differently by way of coupled conditions. Of these conditions, two of the most common with Autism are Sensory Processing Disorder (SPD) and Motor Skill delays.

Additionally, to help with communication and language development, Augmentative and Alternative Communication (AAC) techniques are often used, with tablet AAC applications being one of the …

Vibrio Vulnificus Monitoring Along The Coastal Bend And The Rio Grande Valley, Texas, Louay Bachnak

Honors Theses

Vibrio vulnificus is a common opportunistic pathogen found in marine, coastal, and estuarine waters. This one micrometer microorganism is the leading cause of deaths in the United States due to food poisoning after consumption of raw or undercooked seafood. The optimal temperature for survival is between 15.6°C and 35.0°C with moderate salinities – conditions frequently found in the Gulf of Mexico (Lin, Payne, & Schwarz, 2003).

In the United States, V. vulnificus infections are more common in states bordering the Gulf of Mexico, including Texas. However, infections can still occur in individuals consuming infected food more inland or sustain wounds …

Homoeopathic Research In Vitiligo: Current Scenario, Deepti Dewan, Divya Taneja, Uttam Singh, Renu Mittal, Anil Khurana

Indian Journal of Research in Homoeopathy

Objective: The objective of the study was to conduct a review of the existing literature on homoeopathic research conducted on Vitiligo. Materials and Methods: A comprehensive online and manual search of research studies on vitiligo through Homoeopathy was conducted to identify publications in international search databases and library of Central Council for Research in Homoeopathy published during the period from 2006 to 2016. Relevant research was categorised by study type and appraised according to study design with their clinical outcomes. Results: In this review, 11 articles related to Homoeopathy on vitiligo were identified, of which four clinical observational studies and …

Consciousness In Clay, Sharon Robinson

Electronic Theses and Dissertations

ABSTRACT

Consciousness in Clay is an exhibition consisting of seven tall ceramic sculptures and nine smaller works. Clay is the ideal medium for these designs; the plasticity during the making phase yields to the stoniness of the finished work and traps the hand movement. As life is my metaphor, the ambiguous forms leave much to the imagination— to thoughts of the natural world, and to ideas about color, rhythm, and harmony. Strong lines, undulations, fecundity, dark openings, negative-spaces, the phallic-symbol, and budding new life may all come to mind; but nothing finitely specific emerges. Using my knowledge of biology and …

Doctrinal Evolution And The Living Constitution, Eliot T. Tracz

University of Dayton Law Review

No abstract provided.

As Technologies For Nucleotide Therapeutics Mature, Products Emerge, Jennifer M. Beierlein, Laura M. Mcnamee, Fred D. Ledley

Natural & Applied Sciences Faculty Publications

The long path from initial research on oligonucleotide therapies to approval of antisense products is not unfamiliar. This lag resembles those encountered with monoclonal antibodies, gene therapies, and many biological targets and is consistent with studies of innovation showing that technology maturation is a critical determinant of product success. We previously described an analytical model for the maturation of biomedical research, demonstrating that the efficiency of targeted and biological development is connected to metrics of technology growth. The present work applies this model to characterize the advance of oligonucleotide therapeutics. We show that recent oligonucleotide product approvals incorporate technologies and …

The Supreme People's Court's Annual Report On Intellectual Property Cases (2016) (China), Tianyi (Tammy) Wu, Xiaoyang Wang

Washington International Law Journal

The Supreme People’s Court of China began publishing its Annual Report on Intellectual Property Cases in 2008. The Annual Report summarizes intellectual property cases, such as patent, trademark, copyright, trade secrets, and unfair competition cases. This 2016 Annual Report examines 27 cases and includes general guidelines for legal application. It reflects the Supreme People’s Court’s thoughts and approaches for ruling on new, difficult, and complex IP and competition cases.

The Importance Of Positive Affect: The Role Of Affective Personality In Predicting Organizational Citizenship Behavior, Neila Ramdhani, Djamaludin Ancok, Lillemor Adrianson

Makara Human Behavior Studies in Asia

Previous research demonstrates inconsistent results in predicting how affect influences organizational citizenship behavior (OCB). This study aims to solve the inconsistency by taking the position that positive affect and negative affect are orthogonal, and their interaction produces four types of affective personality. They are ‘Self-fulfilling’ (high positive affect and low negative affect), ‘High affective’ (high positive affect and high negative affect), ‘Low affective’ (low positive affect and low negative affect) and ‘Self-destructive’ (low positive affect and high negative affect). The study hypothesizes that the self-fulfilling group displays the highest mean of OCB while the self-destructive displays the lowest. The high …

Gradients In Wall Mechanics And Polysaccharides Along Growing Inflorescence Stems, Pyae Phyo, Tuo Wang, Sarah N. Kiemle, Hugh O’Neill, Sai Venkatesh Pingali, Mei Hong, Daniel J. Cosgrove

Faculty Publications

© 2017 American Society of Plant Biologists. All Rights Reserved. At early stages of Arabidopsis (Arabidopsis thaliana) flowering, the inflorescence stem undergoes rapid growth, with elongation occurring predominantly in the apical; 4 cm of the stem. We measured the spatial gradients for elongation rate, osmotic pressure, cell wall thickness, and wall mechanical compliances and coupled these macroscopic measurements with molecular-level characterization of the polysaccharide composition, mobility, hydration, and intermolecular interactions of the inflorescence cell wall using solid-state nuclear magnetic resonance spectroscopy and small-angle neutron scattering. Force-extension curves revealed a gradient, from high to low, in the plastic and elastic compliances …

Species Identification Of Vagrant Empidonax Flycatchers In Northeastern North America Via Non-Invasive Dna Sequencing, Nathan R. Goldberg, Nicholas A. Mason

Faculty Publications

Vagrant individuals from cryptic species complexes pose a persistent challenge for accurate species identification, hindering our understanding of vagrancy in these taxa. Here, we used non-invasive sampling of fecal matter to sequence the ND2 mitochondrial gene of 2 vagrant western flycatchers observed in northeastern North America. The DNAsequence data we recovered from these vagrants fell within a clade of known Empidonax difficillis (Pacific-slope Flycatcher) haplotypes. Our work provides robust records of 2 vagrant Pacific-slope Flycatchers in the northeastern US. These findings illustrate the power of non-invasive sampling for species identification of vagrants from cryptic species complexes.