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Vibrational Spectroscopy As A Tool For Studying Drug-Cell Interaction: Could High Throughput Vibrational Spectroscopic Screening Improve Drug Development, Lauren E. Jamieson, Hugh Byrne

Articles

Vibrational spectroscopy is currently widely explored as a tool in biomedical applications. An area at the forefront of this field is the use of vibrational spectroscopy for disease diagnosis, ultimately aiming towards spectral pathology. However, while this field shows promising results, moving this technique into the clinic faces the challenges of widespread clinical trials and legislative approval. While spectral pathology has received a lot of attention, there are many other biomedical applications of vibrational spectroscopy, which could potentially be translated to applications with greater ease. A particularly promising application is the use of vibrational spectroscopic techniques to study the interaction …

Prediction Of Viral Loads For Diagnosis Of Hepatitis C Infection In Human Plasma Samples Using Raman Spectroscopy Coupled With Partial Least Squares Regression Analysis, Hugh Byrne, Franck Bonnier, H. Nawaz, N. Rashid, M. Saleem

Articles

Raman spectroscopy has been used to identify the biochemical changes associated with the presence of the Hepatitis C virus (HCV) in infected human blood plasma samples as compared with healthy samples, as control. The aim of the study was to establish the Raman spectral markers of hepatitis infection, which could be used for diagnostic purposes. Moreover, multivariate data analysis techniques, including Principal Component Analysis (PCA), coupled with Linear Discriminant Analysis (LDA), and Partial Least Square Regression (PLSR) are employed to further demonstrate the diagnostic capability of the technique. The PLSR model is developed to predict the viral loads of the …

Determination Of Spectral Markers Of Cytotoxicity And Genotoxicity Using In Vitro Raman Microspectroscopy: Cellular Responses To Polyamidoamine Dendrimer Exposure, Esen Efeoglu, Alan Casey, Hugh Byrne

Articles

Although consumer exposure to nanomaterials is ever increasing, with potential increased applications in areas such as drug and/or gene delivery, contrast agents and diagnosis, determination of cyto- and geno- toxic effect of nanomaterials on human health and the environment still remains challenging. Although many techniques have been established and adapted to determine the cytotoxicity and genotoxicity of nano-sized materials, these techniques remain limited by the number of assays required, total cost, use of labels and they struggle to explain the underlying interaction mechanisms. In this study, Raman microspectroscopy is employed as an in vitro label free high content screening technique …

Comparison Of Various Technologies In The Acquisition Of Speech Samples For Transcription Purposes: Listener Perception Vs. Acoustic Analysis Of Signal Quality, Alexa Klimes

Honors Program Theses

The purpose of this study was to investigate the quality of recordings obtained with a dedicated recording device in comparison to more readily available devices. Professionals in the field of communication disorders need to identify and transcribe specific details about individuals’ speech and need high quality recordings for this purpose (Louko & Edwards, 2001). The dedicated recording devices that provide high quality signals are not readily available and can be expensive. The available research on this topic focuses on analysis of voice characteristics such as fundamental frequency, amplitude, and stability of amplitude and frequency (Lin, Hornibrook, & Ormond, 2012; Vogel …

A Presidential Paradigm Shift: Changes In Presidential Rhetoric Regarding Cuba, Alyssa Chellan Dixon

Honors Program Theses

On March 22, 2016, United States President Obama and Cuban President Raúl Castro sat side-by-side in the Estadio Latinoamericano baseball stadium, watching the Tampa Bay Rays and the Cuban national team face off in a historic game. Such an event would have been unprecedented in the several decades prior to its occurrence. Indeed, though at the U.S.-Cuba game Obama and Raúl Castro were even as friendly to have participated in doing “the wave” together,ii relations between the U.S. and Cuban governments were anything but, even during the preceding U.S. presidency of George W. Bush.

