Digital Commons Network^™

Association Between Diabetes And Cancer In Indian And Us Populations Using Longitudinal Study Design, Shraddha S. Vyas

Theses and Dissertations

Background: There is growing evidence of association between diabetes and cancer. No studies have been conducted in India evaluating this association. With the current epidemiologic, nutritional and economic transition in India, it becomes extremely important to examine this association in an Indian population. Additionally, difference in association exists based on different cancer subtypes. Research has shown that diabetes is associated with an increased risk of colorectal cancer. However most of these studies suggest detection bias to be one of the probable reasons for this association. Additionally, the common risk factors shared by both these conditions are considered to one of …

Association Of Gestational Weight Gain During Twin Gestations And Adverse Maternal Outcomes, Kerry Spillane

Theses and Dissertations

Objective: To examine the association between gestational weight gain (GWG) in twin gestations and the odds of adverse maternal outcomes.

Setting and Participants: Study population included 3,081 women with a twin gestation delivered between 23-42 gestational weeks from 19 hospitals across the United States (2002-2008) participating in the Consortium on Safe Labor (CSL) study.

Main Outcomes: Main outcomes of interest included: gestational hypertension, preeclampsia, gestational diabetes mellitus, and cesarean delivery.

Methods: Quantile regression estimated the 25th and 75th percentiles of total GWG, respective of pre-pregnancy BMI and gestational age at delivery, and was used to create our new total GWG …

Simulation-Based Interprofessional Education In A Rural Setting, Ann D. Scott

Theses and Dissertations

The purpose of this project was to examine the feasibility and acceptability of a simulation-based IPE experience for pre-licensure nursing, pharmacy, and medical students on a rurally-located campus. Using a mixed-methods, explanatory sequential approach, this project: 1) examined the feasibility of implementing a simulation-based IPE experience using telehealth tools; and 2) evaluated student perceptions of inter-professional teamwork, roles and responsibilities, and patient outcomes for collaborative practice, both pre- and post-scenario.

Quantitative data were analyzed using SPSS. Results revealed 94% agreed/strongly agreed the IPE experience resembled a real-life situation. 100% of nursing/medical students and 80% of the pharmacy students indicated they …

Nondestructive Evaluation And Health Monitoring Of Adhesively Bonded Composite Structures, William Walker Roth

Theses and Dissertations

As the growth of fiber reinforced composite materials continues in many industries, structural designers will have to look to new methods of joining components. In order to take full advantage of composite materials, such as increased stiffness, decreased weight, tailored material properties and increased fatigue life, mechanical fasteners will need to be replaced by adhesive bonding or welding, when possible. Mechanical fasteners require the drilling of holes, which damages the laminate and becomes the source of further fatigue damage. Also, an increase in laminate thickness or inclusion of other features is required for the material to withstand the bearing stress …

Paleodemographic And Biochemical Analysis Of Urbanization, Famine, And Mortality, Brittany S. Walter

Theses and Dissertations

Urbanization is a transitional period often associated with deteriorating population health and increased mortality, as the rapid increase of population density in urban centers facilitates the transmission of infectious diseases, unsanitary living conditions, and precarious food supplies. Research on the transition to an urban environment in the past offers a temporal depth to our understanding of the consequences of urbanization that cannot be accomplished through examination of contemporary populations. This project integrates paleodemographic (hazard analysis) and biochemical (stable isotope analysis) approaches to examine the health and diet of inhabitants in late medieval England (c. 1120-1539 CE), specifically the relationship between …

Maternal Physical Activity And Cardiorespiratory Fitness During Pregnancy And Its Relation To Infant Size, Samantha M. Mcdonald

Theses and Dissertations

Recent evidence indicates that U.S.-born infants are larger today compared to 20 years ago. A strong determinant of neonatal size is maternal body mass, where larger mothers deliver larger infants. Consistent evidence indicates that higher levels of maternal physical activity (PA) during pregnancy reduce the risk of delivering a larger infant. However, this protective effect has only been demonstrated in normal weight pregnant women. Little is known about the relationship between maternal PA and neonatal size in overweight or obese pregnant women. Moreover, no studies have examined the association between maternal cardiorespiratory fitness (CRF), an indicator of habitual PA, on …

