Digital Commons Network^™

Multifaceted Role Of Neuropilins In The Immune System: Potential Targets For Immunotherapy., Sohini Roy, Arup K. Bag, Rakesh Singh, James E. Talmadge, Surinder K. Batra, Kaustubh Datta

Journal Articles: Biochemistry & Molecular Biology

Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 (NRP1) and neuropilin-2 (NRP2), mainly act as coreceptors for class III Semaphorins and for members of the vascular endothelial growth factor family of molecules and are widely known for their role in a wide array of physiological processes, such as cardiovascular, neuronal development and patterning, angiogenesis, lymphangiogenesis, as well as various clinical disorders. Intriguingly, additional roles for NRPs occur with myeloid and lymphoid cells, in normal physiological as well as different pathological conditions, including cancer, immunological disorders, …

On The Origin Of Superoxide Dismutase: An Evolutionary Perspective Of Superoxide-Mediated Redox Signaling., Adam J. Case

Journal Articles: Cellular & Integrative Physiology

The field of free radical biology originated with the discovery of superoxide dismutase (SOD) in 1969. Over the last 5 decades, a plethora of research has been performed in species ranging from bacteria to mammals that has elucidated the molecular reaction, subcellular location, and specific isoforms of SOD. However, while humans have only begun to study this class of enzymes over the past 50 years, it has been estimated that these enzymes have existed for billions of years, and may be some of the original enzymes found in primitive life. As life evolved over this expanse of time, these enzymes …

Investigation Of Co2 Sequestration For The Assessment Of The Impact On Resource Storage With Co-Production Of Brine, Mohammad Junaid Ashfaq

Graduate Theses, Dissertations, and Problem Reports (ETD)

In order to reduce Green House Gases, Carbon-dioxide (CO2) storage in deep saline aquifers is a viable commercial application for minimizing emissions. It is important to understand surface area needed to predict large scale CO2 storage while fully utilizing injection capacity. This study presents results from varying Injection pressure and well spacing to find minimal-effective well spacing required to store CO2. The study shows pressure management to manipulate hydrodynamic behavior of CO 2 in saline formations system. In conjunction, understanding the interplay of CO2 dissolution, buoyancy flow, and capillary forces in regulating the behavior of the injected CO2 plume are …

Associations Between Sleep, Infant Feeding Methods, Brain Development And Behavior: A Multimodal Approach To Assess Plasticity In The Brain, Christopher Edward Bauer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Purpose: Sleep-disordered breathing (SDB) is a spectrum disorder that is estimated to effect a significant proportion of the pediatric population (1-3% in USA). SDB is able to disrupt and fragment sleep through frequent arousals and intermittent hypoxia. In addition, the long term effects of SDB in pediatrics have been well-documented; decreases in intelligence quotient (IQ), executive function, school performance, and alertness have all been observed. Although surgical treatments can be quite effective, there are no widely accepted prophylactic measures to prevent SDB development. Recently, breastfeeding duration in infancy has been demonstrated to be correlated with reduced SDB (lower AHI, RAI, …

Immunological Markers Detected In Peri-Implant Crevicular Fluid Detected By Msd Electromagnetic Elisa Assay - A Pilot Study Of Dental Implant Patients, Paul Canallatos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Objectives: The purpose of this pilot study is to determine if, in healthy states, there are significant differences in cytokine activity in peri-implant crevicular fluid (PICF) between implants restored in an edentulous patient (ES) and implants restored in a dentate patient (DS).;Methods: In this pilot study, peri-implant crevicular fluid was obtained from sixteen total patients --eight dentate patients restored with fixed restoration implants and eight edentulous patients restored with implant retained overdenture. Paper points were used to obtained the peri-implant GCF and then were processed using the MSD Meso Quickplex SQ 120 machine. A 96-well Proinflammatory Panel 1 (human) Kit …

The Analysis Of The Fatty Acid Content Of Fingerprint Residues Using Gas Chromatographymass Spectrometry, Ashley R. Cochran

