Digital Commons Network^™

Race, Age, Gender, Income, And The Experience Of Adult Intimate Partner Violence, Jacquelynn Melnita Hairston

Walden Dissertations and Doctoral Studies

Intimate partner violence (IPV) is a significant public health problem that affects approximately 2.4 million individuals in the United States each year. Race, age, gender, and household income are established correlates of criminal victimization and diverge across various victimization experiences for these individuals. The purpose of this study was to investigate relationships between IPV victimization and the demographic variables of race, age, gender, and household income using race, class, and gender theory as a framework. Logistic regression analyses on data from 3,492 adult male and 3,637 adult female IPV victims obtained from the 2013 National Crime Victimization Survey showed that …

Retired, Unmarried, Male Baby Boomer Attitudes And Behaviors Toward Disease Prevention, Irene Nyawira Ruminjo

Walden Dissertations and Doctoral Studies

Preventive health care is effective in reducing both infectious diseases and chronic conditions among the elderly. Despite efforts to prevent or decrease the risk of illness, unmarried men are less likely to receive selected preventive services compared to married men. The purpose of this cross-sectional survey was to describe disease prevention attitudes and behaviors of retired, unmarried, male baby boomers residing in Harlingen, Texas. Further, the study examined the effects of socioeconomic status on disease prevention attitudes and behaviors. The health belief theory framed the study. A validated questionnaire collected disease prevention attitudes, behaviors, and sociodemographic characteristics data. Data inquiry …

Perceived Job Stress And Life Style Behaviors' Effects On The Quality Of Life Of Registered Nurses, Jennifer Rose Limongiello

Walden Dissertations and Doctoral Studies

The purpose of this quantitative study was to examine to what extent work demands as measured by perceived job stress affected the health-related quality of life (HRQOL) as determined by the number of unhealthy days of registered nurses in the United States. This study was also an investigation of the extent to which other variables such as body-mass index (BMI) and certain lifestyle behaviors affected the HRQOL (number of unhealthy days). The independent variables were perceived job stress, weight (BMI), and lifestyle factors such as tobacco and alcohol use, physical inactivity, and the mindful eating score, and the dependent variable …

Assessing Hand Hygiene Compliance In Healthcare Workers To Reduce Infectious Disease, Ahmed Salem Alhasani

Open Access Dissertations

Hand hygiene is the first line of defense against the prevalence of infectious diseases in healthcare settings. Therefore, healthcare costs can be reduced. However, having rare incidents of healthcare-associated infections (HAI) does not always mean that hand hygiene compliance is high and at its desired level. This research study aims to develop multi-statistical measurements to assess hand hygiene compliance of the medical and nursing groups at the inpatient wards, 5B, 6B and ICU at the Providence Veterans Affairs Medical Center (PVAMC). The PVAMC was trying to identify whether the few cases or rare incidents of HAI that have been reported …

Emotional And Relationship Dynamics Between Hiv Serodiscordance And Concordance Couples: A Narrative Literature Review And Theoretical Framework, Amani Mwakalapuka, Ipyana Mwampagatwa, Theodora Bali, Masumbuko Mwashambwa, Stephen Kibusi, Tumbwene Mwansisya

School of Nursing & Midwifery, East Africa

Tanzania is among the countries with high prevalence of HIV prevalence in the World. Despite the fact that the epidemic has been, and still is a threat to persons of all ages, recent studies have suggested that most new infections occur among couples in stable relationships. Infected couples are categorised into two: the positive concordant, where both the partners are HIV positive; and sero-discordant couples, where one partner is HIV positive while the other is negative. Recently, researchers and many other stake-holders working on the HIV/AIDS epidemic have given a remarkable attention to this astonishing reality. For instance one study …

Association Between Age-Related Macular Degeneration And Sleep-Disordered Breathing, Jeffrey A. Nau

Walden Dissertations and Doctoral Studies

Age-related macular degeneration (AMD) is a chronic, irreversible disease that robs individuals of vision, quality of life, and independence. It is the leading cause of blindness in industrialized countries. Sleep-disordered breathing (SDB) is a condition characterized by repeated episodes of apnea and/or hypopnea, insomnia, short sleep duration, and/or sleep disturbances (snoring, gasping, etc.). Because SDB has been shown to cause chronic hypoxia resulting in oxidative stress on the retina, it has been proposed that SDB may be associated with AMD. Based on the life course theory of chronic disease, this quantitative, cross-sectional study used data from the 2005-2008 National Health …

Characterization Of Novel Borrelia Burgdorferi Transcripts Expressed During Tick And Mammalian Infection, Philip Adams

