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2017

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Methylmercury Bioaccumulation, Transformation, And Trophic Transfer In Marine Food Chains, Cheng-Shiuan Lee Dec 2017

Methylmercury Bioaccumulation, Transformation, And Trophic Transfer In Marine Food Chains, Cheng-Shiuan Lee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Monomethylmercury (MeHg) is a neurotoxic compound that causes adverse health effects in exposed wildlife and humans. It is primarily accumulated through diet and is the only mercury species to build up in aquatic food chains. However, our understanding with respect to MeHg biogeochemical cycling in marine environments and its interactions with marine organisms is still limited. In order to better understand important processes in the MeHg biogeochemical cycling and factors governing its environmental fate, uptake, accumulation, transformation, and trophic transfer of MeHg in the marine chains, I conducted a series of experiments and measurements associated with marine bacterioplankton, phytoplankton, zooplankton, …

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Role And Regulation Of Sphingolipids In Neuropathy, Nicholas Urban Schwartz Dec 2017

Role And Regulation Of Sphingolipids In Neuropathy, Nicholas Urban Schwartz

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Charcot-Marie-Tooth (CMT) disease is the most commonly inherited neurological disorder, but its molecular mechanisms remain unclear. One variant of CMT, Charcot-Marie-Tooth 2F (CMT2F), is characterized by mutations in heat shock protein 27 (Hsp27). Bioactive sphingolipids have been implicated in many neurodegenerative diseases, but it was unknown if they were dysregulated in CMT. Liquid chromatography/mass spectrometry was used to profile sphingolipids in CMT models. Hsp27 KO mice demonstrated decreases in ceramide in peripheral nerve tissue at an increased age, suggesting that sphingolipid metabolism may be involved in CMT2F. Indeed, the disease associated Hsp27 S135F mutant demonstrated decreases in mitochondrial ceramides. Given …

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Quantitative Imaging Of 3d Cerebral Microvascular Network Dynamics By Ultrahigh -Resolution Optical Coherence Doppler Tomography (Μodt), Jiang You Dec 2017

Quantitative Imaging Of 3d Cerebral Microvascular Network Dynamics By Ultrahigh -Resolution Optical Coherence Doppler Tomography (Μodt), Jiang You

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Optical domain technologies can provide high spatiotemporal resolution for biomedical research and therefore attract tremendous interests in multiple disciplines including psychiatry, neurology, ophthalmology, oncology, urology and many more. Optical coherence tomography (OCT), after more than 20 years of development, has been becoming one of the most widely-used bio-optical modalities not only for laboratory-based research but also for clinical applications. For example, OCT becomes the standard of care for diagnosing glaucoma. Additionally, its derived velocimetry, optical coherence Doppler tomography (ODT), also demonstrates the unique capability of mapping cerebral blood flow velocity (CBFv) of vascular networks with capillary resolution (&phis;<6µm) and thus allows for the widespread utilization in numerous neurology studies. Although ODT has been widely used in biomedical research, there remain several technical limitations including the shallow penetration depth, low sensitivity for imaging slow flow in capillary and the measurement error due to Doppler angle. To address these challenges, viable solutions are proposed in this dissertation. Chapter 1 starts with a comprehensive review over basic principle of OCT and ODT. Chapter 2-4 explicitly address these OCT technical challenges, for instance, using a 1310nm super-luminescent Diode (SLD) laser source to extend optical penetration depth, utilizing optical contrast agent: intralipid to enhance ODT’s sensitivity for capillary flow detection, implementing numerical methods to extend ODT’s dynamic range and decouple Doppler angle. In addition to these technical improvements, Chapter 5-6 address two biomedical challenges in oncology and psychiatry. Specifically, Chapter 5 introduces a longitudinal optical access to rodent cerebral vasculature and a method of tumor boundary detection, which provides a powerful insight into the tumor progression. Chapter 6 reveals the close correlation between cocaine-elicited transient ischemic attack (TIA) and hypo-perfused cortex. Chapter 7 focuses on the development of multi-modality system and novel imaging scheme for the study of neurovascular coupling. Chapter 8 briefly concludes the contents presented in this dissertation and outlines the future development and potential applications of ODT. | 129 pages

