Digital Commons Network^™

N-Alkyl 4-Methylamphetamine Enantiomers And The Implication For Potential Modulation Of Abuse Liability And Enhancement Of Psychoactive Drug Targeting., Ramsey Sitta

Theses and Dissertations

Drugs of abuse have a long history in humanity. Currently however, a subject of great interest is the phenylalkylamine family of drugs. Not only is the abuse liability of interest but also the potential therapeutic expansion of the capabilities of this family of drugs by utilizing the unique stereospecific effects of the newly discovered hybrid compounds. Based upon prior data of N-Alkyl 4-MA the enantiomers of N-Methyl, N-Ethyl, and N-Propyl were analyzed in hDAT, hNET, and hSERT. It was found that there was a negative correlation between chain length and potency and dopaminergic component. In agreement with the currently established …

Reversal Of The Npc Phenotype By Start Domain Proteins, Tavis H. Sparrer

Theses and Dissertations

Niemann Pick Type C (NPC) disease is a fatal childhood neurological disease caused by mutations in the NPC-1 protein, resulting in cholesterol buildup in the late endosomes. StarD4 and StarD5 are cholesterol binding proteins that play a role in the intracellular cholesterol transport. In this study we overexpress StarD4 and StarD5 in in vitro and in vivo models, and find evidence of amelioration of the NPC phenotype. This study demonstrates that the overexpression of these proteins has the potential to be a therapeutic treatment for NPC disease.

Designing Effective Messages To Promote Future Zika Vaccine Uptake, Jeanine Guidry

Theses and Dissertations

The Zika virus is associated with the devastating birth defect microcephaly, and while a vaccine was not yet available in early-2017, several were under development. It is imperative to identify effective communication strategies to promote uptake of a new vaccine, particularly among women of reproductive age. Moreover, though the Zika outbreak has received much social media attention, little is known about these conversations on Instagram. The purpose of this dissertation, therefore, was to understand current Zika-focused communication on Instagram and to inform effective communication strategies to promote future Zika vaccine uptake intent.

The study aims were: (1) explore Zika conversations …

Role Of Translation Initiation In Regulation Of Epithelial Junctions And Cell Motility, Fahda Fawaz Alsharief

Theses and Dissertations

The integrity and barrier properties of intestinal epithelium are determined by specialized adhesive structures known as intercellular junctions; composed of adherens junctions (AJs), tight junctions (TJs) and focal adhesions that mediate cell-cell and cell matrix interactions, respectively. These two types of epithelial cell adhesions regulate each other during disruption and restitution of the epithelial barrier. Inflammatory cytokines such as interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα) are elevated during intestinal inflammation. The most notable effects of IFNγ and TNFα on intestinal epithelial homeostasis involve disruption of apical junctions and attenuation of cell migration. Although molecular mechanisms underlying these …

The Characterization Of Chimeric Chaperone Flagrp170 As A Novel Radioprotectant, Tyler L. Nguyen

Theses and Dissertations

Abstract

THE CHARACTERIZATION OF CHIMERIC CHAPERONE FLAGRP170 AS A NOVEL RADIOPROTECTANT

By Tyler Nguyen, M.S.

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University.

Virginia Commonwealth University, 2017

Major Director: Dr. Xiang-Yang (Shawn) Wang, Ph.D., Professor, Department of Human and Molecular Genetics

Radiation therapy (RT) is restricted by toxic effects on adjacent normal tissue, which limits RT efficacy in cancer treatment. Damage to normal tissue, such as radiosensitive intestine and bone marrow compartments, results in acute radiation damage. To reduce normal tissue injury in the setting of RT, we …

The Tea Party Versus Planning: A Study Of Tea Party Activism And Its Impact On Local Government Planning, Spencer A. Norman

Theses and Dissertations

The Tea Party movement’s effect on local and regional planning in Virginia has received little study. This work identifies how conservative political activism has impacted planning in the Commonwealth and how planners have responded. The study relies on a qualitative approach involving 22 semi-structured interviews with activists, planners, and citizens, as well as textual analyses of planning documents, local and regional news reports, and Tea Party social media. The resultant findings show that Tea Party activism is rooted in deep seated ideals about private property rights and individualism. It also reveals that planning processes that increased the amount of public …

Expanding Monoamine Transporters Pharmacology Using Calcium Channels, Iwona Ruchala

Theses and Dissertations

Research in drug development meets many challenges including lengthy, complex and costly procedures to identify novel pharmacotherapies. In our lab, we developed a method for fast screening of small molecules that interact with monoamine transports – dopamine and serotonin (DAT, SERT). These membrane proteins play important roles in brain neurotransmission responsible for cognition, motion and pleasure. Dysfunction in dopaminergic and serotonergic systems result in neurological disorders such as depression, Attention Deficit Hyperactivity Disorder (ADHD), schizophrenia and addiction.

