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2017

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Vanillin Increases Stem Cell Signal And Cell Adhesion In Keratinocytes, Supak Taboonpong, Chayanin Kiratipaiboon, Preeyaporn Plaimee Phiboonchaiyanan, Premjit Junthongjin, Pornlert Trithossadech, Pithi Chanvorachote Jan 2017

Vanillin Increases Stem Cell Signal And Cell Adhesion In Keratinocytes, Supak Taboonpong, Chayanin Kiratipaiboon, Preeyaporn Plaimee Phiboonchaiyanan, Premjit Junthongjin, Pornlert Trithossadech, Pithi Chanvorachote

The Thai Journal of Pharmaceutical Sciences

Keratinocyte stem cells residing in the basal layer of the epidermis are thought to function in the process of the epidermis renewal and maintain the barrier property of the skin. This study has explored for the first time that vanillin, a natural compou.

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Effect Of Different Production Variables On The Physical Properties Of Pellets Prepared By Extrusion-Spheronization Using A Multivariate Analysis, John Rojas Jan 2017

Effect Of Different Production Variables On The Physical Properties Of Pellets Prepared By Extrusion-Spheronization Using A Multivariate Analysis, John Rojas

The Thai Journal of Pharmaceutical Sciences

The spheronization process has been widely used in recent years in multiparticulate oral formulations because it is a simple and rapid technology. It offers advantages over other dosage forms such as tablets due to the more uniform and predictable transp.

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Docking, Synthesis, And Cytotoxic Activity Of N-4-Methoxybenzoyl-N’-(4-Fluorophenyl)Thiourea On Hela Cell Line, Anindi Lupita Nasyanka Jan 2017

Docking, Synthesis, And Cytotoxic Activity Of N-4-Methoxybenzoyl-N’-(4-Fluorophenyl)Thiourea On Hela Cell Line, Anindi Lupita Nasyanka

The Thai Journal of Pharmaceutical Sciences

Tiourea derivatives such as phenylthiourea, benzoyltiourea, tenovin, and many more have been reported as anticancer agent. In this study, we have done some initial step (docking, synthesis, and cytotoxic assay) to develop one of thiourea derivatives, N-4.

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Enhancement Of Solubility And Dissolution Rate Of Quercetin With Solid Dispersion System Formation Using Hpmc Matrix, Dwi Setyawan Jan 2017

Enhancement Of Solubility And Dissolution Rate Of Quercetin With Solid Dispersion System Formation Using Hpmc Matrix, Dwi Setyawan

The Thai Journal of Pharmaceutical Sciences

Purpose : The aim of the present study was to obtain raw quercetin materials using solid dispersion system with better solubility and dissolution rate than pure quercetin. Methods: The solid dispersion of Quercetin-HPMC was prepared by solvent method. Su.

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Gold Nanoparticle-Colocasia Gigantean Conjugates For Enhancing Cytotoxic Effect Against A375 Melanoma Cell Line, Amornpun Sereemaspun Jan 2017

Gold Nanoparticle-Colocasia Gigantean Conjugates For Enhancing Cytotoxic Effect Against A375 Melanoma Cell Line, Amornpun Sereemaspun

The Thai Journal of Pharmaceutical Sciences

Herbs are a prototype of traditional medicine for primary health care. Their knowledge is the basis of many modern medicinal discoveries. With the new invention of nanomaterials for biomedical applications, gold nanoparticles (AuNPs) have been proven to .

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Determination Of Ethionamide In Pharmaceutical By Spectrophotometry Via Oxidation Reaction With Potassium Iodate, Nagib A.S. Qarah, Kanakapura Basavaiah Jan 2017

Determination Of Ethionamide In Pharmaceutical By Spectrophotometry Via Oxidation Reaction With Potassium Iodate, Nagib A.S. Qarah, Kanakapura Basavaiah

The Thai Journal of Pharmaceutical Sciences

Two new spectrophotometric methods are described for the determination of ethionamide (ETM) in pure and tablet forms. Method A is based on the oxidation of ETM by KIO3 in H2SO4 medium, and the in situ generated iodine is extracted into chloroform and mea.

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In Vitro Antimicrobial Activity Of Antidesma Bunius Extracts On Oral Pathogenic Bacteria, Panicha Pongnaratorn, Prakasit Kuacharan, Vayura Kotsuno, Naruwat Pakdee, Pranee Sriraj, Jintana Sattayasai Jan 2017

In Vitro Antimicrobial Activity Of Antidesma Bunius Extracts On Oral Pathogenic Bacteria, Panicha Pongnaratorn, Prakasit Kuacharan, Vayura Kotsuno, Naruwat Pakdee, Pranee Sriraj, Jintana Sattayasai

The Thai Journal of Pharmaceutical Sciences

High antioxidant content of Antidesma bunius may lead to many beneficial pharmaceutical properties such as an anti-bacterial, anti-inflammatory and somatic cell decelerations, as well as cancer prevention. This study aimed at quantifying total phenolic c.

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Analytical Method Development And Validation For Iron And Ascorbic Acid In Ferrous Bisglyciante Effervescent Tablets By Colorimetry And Rp-Hplc., Vasantharaju Sg Jan 2017

Analytical Method Development And Validation For Iron And Ascorbic Acid In Ferrous Bisglyciante Effervescent Tablets By Colorimetry And Rp-Hplc., Vasantharaju Sg

The Thai Journal of Pharmaceutical Sciences

A sensitive colorimetric and reverse phase high performance liquid chromatographic method was developed for estimation of total iron and ascorbic acid in ferrous bisglycinate effervescent tablets. A colorimetric method was developed for total iron us...

