A Novel Method For Synthesis Of Hydroxytyrosol, Emmanuel Onobun

Electronic Theses and Dissertations

Hydroxytyrosol, 3,4-dihydroxyphenolethanol, a naturally occurring polyphenol most common in olive tree (Olea europaea), is one of the most effective member of the polyphenols family, because of its remarkable antioxidant activity, its ability to inhibit oxidation of low density lipids (LDL), and its protection against DNA oxidative damage. Hydroxytyrosol, which is widely used in cosmetics and food supplements industries, can be purchased as an olive oil extract that contains low concentration of hydroxytyrosol besides other polyphenols. The price and low natural abundance of hydroxytyrosol make alternative synthetic sources very attractive. In this research, a novel method for the synthesis of pure …

Putnam County, Tennessee’S Prekindergarten Program As Measured By Test Scores, Gpa, Attendance, And Discipline Reports In 3rd, 7th, And 9th Grade, Christopher J. Winningham

Electronic Theses and Dissertations

The purpose of this quantitative study was to determine if there is a significant difference in the academic and behavioral performance of students who had attended Putnam County’s prekindergarten program and students who qualified for, but had not attended Putnam County’s prekindergarten program. The researcher examined individual student data of specific students in three grade bands (elementary, middle, and high school). The grade levels included 3rd grade, 7th grade, and 9th grade. The data analyzed were students’ individual GPA, ACT Explore scores, MAP Universal Screener scores, number of days absent, and number of discipline referrals of students who had attended …

Pilot Study: Evaluating The Risk Of Allergen Cross-Contact In Ice Cream Scoop Shop Dipper Wells, Lindsey Lake

All Theses

Food allergies are a serious and growing problem in developed countries. Allergen cross-contact at foodservice establishments is a common cause of food allergic reactions. Therefore, this study sought to determine if dipper wells used in ice cream scoop shops pose a relevant risk to food allergy sufferers. First, a matrix study was conducted to evaluate if peanut detection by real-time PCR was inhibited by the ice cream matrix, as fat and proteins are known PCR inhibitors. Frozen ice cream, liquid ice cream mix, and water matrices were tested. Second, a controlled time trial was conducted to evaluate the efficacy of …

Processing And Cooking On Lentil Prebiotics To Reduce Obesity, Niroshan Siva

All Theses

Lentil is a rich source of proteins, range of prebiotic carbohydrates including sugar alcohols (SA), raffinose family oligosaccharides (RFO), fructooligosaccharides (FOS), and resistant starch (RS), minerals, and vitamins. Research indicated that foods rich in prebiotics reduce obesity via modulating gut microbiota. The objectives of this thesis were 1) to determine the effects of lentil processing (dehulling, splitting, and cooking) on SA, RFO, FOS, and RS in three lentil market classes (red, green, and pardina), and 2) to determine the effects of lentil diet on rat body weight, percent body fat, plasma triglycerides (TGs) concentration, and change of fecal bacteria. Lentil …

The Accuracy Of Broselow Pediatric Emergency Tape In Estimating Body Weight Of Pediatric Patients, Amal H. Alsulaibikh, Fahad I. Al-Ojyan, Khalid N. Al-Mulhim, Thabit S. Alotaibi, Faisal O. Alqurashi, Latifa F. Almoaibed, Mohye H. Alwahhas, Mohammad A. Aljumaan

Saudi Medical Journal

Objectives: To determine the accuracy of the Broselow tape on estimating body weights of selected Saudi children. Methods: This is prospective study of children aged 7 days to 13 years who attended the Emergency Department of King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Saudi Arabia, from June 2015 to September 2015. Only children <34 kg were enrolled for the study and children with triage categories I and II were eliminated to avoid delay in providing appropriate treatment in these circumstances. Results: The relationship between the actual and tape estimated body weights showed a correlation coefficient of 0.945 ( p <0.001) for all children. When adjusting the correlation coefficient related to weight groups, the correlation coefficient was 0.911 ( p <0.001) for children with body weights between 10 to 25 kg. Conclusion: The Broselow tape measurements do not provide satisfactory results for all children in the selected population, but do provide highly correlated measurements for those children with body weights between 10 and 25 kg.

