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Meta-Regression: Prognostic Models As Objective Predictors Of Mortality Among Icu Cancer Patients, Sheila Donnell

Nursing Theses and Dissertations

Cancer patients admitted to the intensive care unit (ICU) may be experiencing complications of disease or treatment-related effects. While acute complications related to disease and/or its therapeutic management vary in severity, the approach to ICU-centered care is complicated by actual versus perceived risks of poor outcomes. Prognostic models that inform clinical judgment of nurses and physicians may prove helpful in this population. The Acute Physiology and Chronic Health Evaluation II (APACHE II), Simplified Acute Physiology Score II (SAPS II) and Sequential Organ Failure Assessment (SOFA) are ICU-based models predicting 30-day mortality among the general ICU population. Although studies have been …

The Effect Of Long Term Administration Of Glucocorticoid To Bone Lining Cells Apoptosis, Gadis Meinar Sari

Folia Medica Indonesiana

Glucocorticoid is widely used in medical treatment as an immune system or an inflammation therapy. However its long term administration can cause life-threatening side effects. One of them is bone mass loss which increases the risk of bone fractures in the long-term use. Bone lining cells derived from mesenchymal stem cells, which serve as a backup cell bone-forming osteoblasts. Glucocorticoids acting directly on osteoblasts, bone lining cells when reduced due to increased apoptosis, the reserve cells to bone formation will be decreased. The aim of this study was to count the amount of apoptotic bone lining cells after long term …

Body Size Predicts Cardiac And Vascular Resistance Effects On Men's And Women's Blood Pressure, Joyce M. Evans, Siqi Wang, Christopher Greb, Vladimir Kostas, Charles F. Knapp, Qingguang Zhang, Eric S. Roemmele, Michael B. Stenger, David C. Randall

Biomedical Engineering Faculty Publications

Key Points Summary

• We report how blood pressure, cardiac output and vascular resistance are related to height, weight, body surface area (BSA), and body mass index (BMI) in healthy young adults at supine rest and standing.
• Much inter-subject variability in young adult's blood pressure, currently attributed to health status, may actually result from inter-individual body size differences.
• Each cardiovascular variable is linearly related to height, weight and/or BSA (more than to BMI).
• When supine, cardiac output is positively related, while vascular resistance is negatively related, to body size. Upon standing, the change in vascular resistance is positively related to size. …

Evidence Of Youthful Aging: Chronic Stress And The Association With Dna Damage, Jason M. Fly, M. Catherine Desoto

McNair Scholars Program Summer Research Symposium

Abstract: Persistent elevated basal levels of the hormone cortisol are an indication of chronic stress. Maladaptive response to stress, or chronic psychological stress, is thought to play a crucial role in the biological mechanisms involved in mental disorders, disease, and accelerated aging. In 2011, a critical connection was reported between elevated cortisol and the oxidative damage to DNA associated with aging and disease in a study of elderly participants (ages 63-83) via 24-hour urinary samples (Joergensen, et. al., 2011). This connection, if verified, has implications for how stress may accelerate the aging process and the onset of cancer, diabetes, and …

Galen’S Analogy: Animal Experimentation And Anatomy In The Second Century C.E., Annastasia Conner

Anthós

Galen of Pergamum (129 – ca. 216 C.E.) is truly one of the most pivotal characters in the history of medicine, and particularly the field of anatomy. A physician in the ancient Roman Empire, he did not allow his work to be constrained by contemporary boundaries, instead delving further into the field of anatomy and physiology than any doctor had yet done. He built upon the existing work of his predecessors as well as making new discoveries through which he would shape contemporary and future understandings of anatomy, and of medicine as a whole. Although a luminary in his field, …

Visual Detection Of Small Unmanned Aircraft: Modeling The Limits Of Human Pilots, Gregory Stephen Woo

Doctoral Dissertations and Master's Theses

The purpose of this study was to determine the key physical variables for visual detection of small, Unmanned Aircraft Systems (UAS), and to learn how these variables influence the ability of human pilots, in manned-aircraft operating between 60-knots to 160-knots in the airport terminal area, to see these small, unmanned aircraft in time to avoid a collision. The study also produced a set of probability curves for various operating scenarios, depicting the likelihood of visually detecting a small, unmanned aircraft in time to avoid colliding with it. The study used the known limits of human visual acuity, based on the …

Pulling The Plug On Microscopes In The Anatomy And Physiology Laboratory, Zvi Ostrin, Vyacheslav Dushenkov