DAT and SERT are responsible for uptake of dopamine (DA) or serotonin (5HT) into the synapse and they limit neurotransmitter signaling. Drugs that …

Pnpase In C. Elegans: Mutagenic Analysis To Complement Knockdown Studies, Danielle K. Seibert

Theses and Dissertations

PNPase is a gene implicated as a potential target for cancer therapy; human mutations also present with deafness, myopathies, and neuropathies. In this study, C. elegans was used to investigate the effect of knocking out PNPase in a whole animal. C. elegans knockdown studies have reported an extended lifespan via an increase in ROS production. Further noted are larger mitochondria and an increase in fzo-1 expression. Knockout animals previously constructed using CRISPR/Cas9 were used for this study. We aimed to confirm these findings validating previous studies. It was discovered that PNPase knockout animals demonstrated a similar lifespan extension that was …

Contribution Of Asc-Inflammasome To Vascular Endothelial Dysfunction: Role Of Rna Receptor Rig-I, Ashley Pitzer

Theses and Dissertations

Retinoic acid-inducible gene-I (RIG-I) is a putative RNA helicase and recently identified as a cytosolic RNA receptor in mammalian cells. The role of RIG-I in the regulation of vascular function under physiological and pathological conditions is unknown. Recent studies have shown that the inflammasome serves as a crucial initiator of cytokine-mediated inflammation mediating the pathogenesis of cardiovascular disease. The present study tested whether RIG-I activation triggers inflammasome formation and subsequent cytokine-mediated inflammation in the endothelium of mice coronary arteries. Using both genetic and pharmacological interventions of the RIG-I inflammasome, we first characterized whether specific activation of RIG-I via 3pRNA transfection …

Accurate Acoustic Ranging System Using Android Smartphones, Mohammadbagher Fotouhi

Theses and Dissertations

ACCURATE ACOUSTIC RANGING SYSTEM USING ANDROID SMARTPHONES

By Mohammadbagher Fotouhi, Master of Science

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University

Virginia Commonwealth University 2017

Major Director: Dr. Ruixin Niu, Associate Professor of Department of Electrical and Computer Engineering

In this thesis, we present the design, implementation, and evaluation of an android ranging system, a high-accuracy acoustic-based ranging system which allows two android mobile phones to learn their physical distance from each other.

In this system we propose a practical solution for accurate ranging based on acoustic communication …

Validation Study Of The Science Literacy Assessment: A Measure To Assess Middle School Students' Attitudes Toward Science And Ability To Think Scientifically, Tammy Mckeown

Theses and Dissertations

This study investigated validity evidence for the Science Literacy Assessment, an instrument designed to assess middle school students’ ability to think scientifically as well as their motivation and beliefs about science (Fives, Huebner, Birnbaum, & Nicolich, 2014). Specifically, three sources of evidence were considered; internal structure, concurrent criterion-related, and predictive criterion-related. Exploratory factor analysis was utilized to examine the underlying factor structure of each of the instrument’s two components, motivation and beliefs related to science and demonstrated scientific literacy. Pearson product-moment correlations were calculated to determine the relationship between scores on the motivation and belief component of the Science Literacy …

Taken Back By The Ballpark: The Role Of Nostalgia In The Minor League Baseball Spectator Experience, Mark A. Slavich

Theses and Dissertations

The use of nostalgia has become a feature in baseball ballparks in recent years, with research showcasing the prevalence of nostalgic stimuli including bricks, steel beams, and old-fashioned scoreboards popular in the past. The impact of such stimuli on spectators’ emotions and behavior had yet to be explored, though. Therefore, the purpose of the current study was to investigate the impact of nostalgia on minor league baseball spectator emotional and behavioral responses.

Data collection occurred at three minor league baseball games during June 2017. Utilizing the SOR framework (Mehrabian & Russell, 1974) as the theoretical foundation, a 39-item instrument was …

Amiodarone-Induced Loculated Pleural Effusion Without Pulmonary Parenchymal Involvement: A Case Report And Literature Review, Amer Hawatmeh, Mohammad Thawabi, A Jmeian, Hamid Shaaban, Jihad Slim

NYMC Faculty Publications

Amiodarone is an extremely effective antiarrhythmic drug that is known to cause many adverse effects such as pulmonary, thyroid, and liver toxicities. Of these, pulmonary toxicity is most serious. Pulmonary toxicity can present as interstitial pneumonitis, organizing pneumonia, pulmonary nodules and masses, and very rarely pleural effusions. We present a case of a 73-year-old male who presented with progressive exertional dyspnea, nonproductive cough, generalized fatigue, and weakness. He was found to have multiorgan toxicity secondary to long-term treatment with high doses of amiodarone. This case illustrates that amiodarone may cause toxicity involving multiple organs simultaneously in patients receiving long-term therapy …