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Management Of Undernutrition And Failure To Thrive In Children With Congenital Heart Disease In Low- And Middle-Income Countries, Andrew C. Argent, Rakhi Balachandran, Balu Vaidyanathan, Amina Khan, R. Krishna Kumar Dec 2017

Management Of Undernutrition And Failure To Thrive In Children With Congenital Heart Disease In Low- And Middle-Income Countries, Andrew C. Argent, Rakhi Balachandran, Balu Vaidyanathan, Amina Khan, R. Krishna Kumar

Section of Cardiology

Poor growth with underweight for age, decreased length/height for age, and underweight-for-height are all relatively common in children with CHD. The underlying causes of this failure to thrive may be multifactorial, including innate growth potential, severity of cardiac disease, increased energy requirements, decreased nutritional intake, malabsorption, and poor utilisation of absorbed nutrition. These factors are particularly common and severe in low- and middle-income countries. Although nutrition should be carefully assessed in all patients, failure of growth is not a contraindication to surgical repair, and patients should receive surgical repair where indicated as soon as possible. Close attention should be paid …

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Investigating Parental Involvement In Their Childrens Education In A Government Aided Secondary School In Maracha Uganda, Alesi Judith Dec 2017

Investigating Parental Involvement In Their Childrens Education In A Government Aided Secondary School In Maracha Uganda, Alesi Judith

Master of Education

The concept of parental involvement in their children‟s education has been core in enhancing students‟ academic performance and life in general regardless of their socio economic background. Families provide the base upon which the learners are supported in their social, moral, financial, psychological and academic growth which ushers them into great achievements. This study therefore aimed at investigating parental involvement in their children‟s education in a rural secondary school where most parents are of low socio economic status, and how they offer their support both at school and at home. Based on the context of the study, we should acknowledge …

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Is The State Of The Air-Sea Interface A Factor In Rapid Intensification And Rapid Decline Of Tropical Cyclones?, Alexander Soloviev, Roger Lukas, Mark A. Donelan, Brian K. Haus, Isaac Ginis Dec 2017

Is The State Of The Air-Sea Interface A Factor In Rapid Intensification And Rapid Decline Of Tropical Cyclones?, Alexander Soloviev, Roger Lukas, Mark A. Donelan, Brian K. Haus, Isaac Ginis

Marine & Environmental Sciences Faculty Articles

Tropical storm intensity prediction remains a challenge in tropical meteorology. Some tropical storms undergo dramatic rapid intensification and rapid decline. Hurricane researchers have considered particular ambient environmental conditions including the ocean thermal and salinity structure and internal vortex dynamics (e.g., eyewall replacement cycle, hot towers) as factors creating favorable conditions for rapid intensification. At this point, however, it is not exactly known to what extent the state of the sea surface controls tropical cyclone dynamics. Theoretical considerations, laboratory experiments, and numerical simulations suggest that the air-sea interface under tropical cyclones is subject to the Kelvin-Helmholtz type instability. Ejection of large …

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University Of Dayton Magazine. Winter 2017-18, University Of Dayton Magazine Dec 2017

University Of Dayton Magazine. Winter 2017-18, University Of Dayton Magazine

University of Dayton Alumni Publications

The University of Dayton Magazine is published quarterly by the Office of Communications for alumni, parents, students, faculty/staff, trustees and other friends of UD. Articles include "In Distinguished Company," "What Makes Us Human," and "Maybe Just Give Up and Go Home."

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A Computational And Experimental Investigation Of Lignin Metabolism In Arabidopsis Thaliana., Rohit Jaini Dec 2017

A Computational And Experimental Investigation Of Lignin Metabolism In Arabidopsis Thaliana., Rohit Jaini

Open Access Dissertations

Predominantly localized in plant secondary cell walls, lignin is a highly crosslinked, aromatic polymer that imparts structural support to plant vasculature, and renders biomass recalcitrant to pretreatment techniques impeding the economical production of biofuels. Lignin is synthesized via the phenylpropanoid pathway where the primary precursor phenylalanine (Phe) undergoes a series of functional modifications catalyzed by 11 enzyme families to produce p-coumaryl, coniferyl, and sinapyl alcohol, which undergo random polymerization into lignin. Several metabolic engineering efforts have aimed to alter lignin content and composition, and make biofuel feedstock more amenable to pretreatment techniques. Despite significant advances, several questions pertaining to carbon …