Publications and Research

Virtual microscopy (VM) has been widely available for more than a decade, especially in clinical settings and medical schools. In recent years the movement away from conventional optical microscopy (OM) and towards VM has been accelerating and several VM websites are now available online and readily accessible to educators. VM can enhance the instructor’s ability to teach the histology component of anatomy and physiology classes, facilitate student learning, save time for both students and instructors, and ultimately save money that can be more productively used for other facets of the laboratory. The many pedagogical and practical advantages provided by VM …

An Examination Of The Workloads And The Effectiveness Of An Athlete Monitoring Program In Ncaa Division I Men's Soccer, Matthew L. Sams

Electronic Theses and Dissertations

The purposes of this dissertation were to examine common athlete training and monitoring practices in men’s collegiate soccer and to report the programming strategies and monitoring outcomes for an NCAA Division I men’s collegiate soccer team whose coaching and sport science staff collaborated on a daily basis. The following are the major findings of the dissertation:

Study 1 – Coaches from all divisions of play responded to a custom survey. A majority of coaches developed an in-season training plan that varied both daily and weekly volume and intensity. One-third of the coaches performed no athlete monitoring, and a number of …

Characterization Of Filifactor Alocis And Its Immune Evasion Strategies Employed Against Human Neutrophils., Cortney Linn Armstrong

Electronic Theses and Dissertations

Periodontal disease is among the most common of inflammatory conditions and is caused by bacterial and host derived factors. The presence of bacteria drives the recruitment of neutrophils, professional phagocytes, to migrate to specific oral sites where they produce potent antimicrobials to kill their target. However, this inflammation and production of antimicrobials must be strictly regulated to minimize collateral host tissue damage. Human neutrophils recognized the oral pathogen Filifactor alocis through Toll-like receptor (TLR) 2 and upon binding, activated both p38 MAPK and ERK signaling pathways, known to be involved in neutrophil cell migration and degranulation. F. alocis also stimulated …

Metabolic Regulation By Stress Mediators In Fetal Ovine Skeletal Muscle And Adult Bovine Myoblasts, Elena Marie Merrick

Department of Animal Science: Dissertations, Theses, and Student Research

Our objective was to determine the effect of stress mediators such as inflammatory cytokines and β adrenergic agonists on developing skeletal muscle. Fetal sheep exposed to chronic maternal inflammation had decreased skeletal muscle glucose oxidation rates when stimulated with insulin or TNFα. In addition, activation of Akt by insulin was decreased after maternal inflammation when compared to controls and there were not differences in skeletal muscle fiber type ratios between the two treatment groups. This indicates that maternal inflammation does not affect overall oxidative capacity in the developing fetus, but rather insulin signaling pathways are disrupted.

We sought to determine …

The Effect Of Blinded Hydration State On Thermoregulation And Performance In Male Cyclists, Jon David Adams

Graduate Theses and Dissertations

Purpose: The purpose of these studies was to observe the effect of dehydration on exercise performance while subjects were blinded to their hydration status. Methods: Study 1: Seven male cyclists (weight: 71±8 kg, body fat: 14±6%, VO2peak: 59.4±6 ml∙kg-1·min-1) exercised for 2 hours on a cycle ergometer at 55% VO2peak, in a hot-dry environment (35°C, 30% rh), with a nasogastric (NG) tube under euhydrated (EUH-NT) and hypohydrated (DEH-NT) conditions. In both trials, thirst was matched by drinking 25 mL every 5 min. In the EUH-NT trial sweat losses were fully replaced via the NG tube. Following the 2 hours of …

A Numerical Study Of The Interaction Between One Dimensional Carbyne Chain And Single Stranded Dna, Zeina Salman

Graduate Theses and Dissertations

resolution at the single nucleotide level when developing DNA sequencers. The purpose of this research was to numerically study the electrical properties associated with the interaction between 1D carbon chain, known as carbyne, and ssDNA. First, the electrical properties of the carbyne chain were calculated. Second, the electrical properties of the carbyne chain were calculated in the presence of different ssDNA bases. Analyzing the differences between the two cases led to determining the effects of these different bases on the electrical properties. The numerical simulation approach conducted in this research was based on the first-principle simulation. The first-principle simulation was …

Visualization Of The Cardiac Excitation And Pvc Arrhythmia On A 3d Heart Model, Pranav Sreedharan Veliyara

Masters Theses

Visualization of the cardiac potential movement is important in understanding the physiology of the human heart. A 3D visualization tool will help the cardiology students and others interested in human physiology to understand the functioning of the heart. In this thesis, such a tool is proposed which helps in the visualization of the cardiac potential movement and Premature Ventricular Contraction (PVC) event on a 3D heart model. The cardiac excitation obtained from a limb lead and a precordial lead of a 12 lead electrocardiograph (ECG) is mapped on a 3D heart model with fixed conduction pathways. The 3D heart model …

What Should The U.S. Army Learn From History? Recovery From A Strategy Deficit, Colin S. Gray Dr.

