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Relative Properties And Relative Potency Of Various Hydrazide Compounds That Inhibit Growth Of Mycobacterium Tuberculosis, Ronald Bartzatt

Chemistry Faculty Publications

The molecular properties of compounds expressing growth inhibition of Mycobacterium tuberculosis are determined and examined for underlying relationships by pattern recognition methods. Pattern recognition methods such as hierarchical cluster analysis will show relationships between compounds. Descriptive statistical analysis of molecular properties reveal commonality among bacteriostatic compounds. Outliers within any category of descriptor is identified by Grubb’s test. Potency of growth inhibition measured as MIC (minimum inhibitory concentration) after in vitro evaluation will be compared and analyzed. Structure moieties and their effect on activity is identified. All compounds analyzed showed substantial growth inhibition of Mycobacterium tuberculosis, having MIC values ranging from …

Utrgv School Of Medicine Course Catalog 2017-2018, The University Of Texas Rio Grande Valley. School Of Medicine

UTRGV Catalogs

No abstract provided.

An Analysis Factors Influencing Demand For Poultry And Fish Feeds In Kenya, John Njenga Macharia

All Master’s Theses

Poultry and fish are important sub-sectors in Kenya providing rural farmer households with income and contributing to their food and nutritional security. Although ownership of these enterprises is not gender specific women are the ones involved in taking care of them. The study utilized cross-section data from a sample of 386 poultry farmers and 278 fish farmers randomly selected from three counties which are Nakuru, Kisii and Kirinyaga Counties. The feed demand for both poultry and fish enterprises were analyzed by estimating translog cost functions and a system of cost share functions for the major feed types used for poultry …

Mapping Exposure Of Cattle To Rift Valley Fever Virus Along Their Migratory Routes, Gladys Jebiwot Mosomtai

All Master’s Theses

Aedes mosquito is the primary vector for Rift Valley fever virus which affects humans and animals. Virus transmission pathways in animals occurs when bitten by infected mosquito or when viremic animals relocate to new regions with competent mosquitoes. Though Rift Valley fever is a transboundary disease with serious economic consequences, movement of viremic animals in search of pasture or trade in spreading the diseases is not fully understood. This research was undertaken in order to better understand the cattle spatial ecology, especially for pastrolist and their interaction with vectors habitat. Using 11 collared herds between 2012 to 2015, kernel density …

The Effects Of Vaccinations On Public Health, Caitlin Reveal

Bridges: A Journal of Student Research

This is a review of scholarly literature of the importance of vaccinations and the effects of vaccination uptake and vaccination refusal on public health. It assesses how vaccinations came to exist and what they do in the human body. It highlights reasons parents opt not to vaccinate their children and the side effects vaccinations may cause. There is a major emphasis on the effectiveness of vaccinations, especially in schools, where children are much more likely to be exposed to diseases than the general public. Because health care workers are often at the front line of contracting and/or transmitting diseases, the …

Shinrin-Yoku (Forest Bathing) And Nature Therapy: A State-Of-The-Art Review, Dr. Margaret M. Hansen, Reo Jones, Kirsten Tocchini

Nursing and Health Professions Faculty Research and Publications

Background: Current literature supports the comprehensive health benefits of exposure to nature and green environments on human systems. The aim of this state-of-the-art review is to elucidate empirical research conducted on the physiological and psychological effects of Shinrin-Yoku (or Forest Bathing) in transcontinental Japan and China. Furthermore, we aim to encourage healthcare professionals to conduct longitudinal research in Western cultures regarding the clinically therapeutic effects of Shinrin-Yoku and, for healthcare providers/students to consider practicing Shinrin-Yoku to decrease undue stress and potential burnout. Methods: A thorough review was conducted to identify research published with an initial open date range and then …

Development Of Cellular Assays To Monitor Enzymatic And Biological Activity Of Cd73: A Key Modulator Of Anti-Tumor Immune Response, Alexandra Fanuka

Graduate School of Biomedical Sciences Theses and Dissertations

Ecto-5’-nucleotidase, known as CD73, is an extracellular enzyme that converts adenosine monophosphate (AMP) to adenosine and has recently been identified as a potential drug target for cancer immunotherapy. Its immunosuppressive effects, mediated by the activity of adenosine, are associated with higher rates of tumor invasion and metastasis, as well as poorer prognoses overall in many cancer types. CD73 is often co-expressed with ectonucleoside triphosphate diphosphohydrolase-1 (CD39), which catalyzes the conversion of adenosine triphosphate (ATP) to adenosine diphosphate (ADP), and ADP to AMP on the surface of tumor cells. Dual expression further propagates immunosuppressive effects of adenosine in the tumor microenvironment. …