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the recurring issues in the practice of forensic science is human subjectivity, especially within the field of fingerprint examination. Smudged fingerprints at crime scenes that contain little to no ridge detail often cause problems for examiners who, in turn, are unable to make identifications or exclusions in the absence of DNA markers. In recent years, researchers have explored the chemical composition of fingerprint residues to either provide an alternative means for including or excluding potential donors, or to provide investigative leads. Research into the chemical composition of fingerprints has shown that it may be possible to determine sex, …

Locked Up: Parallel Correctional Officer, Deputy, And Inmate Decision-Making Experiences In County Jails, Mariko Catherine Peshon

Dissertations

Recidivism is a complex phenomenon. Greater than 65 percent of incarcerated adults return to jail within three years. While numerous empirical studies focus on factors that contribute to recidivism, there is limited existing research that examines decision-making as one of these factors. The purpose of this study is to address this gap in the literature and develop an understanding of the influence of decision-making processes on inmates and correctional officers and deputies in the California criminal justice system. An exploratory 2014 pilot study at three California county jails found correctional officers and inmates faced similar challenges related to decision-making as …

A Movement Against And Beyond Boundaries: Exploring The Impact Of Transgressive Teaching On The Student Affairs Practices Of White, Heterosexual Men, Conor Mclaughlin

Dissertations

Transgressive teaching can have a substantive and transformative impact on the experiences of students in primary, secondary, and higher education classrooms. Transgressive teaching is exemplified by the engaged pedagogy outlined by bell hooks in the seminal work Teaching to Transgress, in which teachers seek to engage spaces of learning in deeper and more holistic ways. Scholars have theorized transgressive teaching, when implemented by student affairs professionals, can have similar effects on the experiences of students, especially those from identity groups which have historically been marginalized in higher education. However, there is a limited understanding of the experiences of student affairs …

The Lived Experience Of Intersectionality Among African American Women With Breast Cancer, Teri D. Armour Burton

Dissertations

African American women (AAW) continue to have breast cancer mortality rates that are 42% higher than White women (De Santis et al., 2015). Researchers suggest that an epistemological approach that integrates the biomedical and feminist models would be more effective in addressing health disparities. The concept of intersectionality, which grew out of the Black feminist movement, provides a lens in which to view the lived experiences of AAW with breast cancer. The intersectionality paradigm attempts to address the marginalized, oppressive, intersecting social existence of AAW through the examination of identity, social class, and power.

This qualitative study applied a descriptive …

Second-Generation Thai American Women's Perceptions On Cervical Cancer Screening, Essie Asawapornmongkol

Dissertations

Background: Cervical cancer is one of the most preventable diseases in the United States (US) (Center for Disease Control and Prevention, 2015a). Despite advances in early detection and a vaccine available, it continues to affect Southeast Asian American (SEAA) women in high numbers. Multiple barriers to cervical cancer screening are seen among SEAA women, which include acculturation, age, marital status, apprehension, financial burden, access to healthcare, and knowledge about cervical cancer, screening, and preventative health (Ho & Dinh, 2010). Studies on SEAA women and cervical cancer screening primarily involve women who were born in Southeast Asia. These studies have not …

Blatt V. Cabela's Retail, Inc. And A New Path For Transgender Rights, Kevin M. Barry, Jennifer L. Levi

Faculty Scholarship

Since the Supreme Court recognized marriage equality in Obergefell v. Hodges, civil rights advocates have increasingly set their sights on transgender rights as the next legal frontier. Sex discrimination law, though an essential statutory tool, is not the only potential avenue for securing rights for transgender individuals. Another important federal source of protection for transgender people is disability rights law—in particular, the Americans with Disabilities Act (ADA). Disability rights law, unlike sex discrimination law, applies to public accommodations and government services, and also mandates reasonable accommodations. A transgender litigant successfully invoked the protections of the ADA for the first time …

Challenging Gender In Single-Sex Spaces: Lessons From A Feminist Softball League, Erin E. Buzuvis

Faculty Scholarship

This Article explores transgender inclusion within adult recreational women’s leagues by using the example of the Mary Vazquez Women’s Softball League (MVWSL), in Northampton, Massachusetts. A MVWSL policy addressing transgender inclusion became necessary due to a noticeable increase in gender-identity diversity. The resultant policy respects the league’s core lesbian constituency by providing individuals with the freedom to acknowledge openly a gender identity that has or is evolving from lesbian to something else, and reflects the league’s founding feminist principles by refusing to define for others the suitability of a women’s community.

