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Antifungal Potential Of Copper(Ii), Manganese(Ii) And Silver(I) 1,10-Phenanthroline Chelates Against Multidrug-Resistant Fungal Species Forming The Candida Haemulonii Complex: Impact On The Planktonic And Biofilm Lifestyles, Rafael M. Gandra, Pauraic Mc Carron, Mariana F. Fernandes, Lívia S. Ramos, Thaís P. Mello, Ana Carolina Aor, Marta H. Branquinha, Malachy Mccann, Michael Devereux, André L. S. Santos

Articles

Candida haemulonii, Candida haemulonii var. vulnera and Candida duobushaemulonii, which form the C. haemulonii complex, are emerging etiologic agents of fungal infections known to be resistant to the most commonly used antifungals. The well-established anti-Candida potential ofmetal complexes containing 1,10-phenanthroline (phen) ligands encouraged us to evaluate different copper(II), manganese(II), and silver(I) phen chelates for their ability to inhibit planktonic growth and biofilm of C. haemulonii species complex. Two novel coordination complexes, {[Cu(3,6,9-tdda)(phen)2].3H2O.EtOH}n and [Ag2(3,6,9-tdda)(phen)4].EtOH (3,6,9-tddaH2 = 3,6,9-trioxaundecanedioic acid), were synthesized in a similar fashion to the other, previously documented, sixteen copper(II), manganese(II), and silver(I) chelates employed herein. Three isolates of …

Fertility And Rural Electrification In Bangladesh, Tomoki Fujii, Abu S. Shonchoy

Research Collection School Of Economics

We use a household-level panel dataset from Bangladesh to examine the household-level relationship between fertility and the access to electricity. We find that the household's access to electricity reduces the change in the number of children by about 0.1 to 0.25 children in a period of five years in most estimates. This finding also applies to retrospective panel data and is robust to the choice of covariates and estimation methods. Our finding passes falsification test and corroborates with the predictions of our theoretical model on the households' time use and consumption pattern.

Multi-Material Mesh Representation Of Anatomical Structures For Deep Brain Stimulation Planning, Tanweer Rashid

Computational Modeling & Simulation Engineering Theses & Dissertations

The Dual Contouring algorithm (DC) is a grid-based process used to generate surface meshes from volumetric data. However, DC is unable to guarantee 2-manifold and watertight meshes due to the fact that it produces only one vertex for each grid cube. We present a modified Dual Contouring algorithm that is capable of overcoming this limitation. The proposed method decomposes an ambiguous grid cube into a set of tetrahedral cells and uses novel polygon generation rules that produce 2-manifold and watertight surface meshes with good-quality triangles. These meshes, being watertight and 2-manifold, are geometrically correct, and therefore can be used to …

“El Negro Sin La Oreja”: A Dialectical Approach To The Blackness In Dominican Identity, Kevin E. Nicholes

Institute for the Humanities Theses

This master’s thesis examines ideologies of whiteness through the erasure and denial of blackness in the Dominican Republic and explores the manner in which racial identity has been reinforced and contested. A dialectical approach is utilized to analyze the discourse around the history of the Dominican Republic and a textual analysis is also employed to assist in supporting the findings. The rationale for this study is to access how whiteness became synonymous with Dominicanness and to resuscitate the blackness of Dominican identity which has been relegated to the classification of the “other”. Therefore, drawing conclusions as to how Dominicans

negotiate …

When It Is Troublesome To Do Right: A Narrative Analysis Of The Continual Censorship And “Sivilizing” Of Huckleberry Finn, Angela P. Branyon

Teaching & Learning Theses & Dissertations

This qualitative dissertation is a part of a broader program of research that investigates intellectual freedom. The study focuses on developing understanding in three distinct, but related, research areas – the American historical and cultural narrative of race, the historical discourse of intellectual freedom, and the role The Adventures of Huckleberry Finn can play in adding to and perhaps changing these historic stories. By using historical narrative inquiry, data was examined from each story to find correlations among the discourses Where previous research centers on and develops the reasons why Huck Finn has been challenged, this research focuses on how …

A Case Study Of Hanban’S Chinese Language Teaching Program At Western Kentucky University: Developmental History And Preliminary Outcomes, Sheng-Huei Yu