Children’S Obesogenic Behaviors During Summer Versus School, Keith Brazendale

Theses and Dissertations

Emerging evidence shows children gain 3-5 times the amount of weight and lose cardiorespiratory fitness (CRF) during summer compared to the 9-months of the school year. Notably, this trend is more pronounced in children who are already overweight or obese going into summer and/or from low-income ethnic minority households. There is little evidence to investigating the underlying mechanisms driving the pronounced occurrence of these negative health outcomes during summer.

The purpose of this dissertation as a whole was to investigate children’s obesogenic behaviors (physical activity, sedentary/ screen time, sleep, and diet) during summer versus school, and compare any differences in …

Stilbenes: Therapeutic Interventions Targeting Amyloid Β Protein Aggregation In Alzheimer’S Disease, Yiying Wang

Theses and Dissertations

Alzheimer’s disease (AD) is the most common form of dementia and accounts for 60-80 % of all dementia cases. In the United States, AD is ranked as the 6th leading cause of death and it is the only one among the top 10 that cannot be prevented, treated or even slowed. All FDA approved drugs focus on attenuating the symptoms for a limited time by regulating neurotransmitters without any intervention with the underlying disease process. A major player in the initiation and development of this debilitating disorder is the misfolding and subsequent aggregating of amyloid-β (Aβ) peptide. This aggregation process …

The Nature Of Power And Corruption In Plato And J.R.R. Tolkien, Lily Howard-Hill

Theses and Dissertations

In the collected dialogues of Plato, Plato sets out his arguments on democracy, power, and free-will through Socrates’ interactions with his interlocutors. His understandings of morality and justice suggest that a good and moral person is the foundation for successful societies. In The Hobbit, The Lord of the Rings, and other tales, Tolkien offers a different lens through which to observe philosophical and ethical concepts. Plato’s morality is centered around the organization and the structure of the soul. The soul is ruled by virtues which include justice and knowledge. Here, I present an analysis of key Platonic concepts by offering …

Framing Marijuana: A Study Of How Us Newspapers Frame Marijuana Legalization Stories And Framing Effects Of Marijuana Stories, Hwalbin Kim

Theses and Dissertations

The current study was initially designed to look at how the issue of marijuana legalization was presented in U.S. newspapers and how news frames could influence the audiences’ attitudes or behavioral intentions. To investigate these questions, two different types of research methods were employed: content analysis and experiment. Using framing theory as a theoretical framework, this study found that marijuana legalization has been largely described as a legislation issue or a law enforcement issue, and medical benefit and medical risk were most frequently mentioned attributes to support and oppose marijuana legalization. Findings indicated that news frame could influence the public’s …

Print Referencing Intervention During Shared Storybook Reading For Preschool Children With Hearing Loss, Sara Lawrence

Theses and Dissertations

The purpose of the current study was to evaluate the effectiveness of a print referencing book-reading intervention among children with hearing loss. Two preschool children with hearing loss who are developing listening and spoken language participated in this single subject study. The children participated individually in print referencing book-reading intervention (10 minute session once a week for 7 weeks). Assessment of children’s print knowledge skills occurred at the beginning of each session. Print referencing book-reading intervention was associated with gains in conceptual print knowledge. Further study is needed in this area.

Identifying Associations Between Religious Commitment And Preventive Health Behaviors In A Southeastern Rural County, Nathan A. Peters

Theses and Dissertations

Health disparities within the United States (US) are continuing to impact ethnic minorities living in rural areas nationwide. In response, there is growing interest in using faith-based settings as vehicles to deliver much needed disease prevention interventions. However, few studies have identified the relationship between private and public religious commitment, individually, and the behaviors or risk factors associated with chronic disease. The purpose of this study was to observe the association between religious commitment, both private (i.e., time spent trying to grow in one’s religious understanding) and public (i.e., frequency of attendance, time spent in fellowship with others) individually, and …