The United States has had a …

Utilisation Des Prothèses Auditives En Milieu De Travail Bruyant, Tony Leroux, Chantal Laroche, Christian Giguère, Jérémie Voix

Rapports de recherche scientifique

Le bruit est encore très présent en milieu de travail. Plusieurs travailleurs vivent donc quotidiennement avec une surdité professionnelle. D’autres peuvent par ailleurs présenter une surdité d’origine non professionnelle et enfin, la population active vieillissante présente plus de risques de souffrir d’une perte auditive. Une surdité peut compromettre la réalisation efficace des tâches et la sécurité du travailleur et celle d’autrui lorsqu’elle est accompagnée de difficultés à percevoir des signaux sonores, à comprendre la parole en présence de bruit et à bien localiser la provenance des sons dans l’espace. Afin de maintenir une juste perception de l’environnement sonore …

Inside The Black Box: Political Economy Of The Trans-Pacific Partnership's Encryption Clause, Han-Wei Liu

Research Collection Yong Pung How School Of Law

Among other provisions of the Trans-Pacific Partnership (TPP) Agreement, a new clause on encryption technology (‘Encryption Clause’) is particularly noteworthy. By tracing the history of decades-long encryption control, this article underscores how this clause implicates international order. Modern encryption technology was conceived and developed during World Wars. Painted by such a war-time legacy, encryption has been treated as a ‘dual-use’ technology and has been subject to export control since the end of World War II via the Coordinating Committee for the Control of Multinational Trade (COCOM) and, later, the Wassenaar Arrangement. With the collapse of the Soviet Union, the Western …

The Legality Of Data Residency Requirements: How Can The Trans-Pacific Partnership Help?, Shin-Yi Peng, Han-Wei Liu

Research Collection Yong Pung How School Of Law

Article 14.13 of the Trans-Pacific Partnership (TPP) Agreement – the data localization (DL) clause – represents the first time that a far-reaching preferential trade agreement (PTA) seeks to reduce protectionism arising from data residency (DR) requirements. The DL clause, however, is linked to a loose GATT Article XX-like exception: Article 14.13(3)(b), which allows the parties to maintain DR measures to achieve a legitimate public policy objective as long as the measure in question can satisfy the ‘necessity test’. The ambiguity of the DL exception will be clarified by TPP tribunals when a real dispute occurs. After examining the rationales of …

White Paper Of Democratic Criminal Justice, Joshua Kleinfeld, Laura I. Appleman, Richard A. Bierschbach, Kenworthey Bilz, Josh Bowers, John Braithwaite, Robert P. Burns, R. A. Duff, Albert W. Dzur, Thomas F. Geraghty, Adriaan Lanni, Marah Stith Mcleod, Janice Nadler, Anthony O'Rourke, Paul H. Robinson, Jonathan Simon, Jocelyn Simonson, Tom R. Tyler, Ekow N. Yankah

Journal Articles

This white paper is the joint product of nineteen professors of criminal law and procedure who share a common conviction: that the path toward a more just, effective, and reasonable criminal system in the United States is to democratize American criminal justice. In the name of the movement to democratize criminal justice, we herein set forth thirty proposals for democratic criminal justice reform.

Criminal Trademark Enforcement And The Problem Of Inevitable Creep, Mark P. Mckenna

Journal Articles

This Article, delivered as the 2017 Oldham Lecture at the University of Akron School of Law, focuses on the federal Trademark Counterfeiting Act (TCA), the primary source of federal criminal trademark sanctions. That statute was intended to increase the penalties associated with the most egregious form of trademark infringement — use of an identical mark for goods identical to those for which the mark is registered and in a context in which the use is likely to deceive consumers about the actual source of the counterfeiter’s goods. The TCA was intended to ratchet up the penalties associated with counterfeiting, but …

Evidence And Innovation In Housing Law And Policy, Lee Anne Fennell, Benjamin J. Keys

Books

No abstract provided.

Adultery: Trust And Children, Margaret F. Brinig

Journal Articles

Deborah Rhode writes that while adultery is admittedly not good, it should not be criminal. She argues that it should not generate a tort action either, because the original purposes for which the torts of alienation of affections and criminal conversation come from a time with quite different views about marriage and gender, while no-fault and speedy divorce today give adequate remedies to the wronged spouse. Further, adultery should not affect employment (as a politician or in the military) unless it directly impacts job performance.

