Digital Commons Network^™

Health Starts In The Home: An Assessment Of Efforts To Improve Occupant Health Through Healthy Building Materials In San Francisco’S Affordable Housing, Staci Hoell

Master's Projects and Capstones

Americans spend 90% of their lives indoors, and much of this time is spent at home, surrounded by building materials that typically have added chemicals like flame retardants, highly fluorinated compounds, and antimicrobials. Recent research has linked these chemicals to adverse health outcomes such as asthma, endocrine disruption, cancer, neurodevelopmental issues, and reproductive problems (Bayer et al., n.d.; Green Science Policy Institute). Furthermore, these chronic health conditions disproportionately affect low-income populations. Fortunately, substantial efforts in research, practice, and policy are working to reduce the use of these potentially harmful chemicals in building materials, particularly in San Francisco’s affordable housing sector. …

Horizontal Cybersurveillance Through Sentiment Analysis, Margaret Hu

William & Mary Bill of Rights Journal

This Essay describes emerging big data technologies that facilitate horizontal cybersurveillance. Horizontal cybersurveillance makes possible what has been termed as “sentiment analysis.” Sentiment analysis can be described as opinion mining and social movement forecasting. Through sentiment analysis, mass cybersurveillance technologies can be deployed to detect potential terrorism and state conflict, predict protest and civil unrest, and gauge the mood of populations and subpopulations. Horizontal cybersurveillance through sentiment analysis has the likely result of chilling expressive and associational freedoms, while at the same time risking mass data seizures and searches. These programs, therefore, must be assessed as adversely impacting a combination …

Food Deserts: What Are The Decisions To Achieving A Healthy Life And Well-Being In Low Income €“ Low Access Neighborhoods?, Roxanne Jimenez

Student Scholarship

There has been a great deal of academic material and public policy published on food deserts, however, there still are significant gaps of understanding in regard to the lived experience of those individuals residing within those geographical locations. This study employed a qualitative methodology to elicit the lived experiences of 20 people who are living within a food desert. The findings from this research suggest those residing in food deserts, do not plan their purchases and travel to markets outside of their immediate neighborhoods in search of food products that have quality, variety and lower price points. It was also …

Intrinsic Motivation Factors In Gamified Photography Learning: Direct And Indirect Effects, Domenic Dini, Leping Liu

Journal of Educational Technology Development and Exchange (JETDE)

To help students with motivation to learn, gamification has been explored as a method of delivering content to students in an engaging and motivating way. This study explored the motivation components in gamified design that linked to learning outcomes in a gamified photography curriculum. Six intrinsically motivating factors (challenge, curiosity, control, cooperation, competition, and recognition) were carefully integrated into the game experience design. Participant test scores and survey data were used to develop a maximum likelihood structural equation model. The model showed that among the six intrinsic motivation factors curiosity and control were directly linked to learning outcomes while challenge …

Novel Therapeutic Strategies For Treatment Of Castration-Resistant Prostate Cancer, Matthew A. Ingersoll

Theses & Dissertations

Prostate cancer (PCa) remains the most commonly diagnosed solid tumor and is the third leading cause of cancer-related death in United States men. While androgen deprivation therapy is the current standard-of-care treatment for metastatic PCa, most patients eventually relapse and develop castration-resistant (CR) tumors, for which there is currently no effective treatment. Therefore, synthesis of novel therapeutic agents and identification of alternative target proteins are necessary to improve treatment. Herein, I investigate the efficacy of novel imidazopyridine and statin derivatives as alternative therapeutic compounds. These molecules not only inhibit androgen receptor signaling, but also block activation of the AKT axis, …

Organizational Effects Of Defeminizing Toxicants: Lessons Learned From An Environmental Sentinel Organism, The Fathead Minnow., Jonathan Ali

Theses & Dissertations

Endocrine disrupting compounds (EDCs) are chemicals that interfere with hormone function and are increasingly detected in aquatic environments, where they elicit adverse effects from exposed organisms. The toxicological effects of EDCs can be described as either activational (reversible) or organizational (irreversible), where the latter are associated with adverse outcomes in reproductive performance of adult fish. However, few studies have investigated the organizational impacts of anti-estrogenic or “defeminizing” EDCs, e.g. agrichemicals or pharmacological agents, in an environmentally-relevant or “sentinel” species. The objective of this study was to investigate the impacts of early-life EDC-initiated changes in estrogenic gene expression on organizational effects …

