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2017

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“More Challenging Than I Expected But More Satisfying”: Exploring The Experiences Of New Heads Of Independent Schools And The Leadership Skills They Employ, Andrew O'Brien Dec 2017

“More Challenging Than I Expected But More Satisfying”: Exploring The Experiences Of New Heads Of Independent Schools And The Leadership Skills They Employ, Andrew O'Brien

LSU New Orleans Theses and Dissertations

This study examines leader behavior in an independent school setting. Specifically, this qualitative phenomenological study explores the lived experiences of new heads of schools in independent schools located in Louisiana, Texas, and Oklahoma and their conceptualization of the skills required for the headship. The study explores the knowledge and skills new heads say they use as leaders, how the knowledge and skills they developed in their careers prepared them for leadership, and the ways in which they feel they might have been better prepared for leadership. The study uses the skills-based model of leadership as its theoretical framework, and its …


Reporting Of Underrepresented Populations In Autism Treatment Studies Across 25 Years, Danai Kasambira Fannin Dec 2017

Reporting Of Underrepresented Populations In Autism Treatment Studies Across 25 Years, Danai Kasambira Fannin

Faculty Articles, Papers, and Other Scholarship

Purpose: Eight language and autism related journals published between 1993 and 2017 were analyzed to identify trends in the inclusion of underrepresented populations in empirical studies with social skill, play, joint attention, and expressive language outcomes. Relationships among treatment outcomes, treatment settings, and underrepresented population types were explored. Method: All articles (12,381) were searched to identify intervention studies that included participants with autism and were classified by treatment target and setting (N=291). The selected studies were then examined to determine if any participants were from underrepresented populations (n=138) and categorized by type of underrepresented population. Results: Most studies did not …


Nanomedicine For Immunosuppressive Therapy: Achievements In Pre-Clinical Research, Hanan Al-Lawati, Hamidreza Montazeri Aliabadi, Behzad Sharif Makhmalzadeh, Afsaneh Lavasanifar Dec 2017

Nanomedicine For Immunosuppressive Therapy: Achievements In Pre-Clinical Research, Hanan Al-Lawati, Hamidreza Montazeri Aliabadi, Behzad Sharif Makhmalzadeh, Afsaneh Lavasanifar

Pharmacy Faculty Articles and Research

Introduction: Immunosuppression is the mainstay therapy in organ transplantation and autoimmune diseases. The effective clinical application of immunosuppressive agents has suffered from the emergence of systemic immunosuppression and/or individual drug side effects. Nanotechnology approaches may be used to modify the mentioned shortcomings by enhancing the delivery of immunosuppressants to target cells of the immune system, thus reducing the required dose for function, and/or reducing drug distribution to non-target tissues.

Areas covered: We provide an overview on the development of nanotechnology products for the most commonly used immunosuppressive agents. At first, the rationale for the use of nanoparticles as …


Exploring Science Identity: The Lived Experiences Of Underserved Students In A University Supplemental Science Program, Lynette D. Perrault Dec 2017

Exploring Science Identity: The Lived Experiences Of Underserved Students In A University Supplemental Science Program, Lynette D. Perrault

LSU New Orleans Theses and Dissertations

Underserved students attending under-resourced schools experience limited opportunities to engage in advanced science. An exploration into the influence a supplemental science program has on underserved students’ acquisition of science knowledge and skills to increase their pursuit of science was conducted to help explain science identity formation in students. The proliferation of supplemental science programs have emerged as a result of limited exposure and resources in science for underserved students, thus prompting further investigation into the influence supplemental science programs have on underserved students interest and motivation in science, attainment of science knowledge and skills, and confidence in science to promote …


Stasi Brainwashing In The Gdr 1957 - 1990, Jacob H. Solbrig, Jacob Hagen Solbrig Dec 2017

Stasi Brainwashing In The Gdr 1957 - 1990, Jacob H. Solbrig, Jacob Hagen Solbrig

LSU New Orleans Theses and Dissertations

This thesis examines the methods used by the Ministerium für Staatssicherheit (MfS), more commonly known as the Stasi, or East German secret police, for extraction of information from citizens of the German Democratic Republic for the purpose of espionage and covert operations inside East Germany, as it pertains to the deliberate brainwashing of East German citizens. As one of the most efficient intelligence agencies to ever exist, the Stasi’s main purpose was to monitor the population, gather intelligence, and collect or turn informants. They used brainwashing techniques to control the people of the GDR, keeping the populace paralyzed with fear …