My own reluctance to disengage adultery and law stems from the seriousness of adultery. First, …

Truth And Politics: A Symposium On Peter Simpson's Political Illiberalism: A Defense Of Freedom., Gerard V. Bradley

Journal Articles

There is no more important question in thinking about life-and actually living-in political community than whether it is to be permeated by, and purposefully oriented around, the main truths about human flourishing. It is at least paradoxical that, precisely when the state and its law and political life are shaping people's lives more and more, the professed roots of all this influence are growing thinner, more shallow. Lawmakers who profess and in many cases even think they should be "neutral" about values are more involved with how persons' lives go than, perhaps, ever before.

Of course, any community which has …

The Statewide Standard, 2017, College Of Education

The Statewide Standard

No abstract provided.

From A Muddle To A Mudslide: Murr V. Wisconsin, Nicole Stelle Garnett

Journal Articles

This article analyzes the U.S. Supreme Court's most-recent regulatory takings decision, Murr v. Wisconsin, concluding that the decision further muddies the takings waters and threatens to undermine the already-limited protection of private property provided by the Fifth Amendment's Takings Clause.

Countering The Majoritarian Difficulty, Amy Coney Barrett

Journal Articles

In Our Republican Constitution, Randy Barnett argues that the United States Constitution rests on a foundation of individual rather than collective popular sovereignty. Grounding the legitimacy of the government in the authority given it by each individual rather than by the People as a whole echoes the thesis, advanced in Barnett’s prior work, that the government must justify incursions upon individual liberty. If the People as a body are sovereign and the Constitution is designed to facilitate democratic self-governance, legislation is presumptively legitimate because it represents the sovereign will of the democratic majority. If the individual is sovereign, by contrast, …

Interleukin (Il)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation And Diminishes Circulating Il-18., Robert Z. Harms, Austin J. Creer, Kristina M. Lorenzo-Arteaga, Katie R. Ostlund, Nora Sarvetnick

Journal Articles: Surgery

The cytokine interleukin (IL)-18 is a crucial amplifier of natural killer (NK) cell function. IL-18 signaling is regulated by the inhibitory effects of IL-18 binding protein (IL-18BP). Using mice deficient in IL-18BP (IL-18BPKO), we investigated the impact of mismanaged IL-18 signaling on NK cells. We found an overall reduced abundance of splenic NK cells in the absence of IL-18BP. Closer examination of NK cell subsets in spleen and bone marrow using CD27 and CD11b expression revealed that immature NK cells were increased in abundance, while the mature population of NK cells was reduced. Also, NK cells were polarized to greater …

Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging Of Antiretroviral Drug Particle Tissue-Cell Biodistribution, Bhavesh D. Kevadiya, Christopher J. Woldstad, Brendan M. Ottemann, Prasanta Dash, Balasrinivasa R. Sajja, Benjamin G. Lamberty, Brenda M. Morsey, Ted Kocher, Rinku Dutta, Aditya N. Bade, Yutong Liu, Shannon E. Callen, Howard S. Fox, Siddappa N. Byrareddy, Joellyn M. Mcmillan, Tatiana K. Bronich, Benson J. Edagwa, Michael D. Boska, Howard Gendelman

Journal Articles: Radiology

RATIONALE: Long-acting slow effective release antiretroviral therapy (LASER ART) was developed to improve patient regimen adherence, prevent new infections, and facilitate drug delivery to human immunodeficiency virus cell and tissue reservoirs. In an effort to facilitate LASER ART development, “multimodal imaging theranostic nanoprobes” were created. These allow combined bioimaging, drug pharmacokinetics and tissue biodistribution tests in animal models.

METHODS: Europium (Eu³⁺)- doped cobalt ferrite (CF) dolutegravir (DTG)- loaded (EuCF-DTG) nanoparticles were synthesized then fully characterized based on their size, shape and stability. These were then used as platforms for nanoformulated drug biodistribution.