Multinational Foreign Affiliates In The Least Developed Countries: A Multilevel Approach, R. Scott Hibbs

Theses and Dissertations

Several studies have examined the country-level effects on multinational enterprises that go into the developing countries, including the least developed countries. Few studies have considered the firm-level effects. This study uses the multilevel modeling method as outlined by Klein and Kozlowski (2000), Raudenbush and Bryk (2002), and Bliese and Hanges (2004) to examine whether there are any systemic patterns of multinational enterprises across the least developed countries. This paper uses information on foreign affiliates in the least developed countries to examine the overall trends of multinational firms in the least developed countries. Using data from the United Nations’ most recent …

Effects Of A Mindfulness Based Intervention On Diurnal Cortisol In Cancer Survivors, Susannah Small

Theses and Dissertations

Background. There are approximately 15.5 million individuals alive today in the U.S. with a personal history of cancer. For this large and growing population, ill effects associated with cancer diagnosis and treatment include both physical and psychosocial symptoms adversely affecting quality of life. One low-risk alternative to conventional pharmaceutical use in treating these symptoms is mindfulness practice. Research on self-reported measures provides strong evidence that this type of intervention improves quality of life for cancer survivors, but evidence of impact on objective measures is limited. Cortisol, the body’s primary stress hormone, is one relatively easy to measure indicator that …

Assessing The Relationship Between Periodontal Disease And Subsequent Inflammatory Responses And Headache Disorders, Bryn E. Davis

Theses and Dissertations

Headaches are the sixth leading cause of disability worldwide, and the third leading cause of disability amongst those aged 50 and older. Several headache disorders, including migraines, have been associated with nitric oxide production. It is widely accepted that the pain associated with headache disorders is due to the ability of nitric oxide to function as a vasodilator. While nitric oxide is a known vasodilator and has been linked to headache disorder, it is also produced in response to bacterial infections. Periodontal disease is the result of long term bacterial infections occurring in the gum line and nitric oxide is …

Comparison Of Atypical Bacteriophages That Infect Caulobacter Crescentus, Doreen Nguyen

Theses and Dissertations

Several Caulobacter bacterial genomes have been recently sequenced, and all of the genomes contained one or more clusters of genes with phage origins. This observation indicates that bacteriophages contribute to the Caulobacter gene pool, so in order to understand bacteria genomes we will need to understand phage genomes as well. As part of understanding the phage genomes, we want to isolate novel bacteriophages and study their genomics. This study resulted in the isolation of 12 new phages, including four that differ from the well-studied CbKlike phages. Two of these novel phages are Podoviruses with icosahedral heads and small tails, and …

Characterization Of Subgrade Resilient Modulus For Mepdg And The Effects On Pavement Rutting, Md Mostaqur Rahman

Theses and Dissertations

In 2008, the American Association of State Highway and Transportation Officials (AASHTO) released a modified pavement design method (i.e., the Mechanistic Empirical Pavement Design Guide (MEPDG)) based on Long Term Pavement Performance (LTPP) data from all over the United States. The MEPDG default design parameters developed from the LTPP database are expected to be significantly different than those for South Carolina material, traffic and weather conditions, thus the default design parameters may not be accurate for South Carolina. Therefore, the new pavement design method should be calibrated for South Carolina conditions by performing MEPDG local calibration.

Different input variables should …

A Possible Mechanism For Leptin’S Role In Lung Function Independent Of Body Mass Index: Investigating Leptin’S Genotype, Dna, Methylation, And Serum Protein Levels, Mitra Yousefi

Theses and Dissertations

Background: Leptin, initially believed to simply be a satiety hormone responsible for obesity, is now recognized as a pleiotropic cytokine that is involved in many biological processes; including the body’s host inflammatory response. Clinically, leptin may affect lung function although research in this area is limited. It is also known that the leptin receptor is necessary for the activation of the leptin protein, making it an important protein to consider. Furthermore, single nucleotide polymorphisms (SNPs) and DNA methylations of the leptin and leptin receptor genes (LEP and LEPR respectively) may provide important insight on the relationship that leptin has …