A Randomized Controlled Trial Of A 12-Week Intensive Lifestyle Intervention Program At A Primary Care Obesity Clinic For Adults In Western Saudi Arabia, Riyad Q. Alghamdi

Saudi Medical Journal

Objectives: To assess the ability of a 12-week primary care-based intensive lifestyle intervention (ILI), to facilitate a 5% reduction in baseline weight compared with an education-only active comparator (AC). Methods: A randomized clinical trial was conducted in a primary health care setting in Jeddah, Saudi Arabia between December 2014 and June 2015. Arab participants with obesity, but who were otherwise healthy (n=140), were randomized to the ILI (n=70) or AC (n=70) group. The ILI group received 8 clinical visits throughout the study. The AC group received only an initial health education session. The primary outcome was the proportion of participants …

Celiac Disease In Saudi Children: Evaluation Of Clinical Features And Diagnosis, Anjum Saeed, Asaad Assiri, Hebah Assiri, Anhar Ullah, Mohsin Rashid

Saudi Medical Journal

Objectives: To characterize the clinical presentations and diagnosis including serological tests and histopathological findings in children with celiac disease. Methods: All children (<18 years) with confirmed celiac disease diagnosed over a 6 year period at a private tertiary care health care center in Riyadh, Saudi Arabia were studied retrospectively. Information collected included demographics, clinical presentation and diagnostic modalities with serology and small intestinal histology reported by Marsh grading. Results: A total of 59 children had confirmed celiac disease. Thirty (50.8%) were male. Median age was 8 years (range 1 to 16 years). The mean duration of symptoms before diagnosis was 2.3 (±1.5) years. Classical disease was present only in 30.5%, whereas 69.5% had either non-classical presentations or belonged to high risk groups for celiac disease such as those with type-1 diabetes, autoimmune thyroiditis, Down syndrome and siblings. Failure to thrive was the most common presentation followed by short stature, abdominal pain and chronic diarrhea. Anti-tissue transglutaminase antibody was positive in 91.5%, and titers were no different between those with classical and non-classical disease. All had Marsh-graded biopsy findings consistent with celiac disease. Conclusion: Children with celiac disease usually present with non-classical features. A high index of suspicion needs to be maintained to consider this disorder in the diagnostic workup of pediatric patients. High risk group should be screened early to avoid complications associated with untreated celiac disease.

Oxidative Damage And Associated Inflammatory Risk Factors In Obese Emirati Women: Body Mass Index Versus Waist Circumference, Salah Gariballa, Juma Alkaabi, Javed Yasin, Awad Al Essa

Saudi Medical Journal

Objectives: To establish whether body mass index (BMI) or waist circumference (WC) is a better predictor of cardio metabolic risk factors that are associated with increased visceral fat among obese women from the United Arab Emirates (UAE). Methods: In this cross-sectional study, 333 obese subjects visiting community health centers in Al Ain city, UAE, were recruited between 2012 and 2015. After a written consent subjects had anthropometric, clinical and biochemical measurements. Fasting serum and plasma samples were collected for the measurement of markers of oxidative damage, antioxidants and inflammation. Outcome measures were compared between 4 equal BMI and WC quartiles. …

Borderplex Business Barometer, Volume 1, Number 8, Thomas M. Fullerton Jr., Adam G. Walke, Ernesto Duarte Ronquillo, Omar Solís

Border Region Modeling Project

No abstract provided.