RESULTS: Folic acid (FA) decoration of …

Personal Health Behaviors And Health Counseling Practices Of Professional Psychologists And Trainees Across Setting And Population Types, Alexa Barnett

Theses and Dissertations

This study examined the health behaviors and health counseling practices among psychologists and psychology trainees, focusing on a variety of settings of practice. Both psychologists and trainees self-reported practicing a greater number of health enhancing behaviors compared to equivalent U.S. adults. Results indicated a higher rate of health counseling activity when psychologists and trainees endorsed counseling on health behaviors as more important, and additionally when having more training in health counseling. The results of this study expand upon the growing literature related to health professionals’ personal health behaviors and focuses on population health needs for improved health behaviors. Future research …

Relationships Among Health Counseling Training Experiences And Time Engaged In Counseling, Percentage Of Patients Counseled, Practitioner Confidence, And Perceived Importance, Stephen Edward Lupe

Theses and Dissertations

In the current healthcare system, the need for collaborative care is higher than ever. With current reforms in reimbursement and healthcare policies, it is becoming increasingly necessary for psychologists and other practitioners to break ranks with their traditional roles and to participate as a part of a multidisciplinary team that works in collaboration with other healthcare professionals. This study aims to look at the health counseling behaviors of psychologists and graduate psychology students from an APA accredited clinical psychology graduate program. It aims to examine the relationships among health counseling training variables and time spent engaging in health counseling, highest …

The Organization Of Prosecutorial Discretion, William H. Simon

Faculty Scholarship

Contemporary understanding of prosecutorial discretion is influenced by anachronistic conceptions of judgment and organization. These conceptions have lost ground dramatically in professions like medicine, teaching, and social work. Yet, they remain prominent to a unique degree in law. They are embedded both in the general professional culture and in legal doctrine. Innovative prosecutorial practices have emerged in recent decades, but their progress has been inhibited by attachment to these older conceptions.

The older conceptions understand professional judgment as a substantially tacit and ineffable decision by a single professional grounded in a relatively static and comprehensive discipline. The associated model of …

The Future Of Ir: Ascending! Keynote Lecture At The Pairs Annual Scientific Meeting 2017, Dubai, Uae, Barry Katzen

All Publications

No abstract provided.

Multifaceted Role Of Neuropilins In The Immune System: Potential Targets For Immunotherapy., Sohini Roy, Arup K. Bag, Rakesh Singh, James E. Talmadge, Surinder K. Batra, Kaustubh Datta

Journal Articles: Biochemistry & Molecular Biology

Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 (NRP1) and neuropilin-2 (NRP2), mainly act as coreceptors for class III Semaphorins and for members of the vascular endothelial growth factor family of molecules and are widely known for their role in a wide array of physiological processes, such as cardiovascular, neuronal development and patterning, angiogenesis, lymphangiogenesis, as well as various clinical disorders. Intriguingly, additional roles for NRPs occur with myeloid and lymphoid cells, in normal physiological as well as different pathological conditions, including cancer, immunological disorders, …

On The Origin Of Superoxide Dismutase: An Evolutionary Perspective Of Superoxide-Mediated Redox Signaling., Adam J. Case

Journal Articles: Cellular & Integrative Physiology

The field of free radical biology originated with the discovery of superoxide dismutase (SOD) in 1969. Over the last 5 decades, a plethora of research has been performed in species ranging from bacteria to mammals that has elucidated the molecular reaction, subcellular location, and specific isoforms of SOD. However, while humans have only begun to study this class of enzymes over the past 50 years, it has been estimated that these enzymes have existed for billions of years, and may be some of the original enzymes found in primitive life. As life evolved over this expanse of time, these enzymes …

Investigation Of Co2 Sequestration For The Assessment Of The Impact On Resource Storage With Co-Production Of Brine, Mohammad Junaid Ashfaq

Graduate Theses, Dissertations, and Problem Reports (ETD)