The Author demonstrates the successful creation of a policy …

First Nations And Adaptive Water Governance In Southern Ontario, Canada, Thomas Dyck

Theses and Dissertations (Comprehensive)

Water quality and quantity are prominent concerns for First Nations across Canada. The federal government shares the responsibility with First Nations to ensure water resources on-reserves meet the needs of First Nations. Federal approaches have been predominantly technical, focused on addressing issues related to infrastructure, maintenance, training, and monitoring. This approach is important. However, water issues concerning First Nations go beyond technical issues and relate to inadequate participation in decision making, poorly defined roles and responsibilities, and approaches to managing water resources on-reserve that have not accounted for local context. These issues parallel historical nation-to-nation (i.e., First Nations and federal …

Sedentary Behaviour, Physical Activity, And Mobile Apps Among University Students, Emily E. Dunn

Theses and Dissertations (Comprehensive)

Prolonged sedentary behaviour (SB) poses health risks independent of physical activity (PA) levels (Owen et al., 2010). University students in particular are at risk of engaging in prolonged SB due to the demands of school. Due to the pervasiveness of smartphones, and ability of mobile applications (apps) to target SB (Bond et al., 2014), apps may be used to encourage less SB in this population. Apps for PA have been coded for behaviour change techniques (BCTs) (Conroy et al., 2014; Middelweerd et al., 2014; Yang et al., 2015), however, apps for SB have yet to be assessed for BCTs.

The …

Family Resource Allocation After Firstborns Leave Home: Implications For Secondborns’ Academic Functioning, Alexander C. Jensen Phd, Shawn D. Whiteman, Julia M. Bernard, Susan M. Mchale

Faculty Publications

This study assessed secondborn adolescents’ perceptions of changes in the allocation of family resources following their firstborn siblings’ departure from home after high school, and whether perceived changes were related to changes over 1 year in secondborns’ academic functioning. Participants were secondborn siblings (mean age = 16.58, SD = 0.91) from 115 families in which the older sibling had left the family home in the previous year. Allocation of resources was measured via coded qualitative interviews. Most (77%) secondborns reported increases in at least one type of family resource (i.e., parental companionship, attention, material goods), and many reported an increase …

Racial Identity, Phenotype, And Self-Esteem Among Biracial Polynesian/White Individuals, Kawika Allen, Patton O. Garriott, Carla J. Reyes, Catherine Hsieh

Faculty Publications

This study examined racial identity, self-esteem, and phenotype among biracial Polynesian/White adults. Eighty-four Polynesian/White persons completed the Biracial Identity Attitude Scale, the Rosenberg Self-Esteem Inventory, and a Polynesian phenotype scale. Profile analyses showed participants identified more with their Polynesian parent. A mediation analysis revealed that phenotype did not mediate the relationship between biracial identity and self-esteem.

Effects Of Speech Intensity On Acoustic And Kinematic Articulatory Working Space, Christopher Dromey, Panika Palmer, Jason Whitfield

Faculty Publications

Acoustic measures calculated from the formant frequencies of corner vowels, such as the vowel space areas of triangles or quadrilaterals, have often been used as a window into articulatory function. Other measures, such as the formant centralization ratio (Sapir, Ramig, Spielman, & Fox, 2010), have been suggested as more sensitive alternatives. The purpose of this study was to compare changes in acoustic and kinematic measures of articulation across soft, comfortable, and loud speech conditions using both corner vowel-based and sentence level metrics. There were 19 participants, 9 male and 10 female, with ages ranging from 20 to 34 years. Each …