Books, Monographs & Collaborative Studies

Does history repeat itself? This monograph clearly answers “no,” firmly. However, it does not argue that an absence of repetition in the sense of analogy means that history can have no utility for the soldier today. This monograph argues for a “historical parallelism,” in place of shaky or false analogy. The past, even the distant and ancient past, provides evidence of the potency of lasting virtues of good conduct. This monograph concludes by offering four recommendations: 1) Behave prudently. 2) Remember the concept of the great stream of time. 3) Do not forget that war nearly always is a gamble. …

Conference Program, Wilfred Chen, Nicole Borth, Stefanos Grammatikos

Biochemical and Molecular Engineering XX

No abstract provided.

Oncology Section Edge Task Force On Urogenital Cancer Outcomes: Clinical Measures Of Lymphedema—A Systematic Review, Joy C. Cohn, Hannah Geyer, Jeannette Lee, Mary Insana Fisher

Physical Therapy Faculty Publications

Background: Valid and reliable tools to assess lymphedema are necessary to accurately evaluate status and to objectively document and measure the results of interventions. Understanding the advantages and disadvantages of each measure can inform the clinician's choice of the appropriate tool to be used in the clinic or research setting.

Purpose: To identify reliable and valid measurement techniques that are sensitive to change for assessing edema volume or soft tissue change in the lower extremities or genital region of patients with lymphedema.

Methods: A systematic review of the literature was conducted to assess the published psychometric properties and clinical feasibility …

College Of Pharmacy And Allied Health Professions, South Dakota State University

Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)

[Page] 2 Thomas Gajewski : University of Chicago immunology researcher shares treatment’s progress in the fight against cancer at Francis Miller Lecture. [Page] 4 Endowed positions: The college will soon have three endowed posts on its faculty. Two are in the area of cancer. The other is in community pharmacy. All are considered transformational.
[Page] 6 White Coat: A familiar face, Dave Helgeland, one of the class’s professors, delivered a message on expectations to this year’s group of P1 students.
[Page] 8 Spring convocation: The 2015 Independent Pharmacist of Year visits to teach about enhanced value to payers.
[Page] 10 …

Perspectives Volume 5: Number 2, Summer-Fall 2017, College Of Health Care Sciences

Perspectives

No abstract provided.

Metabolite Profiling Of Infection-Associated Metabolic Markers Of Onchocerciasis., Sasisekhar Bennuru, Sara Lustigman, David Abraham, Thomas B. Nutman

Department of Microbiology and Immunology Faculty Papers

The global efforts for onchocerciasis elimination may require additional tools (safe micro and macrofilaricidal drugs, vaccines and biomarkers) as elimination efforts move toward the "end game". Efforts toward the identification of suitable biomarkers have focused on specific protein(s) and/or nucleic acids, but metabolites present an alternative option as they have limited half-lives and are the result of combinatorial effects. In comparison to previously used methodology of LC-MS for metabolomic approaches, we used a non-targeted capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) to analyze the serum metabolic profiles of Ov-infected and -uninfected individuals (n=20). We identified 286 known metabolites (167 in the …

Biology, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Pre-Professional Curricula, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

The Trio Student Support Services Newsletter, Armstrong State University

TRiO Newsletter (Armstrong) (Archived)

No abstract provided.

Smart Thermoregulating Garments, Kaspar Jansen, Nina Bogerd

Experiential Knowledge (EKSIG) Conference Series

For a human body to function properly the body core temperature needs to lie within a narrow range of about 37 °C. This temperature is, among others, sustained with adjusting the blood flow to the skin, as well as by sweating or shivering. In extreme hot conditions and, in particular when wearing protective clothing, heat gain exceeds heat loss and the body temperature increases. Specifically, every 1°C rise in body core temperature is accompanied by 1% reduction in gross efficiency and may eventually lead to reduced operational performance. Whereas, in cold conditions, peripheral vasoconstriction leads to cold extremities resulting in …

Costs Of Group Locomotion: How Infant-Carrying And Group Members Mediate Walking Speed Decisions In North American And East African Populations, Leah M. Bouterse

Honors Projects

A major portion of humans’ activity-based energy expenditure is taken up by locomotion, particularly walking. Humans can offset the energetic expenditure of walking in numerous ways, both evolutionary (such as changes in body shape) and culturally. Behaviorally, people can choose to walk in a variety of ways, including alone or with a group, carrying loads, and walking quickly or more slowly. All of these behaviors have energetic outcomes and as such can be important windows into how populations and groups adjust to different constraints. While sex differences in speed of paired walkers have been established by others, the dynamics of …