In order to reduce Green House Gases, Carbon-dioxide (CO2) storage in deep saline aquifers is a viable commercial application for minimizing emissions. It is important to understand surface area needed to predict large scale CO2 storage while fully utilizing injection capacity. This study presents results from varying Injection pressure and well spacing to find minimal-effective well spacing required to store CO2. The study shows pressure management to manipulate hydrodynamic behavior of CO 2 in saline formations system. In conjunction, understanding the interplay of CO2 dissolution, buoyancy flow, and capillary forces in regulating the behavior of the injected CO2 plume are …

Associations Between Sleep, Infant Feeding Methods, Brain Development And Behavior: A Multimodal Approach To Assess Plasticity In The Brain, Christopher Edward Bauer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Purpose: Sleep-disordered breathing (SDB) is a spectrum disorder that is estimated to effect a significant proportion of the pediatric population (1-3% in USA). SDB is able to disrupt and fragment sleep through frequent arousals and intermittent hypoxia. In addition, the long term effects of SDB in pediatrics have been well-documented; decreases in intelligence quotient (IQ), executive function, school performance, and alertness have all been observed. Although surgical treatments can be quite effective, there are no widely accepted prophylactic measures to prevent SDB development. Recently, breastfeeding duration in infancy has been demonstrated to be correlated with reduced SDB (lower AHI, RAI, …

Immunological Markers Detected In Peri-Implant Crevicular Fluid Detected By Msd Electromagnetic Elisa Assay - A Pilot Study Of Dental Implant Patients, Paul Canallatos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Objectives: The purpose of this pilot study is to determine if, in healthy states, there are significant differences in cytokine activity in peri-implant crevicular fluid (PICF) between implants restored in an edentulous patient (ES) and implants restored in a dentate patient (DS).;Methods: In this pilot study, peri-implant crevicular fluid was obtained from sixteen total patients --eight dentate patients restored with fixed restoration implants and eight edentulous patients restored with implant retained overdenture. Paper points were used to obtained the peri-implant GCF and then were processed using the MSD Meso Quickplex SQ 120 machine. A 96-well Proinflammatory Panel 1 (human) Kit …

The Analysis Of The Fatty Acid Content Of Fingerprint Residues Using Gas Chromatographymass Spectrometry, Ashley R. Cochran

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the recurring issues in the practice of forensic science is human subjectivity, especially within the field of fingerprint examination. Smudged fingerprints at crime scenes that contain little to no ridge detail often cause problems for examiners who, in turn, are unable to make identifications or exclusions in the absence of DNA markers. In recent years, researchers have explored the chemical composition of fingerprint residues to either provide an alternative means for including or excluding potential donors, or to provide investigative leads. Research into the chemical composition of fingerprints has shown that it may be possible to determine sex, …

Locked Up: Parallel Correctional Officer, Deputy, And Inmate Decision-Making Experiences In County Jails, Mariko Catherine Peshon

Dissertations

Recidivism is a complex phenomenon. Greater than 65 percent of incarcerated adults return to jail within three years. While numerous empirical studies focus on factors that contribute to recidivism, there is limited existing research that examines decision-making as one of these factors. The purpose of this study is to address this gap in the literature and develop an understanding of the influence of decision-making processes on inmates and correctional officers and deputies in the California criminal justice system. An exploratory 2014 pilot study at three California county jails found correctional officers and inmates faced similar challenges related to decision-making as …

A Movement Against And Beyond Boundaries: Exploring The Impact Of Transgressive Teaching On The Student Affairs Practices Of White, Heterosexual Men, Conor Mclaughlin

Dissertations

Transgressive teaching can have a substantive and transformative impact on the experiences of students in primary, secondary, and higher education classrooms. Transgressive teaching is exemplified by the engaged pedagogy outlined by bell hooks in the seminal work Teaching to Transgress, in which teachers seek to engage spaces of learning in deeper and more holistic ways. Scholars have theorized transgressive teaching, when implemented by student affairs professionals, can have similar effects on the experiences of students, especially those from identity groups which have historically been marginalized in higher education. However, there is a limited understanding of the experiences of student affairs …