When Military Fitness Standards No Longer Apply: The High Prevalence Of Metabolic Syndrome In Recent Air Force Retirees, Marcus M. Cranston, Mark W. True, Jana L. Wardian Phd, Rishawn M. Carriere, Tom J. Sauerwein

Journal Articles: Hospital Medicine

BACKGROUND: Metabolic syndrome (MetS) is strongly associated with cardiovascular disease. With MetS prevalence rates increasing in the U.S. population, prevention efforts have largely focused on diet and exercise interventions. Before retirement, military service members have met fitness requirements for at least 20 years, and have lower MetS rates compared to age-matched U.S. population controls (23.4% vs. 39.0%), which suggests a protective effect of the lifestyle associated with military service. However, MetS rates in military retirees have not been previously reported, so it is unknown whether this protective effect extends beyond military service. The purpose of this study was to examine …

One Day This Kid Will Get Larger, Danny Orendorff

DePaul Art Museum Publications

One day this kid will get larger
Edited by Danny Orendorff
Designed by Charles Ryan Long

Table of Contents
Director’s Forward – Julie Rodrigues Widholm
One day this kid will get larger – Danny Orendorff
Artist Project: Untitled (our fight has just begun) – Rami George
“For My Daughter” – Shan Kelley
“On Borrowed Time – Revisited” – Katja Heinemann
“Reflections On Another Image: Black Teens Coming of Age” – Lenn Keller
Artist Project: A Repetition of Survival – Demian DinéYazhi’
Artist Project: You Came Here – Demian DinéYazhi’

Study Potential Of Indigenous Pseudomonas Aeruginosa And Bacillus Subtilis In Bioremediation Of Diesel-Contaminated Water, Mohammad-Saeed Safdari, Hamid-Reza Kariminia, Zahra Ghobadi Nejad, Thomas H. Fletcher

Faculty Publications

Petroleum products which are used in a wide variety of industries as energy sources and raw materials have become a major concern in pollution of terrestrial and marine environments. The purpose of this study was to assess the potential of indigenous microbial isolates for degradation of diesel fuel. Two most proficient bacterial strains among five isolated strains from polluted soil of an industrial refinery were studied. The isolates then were identified as Pseudomonas aeruginosa and Bacillus subtilis using biochemical tests and 16S rRNA gene sequence analyses. P. aeruginosa showed higher biodegradation efficiency than B. subtilis in shaking flask containing diesel-contaminated …

Without The White Coat: An Analysis Of Pathographies By Physicians With Cancer, Jonathan H. Ryder

EMET Projects

No abstract provided.

Muc1 Facilitates Metabolomic Reprogramming In Triple-Negative Breast Cancer, Gennifer Goode, Venugopal Gunda, Nina V. Chaika, Vinee Purohit, Fang Yu, Pankaj K. Singh

Journal Articles: Eppley Institute

BACKGROUND: Mucin1 (MUC1), a glycoprotein associated with chemoresistance and an aggressive cancer phenotype, is aberrantly overexpressed in triple-negative breast cancer (TNBC). Recent studies suggest that MUC1 plays a role in modulating cancer cell metabolism and thereby supports tumor growth. Herein, we examined the role of MUC1 in metabolic reprogramming in TNBC.

METHODS: MUC1 was stably overexpressed in MDA-MB-231 TNBC cells and stably knocked down in MDA-MB-468 cells. We performed liquid chromatography-coupled tandem mass spectrometry-assisted metabolomic analyses and physiological assays, which indicated significant alterations in the metabolism of TNBC cells due to MUC1 expression.