Effect Of Cell Wall Destruction On Anaerobic Digestion Of Algal Biomass, Jessica R. Simpson Dec 2017

Effect Of Cell Wall Destruction On Anaerobic Digestion Of Algal Biomass, Jessica R. Simpson

LSU New Orleans Theses and Dissertations

Research was conducted using algal biomass obtained from the surface of a secondary clarifier at Bridge City Wastewater Treatment Plant and subsequently sent through an electrochemical (EC) batch reactor at various concentrations. The first objective was to achieve maximum cell wall destruction electrochemically using the EC batch reactor and determine the optimal detention time and voltage/current relationship at which this occurred. The second objective was to subject two algal mediums to anaerobic digestion: the algal medium without electrochemical disinfection and the algal medium after disinfection. Every three days, for 12 days, total solids were measured from each apparatus to determine …


The Palimpsest Boys, Brandon Stump, Brandon Stump Dec 2017

The Palimpsest Boys, Brandon Stump, Brandon Stump

LSU New Orleans Theses and Dissertations

These short stories deal with young boys and men who raise themselves in the absence of proper parenting. In particular, they wrestle with big questions about the family unit, sex, and love.


Teaching Organizational Leaders: Application Of Title Vii Of The Civil Rights Act Of 1964 To Hiring Practices And Harassment Prevention In New Orleans, Angela Glaviano Dec 2017

Teaching Organizational Leaders: Application Of Title Vii Of The Civil Rights Act Of 1964 To Hiring Practices And Harassment Prevention In New Orleans, Angela Glaviano

LSU New Orleans Theses and Dissertations

No abstract provided.


Found Missing: Fugitive Slaves, Jailer Ads, And Surveillance In Antebellum New Orleans, Tara L. Garbutt Dec 2017

Found Missing: Fugitive Slaves, Jailer Ads, And Surveillance In Antebellum New Orleans, Tara L. Garbutt

LSU New Orleans Theses and Dissertations

This paper explores fugitive slave advertisements from the pages of the New Orleans Argus in 1828. As the main repository for runaway slave advertisements in New Orleans at the time, the Argus played a critical role in policing and surveillance of the city’s enslaved population just as New Orleans was becoming the largest slave market in the South. Using the Argus as well as historians’ accounts of the city, this thesis argues that as the market in enslaved people grew, slave owners depended upon local jailers in tandem with papers like the Argus, to police the enslaved population. The large …


Possible Breakdown Of Dopamine Receptor Synergism In A Mouse Model Of Huntington's Disease, Samantha F. Kennedy Dec 2017

Possible Breakdown Of Dopamine Receptor Synergism In A Mouse Model Of Huntington's Disease, Samantha F. Kennedy

LSU New Orleans Theses and Dissertations

The model of basal ganglia function proposed by Albin, Young and Penney (1989) describes two anatomically independent motor pathways, the direct and indirect. However, under normal conditions striatal dopamine (DA) is required for the expression of motor behavior, and DAergic control of the two pathways (via D1 and D2 receptors, respectively) is dependent on co-activation. We tested for a possible breakdown of D1/D2 synergism using transgenic R6/1 mice bearing the human huntingtin allele (Htt). Motor stereotypy, observed prior to the onset of HD-related symptoms, was rated on a 5-point scale following activation of: A) D1 receptors alone, B) D2 receptors …


Neurocorrelates Of The Mirror Neuron System In Children With Chromosome 22q11.2 Deletion Syndrome, Ade Marais Dec 2017

Neurocorrelates Of The Mirror Neuron System In Children With Chromosome 22q11.2 Deletion Syndrome, Ade Marais

LSU New Orleans Theses and Dissertations

Activation of brain regions that make up the mirror neuron system (MNS) is thought to reflect processing and perceiving behavior, action, and intentionality of other organisms. Sensing and perceiving motor behavior in others is an important component of understanding and participating in social interactions. Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) are diagnosed with serious medical, cognitive, and socio-emotional symptoms. Atypical development and function of the MNS may underpin some aspects of socio-emotional impairment and autism spectrum disorder (ASD)-like symptomology reported. This study of the MNS investigates differences in activation in the operculum, sensorimotor areas, and basal ganglia (BG) in …