Integration Of Mirna And Mrna Expression Profles Reveals Microrna-Regulated Networks During Muscle Wasting In Cardiac Cachexia, Leonardo N. Moraes, Geysson J. Fernandez, Ivan Jose Vechetti Jr, Paula P. Freire, Rodrigo W. A. Souza, Rolando A.R. Villacis, Silvia R. Rogatto, Patricia P. Reis, Maeli Dal-Pai-Silvia, Robson F. Carvalho

Department of Nutrition and Health Sciences: Faculty Publications

Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during CC, its pathogenesis is still not understood. Here, we described an integrative analysis between miRNA and mRNA expression profiles of muscle wasting during CC. Global gene expression profiling identified 1,281 genes and 19 miRNAs differentially expressed in muscle wasting during CC. Several of these deregulated genes are known or putative targets of the altered miRNAs, including miR-29a-3p, miR-29b-3p, miR-210-5p, miR-214, and miR-489. Gene ontology analysis on integrative mRNA/miRNA expression profiling …

Psychological Determinants Of Physical Activity Across The Life Course: A "Determinants Of Diet And Physical Activity" (Dedipac) Umbrella Systematic Literature Review, Cristina Cortis, Anna Puggina, Caterina Pesce, Katina Aleksovska, Christoph Buck, Con Burns, Greet Cardon, Angela Carlin, Chantal Simon, Donatella Ciarapica, Giancarlo Condello, Tara Coppinger, Sara D’Haese, Marieke De Craemer, Andrea Di Blasio, Sylvia Hansen, Licia Iacoviello, Johann Issartel, Pascal Izzicupo, Lina Jaeschke, Martina Kanning, Aileen Kennedy, Fiona Chun Man Ling, Agnes Luzak, Giorgio Napolitano, Julie Anne Nazare, Grainne O’Donoghue, Camille Perchoux, Tobias Pischon, Angela Polito, Alessandra Sannella, Holger Schulz

Publications

Low levels of physical activity (PA) are reported to contribute to the occurrence of non-communicable diseases over the life course. Although psychological factors have been identified as an important category concerning PA behavior, knowledge on psychological determinants of PA is still inconclusive. Therefore, the aim of this umbrella systematic literature review (SLR) was to summarize and synthesize the scientific evidence on psychological determinants of PA behavior across the life course. A systematic online search was conducted on MEDLINE, ISI Web of Science, Scopus, and SPORTDiscus databases. The search was limited to studies published in English from January 2004 to April …

Gsk3b Regulates Epithelial-Mesenchymal Transition And Cancer Stem Cell Properties And Is A Novel Drug Target For Triple-Negative Breast Cancer, Geraldine Vidhya Raja

Dissertations and Theses (Open Access)

Abstract

GSK3β regulates Epithelial-Mesenchymal-Transition and Cancer Stem Cell properties and is a novel drug target for Triple-Negative Breast Cancer.

Geraldine Vidhya Raja, MS.

Advisory Professor: Sendurai Mani, Ph.D.

Triple-Negative breast cancers (TNBCs) are highly aggressive and lack the expression of Estrogen Receptor (ER), Progesterone Receptor (PR) as well as Human Epidermal Growth Factor Receptor (HER2). Consequently, patients diagnosed with TNBCs have poor overall- and disease-free survival rates compared to other subtypes of breast cancer due to lack of targeted therapies as well as de novo or acquired chemoresistance, disease recurrence, and lack of targeted therapy. Hence it is critical to …

Application Of Glycoconjugate-Functionalized Magnetic Nanoparticles As Potent Anti-Adhesion And Anti-Bacterial Agents, Yash S. Raval

All Dissertations

Magnetic nanoparticles (MNPs) are currently being extensively in multitude of biomedical applications on account of their exceptional biocompatibility. By attaching different targeting ligands/molecules, MNPs have been broadly used in magnetic hyperthermia, cancer therapy, targeted drug delivery, MRI imaging, pathogen detection, and biological cell-separation. In this dissertation, MNPs coated with polyethylene oxide (PEO) based polymer (PEO-MNPs) and functionalized with bacterial adhesin-specific glycoconjugate molecule Neu5Ac(α2-3)Gal(β1-4)-Glcβ-sp (GM3-MNPs), are investigated for their interactions with enterotoxigenic Escherichia coli (E. coli). It also describes the feasibility of using alternating magnetic fields (AMF) for targeted killing of E. coli K99 (EC K99) strain using MNPs. Lastly, the …