Examining The Evolution Of A Teacher Induction Program In A Diverse, Urban, Southeastern School District, Karen Pack

Theses and Dissertations

Educational institutions struggle to increase student achievement. While the educational needs of students remain at the forefront, teachers’ needs must also be met—before and after entering the classroom. My experience in public education has shown most beginning teachers depend on the support a teacher induction program provides to manage the multitude of new responsibilities faced during the first year in the classroom. Induction programs are constructed and implemented within school districts in a variety of ways. This study is an in-depth analysis that identifies factors that impacted an effective teacher induction program, examines how the program changed as a result, …

The Effect Of Energy-Matched Exercise Intensity On Brain-Derived Neurotrophic Factor And Motor Learning, Jessica F. Baird

Theses and Dissertations

Brain plasticity is important to motor learning, and is a critical component of motor rehabilitation. Exercise prior to motor training may facilitate plasticity by increasing brain-derived neurotrophic factor (BDNF). However, many studies that have investigated exercise-enhanced plasticity have assessed motor skill performance on tasks involving single finger button presses or small movements of a joystick, results that may not relate to more complex, real-world movements. Additionally, while high-intensity exercise has been shown to benefit motor learning, the effects of low-intensity exercise have yet to be fully investigated. A bout of low-intensity exercise, when completed at an energy expenditure that is …

“An Uphill Battle”: Psychosocial Health And Self-Care Among Advocates Who Work Against Gender-Based Violence In South Carolina, Ebru Cayir

Theses and Dissertations

Gender-based violence (GBV) is one of the most pressing public health and human rights issues in the United States overall, and more specifically, in South Carolina (SC). SC consistently ranked among the highest in the nation in terms of female homicide rates. Non-profit organizations (NPOs) that focus their work specifically on GBV constitute an essential component of prevention and mitigation efforts in SC. Advocates who work for GBV-specific NPOs experience a wide range of psychosocial health and well-being benefits and risks due to their work. This study aimed to: 1) Identify the relationships between engaging in paid GBV-specific advocacy and …

Patterns Of Participation And Performance In Youth Baseball Players, Amanda Arnold

Theses and Dissertations

Baseball is a popular sport to play in the United States, with approximately 13-17 million athletes participating across all levels of competition. Youth (9-12 years) and adolescent (13-18 years) players comprise the majority of this population playing at the club and high school levels, yet less than 10% of research studies include athletes <18 years old. Despite increased awareness of the risks surrounding sports participation, youth and adolescent baseball players continue to report overuse injuries at alarming rates.

The lack of high-quality research describing athletic performance and injury risk factors, such as sport specialization, in young athlete populations poses a significant knowledge gap in the literature. The current investigation sought to establish the incidence of upper extremity (UE) injuries while examining population-specific risk factors in …

Environmental Relationships And Predator-Prey Interactions Within The Snapper-Grouper Complex In The Southeastern U.S. Atlantic – Implications For Fisheries Management, Dawn M. Glasgow

Theses and Dissertations

Stock assessments indicate many valuable fish species are declining, or are considered overfished and/or are undergoing overfishing. Fisheries scientists and managers in the southeastern U.S. typically have utilized a single-species approach, and relied on catch per unit effort data derived from fishery-independent surveys to determine indices of abundance for economically important reef fish. However, catchability for these surveys vary for many reasons including environmental and predator-prey relationships. This research was developed to elucidate environmental influences on reef fish assemblages and distribution of reef-associated marine predators, and examine predator-prey dynamics that may influence relative abundance of large predators based on chevron …

Marine Phosphorus Biogeochemistry Ecological Insights From Analytical Chemistry, Douglas W. Bell

Theses and Dissertations

The supply of phosphorus (P) directly impacts the growth and speciation of marine microbes (i.e., phytoplankton, bacteria, Archaea). In turn, microbial communities shape the magnitude and rate of marine biogeochemical cycles, ultimately affecting global climate and food production. This dynamic reflects the continuum of temporal and spatial scales at which the marine P cycle operates. However, linking multiple scales of cycling remains a consistent challenge. The primary objective of my dissertation was to gain insight into marine P biogeochemistry, by means of analytical chemistry, at the molecular and environmental scales of cycling. The first component of my research was to …