Dissertations

This case study provides a historical overview of foreign language development (especially Chinese) in the United States and the growing number of Confucius Institutes (CIs) established in the U.S through Hanban, China’s National Office for Teaching Chinese as a Foreign Language. This case study specifically captures the growth of the Western Kentucky University (WKU) CI from its inception in 2010. According to Hanban’s annual assessment reporting guidelines, since the conception of CIs sheer quantity of teachers and students has always been the primary focus. Therefore, the growth in the numbers of Hanban Chinese teachers and number of students enrolled in …

Effects Of Oceanographic Variability On The Trophic Ecology Of Eight Species Of Coral Reef Fishes From The Remote Central Pacific, Scott Donald Miller

Capstone Projects and Master's Theses

Ecologists have long been interested in the factors that influence species’ ecological niches. Factors such as inter- and intraspecific competition, predation risk, and resource availability have been demonstrated to cause either expansions or constrictions in populations’ niches. Coral reefs represent complex systems rich in ecological interactions to study these effects on species’ niches. However, much of our knowledge of the ecological processes responsible for regulating community structure and function in tropical coral reefs originated in areas that were already strongly influenced by anthropogenic factors, such as fishing and eutrophication. In this study, I examined the role of natural oceanographic variation …

Biology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Economics, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Environmental And Earth Science Programs, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Pre-Professional Curricula, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Theology & Religious Studies, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Sociology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Contents, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Allied Health Science, Saint Mary's College Of California

Academic Catalog

No abstract provided.

The Chondrocyte Channelome: A Novel Ion Channel Candidate In The Pathogenesis Of Pectus Deformities, Anthony J. Asmar

Biological Sciences Theses & Dissertations

Costal cartilage is a type of rod-like hyaline cartilage connecting the ribs to the sternum. The chest wall deformities pectus excavatum (PE) and pectus carinatum (PC) involve displacement of the sternum causing a depression or protrusion of the chest. There is little knowledge about costal cartilage and pectus deformities with much of its understanding based on assumptions from articular cartilage. Chondrocytes are subjected to a constantly changing environment with fluctuations in pH and osmolarity. Ion channels detect these changes and in turn regulate proliferation, differentiation, and extracellular matrix production. Using ion channel qPCR arrays, we produced expression profiles for normal, …

Delayed Changes In Auditory Status In Cochlear Implant Users With Preserved Acoustic Hearing, Rachel Scheperle, Viral D. Tejani, Julia K. Omtvedt, Carolyn J. Brown, Paul J. Abbas, Marlan R. Hansen, Bruce J. Gantz, Jacob J. Oleson, Marie V. Ozanne

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

This retrospective review explores delayed-onset hearing loss in 85 individuals receiving cochlear implants designed to preserve acoustic hearing at the University of Iowa Hospitals and Clinics between 2001 and 2015. Repeated measures of unaided behavioral audiometric thresholds, electrode impedance, and electrically evoked compound action potential (ECAP) amplitude growth functions were used to characterize longitudinal changes in auditory status. Participants were grouped into two primary categories according to changes in unaided behavioral thresholds: (1) stable hearing or symmetrical hearing loss and (2) delayed loss of hearing in the implanted ear. Thirty-eight percent of this sample presented with delayed-onset hearing loss of …

Lignin Contribution To The Global Carbon Pool: Investigating The Abiotic Modification Of Lignin By Reactive Oxygen Species, Derek Charles Waggoner

Chemistry & Biochemistry Theses & Dissertations

Evidence suggests that reactive oxygen species (ROS), largely generated through photochemical processes, are important in transforming the chemical composition of the large pool of terrestrially-derived dissolved organic matter (DOM) exported from land to water annually. However, due to the challenges inherent in isolating the effects of individual ROS on DOM composition, the role of ROS in the photochemical alteration of DOM remains poorly characterized. The main focus of the studies within this dissertation aim to more thoroughly characterize the alterations to lignin, used as an analog for terrestrial DOM, resulting from reactions with ROS.