Electronic Theses and Dissertations

The purpose of this dissertation is to characterize the transcriptome of Borrelia (Borreliella) burgdorferi to discover novel transcripts, important for pathogenesis. As a spirochete and the etiological agent of Lyme disease, the foremost vector-borne bacterial infection in the world, B. burgdorferi fulfills a distinctive niche among bacterial pathogens. Persisting in the disparate environments of a tick vector and mammalian reservoirs, it is absolutely dependent on its hosts for transmission and nutrient acquisition. B. burgdorferi harbors a complex fragmented genome which is largely linear, unlike that of most prokaryotes, lacks an array of classically described metabolic genes, and contains an unusually …

The Global State Of Evidence On Interventions To Prevent Child Marriage, Sophia Chae, Thoai Ngo

Poverty, Gender, and Youth

Growing recognition of the harmful effects of child marriage has placed its elimination on the global and national agenda. To address this problem, through the Girl Innovation, Research, and Learning (GIRL) Center, the Population Council reviewed the global state of evidence on what works to prevent child marriage. The research focuses exclusively on rigorously evaluated interventions—randomized controlled trial (RCT), quasi-experimental study, or a natural experiment—and incorporates new results not included in previous reviews. This research brief reports on the study’s findings about types of child-marriage interventions and approaches used, assesses what works best (and what does not work) to reduce …

Bid-Induced Release Of Aif/Endog From Mitochondria Causes Apoptosis Of Macrophages During Infection With, Wei-Lin Hu, Hai-Yan Dong, Yang Li, David M. Ojcius, Shi-Jun Li, Jie Yan

All Dugoni School of Dentistry Faculty Articles

Leptospirosis is a global zoonotic infectious disease caused by pathogenic Leptospira species. Leptospire-induced macrophage apoptosis through the Fas/FasL-caspase-8/3 pathway plays an important role in the survival and proliferation of the pathogen in hosts. Although, the release of mitochondrial apoptosis-inducing factor (AIF) and endonuclease G (EndoG) in leptospire-infected macrophages has been described, the mechanisms linking caspase and mitochondrion-related host-cell apoptosis has not been determined. Here, we demonstrated that leptospire-infection induced apoptosis through mitochondrial damages in macrophages. Apoptosis was caused by the mitochondrial release and nuclear translocation of AIF and/or EndoG, leading to nuclear DNA fragmentation. However, the mitochondrion-related CytC-caspase-9/3 pathway was …

Mononuclear-Macrophages But Not Neutrophils Act As Major Infiltrating Anti-Leptospiral Phagocytes During Leptospirosis., Xu Chen, Shi-Jun Li, David M. Ojcius, Ai-Hua Sun, Wei-Lin Hu, Xu'ai Lin, Jie Yan

All Dugoni School of Dentistry Faculty Articles

OBJECTIVE: To identify the major infiltrating phagocytes during leptospirosis and examine the killing mechanism used by the host to eliminate Leptospira interrogans.

METHODS: Major infiltrating phagocytes in Leptospira-infected C3H/HeJ mice were detected by immunohistochemistry. Chemokines and vascular endothelial cell adhesion molecules (VECAMs) of Leptospira-infected mice and leptospirosis patients were detected by microarray and immunohistochemistry. Leptospira-phagocytosing and -killing abilities of human or mouse macrophages and neutrophils, and the roles of intracellular ROS, NO and [Ca2+]i in Leptospira-killing process were evaluated by confocal microscopy and spectrofluorimetry.

RESULTS: Peripheral blood mononuclear-macrophages rather than neutrophils were the main infiltrating phagocytes in the lungs, liver …

Chief Student Affairs Officers’ Perceptions Of Institutional Crisis Management, Preparedness, And Response, Heather Studenberg

Department of Conflict Resolution Studies Theses and Dissertations

This dissertation examined chief student affairs officers’ perceptions of institutional crisis management, preparedness, and response. A goal of this study was to uncover findings that can benefit crisis management protocols or best practices regarding crisis management team training, plan communications, and emergency management personnel on campus, as well as, learn if size of enrollment impacts crisis preparedness and response. Research questions assessed if a significant relationship exists between preparedness in responding to crisis with the number of training topics covered with a crisis management team, the number of modes used to communicate the crisis management plan, size of enrollment and …

Incarceration As A Threat To Reproductive Justice In Massachusetts And The United States, Rachel Roth

Western New England Law Review

This Article is an edited and expanded version of Rachel Roth’s presentation at the 2016 Western New England Law Review Symposium on Gender and Incarceration. It provides an overview of reproductive justice and describes (1) how prisons and jails undermine reproductive health, rights, and justice for the people they confine, and (2) how mass incarceration undermines the prospect for reproductive justice in the United States overall. It focuses on examples from women’s prisons and includes issues and advocacy work from Massachusetts and across the country.