Validation Of A Membrane Touch Biosensor For The Qualitative Detection Of Igg Class Antibodies To Herpes Simplex Virus Type 2, Tony Loughman, Baljit Singh, Brian Seddon, Philip Noone, Padmanabhan Santhosh

Articles

A novel type of biosensor was assessed for application to the qualitative determination of circulating antibodies to herpes simplex virus type 2 (HSV-2). The device utilises a high activity HSV-2 type specific gG2 antigen for antibody capture and commercially available ELISA reagents. The study compares the diagnostic performance of a prototype HSV-2 biochip to well-established in vitro tests routinely applied in clinical procedures. A panel of human serum samples (n = 60) previously characterised for HSV-2 serological status using the DiaSorin LIAISON® HSV-2 chemiluminescent immunoassay were assayed on the HSV-2 biochip and the Focus Diagnostics HerpeSelect® 2 ELISA IgG kit …

The Md/Mba Effect: A Study Of How Residency Directors Perceive Applicants With An Mba, A Ten-Year Comparison Study From 2006 To 2016, Jay Pravin Patel

Yale Medicine Thesis Digital Library

Background: Over the past decade, the landscape of healthcare has changed

dramatically, demanding the close integration of business and management with the

delivery of clinical care. In response, there has been a continuation of the trend towards

additional training for physicians through an MBA program that has been seen over the

last thirty years. However, some medical students have encountered some negative

perceptions voiced by senior physicians about MD/MBA training. As most MD/MBA

joint-degree candidates consider clinical careers, it is vital to understand the views of

residency program directors who hold the gates to graduate medical education.

Purpose: Therefore in …

Screening Families For Unmet Social Needs In A Pediatric Clinic, Elizabeth Evans Peterson

Master of Public Health Program Student Publications

Background: Previous research indicates that at least 60% of preventable deaths are caused by modifiable factors. Children, especially those under the age of five, are the most at-risk population for negative social determinants of health. Identifying and mitigating these factors could break the poverty impact cycle and promote wellness into adulthood, improving community health outcomes.

Purpose: The purpose of this study was to describe trends in unmet social needs of children attending a well-child visit in Dayton, Ohio. Methods: Families attending a hospital-affiliated clinic during a well-child visit were asked to complete a simple, 10-item questionnaire. This cross-sectional study utilized …

Graduate Medical Education 2016-2017 Annual Report, Children's Mercy Hospital

GME Annual Reports

Annual report of the Children's Mercy Hospital Graduate Medical Education department, including pediatric residency, internal medicine/pediatrics residency, fellowship programs, medical students, continuing medical education, and library services.

2017 Annual Report, The Jackson Laboratory

Annual Reports

No abstract provided.

The “Princelings” And The Banks: When Does A Legitimate Business Practice Become Criminal Corruption In Violation Of The Foreign Corrupt Practices Act?, Beverley Earle & Anita Cava

Northwestern Journal of International Law & Business

The Foreign Corrupt Practices Act (FCPA) prohibits the bribery of foreign public officials. When does hiring a relative of a foreign official cross the line into criminal activity in violation of the Act? We suggest that there should not be an absolute prohibition on hiring qualified relatives of foreign officials. Rather, there must be clear safeguards to prevent quid pro quo arrangements that further corruption.

We examine the lack of case precedents under the statute and look to cases under other statutes that examine the definition of quid pro quo to look for analogies to the FCPA. We conclude with …

Teaching Public Policy Drafting In Law School: One Professor's Approach, Lisa A. Rich

Duquesne Law Review

This article provides an overview of the Drafting for Public Policy course offered at the Texas A&M University School of Law. The article addresses the theoretical and pedagogical underpinnings of the course, including how such a course easily encompasses the teaching of cultural context and awareness, as well as professional identity, and encourages students to engage deeply in the policymaking process. It also explores the continued relevance of the work of Harold D. Lasswell, as well as that of Myres McDougal and Anthony Kronman. These works, from 1943 and 1993 respectively, resonate now because they called on law schools to …

Sb-277 Calls The Shots: How California Can Mend The Divide Between Proponents And Opponents Of Mandatory Vaccination Laws, Jennifer Yeung

Duquesne Law Review

No abstract provided.