Application Of Low-Cost Color Sensor Technology In Soil Data Collection And Soil Science Education, Roxanne Y. Stiglitz

All Dissertations

Sensor technologies provide opportunities to increase the quality and quantity of soils data while introducing new techniques and tools for classrooms. Linear regression models were developed for organic carbon prediction using color data gathered with the Nix Pro™ for dry (R2 = 0.7978, MSPE = 0.0819), and moist soils (R2 = 0.7254, MSPE = 0.1536). A mobile application, the Soil Scanner app, was created to allow for a more soil science dedicated interface that would allow users to create their own database consisting of GPS location and soil color data gathered using the Nix Pro™. The final application produced results …

Adaptive Robust Methodology For Parameter Estimation And Variable Selection, Tao Yang

All Dissertations

The dissertation consists of three distinct but related projects. We consider regression model fitting, variable selection in regression, and autocorrelation estimation in time series. In each procedure we formulate the problem in terms of minimizing an objective function which adapts to the given data. First we propose a robust M-estimation procedure for regression. The main purpose of the proposed methodology is to develop a procedure that adapts to light/heavy tailed, symmetric/asymmetric distributions with/without outliers. We focus on studying the properties of the maximum likelihood estimator of the asymmetric exponential power distribution, a broad distribution class that holds both Normal and …

Evaluating The Impact Of An All-Vegetable Protein Supplement Containing Fat Emulsifiers And Probiotics On Broiler Performance, Jordan Weil

Graduate Theses and Dissertations

Currently, several niche markets, such as organic and “all natural”, are marketed within the poultry industry. However, little research has been undertaken to determine the cost-effectiveness of poultry diets used to produce chicken within these markets. Specifically, the economics and resulting profits associated with raising chicken with antibiotic-free, all-vegetable (AV) diets are not evaluated. As national chain restaurants such as Chick-fil-A and Panera Bread begin to mandate poultry suppliers raise chicken without antibiotics and use AV diets, it becomes increasingly important to evaluate the economics for integrators. Given the rapidly changing feeding strategies necessary to respond to consumers’ and wholesalers’ …

The Case Against Physician-Assisted Suicide And Voluntary Active Euthanasia: A Jurisprudential Consideration, Seow Hon Tan

Research Collection Yong Pung How School Of Law

Twenty years after the Advance Medical DirectiveAct came into force in Singapore, the issue of the legalisation ofphysician-assisted suicide and voluntary active euthanasia remains live. Thisarticle examines the case for legalisation, replying to the points raised inthe article by Toh Puay San and Stanley Yeo, “Decriminalisingphysician-assisted suicide in Singapore” (2010) 22 SAcLJ 379–412, which hadincluded draft legislation in its proposal. It critically discusses thetheoretical underpinnings of such legalisation and argues that the contentionof the authors that the benefits of allowing terminally-ill patients the optionof physician-assisted suicide far outweigh the harms is not supported. Afortiori, voluntary active euthanasia should not be …

A Study Of Salmonid Growth In Two Southern Appalachian Headwater Streams, Joshua Argo

Electronic Theses and Dissertations

This study sampled salmonid populations in two headwater streams in East Tennessee, Briar Creek and Left Prong Hampton Creek. Length and weight data were used to calculate the growth of these populations to determine if significant variation exists between isolated brook trout populations. Slope comparisons concluded that there was a difference in growth between brook trout populations of these streams (p

Mri T2 Signal Changes Indicate Tau Pathophysiology In A Murine Alzheimer's Disease Model, Rajan Deep Adhikari

Theses and Dissertations

Pathogenesis, diagnosis and treatment, the essential domains in medical practice, seem helpless to address Alzheimer's disease (AD). With a huge mortality rate, it is looming and threatening the socioeconomic barrier. Despite many different studies, the pathogenesis of AD remains inconclusive. However, growing numbers of studies suggest oxidative stress to contribute to the initiation and progression of AD. We propose an iron hypothesis: iron mediated oxidative damage by reactive oxygen species (ROS), which induces protective roles of amyloid beta and hyper-phosphorylated tau (HP-tau) to sequester iron and limit the disease. We propose to study such mechanism using transgenic mice models for …

August 2017 Commencement Program, Bowling Green State University

Commencement Programs

No abstract provided.