A Role For Δ-Catenin In Synaptic Regulation, Li Yuan

Theses & Dissertations

The cadherin-catenin complex regulates cell-cell adhesion and signal transduction in epithelial cells. It is becoming increasingly evident that components of the complex regulate various aspects of neuronal architecture and function. δ-catenin is a cytosolic component of the cadherin-catenin complex and is predominantly expressed in the central nervous system. Loss of CTNND2, which encodes δ-catenin, is associated with intellectual disability and mutations in CTNND2 have been identified in autism, suggesting that δ-catenin is a critical component of the molecular machinery underlying neural circuit function. We have previously demonstrated that δ-catenin regulates multiple aspects of synaptic and dendritic development, including dendritic …

Evaluation Of Aminopyrazole Analogs As Cyclin-Dependent Kinase Inhibitors For Colorectal Cancer Therapy, Caroline Robb

Theses & Dissertations

Colorectal cancer (CRC) remains one of the leading causes of cancer related deaths in the United States. Currently, there are limited therapeutic options for CRC patients, none of which focus on the cell signaling mechanisms controlled by members of the cyclin dependent kinase (CDK) family. CDK5 has been implicated in a variety of cancers, and most recently as a tumor promoter in CRC.

As such, we evaluated a compound developed by Pfizer, CP-668863 (a.k.a. 20-223), that inhibits CDK5 in neurodegenerative disorders. In our CRC xenograft model, 20-223 reduced tumor growth and tumor weight, indicating its value as a potential anti-CRC …

Effects Of Gm-Csf On Dendritic Cells And Regulatory T Cells In Parkinson’S Disease Patients And Models Of Parkinson’S Disease, Charles Schutt

Theses & Dissertations

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder. Pathologically, loss of nigrostriatal neurons and dopamine released by these neurons are responsible for PD motor symptoms. During PD, activation of resident microglia and infiltrating lymphocytes leads to progressive neuroinflammation and reduction in the number and function of regulatory immune cells. Neuroinflammation contributes to progressive neurodegeneration and declining motor function. Reducing neuroinflammation is the target for novel PD therapeutics. Our goal is to increase the number and function of regulatory T cells (Tregs) in PD patients to decrease neuroinflammation and reduce PD symptoms. One potential therapy is granulocyte-macrophage colony stimulating …

Role Of Ezrin In Colorectal Cancer Cell Survival Regulation, Premila Leiphrakpam

Theses & Dissertations

Colorectal cancer (CRC) is the second most common cause of cancer related deaths in the United States, mainly due to metastasis to the distant organ sites. However, the molecular basis of CRC metastasis is poorly understood. Therefore, identification and characterization of novel potential anti-cancer therapeutic targets CRC is of urgent need. Utilizing a 2D-DIGE proteomics approach ezrin was identified as a protein that is differentially expressed between primary colon tumors xenografts, orthotopically implanted in athymic nude mice, and corresponding and liver metastatic deposits. Ezrin, a cytoskeletal protein belonging to the ezrin–radixin–moesin (ERM) family plays important roles in cell motility, invasion …

Perturbing Anti-Apoptotic Proteins To Develop Novel Cancer Therapies, Jacob Contreras

Theses & Dissertations

The apoptotic pathway involves a tightly regulated network of proteins which respond to various stimuli. Previous studies have indicated Mcl-1 and Bcl-xL are intimately involved in determining cell fate, and if both are concurrently neutralized, it activates the apoptotic pathway. The inactivation of Bcl-xL and Mcl-1 as a mechanism to trigger the intrinsic apoptotic response can be used as a platform to develop therapeutic strategies to target cancer cells. The apoptotic pathway is largely dysregulated and often leads to therapy resistance in cancer cells. Although direct inhibitors of Bcl-xL have been developed and have advanced to clinical trials, development of …

Building Social Support: A Mixed Methods Study Exploring How College Students Self-Disclose Emotions With Others In Order To Build Social Support, Aimee Brickner

Dissertations, 2014-2019

The purpose of this study was to examine the process by which college students self-disclose feelings of sadness or depression to create social support. This mixed methods study, which focused primarily on qualitative data, explored the lived experience of participants through an online survey and face-to-face semi-structured interviews. Results indicated that college students who are experiencing negative feelings grapple with challenges such as identifying someone to share their emotions with and choosing what information to share with others. Findings also demonstrated the importance of social support to college students who are dealing with feelings of sadness and depression in order …

Enhancing Icvd Modification Of Electrospun Membranes For Membrane Distillation Through A 3d Printed Scaffold, Nicole Beauregard