To investigate the possibility that the …

Studies In Directed Catalytic Asymmetric Hydroboration Of 1,2-Disubstituted Unsaturated Amide, Shuyang Zhang

Department of Chemistry: Dissertations, Theses, and Student Research

The Rh-catalyzed, substrate directed catalytic asymmetric hydroboration of γ,δ-unsaturated amides provides a direct route to enantioenriched acyclic secondary γ-borylated carbonyl derivatives with high regio- and enantioselectivity. The catalytic condition optimization and substrate scope study is discussed, including the effects in catalytical asymmetric hydroboration on pre-installed chiral γ,δ-unsaturated amides. A mechanistic study from kinetic approach by graphical manipulation (reaction progress kinetic analysis for substrate orders and normalized time analysis for catalyst order.) was discussed in this thesis

Advisor: Professor James M. Takacs

Rodenticide Incidents Of Exposure And Adverse Effects On Non-Raptor Birds, Nimish B. Vyas

United States Geological Survey: Staff Publications

Interest in the adverse effects of rodenticides on birds has focused primarily on raptors. However, non-raptor birds are also poisoned (rodenticide exposure resulting in adverse effects including mortality) by rodenticides through consumption of the rodenticide bait and contaminated prey. A literature search for rodenticide incidents (evidence of exposure to a rodenticide, adverse effects, or exposure to placebo baits) involving non-raptor birds returned 641 records spanning the years 1931 to 2016. The incidents included 17 orders, 58 families, and 190 non-raptor bird species. Nineteen anticoagulant and non-anticoagulant rodenticide active ingredients were associated with the incidents. The number of incidents and species …

Dietary Red And Processed Meat Intake And Markers Of Adiposity And Inflammation: The Multiethnic Cohort Study, Weiwen Chai, Yukiko Morimoto, Robert V. Cooney, Adrian A. Franke, Yurii B. Shvetsov, Loïc Le Marchand, Christopher A. Haiman, Laurence N. Kolonel, Marc T. Goodman, Gertraud Maskarinec

Department of Nutrition and Health Sciences: Faculty Publications

Objective—The potential influence of dietary factors on inflammation is important for cancer prevention. Utilizing data from control participants (312 men, 911 women) in two nested case-control studies of cancer within the Multiethnic Cohort, we examined the associations of red and processed meat intake with serum levels of leptin, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 and the mediator effect of body mass index (BMI) on the above associations (if present).

Methods—Multivariable linear models were applied to assess the association between red and processed meat intake at cohort entry and serum biomarker levels measured 9.1 …

Dorian Mode: An Examination Of Its Usage And Context In Film Music, Sean Goldman

Scoring for Film, Television, and Video Games

It is the goal of the paper to identify the aspects of Dorian that allow for its frequent and effective use. Since the practice of music notation, the pitch set currently understood as Dorian has been used as a prominent scale with a wide range of usages. Ultimately, the underlying thesis indicates that the Dorian church mode’s large range of affective qualities and general versatility is the product of its underlying inherent neutrality.

Stair Negotiation Made Easier Using Novel Interactive Energy-Recycling Assistive Stairs, Yun Seong Song, Sehoon Ha, Hsiang Hsu, Lena H. Ting, C. Karen Liu

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Here we show that novel, energy-recycling stairs reduce the amount of work required for humans to both ascend and descend stairs. Our low-power, interactive, and modular steps can be placed on existing staircases, storing energy during stair descent and returning that energy to the user during stair ascent. Energy is recycled through event-triggered latching and unlatching of passive springs without the use of powered actuators. When ascending the energy-recycling stairs, naive users generated 17.4 ± 6.9% less positive work with their leading legs compared to conventional stairs, with the knee joint positive work reduced by 37.7 ± 10.5%. Users also …

Task Assignment And Path Planning For Multiple Autonomous Underwater Vehicles Using 3d Dubins Curves, Wenyu Cai, Meiyan Zhang, Y. Rosa Zheng

Electrical and Computer Engineering Faculty Research & Creative Works

This paper investigates the task assignment and path planning problem for multiple AUVs in three dimensional (3D) underwater wireless sensor networks where nonholonomic motion constraints of underwater AUVs in 3D space are considered. The multi-target task assignment and path planning problem is modeled by the Multiple Traveling Sales Person (MTSP) problem and the Genetic Algorithm (GA) is used to solve the MTSP problem with Euclidean distance as the cost function and the Tour Hop Balance (THB) or Tour Length Balance (TLB) constraints as the stop criterion. The resulting tour sequences are mapped to 2D Dubins curves in the X − …