The Perceptions Of Father Involvement In Elementary Schools, Myles J. Hebrard

Electronic Theses and Dissertations

The purpose of this phenomenological study was to understand the perceptions of father involvement in elementary schools. The focus of the study was to allow the researcher to develop a greater understanding of perceptions of father involvement, from both a father and teacher perspective. Data was collected from teachers and fathers through surveys and interviews. Specific content areas of the father survey included communication, activities fathers engaged in, training opportunities provided at the school, parent conferences, when events were offered, availability, and suggestions for school staff. Specific content areas of the teacher survey included communication, activities fathers engaged in, training …

Early Childhood Adversity And Chronic Illness: An Examination Of A High Risk- Forensic Inpatient Population, Courtney L. Cook

Electronic Theses and Dissertations

Individuals exposed adverse childhood experiences (ACEs) are at increased risk of developing chronic illnesses in adulthood including heart disease, cancer, diabetes, and chronic pain. A relationship between ACEs and health risk factors contributing to chronic disease such as smoking, obesity, and sedentary lifestyle has also been established in prior literature. There is evidence that higher that individuals in forensic inpatient mental health samples are disproportionally exposed to ACEs, which may increase odds of chronic disease development. Despite this evidence, little research has examined the prevalence of ACEs and relationships between ACEs and chronic health conditions and risky health behaviors in …

Nafta And Its Effect On Corn, Migration And Human Rights In Mexico, Thomas Nisivaco

College of Liberal Arts & Social Sciences Theses and Dissertations

This paper will attempt to show that U.S. corn subsidies that has led to the flooding of Mexican markets with corn, is the primary factor responsible for the internal displacement of rural farmers in Mexico. The NAFTA trade agreement has eliminated trade barriers and placed Mexico’s domestically produced corn in direct competition with U.S. highly subsidized corn that has led to Mexican corn farmers, who comprise the majority of the country’s agricultural sector, to experience a drastic decline in the price of their product causing them to have difficulties in sustaining a living in this market. Therefore, we can see …

The Efficacy Of Pressure Ulcer Treatment With Cathodal And Cathodal-Anodal High-Voltage Monophasic Pulsed Current: A Prospective, Randomized, Controlled Clinical Trial, Anna Polak, Luther C. Kloth, Edward Blaszczak, Jakub Taradaj, Agnieszka Nawrat-Szoltysik, Tomasz Ickowicz, Ewa Hordynska, Andrzej Franek, Cezary Kucio

Physical Therapy Faculty Research and Publications

Background. Studies show that anode and cathode electrical stimulation (ES) promotes the healing of wounds, but specific protocols for both electrodes are not available.

Objective. To compare the effectiveness of cathodal versus cathodal+anodal ES in the treatment of Category II-IV pressure ulcers (PrUs).

Design. Prospective, randomized, controlled, clinical study.

Setting. Three nursing and care centers.

Patients. Sixty-three participants with PrUs were randomly formed into a cathodal ES group (CG: N = 23; mean age of 79.35; SD 8.48), a cathodal+anodal ES group (CAG: N = 20; mean age of 79.65; SD 11.44) and a placebo ES group (PG: N = …