Mercury Bioaccumulation In Three Popular Subsistence And Recreational Estuarine Fishes From Southeastern U.S.A., Taylor Cannon

Theses and Dissertations

A rising concern in recent years has occurred over the presence of methylmercury in seafood, particularly fishes, and its impact on human health. However, fish also provide many health benefits, including improved cardiovascular health and neurodevelopment. Because fishes are the main source of methylmercury exposure to humans, and are such an integral part of the human diet, understanding the risks versus the benefits of fish consumption is imperative in allowing the public to make healthy, educated choices. One way that state and federal governments attempt to do this is through issuing fish consumption advisories. Unfortunately, these advisories do not always …

Blind Change Point Detection And Regime Segmentation Using Gaussian Process Regression, Sourav Das

Theses and Dissertations

Time-series analysis is used heavily in modeling and forecasting weather, economics, medical data as well as in various other fields. Change point detection (CPD) means finding abrupt changes in the time-series when the statistical property of a certain part of it starts to differ. CPD has attracted a lot of attention in the artificial intelligence, machine learning and data mining communities. In this thesis, a novel CPD algorithm is introduced for segmenting multivariate time-series data. The proposed algorithm is a general pipeline to process any high dimensional multivariate time-series data using nonlinear non-parametric dynamic system. It consists of manifold learning …

Cable Health Monitoring System Built Into Power Converter Using Time Domain Reflectometry, Hossein Baninajar

Theses and Dissertations

Aging cables are a critical reliability concern for many electrical systems. Cables run over long distances, are often exposed to harsh environments and are intended to work for several decades. Cable faults can be a serious problem because cables are usually hard to repair or replace. Condition based maintenance is a popular approach that provides high reliability and low maintenance cost at the same time. This is a non-destructive method that collects information about the health condition of the cable under test without causing any potential damage.

Nowadays, in several applications power cables are connected to power converters and it …

Emergence Of Stranger Fear In Preschoolers With Fragile X Syndrome And Idiopathic Autism Spectrum Disorder, Jessica Scherr

Theses and Dissertations

This study investigated multiple behavioral indicators of social fear and their relationship to symptoms of autism in preschool boys with atypical and normative development using a stranger approach design. Participants consisted of 101 male preschoolers that were categorized into four groups: boys with fragile X syndrome (FXS; N= 29), FXS with elevated autism symptoms (fxASD; N = 25), idiopathic autism spectrum disorder (iASD; N = 11), and typically developing boys (TD; N = 36). Results indicated specific behavioral responses to a stranger differentiated preschoolers with more severe symptoms of autism (e.g. fxASD and iASD groups) from those with low autism …

Supercritical Carbon Dioxide Treatment Of Natural Biomaterials For Tissue Engineering Applications, Dominic M. Casali

Theses and Dissertations

The number of people requiring an organ transplant in the United States has increased considerably over the past 25 years, but the number of organ donations has stagnated; over 8,000 people now die annually while awaiting a transplant or become too sick to receive one. Tissue engineering (TE), the design and production of artificial tissues and organs in vitro, has been proposed to alleviate this problem. Though synthetic polymers offer tunable mechanical and biochemical properties, natural biomaterials have recently garnered attention in TE for their high degree of biocompatibility and ability to direct cell proliferation and constructive tissue remodeling. Yet …

The Private University Faculty Perspective Of Community College Transfer Students: An Ethnographic Interview Study, Sally E. Hyatt

Theses and Dissertations

Faculty/student relationships have a significant impact on student retention and success (Tinto, 1975, 1993). However, little is known about how faculty perceive community college transfer students and how they make meaning of their interactions with these students. This qualitative, descriptive, ethnographic interview study describes faculty/student interaction and the ways in which community college transfer students are perceived by the faculty at one small, private, nonprofit, masters-level university. The research questions used for this study were designed to investigate the faculty’s perception of community college students, the students’ academic experiences and the faculty/student relationship.

The researcher gathered data during 12 in-depth …