Putative Periodontopathic Bacteria And Herpes Viruses Interactions In The Subgingival Plaque Of Patients With Aggressive Periodontitis And Healthy Controls, Amal Elamin, Raouf Wahab Ali, Vidar Bakken

All Works

©2017 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. The microbial profile of aggressive periodontitis patients is considered to be complex with variations among populations in different geographical areas. The aim of this study was to assess the presences of 4 putative periodontopathic bacteria (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) and 2 periodontal herpes viruses (Epstein–Barr virus type 1 [EBV-1] and human cytomegalovirus [HMCV]) in subgingival plaque of Sudanese subjects with aggressive periodontitis and healthy controls. The study group consisted of 34 subjects, 17 aggressive periodontitis patients and 17 periodontally healthy …

Pattern Matching Of Signature-Based Ids Using Myers Algorithm Under Mapreduce Framework, Monther Aldwairi, Ansam M. Abu-Dalo, Moath Jarrah

All Works

© The Author(s). 2017. The rapid increase in wired Internet speed and the constant growth in the number of attacks make network protection a challenge. Intrusion detection systems (IDSs) play a crucial role in discovering suspicious activities and also in preventing their harmful impact. Existing signature-based IDSs have significant overheads in terms of execution time and memory usage mainly due to the pattern matching operation. Therefore, there is a need to design an efficient system to reduce overhead. This research intends to accelerate the pattern matching operation through parallelizing a matching algorithm on a multi-core CPU. In this paper, we …

Life In The Fast Lane: Expediting Rate Cases While Preserving The Sound Economic Principles Of The Surface Transportation Board's Rate Regulatory Regime, John M. Scheib

Transportation Law Journal

No abstract provided.

Will The Growth Of Uber Increase Economic Welfare, Hubert Horan

Transportation Law Journal

No abstract provided.

The Impact Of Mass Incarceration And Social Issues Of Institutionalization On School Violence In Youths, Stephen C. Stanko, Gordon A. Crews

Criminal Justice Faculty Publications

In this chapter the authors examine the impact that mass incarceration has had upon children in the United States over the last several decades. Inherent in this examination is to discuss the impact of institutionalization on the propensity of committing violent acts by children. The authors also discuss the impact of these American phenomena on many aspects of juvenile delinquency and violence.

School Killers Speak: A Comprehensive Examination Of Gang-Related School Violence Perpetrators In K-12 American Schools, Gordon A. Crews

Criminal Justice Faculty Publications

The purpose of this work is to examine the perpetrators of acts of school violence in K–12 schools in the United States. It is hoped that this examination will offer new and unique insight into the extremely complex issues surrounding juvenile violence in general and school violence in particular. There have been myriad works categorizing, theorizing, and profiling the causes of these types of events and the offenders who commit them. The problem is that very few have actually sought answers where they lie, from those who actually know why an event happened—the individuals who committed the act. …

School Killers Speak: A Comprehensive Examination Of Traditional School Violence Perpetrators In K-12 American Schools, Gordon A. Crews

Criminal Justice Faculty Publications

No abstract provided.

School Killers Speak: A Comprehensive Examination Of Associated And/Or Mentally Ill And Non-Associated And/Or Mentally Ill School Violence Perpetrators In K-12 American Schools, Gordon A. Crews

Criminal Justice Faculty Publications

No abstract provided.

The Medium Is The Message, Steven Ferrey

Suffolk University Law School Faculty Works

The Medium matters; Details matter. Two important, somewhat overlooked Supreme Court decisions, reconfigured the law on the most important technology in the United States. One decision of the Court was unanimous, and together these decisions determine the future of American power. The two Supreme Court decisions created a simultaneous legal equation with a clear independent variable, a dependent variable, and a constant term now to be solved in the regulation of energy in America.

The independent variable is the new technological ‘medium’ of fast-evolving renewable electric generation options, to mitigate global climate warming and to preserve the Planet.

The U.S. …

The Refuge: Enabling Transformative Healing And Educational Advancements Through The Integration Of Urban Agricultural Techniques In Detroit Lakes, Mn, Emily Schoenrock

Landscape Architecture Theses

Current urban agriculture is comprised of a variety of typologies and each are applied in site specific ways thus creating a vast web of possibilities when trying to implement the ideology of urban farming into a new location. My thesis hinges on the assumption that urban agriculture is currently working to lessen the monetary burden of produce on the caretakers of the urban gardens. Not only can urban farming techniques lessen the monetary burden of produce they can also teach owners selfsustainability, give them a sense of ownership, and better the local ecosystems and the planet by minimizing the amount …

Evaluation Of Combined Low-Salinity Water And Microgel Treatments To Improve Oil Recovery Using Partial Fractured Carbonate Models, Ali K. Alhuraishawy, Baojun Bai