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Functional Characterization Of Two Novel Myofiber Type-Specific Non-Histone Protein Methyltransferases, Chao Wang Dec 2017

Functional Characterization Of Two Novel Myofiber Type-Specific Non-Histone Protein Methyltransferases, Chao Wang

Open Access Dissertations

Skeletal muscles are composed of muscle cells or myofibers which are classified as four types (I, IIa, IIx/d, and IIb), with different physiological, biochemical, structural and metabolic characteristics. The molecular regulation of myofiber identify is not completely understood. I identified methyltransferase like 21 (Mettl21) e and Mettl21c as the type IIb and type I myofiber- specific protein, respectively. The aim of this dissertation was to determine the function of Mettl21e and Mettl21c in regulating myofiber identity. In the first part of the thesis, I used in silico approaches to identify Mettl21e as one of the top up-regulated genes in myostatin …

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Heritable Sperm Chromatin Epigenetics: A Break To Remember, Ralph G. Meyer, Chelsea C. Ketchum, Mirella L. Meyer-Ficca Dec 2017

Heritable Sperm Chromatin Epigenetics: A Break To Remember, Ralph G. Meyer, Chelsea C. Ketchum, Mirella L. Meyer-Ficca

UAES Publications

Sperm chromatin not only has a unique structure to condense and protect the paternal DNA in transit, but also provides epigenetic information that supports embryonic development. Most of the unique sperm nuclear architecture is formed during the sweeping postmeiotic chromatin remodeling events in spermiogenesis, where the majority of nucleosomes are removed and replaced by protamines. The remaining histones and other chromatin proteins are located in structurally and transcriptionally relevant positions in the genome and carry diverse post-translational modifications relevant to the control of embryonic gene expression. How such postmeiotic chromatin-based programming of sperm epigenetic information proceeds, and how susceptible the …

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A Retrospective Chart Review Comparing Nutritional Screening Tools (Mna-Sf And Must) In Identifying Malnutrition In Older Adults Admitted To A Hospital In 2016, Elizabeth Schneider Dec 2017

A Retrospective Chart Review Comparing Nutritional Screening Tools (Mna-Sf And Must) In Identifying Malnutrition In Older Adults Admitted To A Hospital In 2016, Elizabeth Schneider

2017 Fall Honors Capstone Projects - Archive

There are many factors that contribute toward negative outcomes in the healthcare setting for hospitalized older adults (Tappenden, Quatrara, Parkhurst, Malone, Fanjiang, & Ziegler, 2013). One of these factors includes meeting nutritional requirements. Unfortunately, many cases of malnutrition in patients 65 years and older, who are admitted to the hospital, go unnoticed due to the lack of nutritional screening tool implementation (Tappenden et al., 2013). Therefore, this study looks at two of the most popular nutritional screening tools, the MNA-SF and MUST, to identify malnutrition in older adults with a preexisting diagnosis of either malnutrition or failure to thrive and …

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Effects Of Exercise Environments On Stress With Premedical And Predental College Students, Islam Hammad Dec 2017

Effects Of Exercise Environments On Stress With Premedical And Predental College Students, Islam Hammad

2017 Fall Honors Capstone Projects - Archive

The purpose of this study is to measure effects of exercise environments on stress in premedical and predental students, and how to provide a method that would strive to reduce stress levels in college students. To further understand the different ways stress levels can be reduced, a method was performed to see if exercise environments have an effect on stress in premedical and predental students. Participants took the Perceived Stress Survey Inventory (PSSI) and were then instructed to walk one mile every day for one week at the University of Texas Arlington (UTA) or a park. It was hypothesized by …

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Improving Cell Seeding Of Decellularized And Porated Porcine Arterial Scaffolds, Harrison Smallwood Dec 2017

Improving Cell Seeding Of Decellularized And Porated Porcine Arterial Scaffolds, Harrison Smallwood

All Theses

Coronary artery disease is one of the number one killers in the U.S. Current treatment of using CABG surgery has limitations from availability of autologous grafts, and low patency of artificial grafts. Tissue engineered grafts would ideally provide more availability, while also replicating the mechanical properties of the native grafts. Current issues in tissue engineering arteries lie in using an effective scaffold to get correct mechanical properties, and allowing for cell infiltration to assist in integrating with native tissue once implanted. This study shows the use of a decellularized and chemically and mechanically porated porcine carotid artery in mechanical characterization …