Frameworks Of Recovery: Exploring The Intersection Of Policy & Decision-Making Processes After Hurricane Katrina, Kim Mosby Dec 2017

Frameworks Of Recovery: Exploring The Intersection Of Policy & Decision-Making Processes After Hurricane Katrina, Kim Mosby

LSU New Orleans Theses and Dissertations

This study seeks to understand how local and national newspaper articles and African American residents frame obstacles to returning to New Orleans after Hurricane Katrina. It explores how recovery planning processes and policy changes influenced the decision-making processes of African Americans displaced to Houston through a content analysis of the media and qualitative interviews with displaced and returned residents. The study shows the media and participants framed disaster recovery policies as creating opportunities and gaps in assistance that varied by location. Participants described how policy decisions that created gaps in assistance compounded the difficulty of returning for working- and middle-class …


Faculty Grievance Committee 2017-2018, Georgia Southern University Dec 2017

Faculty Grievance Committee 2017-2018, Georgia Southern University

Faculty Senate: Membership Lists

No abstract provided.


Athletics Committee 2017-2018, Georgia Southern University Dec 2017

Athletics Committee 2017-2018, Georgia Southern University

Faculty Senate: Membership Lists

No abstract provided.


Uv-Visible Optical Absorbance Of Graphene Oxide Synthesized From Zinc-Carbon Battery Waste Via A Custom-Made Ultrasound Generator Based On Liquid Sonication Exfoliation Method, Rhyko Irawan Wisnuwijaya, Agus Purwanto, Wipsar Sunu Brams Dwandaru Dec 2017

Uv-Visible Optical Absorbance Of Graphene Oxide Synthesized From Zinc-Carbon Battery Waste Via A Custom-Made Ultrasound Generator Based On Liquid Sonication Exfoliation Method, Rhyko Irawan Wisnuwijaya, Agus Purwanto, Wipsar Sunu Brams Dwandaru

Makara Journal of Science

The objectives of this study are i) to synthesize graphene oxide (GO) from the waste materials of zinc-carbon (ZnC) batteries via the liquid sonication exfoliation (LSE) method using tweeter piezoelectric probes as speakers, and ii) to study the optical absorbance of the GO produced using a UV-Vis spectrophotometer by varying the mass of the graphite materials obtained from ZnC battery waste. The graphite materials are obtained from the carbon rods of the ZnC batteries, which are ground into powder. The powder is then mixed with distilled water, with powder mass variations of 0.4, 0.6, 0.8, and 1.0 grams. The solutions …


Ten Um Freshmen Named 2017 Stamps Scholars, Edwin B. Smith Dec 2017

Ten Um Freshmen Named 2017 Stamps Scholars, Edwin B. Smith

University of Mississippi News

Students exemplify best of scholarship, community service and leadership


Midbrain Circuit Regulation Of Individual Alcohol Drinking Behaviors In Mice, Barbara Juarez, Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edward, Amanda Roberts, Georgia E. Hodes, Yongke Lu, Erin S. Calipari, Dipesh Chaudhury, Allyson K. Friedman, Ming-Hu Han Dec 2017

Midbrain Circuit Regulation Of Individual Alcohol Drinking Behaviors In Mice, Barbara Juarez, Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edward, Amanda Roberts, Georgia E. Hodes, Yongke Lu, Erin S. Calipari, Dipesh Chaudhury, Allyson K. Friedman, Ming-Hu Han

Publications and Research

Alcohol-use disorder (AUD) is the most prevalent substance-use disorder worldwide. There is substantial individual variability in alcohol drinking behaviors in the population, the neural circuit mechanisms of which remain elusive. Utilizing in vivo electrophysiological techniques, we find that low alcohol drinking (LAD) mice have dramatically higher ventral tegmental area (VTA) dopamine neuron firing and burst activity. Unexpectedly, VTA dopamine neuron activity in high alcohol drinking (HAD) mice does not differ from alcohol naive mice. Optogenetically enhancing VTA dopamine neuron burst activity in HAD mice decreases alcohol drinking behaviors. Circuit-specific recordings reveal that spontaneous activity of nucleus accumbens-projecting VTA (VTA-NAc) neurons …