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Combining two methods in one process to enhance oil recovery represents a needed cost savings in the oil industry. Microgels are used as conformance control agents to improve oil sweep efficiency and control excess water production. Low-salinity waterflooding (LSWF) is used as a wettability alteration agent in carbonate reservoirs and improves displacement efficiency. This paper offers a comprehensive understanding of the combined technology through laboratory experiments. The focus of this study is to see how microgels and low water salinity perform in porous media by creating flow resistance to injected fluid thereby changing the wettability and enhancing the sweep and …

Analysis Of Ior Pilots In Bakken Formation By Using Numerical Simulation, Dheiaa Alfarge, Mingzhen Wei, Baojun Bai, Mortadha Alsaba

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Bakken is the most productive formation among unconventional plays in North America. This formation has 7.4 billion barrels of recoverable oil. However, the primary oil recovery is still low as 5-10%. Miscible natural gas and carbon dioxide (CO₂) might be the most two potential strategies to improve oil recovery in such complex play. In this study, some of the IOR pilots which have been conducted in Montana, North Dakota, and South Saskatchewan have been presented. The performance results of these pilots in US-Bakken versus Canadian-Bakken have been compared. Moreover, the reasons beyond the successful IOR pilots in Canadian-Bakken …

Skinface, Islam Shehab

Theses and Dissertations

Throughout history, skin manipulation was primarily practiced for cultural, tribal, or religious purposes. In the contemporary landscape, skin manipulation has been objectified and commercialized. This is exemplified through bio-upholstery, foreign materials under our skin and changing the skin structure.

This thesis investigates skin manipulation, with the intent to focus experimentation on the skin’s lines of cleavage, a topographical map drawn on our skin and used to define the direction where skin has the most and least flexibility. The aim is to connect and explore materials that can be used as a second skin, while at the same time examining and …

Towards A Model Of Internal/External Motivation To Respond Without Prejudice: An Examination Of White Racial Identity And Affect, Christina Barnett

Theses and Dissertations

The current study explored how White racial identity influences the relationship between affective reactions to racism and one’s internal or external motivation to respond without prejudice. The first aim was to examine the bivariate relationships between White racial identity ego schemas and affective reactions to racism. The second aim examined the bivariate relationships between affective reactions to racism and an internal/external motivation to respond without prejudice. The third aim explored whether Phase I or Phase II White racial identity ego schemas explained the relation of affective reactions to racism and internal/external motivation to respond without prejudice. PROCESS mediation models were …

Identity Politics, State Standards, And On The Ground Realities: A Critical Policy Analysis Of Teaching/Learning Gender/Sexuality In A Virginia Elementary School, Stefanie Hudson

Theses and Dissertations

Even though America has seen an increase in the level of acceptance for people who identify as LGBTQ and/or gender non-conforming, certain aspects within society continue to hinder their rights, especially within public education. Specifically, there are insufficiencies regarding content of and attitudes toward including LGBTQ issues in teaching and leadership training programs. Add to that, the deficits in most Family Life Education (FLE) programs in elementary schools as they lack adequate coverage of developmentally appropriate teaching and learning about gender and sexuality. Taken together, it remains questionable whether the needs of LGBTQ and/or gender non-conforming children can truly be …

'The Writing Writes Itself': Deleuzian Desire And The Creative Writing Mfa Degree, Ginger Walker

Theses and Dissertations

This post-qualitative inquiry project investigated subjectivity (sense of self) among graduates of creative writing Master of Fine Arts (MFA) programs. The project asked how subjectivity is involved in the creative writing process and how that process fuels further writing after a creative piece (such as the MFA thesis) is completed. A post-qualitative, thinking-with-theory approach was used to explore the role of subjectivity among four anonymous graduates of creative writing MFA programs who provided writing samples describing their creative writing processes. Following the thinking-with-theory approach, the data were analyzed using Deleuze and Guattari’s theory of productive desire. Study findings are presented …

A Comparative Study Of Intraradicular Enterococcus Faecalis Biofilm Removal With Three Root Canal Treatment Systems: A Scanning Electron Microscopy Evaluation, Cyrous Ardalan

Theses and Dissertations

The objective of this study was to evaluate the biofilm removal efficacy of three root canal treatment systems: ProUltra® PiezoFlow™, traditional needle irrigation, and the GentleWave® system in an ex-vivo benchtop study. Twenty-four extracted maxillary and mandibular molars were selected. Teeth were all instrumented to a master apical file size #25 with 4% taper. Teeth were then randomly divided into four experimental groups and two control groups. The root canals were inoculated with a culture of Enterococcus faecalis and incubated for five weeks to form a biofilm. Each group was then treated with one of the different root canal treatment …