Physical Activity Modulates Corticospinal Excitability Of The Lower Limb In Young And Old Adults, Hamidollah Hassanlouei, Christopher W. Sundberg, Ashleigh E. Smith, Andrew Kuplic, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Aging is associated with reduced neuromuscular function, which may be due in part to altered corticospinal excitability. Regular physical activity (PA) may ameliorate these age-related declines, but the influence of PA on corticospinal excitability is unknown. The purpose of this study was to determine the influence of age, sex, and PA on corticospinal excitability by comparing the stimulus-response curves of motor evoked potentials (MEP) in 28 young (22.4 ± 2.2 yr; 14 women and 14 men) and 50 old adults (70.2 ± 6.1 yr; 22 women and 28 men) who varied in activity levels. Transcranial magnetic stimulation was used to …

Strategies For Increasing The Release Of Pigments In Red Wine, Briana Heywood

Master's Theses

The perception of wine’s quality is directly influenced by its color. Anthocyanin molecules are responsible for imparting color to red wines. They are extracted from grape skins during alcoholic fermentation. This work compares the effects of three parameters: berry integrity, enzyme addition, and fermentation temperature, on phenolic compound extraction (total phenol, tannin and anthocyanin) during the production of Paso Robles’ Cabernet Sauvignon wine. Analyses on phenolic compounds were completed during alcoholic fermentation and barrel aging over the course of eighteen months. Berry integrity compared the degree of berry crushing (whole destemmed berries versus fully crushed berries). Results showed that phenolic …

Metabolic Regulation By Stress Mediators In Fetal Ovine Skeletal Muscle And Adult Bovine Myoblasts, Elena Marie Merrick

Department of Animal Science: Dissertations, Theses, and Student Research

Our objective was to determine the effect of stress mediators such as inflammatory cytokines and β adrenergic agonists on developing skeletal muscle. Fetal sheep exposed to chronic maternal inflammation had decreased skeletal muscle glucose oxidation rates when stimulated with insulin or TNFα. In addition, activation of Akt by insulin was decreased after maternal inflammation when compared to controls and there were not differences in skeletal muscle fiber type ratios between the two treatment groups. This indicates that maternal inflammation does not affect overall oxidative capacity in the developing fetus, but rather insulin signaling pathways are disrupted.

We sought to determine …

Evaluation Of Distillers' Grains Components For Finishing Beef Cattle, Jordan E. Burhoop

Department of Animal Science: Dissertations, Theses, and Student Research

With the large expansion of the ethanol industry in previous years, there has been an increase in supply of distillers grains plus solubles (DGS) for the feedlot industry. Distiller’s grains are a common byproduct used in feedlot diets for added protein or energy. Recently, ethanol companies have been using different extraction techniques to remove various parts of the DGS to sell separately, such as corn oil and fiber. Previous research trials have tried to determine the contribution of individual nutrients in distillers grains that improve performance in order to predict the impact of removing certain components. In previous studies, fiber …

Are Fair Weather Fans Affected By Weather? Rainfall, Habit Formation And Live Game Attendance, Qi Ge, Brad Humphreys, Kun Zhou

Economics Faculty Working Papers Series

We analyze habit formation in sports attendance utilizing rainfall as an unexpected, transitory shock to attendance costs. Using attendance data from Major League Baseball (MLB) and NOAA weather data, we analyze the impact of variation in game day weather conditions on current and future MLB attendance. The empirical strategy permits identification of both the formation and persistence of habit from exogenous weather shocks. Past adverse weather shocks increase future attendance by about 200 fans per game. Our study contributes to the literature developing empirical evidence of habit formation in the field and provides policy implications for optimal ticket pricing strategies.

Experiences Of Students Utilizing A Campus Food Pantry, Jamie Daugherty

Dissertations

Food insecurity is a phenomenon with far-reaching impacts on the social, economic, health, and well-being of college students’ lives impacting how they procure food, food choices, and food experiences. A qualitative narrative inquiry explored experiences of three students facing food insecurity and using a campus food pantry. Data collection methods included in-depth semi-structured interviews, journaling, and photo elicitation. Data analysis illustrated five themes: a) financial challenge identification; b) strategizing budget priorities; c) prioritizing health; d) food pantry uses and strategies; and e) having enough. Students’ experiences were impacted by social and physical implications due to their financial challenges. The food …