Cytokine Expression, Cytoskeleton Organization, And Viability Of Sim-A9 Microglia Exposed To Staphylococcus Aureus-Derived Lipoteichoic Acid And Peptidoglycan, Erin Roberts

Browse all Theses and Dissertations

In these experiments, SIM-A9 microglia were exposed to Staphylococcus aureus cell wall components lipoteichoic acid (LTA) and peptidoglycan (PGN) at a concentration of 5 ug/mL for six, twelve, eighteen, and twenty-four hours and the cytokine expression, cytoskeleton organization, and cell viability of the cells were observed. Following LTA and PGN exposure, TNF-a; secretion increased at each time interval and was highest observed at 24 hours. No significant IL-10 secretion was detected. Over the 24 hour period, cell viability and cytotoxicity of LTA and PGN treatment groups were not significantly different from the control, indicating the observed inflammatory cytokine response was …

Assessing Very Early Infant Diagnosis Turnaround Times: Findings From A Birth Testing Pilot In Lesotho, Michelle Gill, Heather J. Hoffman, Majoalane Mokone, Vincent Tukei, Matsepeli Nchephe, +Several Additional Authors

Epidemiology Faculty Publications

Very early infant diagnosis (VEID) (testing within two weeks of life), combined with rapid treatment initiation, could reduce early infant mortality. Our study evaluated turnaround time (TAT) to receipt of infants’ HIV test results and ART initiation if HIV-infected, with and without birth testing availability. Data from facility records and national databases were collected for 12 facilities offering VEID, as part of an observational prospective cohort study, and 10 noncohort facilities. HIV-exposed infants born in January–June 2016 and any cohort infant diagnosed as HIV-infected at birth or six weeks were included. The median TAT from blood draw to caregiver result …

Combating Antibiotic Resistance: A Policy Roadmap To Reduce Use Of Medically Important Antibiotics In Livestock, Expert Commission On Addressing The Contribution Of Livestock To The Antibiotic Resistance Crisis 2017

Antibiotic Resistance Action Center (ARAC)

No abstract provided.

Nsu Translational Research And Economic Development Fy 2017 Annual Report, Nova Southeastern University

Annual Reports

No abstract provided.

Icd-9-Cm Coding For Multidrug Resistant Infection Correlates Poorly With Microbiologically Confirmed Multidrug Resistant Infection, Jason P. Burnham, Jennie H. Kwon, Hilary M. Babcock, Margaret A. Olsen, Marin H. Kollef

Open Access Publications

No abstract provided.

Genomic Vs. Non-Genomic Role Of The Ahr In Human Immunoglobulin Expression, Nasser Alhamdan

Browse all Theses and Dissertations

The immunoglobulin heavy chain gene (Igh) in various animal models is regulated by numerous regulatory elements including the 3’Igh regulatory region (3’IghRR). Several transcription factors are involved in modulating the 3’IghRR including the aryl hydrocarbon receptor (AhR). The AhR is a ligand-activated transcription factor that mediates the transcription of genes involved in the metabolism of environmental toxicants such as TCDD. TCDD binds AhR and regulates immunoglobulin (Ig) expression in B cells. This modulation appears to be directly mediated by binding of the AhR to dioxin response elements (DRE) within the 3’IghRR. In human B cells, IgG secretion inhibited by TCDD …

Residential Schools And The Effects On Indigenous Health And Well-Being In Canada - A Scoping Review, Piotr Wilk, Alana Maltby, Martin Cooke

Paediatrics Publications

Background: The history of residential schools has been identified as having long lasting and intergenerational effects on the physical and mental well-being of Indigenous populations in Canada. Our objective was to identify the extent and range of research on residential school attendance on specific health outcomes and the populations affected. Methods: A scoping review of the empirical peer-reviewed literature was conducted, following the methodological framework of Arksey and O'Malley (2005). or this review, nine databases were used: Bibliography of Native North Americans, Canadian Health Research Collection, CINAHL, Google Scholar, Indigenous Studies Portal, PubMed, Scopus, Statistics Canada, and Web of Science. …

2017 Annual Campus Security And Fire Safety Report, University Of Nebraska-Lincoln, University Police, University Of Nebraska-Lincoln

University of Nebraska-Lincoln, University Police

2017 Annual Campus Security and Fire Safety Report, University of Nebraska-Lincoln

Safety and security information for the University of Nebraska-Lincoln, including crime and fire statistics for the 2016 calendar year, and the information required by the Drug-Free Schools and Communities Act of 1989. All data are submitted to the United States Department of Education according to law.