Master's Theses

In this work, initiated chemical vapor deposition, iCVD, is used as a modification technique for electrospun membranes. Electrospun membranes are often hydrophilic and cannot be used in membrane distillation which requires high hydrophobicity. In membrane distillation, a thermal driving force is supplied to create a vapor pressure difference across a membrane allowing vapor molecules to pass through while rejecting liquid and solids. iCVD can be used to conformally coat the individual nanofibers with a hydrophobic polymer to render the membrane viable for the MD process. The standard coating procedure uses natural convective diffusion as the method of transport of the …

Using Learning Analytics To Improve Instructional Support Design For Online Learning, Lin Zhong

Journal of Educational Technology Development and Exchange (JETDE)

Learning analytics has been demonstrated as a great tool to evaluate quality of instructional design. This study examined how instructors can utilize learning analytics to improve online learning support design. 128 students from a southern university in United States participated in this study. All learning data related to learners and online learning environment was collected and analyzed. Results showed that learning analytics results were very helpful for instructors to improve online instructional support timing, adjust learning module design, and enhance learning materials accessibility.

Factors Affecting Faculty Use Of Video Conferencing In Teaching: A Mixed-Method Study, Juhong Christie Liu, Rob Alexander

Journal of Educational Technology Development and Exchange (JETDE)

Teaching and learning can now utilize a variety of real-time technologies to build online social presence and learning interactions. However, teachers and students must effectively prepare for this experience; and the identification of contextual and perceptual influences become evolving and necessary (Lehman & Conceição, 2010; Liu & Kaye, 2016). In this paper, the authors explore factors that impact faculty use of synchronous video conferencing (VC) in teaching. The two-phase mixed-method study spanned a year, converging qualitative and quantitative approaches through observations and recordings during a 6-week faculty professional development program, a campus-wide survey, and focus groups. Thematic analysis was used …

Institutional Negligence: The Aids Crisis In 1980s America, Alison Patterson

History & Classics Undergraduate Theses

Previous scholarship published on the AIDS crisis has also sought to assign blame to the various institutions that control American society. Whether it was the lack of media attention, the Reagan administration, or other social factors, historians and critics have blamed numerous characters in AIDS history for their lack of action. This study avoids placing blame on a single actor or institution and, instead, explains how the bureaucratic process allowed for avoidance of the epidemic. Partisanship also played a large role in the responses of the government, as those placed in government and health agency jobs worked for a conservative …

The Impacts Of Explicit Systematic Phonics Instruction On The Areas Of Decoding And Fluency For Students With A Specific Learning Disability In Reading, Marina Hingston

Capstones, Research Projects, and Curricula

The purpose of this embedded, mixed methods action research study was to examine the impacts of explicit, systematic phonics instruction on students with a specific learning disability in reading. A phonics intervention program, S.P.I.R.E., was implemented over the course of four weeks. The participants were two 4th graders and one 6th grader, all who had an identified specific learning disability in the area of reading. Data was collected on decoding accuracy pre and post intervention, as well as on reading fluency using timed one minute fluency drills. In addition, student perceptions of the S.P.I.R.E. program were also gathered using a …

A Multi-Prong Fall Awareness Program To Reduce The Occurrence Of Falls In A Skilled Nursing Unit, Cheri Labrador

Master's Projects and Capstones

Abstract

A multi-prong falls awareness program to reduce the occurrence of falls in a skilled nursing unit

Keywords: Fall awareness program, skilled nursing unit, fall rate

The project goal was to reduce the patient fall rate by 20% by implementing a fall awareness program for clinical staff. The program had two prongs and began with a pre-survey to determine current fall prevention knowledge. The staff was encouraged to participate in the training by providing risk factors that contribute to falls and simple strategies to prevent falls based on their knowledge of the patients (Boushon et al, 2012). A post-survey was …

The Effectiveness Of K-12 Principal’S Digital Leadership In Supporting And Promoting Communication And Collaboration Regarding Ccss Implementation, Lin Zhong

Journal of Educational Technology Development and Exchange (JETDE)

Technology plays an important role in supporting successful College-and Career- State Standards (CCSS) implementation, which requires principals and educators effectively communicate and collaborate at the local, state, and national level. This study aims to investigate the effectiveness of digital leadership in supporting communication and collaboration regarding CCSS implementation in K-12 schools. In this study, 254 public school teachers from five school districts in Mississippi were surveyed. Results showed that principals were most effective in supporting professional development and digital citizenship. In addition, teachers’ age and teaching grades have an impact on the effectiveness of principals’ digital leadership strategies. Implications are …

The Crème De La Crème: Old Favourites, New-Fangled Works, And Other Fictions, Willy Maley

Studies in Scottish Literature

Introduces the SSL Debate, in which 18 contributors react to and add to the BBC Scotland poll on Scotland's Favourite Novel, discussing the purposes and limitations of various lists that have ranked recent Scottish fiction, and commenting briefly on the differences between this debate and the deliberations of a selection panel.