Histomorphology Of Trauma In Charred And Decomposed Remains, Mariya Bezugly Dec 2017

Histomorphology Of Trauma In Charred And Decomposed Remains, Mariya Bezugly

Student Theses

Decomposition and burning of human remains are frequently encountered in forensic cases, and pose a challenge at determining an accurate cause of death. At autopsy, macroscopic techniques fail to reach beyond superficial layers of degraded tissue to identify wound morphology that characterizes blunt-force gunshot, and sharp-force trauma. The postmortem damage imparted on tissue with pre-existing injuries, obstructs the external features of trauma. Exploring beyond charred and decayed superficial tissue, histo-morphological patterns of injury are still identifiable as shown in this thesis. With detailed observation to the pattern of tissue disruption- an understanding of the type of trauma imposed can be …


Snail Determines The Therapeutic Response To Mtor Kinase Inhibitors By Transcriptional Repression Of 4e-Bp1, Jun Wang, Qing Ye, Yanan Cao, Yubin Guo, Xiuping Huang, Wenting Mi, Side Liu, Chi Wang, Hsin-Sheng Yang, Binhua P. Zhou, B. Mark Evers, Qing-Bai She Dec 2017

Snail Determines The Therapeutic Response To Mtor Kinase Inhibitors By Transcriptional Repression Of 4e-Bp1, Jun Wang, Qing Ye, Yanan Cao, Yubin Guo, Xiuping Huang, Wenting Mi, Side Liu, Chi Wang, Hsin-Sheng Yang, Binhua P. Zhou, B. Mark Evers, Qing-Bai She

Markey Cancer Center Faculty Publications

Loss of 4E-BP1 expression has been linked to cancer progression and resistance to mTOR inhibitors, but the mechanism underlying 4E-BP1 downregulation in tumors remains unclear. Here we identify Snail as a strong transcriptional repressor of 4E-BP1. We find that 4E-BP1 expression inversely correlates with Snail level in cancer cell lines and clinical specimens. Snail binds to three E-boxes present in the human 4E-BP1 promoter to repress transcription of 4E-BP1. Ectopic expression of Snail in cancer cell lines lacking Snail profoundly represses 4E-BP1 expression, promotes cap-dependent translation in polysomes, and reduces the anti-proliferative effect of mTOR kinase inhibitors. Conversely, genetic …


Infanticide In Chimpanzees: Taphonomic Case Studies From Gombe, Claire A. Kirchhoff, Michael L. Wison, Deus C. Mjungu, Jane Raphael, Shadrack Kamenya, D. Anthony Collins Dec 2017

Infanticide In Chimpanzees: Taphonomic Case Studies From Gombe, Claire A. Kirchhoff, Michael L. Wison, Deus C. Mjungu, Jane Raphael, Shadrack Kamenya, D. Anthony Collins

Biological Sciences Faculty Research and Publications

Objectives

We present a study of skeletal damage to four chimpanzee (Pan troglodytes) infanticide victims from Gombe National Park, Tanzania. Skeletal analysis may provide insight into the adaptive significance of infanticide by examining whether nutritional benefits sufficiently explain infanticidal behavior. The nutritional hypothesis would be supported if bone survivorship rates and skeletal damage patterns are comparable to those of monkey prey. If not, other explanations, such as the resource competition hypothesis, should be considered.