RESULTS: Differential analyses identified significant differences in …

Genomic Alterations In Mucins Across Cancers, Ryan King, Fang Yu, Pankaj K. Singh

Journal Articles: Eppley Institute

The significance of mucins in cancers has led to the development of novel biomarkers and therapeutic agents against cancers. Despite significant advances in the understanding of mucins, systemic investigations into the role of mucins in cancer biology focusing particularly on the histological subtypes and stages, along with other variables, are yet to be carried out to discover potential novel functions and cancer-specific roles. Here, we investigated 11 mucin expressing cancers for DNA mutations, mRNA expression, copy number, methylation, and the impacts these genomic features may have on patient survival by utilizing The Cancer Genome Atlas dataset. We demonstrate that mucin …

God Cannot Do Without America: Matthew Simpson And The Apotheosis Of Protestant Nationalism, Darius Salter

Academic Books

No abstract provided.

Teaching Christian Mission In An Age Of World Christianity, Robert A. Danielson, Linda Whitmer

Academic Books

No abstract provided.

Randomized Trial Of Two Doses Of Vitamin D3 In Preterm Infants <32 Weeks: Dose Impact On Achieving Desired Serum 25(Oh)D3 In A Nicu Population., Ann Anderson-Berry, Melissa Thoene, Julie Wagner, Elizabeth Lyden, Glenville Jones, Martin Kaufmann, Matthew Van Ormer, Corrine K. Hanson

Journal Articles: Pediatrics

BACKGROUND: Recommendations for vitamin D supplementation for preterm infants span a wide range of doses. Response to vitamin D supplementation and impact on outcomes in preterm infants is not well understood.

OBJECTIVE: Evaluate serum 25(OH)D3 concentration changes after 4 weeks in response to two different doses of vitamin D3 supplementation in a population of premature infants and quantify the impact on NICU outcomes.

DESIGN: 32 infants born at 24-32 weeks gestation were prospectively randomized to receive 400 or 800 IU/day vitamin D3 supplementation. Serum 25(OH)D3 levels were measured every 4 weeks. The Wilcoxon signed rank test was used to compare …

Ultrasound-Induced Microbubble Cavitation For The Treatment Of Catheterization-Induced Vasospasm, Shelby Kutty, Na Liu, Jia Zhou, Yunbin Xiao, Juefei Wu, David A. Danford, John Lof, Feng Xie, Thomas R. Porter

Journal Articles: Pediatrics

No abstract provided.

Atrial Fibrillation Induction In A Pediatric Patient During Adenosine Administration, Jeffrey A. Robinson, Christopher S. Snyder

Journal Articles: Pediatrics

Adenosine by rapid intravenous bolus is frequently utilized in clinical practice as both a pharmacologic treatment for supraventricular (reentrant) tachycardia and in provocative testing for the diagnosis of Wolff-Parkinson-White (WPW) syndrome. This is a case report of an otherwise healthy adolescent female who received adenosine during a provocative test for WPW syndrome. Immediately after receiving adenosine, the patient had a self-limited episode of atrial fibrillation. When administering adenosine, teams should be aware of the potential adverse effects and be prepared to treat appropriately.

Astroturf Activism, Melissa (M.J.) Durkee

Scholarship@WashULaw

Corporate influence in government is more than a national issue; it is an international phenomenon. For years, businesses have been infiltrating international legal processes. They secretly lobby lawmakers through front groups: “astroturf” imitations of grassroots organizations. But because this business lobbying is covert, it has been underappreciated in both the literature and the law. This Article unearths the “astroturf activism” phenomenon. It offers an original descriptive account that classifies modes of business access to international officials and identifies harms, then develops a critical analysis of the laws that regulate this access. I show that the perplexing set of access rules …

Data-Driven Discrimination At Work, Pauline Kim

Scholarship@WashULaw

A data revolution is transforming the workplace. Employers are increasingly relying on algorithms to decide who gets interviewed, hired, or promoted. Although data algorithms can help to avoid biased human decision-making, they also risk introducing new sources of bias. Algorithms built on inaccurate, biased, or unrepresentative data can produce outcomes biased along lines of race, sex, or other protected characteristics. Data mining techniques may cause employment decisions to be based on correlations rather than causal relationships; they may obscure the basis on which employment decisions are made; and they may further exacerbate inequality because error detection is limited and feedback …