Phytochemical Analysis And Evaluation Of Antioxidant Potential Of Ethanol Extract Of Allium Cepa And Ultra-High Homoeopathic Dilutions Available In The Market: A Comparative Study, Ekta Arora, Vibha Sharma, Anil Khurana, Ananya Manchanda, Dilsheen Sahani, Sijo Abraham, Deepa Kundu, Himani Gupta, Lunthanglien Chiru

Indian Journal of Research in Homoeopathy

Introduction: As per statistics available with the WHO, 80% of the earth's population rely on traditional medicine for their primary health-care needs and most of this therapy involves the use of plant extracts and their active components. Objectives: To confirm the presence of alkaloids, fats, steroids, tannins, flavonoids, sugars, amino acids and saponins in Allium cepa extract. Method: A qualitative phytochemical analysis has been performed to confirm the presence of these components in Allium cepa extract and its homoeopathic formulations (mother tincture [MT], Allium cepa 30C and Allium cepa 200C). The total phenolic content, flavonoid content and antioxidant potential of …

An Ergonomics Investigation Of The Application Of Virtual Reality On Training For A Precision Task, Delaney M. Bales

Master's Theses

Virtual reality is rapidly expanding its capabilities and accessibility to consumers. The application of virtual reality in training for precision tasks has been limited to specialized equipment such as a haptic glove or a haptic stylus, but not studied for handheld controllers in consumer-grade systems such as the HTC Vive. A straight-line precision steadiness task was adopted in virtual reality to emulate basic linear movements in industrial operations and disability rehabilitation. This study collected the total time and the error time for the straight-line task in both virtual reality and a physical control experiment for 48 participants. The task was …

Weather And Children’S Physical Activity; How And Why Do Relationships Vary Between Countries?, Flo Harrison, Anna Goodman, Ester M.F. Van Sluijs, Lars Bo Carson, Greet Cardon, Rachel Davey, Kathleen F. Janz, Susi Kriemler, Lynn Molly, Angie S. Page, Russell R. Pate, Jardena J. Puder, Luis B. Sardinha, Anna Timperio, Niels Wedderkopp, Andy P. Jones

Faculty Publications

Background

Globally most children do not engage in enough physical activity. Day length and weather conditions have been identified as determinants of physical activity, although how they may be overcome as barriers is not clear. We aim to examine if and how relationships between children’s physical activity and weather and day length vary between countries and identify settings in which children were better able to maintain activity levels given the weather conditions they experienced.

Methods

In this repeated measures study, we used data from 23,451 participants in the International Children’s Accelerometry Database (ICAD). Daily accelerometer-measured physical activity (counts per minute; …

How Long Can You Hold Your Breath?, Felicia Leroy

Masters Theses

I began freediving, a sport in which one dives as deep as possible on single breath hold, as a way to approach the inaccessible space of the deep, to expand my understanding of the unobtainable.

This space (the deep) seemed to me to be representative of something that is totally unknown, its power existing in its inaccessibility, in its un-know-ability.

Through training/experiential data collection and using human physiology at depth as a framework, this thesis work book explores a single breath hold to the other side.

Work made in support of this exploration touches on darkness, depth, the edge, the …

Emotions And Behavior Regulation In Decision Dilemmas, Joaquín Gómez-Miñambres, Eric Schniter

ESI Publications

We introduce a dynamic model of emotional behavior regulation that can generalize to a wide range of decision dilemmas. Dilemmas are characterized by availability of mutually exclusive goals that a decision maker is dually motivated to pursue. In our model, previous goal pursuant decisions produce negative emotions that regulate an individual’s propensity to further pursue those goals at future times. This emotional regulation of behavior helps explain the non-stationarity and switching observed between so-called “preferences” revealed in repeated decision dilemmas (e.g., by choosing A over B at time 1, then choosing B over A at time 2). We also explain …

A Synergistic Wearable Health Monitoring System Using Cellular Network Technology, Nagarjuna Pamidi

Engineering

This thesis presents a synergistic approach to healthcare applications by integrating a wearable health monitoring system into a smart home system. By exploiting synergy within each system and between these two systems, this thesis shows that the efficiency of the health care can be increased while providing the added advantage of utmost user-friendly environment. Initially, a wearable health monitoring prototype system was developed for vital sign data collection and processing. The developed system used biosensor integration to distinguish amongst multiple physical activities and to compare the variations in physiological conditions according to physical activity of the user. Afterward, system learning …