Methods

Taphonomic assessment of two chimpanzee infants included description of breakage and surface modification, data on MNE, %MNE, and bone survivorship. Two additional infants …


Fisher’S Exact Approach For Post Hoc Analysis Of A Chi-Squared Test, G Shan, S Gerstenberger Dec 2017

Fisher’S Exact Approach For Post Hoc Analysis Of A Chi-Squared Test, G Shan, S Gerstenberger

Environmental & Global Health Faculty Research

This research is motivated by one of our survey studies to assess the potential influence of introducing zebra mussels to the Lake Mead National Recreation Area, Nevada. One research question in this study is to investigate the association between the boating activity type and the awareness of zebra mussels. A chi-squared test is often used for testing independence between two factors with nominal levels. When the null hypothesis of independence between two factors is rejected, we are often left wondering where does the significance come from. Cell residuals, including standardized residuals and adjusted residuals, are traditionally used in testing for …


Responsible Pet Ownership: Dog Parks And Demographic Change In Portland, Oregon, Matthew Harris Dec 2017

Responsible Pet Ownership: Dog Parks And Demographic Change In Portland, Oregon, Matthew Harris

Dissertations and Theses

Dog parks are the fastest growing type of park in U.S. cities; however, their increasing popularity has been met with increasing criticism of pets in public space. Dogs have shown to be a deep source of neighborhood conflict, and the provision of dog parks, or off-leash areas, is a seemingly intractable controversy for city officials. In 2003, Portland, Oregon established a network of 33 off-leash areas which remains the second largest both in count and per capita in the country. The purpose of my research is to understand the public debate over off leash dogs during the establishment of Portland's …


Virtual Reality As A Training Tool To Treat Physical Inactivity In Children, Adam W. Kiefer, David Pincus, Michael J. Richardson, Gregory D. Myer Dec 2017

Virtual Reality As A Training Tool To Treat Physical Inactivity In Children, Adam W. Kiefer, David Pincus, Michael J. Richardson, Gregory D. Myer

Psychology Faculty Articles and Research

Lack of adequate physical activity in children is an epidemic that can result in obesity and other poor health outcomes across the lifespan. Physical activity interventions focused on motor skill competence continue to be developed, but some interventions, such as neuromuscular training (NMT), may be limited in how early they can be implemented due to dependence on the child’s level of cognitive and perceptual-motor development. Early implementation of motor-rich activities that support motor skill development in children is critical for the development of healthy levels of physical activity that carry through into adulthood. Virtual reality (VR) training may be beneficial …


Protecting Civilians With Disabilities In Conflicts, Janet E. Lord, Gerard Quinn, Shantha Rau Barriga, Catalina Devandas Dec 2017

Protecting Civilians With Disabilities In Conflicts, Janet E. Lord, Gerard Quinn, Shantha Rau Barriga, Catalina Devandas

All Faculty Scholarship

No abstract provided.


Comparison Of Equations For Estimating Glomerular Filtration Rate In Screening For Chronic Kidney Disease In Asymptomatic Black Africans: A Cross Sectional Study, Geoffrey Omuse, Daniel Maina, Jane Mwangi, Caroline Wambua, Alice Kiyua, Elizabeth Kagotho, Angela Amayo, Peter Ojwang, Rajiv Erasmus Dec 2017

Comparison Of Equations For Estimating Glomerular Filtration Rate In Screening For Chronic Kidney Disease In Asymptomatic Black Africans: A Cross Sectional Study, Geoffrey Omuse, Daniel Maina, Jane Mwangi, Caroline Wambua, Alice Kiyua, Elizabeth Kagotho, Angela Amayo, Peter Ojwang, Rajiv Erasmus

Pathology, East Africa

Background: Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of the equations provide a correction factor for African-Americans due to their relatively increased muscle mass and this has been extrapolated to black Africans. Studies carried out in Africa in patients with CKD suggest that using this correction factor for the black African race may not be appropriate. However, these studies were not carried out in healthy individuals and as such the extrapolation of the findings to an asymptomatic black …


High Levels Of Resistance In A Culex Quinquefasciatus Population To The Insecticide Permethrin In Filariasis Endemic Areas In Central Java, Irfanul Chakim, Sayono, Rahayu Astuti Dec 2017

High Levels Of Resistance In A Culex Quinquefasciatus Population To The Insecticide Permethrin In Filariasis Endemic Areas In Central Java, Irfanul Chakim, Sayono, Rahayu Astuti

Makara Journal of Science

Resistance among Culex mosquitoes to various insecticides has been reported in many countries. However, there have been no studies of the resistance status of Culex in Indonesia. There is a need for such studies to develop a database for use in vector control management. This study aimed to investigate the insecticide resistance status of C. quenquefasciatus, which is the primary vector of filariasis, to aid the planning of a vector control management program. In the present study, Culex quinquefasciatus larvae were collected from five districts/municipalities where filariasis is endemic in Central Java. The larvae were reared to adult stage, and …