Preparation Of Au/Ag Nanoshells Through A Galvanic Replacement Reaction, Elizabeth Maschmeyer

All Capstone Projects

It generally requires solid metal templates of hollow metal structures with uniform morphology by the present galvanic replacement mediated-growth approaches. In this project report, we present a new and simple approach for the controllable synthesis of Au/Ag alloy nanoshells (NSs) by applying galvanic replacement reaction on hollow Ag template in the presence of gold salt. High quality thiol-coated spherical shape Au/Ag NSs were produced via this new synthetic approach and the hollow interior of the Ag template is very well preserved during the galvanic replacement reaction. Plasmonic property measurements reveal that Au/Ag NSs exhibit strong absorption peak and more importantly, …

Identification Of Chemical Compounds That Inhibit Protein Synthesis In Pseudomonas Aeruginosa, Stephanie O. Palmer, Yanmei Hu, Megan Keniry, James M. Bullard

School of Integrative Biological & Chemical Sciences Faculty Publications

Four inhibitory compounds were identified using a poly-uridylic acid (polyU) mRNA-directed aminoacylation/translation (A/T) protein synthesis system composed of phenylalanyl-tRNA synthetases (PheRS), ribosomes, and ribosomal factors from Pseudomonas aeruginosa in an in vitro screen of a synthetic compound library. The compounds were specific for inhibition of bacterial protein synthesis. In enzymatic assays, the compounds inhibited protein synthesis with IC50 values ranging from 20 to 60 μM. Minimum inhibitory concentrations (MICs) were determined in cultures for a panel of pathogenic organisms, including Enterococcus faecalis, Escherichia coli, Haemophilus influenzae, P. aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. All the compounds were observed to have …

Linking Plant Hydraulics And Beta Diversity In Tropical Forests, Bradley O. Christoffersen, Patrick Meir, Nate G. Mcdowell

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

This article is a Commentary on Cosme et al., 215: 113–125.

Expression Of Sex-Determining Region Y-Box Protein 2 In Breast Cancer And Its Clinical Significance, Xuesong Feng, Mingqian Lu

Saudi Medical Journal

Sex-determining region Y-box protein 2 (SOX2) is an embryo transcription factor located on chromosome 3q26.3-q27. It plays an important role in the maintenance of differentiation and self-renewal of pluripotent stem cells. Studies have shown that SOX2 is associated with multiple cancers and is overexpressed in many different phenotypes of breast cancer. To study the relationship between SOX2 and clinicopathological parameters of breast cancer patients, we found that the expression of SOX2 was closely related to the increase in tumor size, histological grade, lymph node metastasis, and high invasiveness. Therefore, studies on the role of SOX2 in breast cancer may provide …

Preference And Usage Of Intracanal Medications During Endodontic Treatment, Ahmad A. Madarati, Muhammad S. Zafar, Aya M.N. Sammani, Ayman O. Mandorah, Hamzah A. Bani-Younes

Saudi Medical Journal

Objectives: To investigate the preferences of general dental practitioners (GDPs) and endodontists in using endodontic intra-canal medications (ICMs). Methods: This observational and descriptive study was conducted in 2014 in the western province of Saudi Arabia. Following ethical clearance and 2 pilot studies, a web-based questionnaire was electronically sent to 375 randomly and systematically selected GDPs and all endodontists in the western province (n=49). An accompanying e-mail explained the study’s aims and confirmed that the data yielded would remain confidential. The responses were collected, and the data was analyzed using the Chi-square test at p =0.05. Results: Significantly, the highest proportion …

Efficient Coarse-Grained Brownian Dynamics Simulations For Dna And Lipid Bilayer Membrane With Hydrodynamic Interactions, Szu-Pei Fu

Dissertations

The coarse-grained molecular dynamics (CGMD) or Brownian dynamics (BD) simulation is a particle-based approach that has been applied to a wide range of biological problems that involve interactions with surrounding fluid molecules or the so-called hydrodynamic interactions (HIs). From simple biological systems such as a single DNA macromolecule to large and complicated systems, for instances, vesicles and red blood cells (RBCs), the numerical results have shown outstanding agreements with experiments and continuum modeling by adopting Stokesian dynamics and explicit solvent model. Finally, when combined with fast algorithms such as the fast multipole method (FMM) which has nearly optimal complexity in …