Environmental Injustice And The Pursuit Of A Post-Carbon World: The Unintended Consequences Of The Clean Air Act As A Cautionary Tale For Solar Energy Development, Shannon Elizabeth Bell

Brooklyn Law Review

Most policy decisions aimed at improving the environment have been conceived and implemented without attention to issues of environmental justice, creating what sociologist Julian Agyeman calls an “equity deficit” in the discourse and practice of environmental sustainability. This article presents the unintended consequences of the Clean Air Act (CAA) and its amendments as a cautionary tale for what can happen when environmental regulations are enacted without adequately considering environmental justice concerns. Although the CAA has been responsible for much good in the United States as a whole—including significant reductions in acid rain and health-harming pollutants—it has also brought significant harm …

Grassroots Innovation Systems For The Post-Carbon World: Promoting Economic Democracy, Environmental Sustainability, And The Public Interest, Shobita Parthasarathy

Brooklyn Law Review

This article uses a sociotechnical systems approach to advocate for an alternative way of thinking about the role of innovation in international development efforts, specifically those focused on environmental sustainability and a post-carbon world. This approach views technology and society as inextricably linked, highlighting how particular values, norms, individual rights and responsibilities, social practices and relationships, and aspects of political culture are embedded in the design, development, implementation, and use of technology. Using the example of clean cookstoves, this article argues that technologies customarily deployed to achieve international development goals are embedded in particular values, assumptions, and social structures that …

Moving Public Health Learners To The Skeptical Edge With Information Creation As A Process, Xan Goodman

Library Faculty Research

No abstract provided.

Risk Stacking Of Pneumococcal Vaccination Indications Increases Mortality In Unvaccinated Adults With Streptococcus Pneumoniae Infections, Jacob B. Morton, J. Morrill, Kerry L. Laplante, Aisling R. Caffrey

Pharmacy Practice and Clinical Research Faculty Publications

Background

Several chronic disease states have been identified as pneumococcal vaccination indications due to their ability to increase pneumococcal disease development and subsequent mortality. However, the risk of mortality according to the number of these disease states present is unknown. We sought to determine the impact of concomitant, multiple risk factors (stacked risks) for pneumococcal disease on 30-day mortality in adults.

Methods

This was a national case-control study of unvaccinated older Veterans (≥50 years of age) admitted to Veterans Affairs medical centers from 2002 to 2011 with serious pneumococcal infections (pneumonia, bacteremia, meningitis) based on positive S. pneumoniae blood, cerebrospinal …

Evidence To Support Continuation Of Statin Therapy In Patients With Staphylococcus Aureus Bacteremia, Aisling R. Caffrey, T. Timbrook, Eunsun Noh, George Sakoulas, Steven M. Opal, Victor Nizet, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

In addition to cholesterol-lowering capabilities, statins possess anti-inflammatory and immunomodulatory effects. We sought to quantify the real-world impact of different statin exposure patterns on clinical outcomes in Staphylococcus aureus bacteremia. We conducted a retrospective cohort study among hospitalized patients with positive S. aureus blood cultures receiving appropriate antibiotics within 48 h of culture collection (Veterans Affairs hospitals, 2002 to 2013). Three statin exposure groups were compared to nonusers: pretreated statin users initiating therapy in the 30 days prior to culture and either (i) continuing statin therapy after culture or (ii) not continuing after culture, and (iii) de novo users initiating …

Thrombocytopenia With Tedizolid And Linezolid, Erica Yookyung Lee, Aisling R. Caffrey

Pharmacy Practice and Clinical Research Faculty Publications

Objective: Though thrombocytopenia is a known adverse effect with linezolid, the first-in class oxazolidinone antibiotic, some have suggested a lower risk of thrombocytopenia with tedizolid, the second-in-class oxazolidinone antibiotic. We sought to evaluate adverse event reports for thrombocytopenia with tedizolid and linezolid from the Food and Drug Administration Adverse Event Reporting System (FAERS).