'Not In Egerer'? (Some Of) What We Still Don't Know About Burns Bibliography, Patrick Scott

Studies in Scottish Literature

Briefly reviews developments in Burns bibliography since J.W. Egerer's Bibliography of Robert Burns (1964), examines the kinds of material that Egerer aimed to include and exclude, and presents a series of brief case-studies illustrating the desirability of additional research, especially on early publication in non-book formats, for obtaining a fuller picture of Burns's textual history and readership.

Books Noted And Received, Patrick Scott

Studies in Scottish Literature

Short reviews and brief notices of twenty-one recent books in Scottish literary studies.

Paraguay’S 2018 Presidential Race Encumbered By Shady Deal-Making, Andrã©S Gaudã­N

NotiSur

No abstract provided.

Tastes Of Faith: Jewish Eating In The United States, Leah Hochman

The Jewish Role in American Life: An Annual Review

"Tell me what you eat, and I will tell you what you are," wrote the 18th Century French politician and musician Jean Brillat-Savarin, giving expression to long held assumptions about the role of food, taste, and eating in the construction of cultural identities.

Foodways—the cultural, religious, social, economic, and political practices related to food consumption and production—unpack and reveal the meaning of what we eat, our tastes. They explain not just our flavor profiles, but our senses of refinement and judgment. They also reveal quite a bit about the history and culture of how food operates and performs in society. …

Lindenwood Digest, December 15, 2017, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been an employee newsletter since 2009.

Occupational Therapy Treatment Of Distal Radius Fractures: Best Practices, Erika Schleis

Honors Theses

This paper describes information on best practices for occupational therapy treatment of distal radius fractures including current information about etiology, incidence and prevalence, diagnostic criteria, comorbidities, associated client factors involved in this injury and the effects of this condition on occupational performance. Two hypothetical case studies are presented using evidence-based treatment information. Discussion of additional research necessary to continue to determine best practice approaches is presented.

The Vibe, Sarah P. Douglass

Capstones

The Vibe is a long-form narrative about where tech is taking the female orgasm. The piece concludes that physiological research is a required next step when creating the climax of the future.

http://sarahpdouglass.com

Breadcrumbs: Privacy As A Privilege, Prachi Bhardwaj

Capstones

Breadcrumbs: Privacy as a Privilege Abstract

By: Prachi Bhardwaj

In 2017, the world saw more data breaches than in any year prior. The count was more than the all-time high record in 2016, which was 40 percent more than the year before that.

That’s because consumer data is incredibly valuable today. In the last three decades, data storage has gone from being stored physically to being stored almost entirely digitally, which means consumer data is more accessible and applicable to business strategies. As a result, companies are gathering data in ways previously unknown to the average consumer, and hackers are …

Sexual Health Education In New Mexico Public Secondary Schools, Elizabeth Dickson

Nursing ETDs

Previous research has shown that comprehensive sexual health education (SHE) can significantly reduce risky sexual behavior and can increase protective behavior in adolescents. While an important component for all adolescents, this is particularly important for adolescents at high risk for adverse health outcomes, such as unplanned adolescent pregnancy and sexually transmitted infections. The aims of this descriptive study were to explore the content and delivery of SHE in New Mexico and to describe influences on decisions pertaining to implementation of state SHE policy. The social ecological model (SEM) was used as a theoretical framework to better understand levels of influence …

Teaching Efl/Esl College-Level Learners Through Current Global Topics: Integrated Lessons For Efl/Esl Teachers, Chaiyeon Sylvia Lee

Master's Projects and Capstones

The importance of educating effective English users competent in communicating and interacting in a variety of social settings is highlighted in today’s highly globalized world. Being able to understand and discuss complex global topics related to current cultural, social, and business issues and events has become an integral skill of English learners to achieve greater international connectivity. Unfortunately, many EFL/ESL college-level students, specifically Korean EFL students, do not seem to have sufficient preparation to build English communicative competence and cultural awareness necessary to cope with various situations in which they need to communicate meaningfully and purposefully as effective English users. …