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Culinary Nutrition Camp; Healthy Lifestyles Cooking Like A Chef (Hlclc) Program: Implementation And Evaluation, Shannon Lynn Monnier Evers Dec 2017

Culinary Nutrition Camp; Healthy Lifestyles Cooking Like A Chef (Hlclc) Program: Implementation And Evaluation, Shannon Lynn Monnier Evers

All Theses

Healthy Lifestyles Cooking Like a Chef (HLCLC) is a culinary nutrition curriculum based on social cognitive theory. The aim for the HLCLC program is to inspire kitchen confidence and to improve cooking skills and nutrition knowledge, thereby encouraging positive cooking and food choice behaviors. HLCLC aims to expose adolescents to a wide variety of healthy ingredients, teach cooking skills, apply nutrition information, and practice safe food handling. The program objectives are (1) Increase knowledge of healthy food choices through discussion and exposure, (2) Present healthy versions of familiar foods that are inexpensive, tasty, and easy and quick to prepare, (3) …

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Enantioselective Synthesis Of An Anticancer Ruthenium Polypyridyl Complex (Rpc) And Influence Of Chiral Selectivity On Dna Photocleavage, Shomita Ferdous Dec 2017

Enantioselective Synthesis Of An Anticancer Ruthenium Polypyridyl Complex (Rpc) And Influence Of Chiral Selectivity On Dna Photocleavage, Shomita Ferdous

Chemistry & Biochemistry Theses - Archive

Ruthenium polypyridyl complexes (RPCs) represent a promising therapeiutic class of drugs for transition-metal based anticancer drug development. The complex [(phen)2Ru(tatpp)Ru(phen)2] (44+) is a RPC which has shown success in both cell free and cellular assay. Unlike many other RPCs, 44+ can selectively kill malignant cells without light irradiation from external sources. This binuclear complex 44+ is a DNA intercalator containing redox-active ligand tatpp (9,11,20,22-Tetraaza tetrapyrido[3,2-a:2'3'-c:3'',2''- 1:2''',3''']-pentacene) which cleaves DNA in presence of a mild reducing agent, i.e. glutathione (GSH).1,2,3 The cellular assay (MTT assay) with different types of malignant cells has also established this as an equally potent cytotoxic agent …

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Diversification On Continents And Islands: A Herpetological Perspective, Kyle Anthony O'Connell Dec 2017

Diversification On Continents And Islands: A Herpetological Perspective, Kyle Anthony O'Connell

Biology Dissertations - Archive

This dissertation seeks to understand the geological and climatological processes that have promoted diversification on continental and island systems. Using molecular genetic data generated using Sanger sequencing and Next Generation Sequencing platforms, I conduct phylogenetic and biogeographic analyses, estimate gene flow, and conduct species delimitation. Using these analyses, I explore diversification processes on continents and islands using reptile and amphibian systems. In Chapter 2 I evaluate the role of geographical features to whipsnake diversification. Chapter 3 resolves the taxonomy of several poorly understood whipsnakes species and tests the effect of missing data on species delimitation. Chapter 4 investigates the biogeographical …

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Decoding Critical Long Non-Coding Rna In Ovarian Cancer Epithelial-To-Mesenchymal Transition., Ramkrishna Mitra, Xi Chen, Evan J. Greenawalt, Ujjwal Maulik, Wei Jiang, Zhongming Zhao, Christine M. Eischen Dec 2017

Decoding Critical Long Non-Coding Rna In Ovarian Cancer Epithelial-To-Mesenchymal Transition., Ramkrishna Mitra, Xi Chen, Evan J. Greenawalt, Ujjwal Maulik, Wei Jiang, Zhongming Zhao, Christine M. Eischen

Department of Cancer Biology Faculty Papers

Long non-coding RNA (lncRNA) are emerging as contributors to malignancies. Little is understood about the contribution of lncRNA to epithelial-to-mesenchymal transition (EMT), which correlates with metastasis. Ovarian cancer is usually diagnosed after metastasis. Here we report an integrated analysis of >700 ovarian cancer molecular profiles, including genomic data sets, from four patient cohorts identifying lncRNA DNM3OS, MEG3, and MIAT overexpression and their reproducible gene regulation in ovarian cancer EMT. Genome-wide mapping shows 73% of MEG3-regulated EMT-linked pathway genes contain MEG3 binding sites. DNM3OS overexpression, but not MEG3 or MIAT, significantly correlates to worse overall patient survival. DNM3OS knockdown results in …