The Abundance Of Nitrogen Fixing, Nitrifying, Denitrifying And Ammonifying Bacteria In The Soil Of Tropical Rainforests And Oil Palm Plantations In Jambi, Zulfarina, Iman Rusmana, Nisa Rachmania Mubarik, Dwi Andreas Santosa Dec 2017

The Abundance Of Nitrogen Fixing, Nitrifying, Denitrifying And Ammonifying Bacteria In The Soil Of Tropical Rainforests And Oil Palm Plantations In Jambi, Zulfarina, Iman Rusmana, Nisa Rachmania Mubarik, Dwi Andreas Santosa

Makara Journal of Science

Alterations in the use of land for oil palm plantations can change the domination and activity of soil bacteria. More specifically, alteration in soil microbial communities can directly affect soil ecosystem functioning, particularly with respect to carbon and nitrogen cycles. Nitrogen can be a limiting nutrient, and the availability of nitrogen in the soil environment becomes a major factor in controlling the production of biomass. This research project aimed at studying the abundance of nitrogen-fixing, nitrogen-oxidizing, nitrogen-reducing, and ammonifying bacteria based on their functional genes in the tropical rain forests of Taman Nasional Bukit Duabelas (TNBD) and the oil palm …


Identification Of Avian Influenza Genetic Resistance Gene Marker In Chickens, R Susanti, Nur Rahayu Utami, Margareta Rahayuningsih, Fidia Fibriana Dec 2017

Identification Of Avian Influenza Genetic Resistance Gene Marker In Chickens, R Susanti, Nur Rahayu Utami, Margareta Rahayuningsih, Fidia Fibriana

Makara Journal of Science

The Mx gene is a potential candidate as a genetic resistance marker to the avian influenza virus in chickens. The purpose of this study is to identify the potential of Mx gene as a marker of resistance to avian influenza viruses in various breeds of chicken. The study used an exploratory design using three common chicken breeds. The Kampong chicken, the Hy-Line Brown laying hen strain, and the White Leghorn broiler strain were collected from the local farms, and blood samples were drawn from each. The DNA of each sample was amplified by a pair of Mx gene primers (NE-F2/F …


Mitigating Projected Impacts Of Climate Change And Building Resiliency Through Permaculture: A Community ‘Bee Inspired Gardens’ Movement In The Desert Southwest, Usa, Roslynn Brain, Jeffrey Adams, Jeremy Lynch Dec 2017

Mitigating Projected Impacts Of Climate Change And Building Resiliency Through Permaculture: A Community ‘Bee Inspired Gardens’ Movement In The Desert Southwest, Usa, Roslynn Brain, Jeffrey Adams, Jeremy Lynch

Environment and Society Faculty Publications

Permaculture, an integrative design process creating resilient and productive landscapes and communities, can serve as a useful mitigation tool for projected climate change impacts. In the United States, the desert southwest town of Moab, Utah, has employed permaculture design in a community initiative called ‘Bee Inspired Gardens.’ This initiative has harnessed social capital to create resilient landscapes demonstrating pollinator health, water conservation, and perennial food and forage systems. Bee Inspired Gardens have been designed at a University, middle school, charter school, Bureau of Land Management property, hotel, public park, environmental education non-profit, and more. Community members are now harvesting fruit …


Ls301 Fluorescence-Guided Photodynamic Therapy Of Brain Cancer Using Ppix Photosensitizer, Haini Zhang Dec 2017

Ls301 Fluorescence-Guided Photodynamic Therapy Of Brain Cancer Using Ppix Photosensitizer, Haini Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Incomplete brain tumor removal always causes neurologic deficit, disease recurrence and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a photosensitizer for photodynamic therapy (PDT). However, the accurate tumor delineation using PpIX is limited by autofluorescence and superficial penetration depth. LS301 is a tumor-targeted near-infrared (NIR) contrast agent developed in our lab which allows deeper tumor imaging and avoids autofluorescence. My project aims to investigate whether LS301 can improve PpIX mediated PDT and tumor removal surgery. We have demonstrated co-localization of …