Methods: To assess the period since tedizolid approval, we included initial FAERS reports from July 2014 through December 2016. To evaluate historical rates with linezolid prior to tedizolid approval, we assessed AERSMine data from January 2004 through June 2014. Reporting odds ratios (ROR) and proportional reporting ratios …

Assessments Of Opportunities To Improve Antibiotic Prescribing In An Emergency Department: A Period Prevalence Survey, Tristan T. Timbrook, R. Caffrey, Anais Ovalle, Maya Beganovic, William Curioso, Melissa Gaitanis, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Introduction

Approximately 30% of all outpatient antimicrobials are inappropriately prescribed. Currently, antimicrobial prescribing patterns in emergency departments (ED) are not well described. Determining inappropriate antimicrobial prescribing patterns and opportunities for interventions by antimicrobial stewardship programs (ASP) are needed.

Methods

A retrospective chart review was performed among a random sample of non-admitted, adult patients who received an antimicrobial prescription in the ED from January 1 to December 31, 2015. Appropriateness was measured using the Medication Appropriateness Index, and was based on provider adherence to local guidelines. Additional information collected included patient characteristics, initial diagnoses, and other chronic medication use.

Results

Of …

A Pharmacist-Driven Academic Detailing Program To Increase Adult Pneumococcal Vaccination, Aisling R. Caffrey, M. Deangelis, Kristina E. Ward, Katherine Kelly Orr, Haley J. Morrill, Michael Gosciminski, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Objectives

To describe our statewide, pharmacist-led education campaign to increase knowledge and awareness of pneumococcal immunization recommendations.

Setting

Immunization providers and residents in the state of Rhode Island.

Practice description

A clinical pathway (i.e., decision-support tool) was developed to educate health professionals about appropriate indications, administration schedules, and frequently asked questions for the 2 different adult pneumococcal vaccines. Academic detailing and distribution of the clinical pathway to health professionals was conducted across Rhode Island. Community outreach activities included radio ads as well as distribution of patient handouts and wallet cards at community events.

Practice innovation

To our knowledge, this was …

Antimicrobial Resistance Of Escherichia Coli Urinary Isolates In The Veterans Affairs Healthcare System, Haley J. Morrill, B. Morton, Aisling R. Caffrey, Lan Jiang, David Dosa, Leonard A. Mermel, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

We reviewed data for almost 300,000 clinical Escherichia coli urinary isolates (collected in 2009 through 2013) from 127 inpatient and outpatient facilities, to assess antibiotic resistance among Veterans Affairs health care system patients using Clinical and Laboratory Standards Institute and Centers for Disease Control and Prevention National Healthcare Safety Network definitions or guidance. Rates of resistance to amoxicillin or ampicillin/β-lactamase inhibitors were approximately 40% and rates of resistance to fluoroquinolones and trimethoprim-sulfamethoxazole approached 30%. Rates of resistance to nitrofurantoin, antipseudomonal penicillin/β-lactamase inhibitors, and carbapenems remained less than 10%. The percentage of isolates that were considered multidrug resistant varied (4% to …

A Stinging Effect: The Legal Implications Biting Into The Effects Of The Zika Virus, Keanu Bader Mr

Honors Undergraduate Theses

People are afraid of contagious diseases. The thought that disease can spread throughout an entire population tends to make people wary of their interactions with their surrounding environment. Hearing about, or even seeing pictures of mosquitoes can make people squeamish or even stimulate an itch. Throughout the ages, the reaction to contagious diseases has been to quarantine and isolate. From the bubonic plague to the 1918 “Spanish” flu, the protocol was to quarantine those infected and isolate the rest. It may be this practice that inspired such precautions be taken by the public. Often these precautions are not warrantless and …

When Children Are Water: Representation Of Central American Migrant Children In Public Discourse And Implications For Educators, Theresa Catalano

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Since June, 2014 when the U.S. government began to document an increase in unaccompanied/separated children arriving in the United States from Central America, these children have become a frequent topic in media discourse. Because rhetoric about immigration issues have been shown to affect schooling of these children, the present paper aims to examine how these children are represented in the discourse of one community. Findings from this critical multimodal discourse analysis reveal multiple strategies of representation that result in the dominant metaphor of IMMIGRANT CHILDREN ARE DANGEROUS WATER and negative perceptions that have implications for the education of these students.

The Daily Gamecock, Thursday, October 26, 2017, University Of South Carolina, Office Of Student Media

October

No abstract provided.