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Effects Of Ocean Warming And Acidification On Fertilization Success And Early Larval Development In The Green Sea Urchin, Lytechinus Variegatus, Brittney L. Lenz Dec 2017

Effects Of Ocean Warming And Acidification On Fertilization Success And Early Larval Development In The Green Sea Urchin, Lytechinus Variegatus, Brittney L. Lenz

HCNSO Student Theses and Dissertations

Climate change is predicted to affect the larval stages of many marine organisms. Ocean warming can reduce larval survival and hasten larval development, whereas ocean acidification can delay larval development. Ocean acidification is especially concerning for marine organisms that develop and grow calcified shells or skeletons in an environment undersaturated with calcium carbonate minerals. This study assessed the effects of ocean warming and acidification on the fertilization and larval development of the green sea urchin, Lytechinus variegatus, a tropical species common in Florida and the Caribbean. After spawning, gametes were fertilized and embryos/larvae were reared at: 1) 28°C and …

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Variation In Coral Recruitment And Juvenile Distribution Along The Southeast Florida Reef Tract, Leah M. Harper Dec 2017

Variation In Coral Recruitment And Juvenile Distribution Along The Southeast Florida Reef Tract, Leah M. Harper

HCNSO Student Theses and Dissertations

Coral recruitment in Southeast Florida is being outpaced by mortality, resulting in population declines in many species. Identifying the coral species most likely to recruit and survive on Southeast Florida reefs and evaluating spatial variation in recruitment and survivorship is crucial for managing decreasing coral populations. This study focuses on 12 sites in Broward and Miami-Dade counties that have served as long-term stations for monitoring adult coral cover and demographics. At each site, thirty-two 225cm2 grooved terracotta settlement tiles were attached to the substrate in winter of 2015 and retrieved in winter of 2016 to evaluate scleractinian and octocoral …

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Implementing Evidence-Based Opioid Prescription Practices In A Primary Care Setting, Cyril Gaiennie Dec 2017

Implementing Evidence-Based Opioid Prescription Practices In A Primary Care Setting, Cyril Gaiennie

Doctor of Nursing Practice

The use and misuse of opioid pain medication has reached epidemic proportions in the United States. More than 16,000 people die each year due to the misuse or abuse of prescription opioid medications, which is more than from heroin, cocaine, and benzodiazepines combined. The purpose of this evidence-based practice project is to establish processes enabling a primary care clinic to implement and adhere to the 2016 Centers for Disease Control’s guidelines for opioid prescription practices in the primary care setting. A retrospective chart review conducted prior to implementation of the guidelines demonstrated that four of six of the CDC’s recommendations …

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Provider Adherence To Prescribing The Elimination Diet, Seth Osgood Dec 2017

Provider Adherence To Prescribing The Elimination Diet, Seth Osgood

Doctor of Nursing Practice

Allergy-related diseases, chemical sensitivities, and food intolerances have increased dramatically over the last 20 years in both the pediatric and adult populations, contributing to escalating rates of morbidity. Despite an abundance of literature supporting the negative impact food reactions can have in multiple disease states, food reactions continue to be seen as a modern enigma in medicine and are often met with great skepticism. There are a variety of interventions available to identify food reactions in both adults and children; yet, the traditional elimination diet remains the standard of care. Regardless of its utility and clinical effectiveness in the healthcare …

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Gastrointestinal Parasites In Captive And Free-Ranging Cebus Albifrons In The Western Amazon, Ecuador, Sarah Martin-Solano, Gabriel A. Carrillo-Bilbao, William Ramirez, Maritza Celi-Erazo, Marie-Claude Huynen, Bruno Levecke, Washington Benitez-Ortiz, Bertrand Losson Dec 2017