Israel : Translocation Of Rabies, Sarah Baker

Global Public Health

Israel is now faced with a steady growing public health threat as canine rabies has reemerged in the northern region of Israel. While the steady increase in cases is of notable alarm, moreover the close contact most often shared between dog and human populations is of much more concern from a public health prospective. Rabies is a vaccine-preventable disease. Vaccinating dogs has proven to be the most cost-effective strategy for preventing rabies in people. Additionally, education on bite prevention and rabid animal behaviors for both children and adults is an essential extension of the long term rabies vaccination program that …

Madagascar : Plague In Madagascar, Matthew Donald Hesch

Global Public Health

This public health brief calls attention to a disease issue in the country Madagascar. We show reasons as to why Madagascar has such a problem with the plague and what they should do to solve the issue. Madagascar has many areas that are high poverty because of a political crisis and this results in the easy spread of the plague. We show that Madagascar needs an increase in funds so that they can get out of the political crisis and begin fixing the plague issue. I offer ideas on how Madagascar could use the extra funds to overcome the plague …

Sleep Disturbance And The Immunological Acute Phase Response In Hospitalized Post-Operative Adults., Jean Dorothy Humphries

Wayne State University Dissertations

Abstract

Sleep Disturbance and the Immunological Acute Phase Response

in Postoperative Hospitalized Adults

Abstract

The purpose of this study was to examine the subjective and objective (actigraphy) sleep patterns, the immunological acute phase response of IL1-β and TNF-α, and the physiological stress response of cortisol and systolic blood pressure in post-operative abdominal surgical patients. Nineteen subjects, 10 men and 9 women, mean age 45.63 years (SD = 11.44) were enrolled between April 2015 and March 2016. All subjects were elective major invasive abdominal surgery patients. Laparoscopic surgery occurred in 10 patients and incisional surgery occurred in 9 patients. This descriptive …

Synthesis Of Netilmicin And Apramycin Derivatives For The Treatment Of Multidrug-Resistant Infectious Diseases, Amr Sayed Motawi Sonousi

Wayne State University Dissertations

The ever-growing bacterial resistance to existing antibiotics is alarming to humanity. Many researchers decided to revisit aminoglycosides with renewed emphasis on chemical modification as they have long been used as highly potent antibiotics for treating severe bacterial infections. The bactericidal effect of aminoglycosides is mainly due to protein synthesis inhibition by binding to the A-site of the bacterial ribosomes. However, the high potency and the broad spectrum of aminoglycosides has been outweighed by their side effects, especially ototoxicity, and by the resistance of pathogens. The goal of this research was the modification of existing aminoglycosides to develop derivatives which are …

Vancomycin Plus Piperacillin/Tazobactam And Acute Kidney Injury In Adults: A Systematic Review And Meta-Analysis, Megan Luther, Timbrook, Aisling R. Caffrey, David Dosa, Thomas Lodise, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Objectives: The objective of this systematic review and meta-analysis was to assess acute kidney injury with combination therapy of vancomycin plus piperacillin-tazobactam, in general, adult patients and in critically ill adults. Rates of acute kidney injury, time to acute kidney injury, and odds of acute kidney injury were compared with vancomycin monotherapy, vancomycin plus cefepime or carbapenem, or piperacillin-tazobactam monotherapy.

Data Sources: Studies were identified by searching Pubmed, Embase, Web of Science, and Cochrane from inception to April 2017. Abstracts from selected conference proceedings were manually searched.

Study Selection: Articles not in English, pediatric studies, and case reports were excluded. …

Inappropriate Prescribing In Outpatient Healthcare: An Evaluation Of Respiratory Infection Visits Among Veterans In Teaching Versus Non-Teaching Primary Care Clinics, Diane M. Parente, T. Timbrook, Aisling R. Caffrey, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

A recent study led by the Centers for Disease Control and Prevention (CDC) revealed at least 30% of antibiotic prescriptions in the outpatient setting were inappropriate. In this study of all ages, among adult patients, results were similar to the overall population, with the majority of inappropriate prescribing relating to respiratory infections. We applied the same methodology to investigate rates of antibiotic prescribing for respiratory tract infections in outpatient primary care clinics at the Providence Veterans Affairs Medical Center. The results of our evaluation reflected comparable rates of inappropriate prescribing, but when stratified by teaching versus nonteaching primary care clinics, …

Unm Pathology Pathfinder Winter 2017, Unm Department Of Pathology

Newsletters

No abstract provided.