Differential Phenotypes Of Memory Cd4 And Cd8 T Cells In The Spleen And Peripheral Tissues Following Immunostimulatory Therapy., Gail D Sckisel, Annie Mirsoian, Christine M Minnar, Marka R Crittenden, Brendan Curti, Jane Q Chen, Bruce R Blazar, Alexander D Borowsky, Arta M Monjazeb, William J Murphy

Articles, Abstracts, and Reports

BACKGROUND: Studies assessing immune parameters typically utilize human PBMCs or murine splenocytes to generate data that is interpreted as representative of immune status. Using splenocytes, we have shown memory CD4-T cells that expand following systemic immunostimulatory therapies undergo rapid IFNg-mediated activation induced cell death (AICD) resulting in a net loss of total CD4-T cells which correlates with elevated PD-1 expression. This is in contrast to CD8-T cells which expand with minimal PD-1 upregulation and apoptosis. In this study we expand upon our previous work by evaluating CD4 and CD8-T cell phenotype and distribution in peripheral organs which are more representative …

The Burden Of Mental Disorders In The Eastern Mediterranean Region, 1990-2013, Raghid Charara, Ali S. Akanda, Et Al

Civil & Environmental Engineering Faculty Publications

The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost–YLLs) and nonfatal outcomes (years lived with disability–YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group. In 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 …

Is It Time For Synthetic Biodiversity Conservation?, Antoinette J. Piaggio, Gernot Segelbacher, Philip J. Seddon, Luke Alphey, Elizabeth L. Bennett, Robert H. Carlson, Robert M. Friedman, Dona Kanavy, Ryan Phelan, Kent H. Redford, Marina Rosales, Lydia Slobodian, Keith Wheeler

United States Department of Agriculture Wildlife Services: Staff Publications

Evidence indicates that, despite some critical successes, current conservation approaches are not slowing the overall rate of biodiversity loss. The field of synthetic biology, which is capable of altering natural genomes with extremely precise editing, might offer the potential to resolve some intractable conservation problems (e.g., invasive species or pathogens). However, it is our opinion that there has been insufficient engagement by the conservation community with practitioners of synthetic biology. We contend that rapid, large-scale engagement of these two communities is urgently needed to avoid unintended and deleterious ecological consequences. To this point we describe case studies where synthetic biology …

Management And Modeling Approaches For Controlling Raccoon Rabies: The Road To Elimination, Stacey A. Elmore, Richard B. Chipman, Dennis Slate, Kathryn P. Huyvaert, Kurt C. Vercauteren, Amy T. Gilbert

United States Department of Agriculture Wildlife Services: Staff Publications

Rabies is an ancient viral disease that significantly impacts human and animal health throughout the world. In the developing parts of the world, dog bites represent the highest risk of rabies infection to people, livestock, and other animals. However, in North America, where several rabies virus variants currently circulate in wildlife, human contact with the raccoon rabies variant leads to the highest per capita population administration of post-exposure prophylaxis (PEP) annually. Previous rabies variant elimination in raccoons (Canada), foxes (Europe), and dogs and coyotes (United States) demonstrates that elimination of the raccoon variant from the eastern US is feasible, given …

Rabies Virus Antibodies From Oral Vaccination As A Correlate Of Protection Against Lethal Infection In Wildlife, Susan M. Moore, Amy Gilbert, Ad Vos, Conrad M. Freuling, Christine K. Ellis, Jeannette Kliemt, Thomas Müller

United States Department of Agriculture Wildlife Services: Staff Publications

Both cell-mediated and humoral immune effectors are important in combating rabies infection, although the humoral response receives greater attention regarding rabies prevention. The principle of preventive vaccination has been adopted for strategies of oral rabies vaccination (ORV) of wildlife reservoir populations for decades to control circulation of rabies virus in free-ranging hosts. There remains much debate about the levels of rabies antibodies (and the assays to measure them) that confer resistance to rabies virus. In this paper, data from published literature and our own unpublished animal studies on the induction of rabies binding and neutralizing antibodies following oral immunization of …

The Impact Of Poverty On Dog Ownership And Access To Canine Rabies Vaccination: Results From A Knowledge, Attitudes And Practices Survey, Uganda 2013, Ryan M. Wallace, Jason Mehal, Yoshinori Nakazawa, Sergio Recuenco, Barnabas Bakamutumaho, Modupe Osinubi, Victor Tugumizemu, Jesse D. Blanton, Amy T. Gilbert, Joseph Wamala

United States Department of Agriculture Wildlife Services: Staff Publications

Background: Rabies is a neglected disease despite being responsible for more human deaths than any other zoonosis. A lack of adequate human and dog surveillance, resulting in low prioritization, is often blamed for this paradox. Estimation methods are often employed to describe the rabies burden when surveillance data are not available, however these figures are rarely based on country-specific data.

Methods: In 2013 a knowledge, attitudes, and practices survey was conducted in Uganda to understand dog population, rabies vaccination, and human rabies risk factors and improve in-country and regional rabies burden estimates. Poisson and multi-level logistic regression techniques were conducted …