Gastrointestinal Parasites In Captive And Free-Ranging Cebus Albifrons In The Western Amazon, Ecuador, Sarah Martin-Solano, Gabriel A. Carrillo-Bilbao, William Ramirez, Maritza Celi-Erazo, Marie-Claude Huynen, Bruno Levecke, Washington Benitez-Ortiz, Bertrand Losson

All Faculty Scholarship for the College of the Sciences

Currently, there is a lack of surveys that report the occurrence of gastrointestinal parasites in the whiteheaded capuchin monkey (Cebus albifrons). We therefore assessed the presence and richness (= number of different parasite genera) of parasites in C. albifrons in wildlife refuges (n = 11) and in a free-ranging group near a human village (n = 15) in the Ecuadorian Amazon. In the 78 samples collected (median of 3 samples per animal), we identified a total of 6 genera of gastrointestinal parasites, representing protozoa, nematodes, acanthocephalans and cestodes. We observed a high prevalence (84%) across the 26 individuals, with the …

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Proteomics Standards Initiative: Fifteen Years Of Progress And Future Work., Eric W Deutsch, Sandra Orchard, Pierre-Alain Binz, Wout Bittremieux, Martin Eisenacher, Henning Hermjakob, Shin Kawano, Henry Lam, Gerhard Mayer, Gerben Menschaert, Yasset Perez-Riverol, Reza M Salek, David L Tabb, Stefan Tenzer, Juan Antonio Vizcaíno, Mathias Walzer, Andrew R Jones Dec 2017

Proteomics Standards Initiative: Fifteen Years Of Progress And Future Work., Eric W Deutsch, Sandra Orchard, Pierre-Alain Binz, Wout Bittremieux, Martin Eisenacher, Henning Hermjakob, Shin Kawano, Henry Lam, Gerhard Mayer, Gerben Menschaert, Yasset Perez-Riverol, Reza M Salek, David L Tabb, Stefan Tenzer, Juan Antonio Vizcaíno, Mathias Walzer, Andrew R Jones

Articles, Abstracts, and Reports

The Proteomics Standards Initiative (PSI) of the Human Proteome Organization (HUPO) has now been developing and promoting open community standards and software tools in the field of proteomics for 15 years. Under the guidance of the chair, cochairs, and other leadership positions, the PSI working groups are tasked with the development and maintenance of community standards via special workshops and ongoing work. Among the existing ratified standards, the PSI working groups continue to update PSI-MI XML, MITAB, mzML, mzIdentML, mzQuantML, mzTab, and the MIAPE (Minimum Information About a Proteomics Experiment) guidelines with the advance of new technologies and techniques. Furthermore, …

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Nadph Oxidase 5 (Nox5)-Induced Reactive Oxygen Signaling Modulates Normoxic Hif-1Α And P27, Smitha Antony, Guojian Jiang, Yongzhong Wu, Jennifer L Meitzler, Hala R Makhlouf, Diana C Haines, Donna Butcher, Dave S B Hoon, Jiuping Ji, Yiping Zhang, Agnes Juhasz, Jiamo Lu, Han Liu, Iris Dahan, Mariam Konate, Krishnendu K Roy, James H Doroshow Dec 2017

Nadph Oxidase 5 (Nox5)-Induced Reactive Oxygen Signaling Modulates Normoxic Hif-1Α And P27, Smitha Antony, Guojian Jiang, Yongzhong Wu, Jennifer L Meitzler, Hala R Makhlouf, Diana C Haines, Donna Butcher, Dave S B Hoon, Jiuping Ji, Yiping Zhang, Agnes Juhasz, Jiamo Lu, Han Liu, Iris Dahan, Mariam Konate, Krishnendu K Roy, James H Doroshow

Articles, Abstracts, and Reports

NADPH oxidase 5 (NOX5) generated reactive oxygen species (ROS) have been implicated in signaling cascades that regulate cancer cell proliferation. To evaluate and validate NOX5 expression in human tumors, we screened a broad range of tissue microarrays (TMAs), and report substantial overexpression of NOX5 in malignant melanoma and cancers of the prostate, breast, and ovary. In human UACC-257 melanoma cells that possesses high levels of functional endogenous NOX5, overexpression of NOX5 resulted in enhanced cell growth, increased numbers of BrdU positive cells, and increased γ-H2AX levels. Additionally, NOX5-overexpressing (stable and inducible) UACC-257 cells demonstrated increased normoxic HIF-1α expression and decreased …

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The Effect Of Superparamagnetic Iron Oxide Nanoparticle Surface Charge On Antigen Cross-Presentation., Yongbin Mou, Yun Xing, Hongyan Ren, Zhihua Cui, Yu Zhang, Guangjie Yu, Walter J Urba, Qingang Hu, Hongming Hu Dec 2017

The Effect Of Superparamagnetic Iron Oxide Nanoparticle Surface Charge On Antigen Cross-Presentation., Yongbin Mou, Yun Xing, Hongyan Ren, Zhihua Cui, Yu Zhang, Guangjie Yu, Walter J Urba, Qingang Hu, Hongming Hu

Articles, Abstracts, and Reports

Magnetic nanoparticles (NPs) of superparamagnetic iron oxide (SPIO) have been explored for different kinds of applications in biomedicine, mechanics, and information. Here, we explored the synthetic SPIO NPs as an adjuvant on antigen cross-presentation ability by enhancing the intracellular delivery of antigens into antigen presenting cells (APCs). Particles with different chemical modifications and surface charges were used to study the mechanism of action of antigen delivery. Specifically, two types of magnetic NPs, γFe

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Quantification Of The Spatial Distribution Of Radionuclides In Field Lysimeters With A Collimated High-Resolution Gamma-Ray Spectrometer, Bryan James Erdmann Dec 2017

Quantification Of The Spatial Distribution Of Radionuclides In Field Lysimeters With A Collimated High-Resolution Gamma-Ray Spectrometer, Bryan James Erdmann

All Theses

The objective of this work is to quantify the one-dimensional spatial distribution of radionuclides in field lysimeters from the Radionuclide Field Lysimeter Experiment (RadFLEX) facility at the Savannah River Nationals Laboratory (SRNL). The lysimeters, containing 137Cs, 60Co, 133Ba and 152Eu incorporated either into solid wasteforms (Portland cement and reducing grout) or introduced into soil via a filter paper wasteform, were weathered for three to four years. The initial contaminant activities range from 4.0 to 9.0 MBq for the cementitious wasteforms and 0.25 to 0.47 MBq for the filter paper wasteform. An analytical method was developed to …

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Homelessness Among Women Veterans: A Systematic Review Of The Risk Factors, Staceyann Graham Dec 2017

Homelessness Among Women Veterans: A Systematic Review Of The Risk Factors, Staceyann Graham

Social Work Theses - Archive

Background: As more women joined the armed forces the population of women veterans inevitably increased and with it so did the rates of women veteran homelessness. Women veterans are a unique group of women who also possess protective factors from homelessness, yet are 3 to 4 times likely to become homeless than non-veteran women. The purpose of this systematic review is to glean from other articles and studies what the risk factors for women veteran homelessness are. Method: A systematic review of 7 articles were conducted using the PRISMA method as a guideline for selecting the articles. Results: 5 articles …

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Measuring The Effects Of Culturing A549 Non-Small Lung Cancer Cells On Collagen, Engineered Basal Lamina, And Traditional 2d Cell Culture, Nicholas Prasatporn Dec 2017

Measuring The Effects Of Culturing A549 Non-Small Lung Cancer Cells On Collagen, Engineered Basal Lamina, And Traditional 2d Cell Culture, Nicholas Prasatporn

McNair Scholars Research Journal

No abstract provided.

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Reverse Transcriptase Domain Of Rc Bombyx Mori Non-Ltr Retrotransposons, Zaynab Omisade Dec 2017

Reverse Transcriptase Domain Of Rc Bombyx Mori Non-Ltr Retrotransposons, Zaynab Omisade

McNair Scholars Research Journal

No abstract provided.

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Personhood Under The Fourteenth Amendment, Vincent J. Samar Dec 2017

Personhood Under The Fourteenth Amendment, Vincent J. Samar

Marquette Law Review

This Article examines recent claims that the fetus be afforded the status of a person under the Fourteenth Amendment. It shows that such claims do not carry the necessary objectivity to operate reasonably in a pluralistic society. It then goes on to afford what a better view of personhood that could so operate might actually look like. Along the way, this Article takes seriously the real deep concerns many have for the sanctity of human life. By the end, it attempts to find a balance for those concerns with the view of personhood offered that should engage current debates about …

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