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The Reform Of Drug Patent System In Thailand, Wanna Sriviriyanupap Jan 2017

The Reform Of Drug Patent System In Thailand, Wanna Sriviriyanupap

The Thai Journal of Pharmaceutical Sciences

Drug patent system has a direct impact on the health care cost and the access of the drugs of people. Previously, the drug patent system in Thailand encounters the problems both efficiency and quality of patent approval. This study aims to analyze the pr.

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Effects Of The Standardized Extract Of Centella Asiatica Eca233 On Hepatic Phase Ii Drug-Metabolizing Enzymes In Rats, Pitchayapa Seeka, Nuansri Niwattisaiwong, Mayuree H. Tantisira, Songpol Chevapat, Kridsada Anuntawuttikul, Khemchat Apipalakul, Somsong Lawanprasert Jan 2017

Effects Of The Standardized Extract Of Centella Asiatica Eca233 On Hepatic Phase Ii Drug-Metabolizing Enzymes In Rats, Pitchayapa Seeka, Nuansri Niwattisaiwong, Mayuree H. Tantisira, Songpol Chevapat, Kridsada Anuntawuttikul, Khemchat Apipalakul, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

The standardized extract of C. asiatica ECa233 (ECa 233) was shown to possess neuroprotective and wound healing effects. The purpose of this study was to investigate effects ECa 233 on the activities of phase II drug metabolizing enzymes including UDP-gl.

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Application Of Ion-Pair Complexation Reaction For The Spectrophotometric Determination Of Clarithromycin In Pharmaceutical Formulations, Sameer A. M. Abdulrahman Jan 2017

Application Of Ion-Pair Complexation Reaction For The Spectrophotometric Determination Of Clarithromycin In Pharmaceutical Formulations, Sameer A. M. Abdulrahman

The Thai Journal of Pharmaceutical Sciences

Two simple, rapid, sensitive, selective and extraction-free spectrophotometric methods have been developed for the determination of clarithromycin (CLR) both in pure form and in pharmaceutical formulations. The developed methods are based on ion-pair com.

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High-Performance Thin-Layer Chromatography Analysis Of (E)-4-(3?,4?-Dimethoxyphenyl)But-3-En-1-Ol (Compound D) In Zingiber Cassumunar Roxb Rhizome Extract: An Application On Genetic Differentiation, Prasan Tangyuenyongwatana, Piyarat Parinyapong Chareonsap, Wandee Gritsanapan Jan 2017

High-Performance Thin-Layer Chromatography Analysis Of (E)-4-(3?,4?-Dimethoxyphenyl)But-3-En-1-Ol (Compound D) In Zingiber Cassumunar Roxb Rhizome Extract: An Application On Genetic Differentiation, Prasan Tangyuenyongwatana, Piyarat Parinyapong Chareonsap, Wandee Gritsanapan

The Thai Journal of Pharmaceutical Sciences

Objectives: This study focused on developing high performance thin-layer chromatography (HPTLC) quantitative analysis method for compound D, a major anti-inflammatory compound in Zingiber cassumunar extract. In addition, the amplified fragment length pol.

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Hepatoprotective And Hepatoregenerative Therapeutic Effects Of Polyherbal Medicine Heparmin Tm On Rattus Norvegicus Wistar With Liver Fibrosis, Diana Lyrawati, Amalia Ghassani Muslimah, Dewi Laksmita, Dian Indrawati Santoso, Erlien Lindawati Poernomo, Karina Larasati, Lina Zahrotus Sajidah, Oktavia Rahayu Adianingsih, Rosida Dewi Agusningtyas, Mudjiwijono Handaru Eko, Bogi Pratomo Wibowo Jan 2017

Hepatoprotective And Hepatoregenerative Therapeutic Effects Of Polyherbal Medicine Heparmin Tm On Rattus Norvegicus Wistar With Liver Fibrosis, Diana Lyrawati, Amalia Ghassani Muslimah, Dewi Laksmita, Dian Indrawati Santoso, Erlien Lindawati Poernomo, Karina Larasati, Lina Zahrotus Sajidah, Oktavia Rahayu Adianingsih, Rosida Dewi Agusningtyas, Mudjiwijono Handaru Eko, Bogi Pratomo Wibowo

The Thai Journal of Pharmaceutical Sciences

Chronic injury severely impairs liver regeneration through excess inflammation, scarring and epithelial abnormalities, since injured cells may shift response from pro-regeneration into pro-fibrosis which leads to cirrhosis and total liver failure. An Ind.

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Fp-17-25 Marriage Rate In The U.S. Geographic Variation, 2016, Paul Hemez Jan 2017

Fp-17-25 Marriage Rate In The U.S. Geographic Variation, 2016, Paul Hemez

National Center for Family and Marriage Research Family Profiles

No abstract provided.

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Individual And Institutional Level Factors That Influence Hiv Testing And Counseling Utilization During Antenatal Care In Nigeria, Modupeoluwa O. Durojaiye Jan 2017

Individual And Institutional Level Factors That Influence Hiv Testing And Counseling Utilization During Antenatal Care In Nigeria, Modupeoluwa O. Durojaiye

All ETDs from UAB

Of the estimated 150,000 new HIV infections in children in 2015, 122,000 occurred in sub-Saharan Africa (SSA), with Nigeria accounting for a third of all cases. Most of these infections were acquired via mother-to-child transmission (MTCT). HIV testing and counseling, a critical first step in the prevention of MTCT (PMTCT), can ensure that HIV-positive women access services that can reduce HIV transmission risk. Incorporating HIV testing and counseling into antenatal care (ANC) is an integral component of the World Health Organization (WHO) strategies. This dissertation aims to understand factors that influence HIV testing and counseling during ANC. It is comprised …

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Publc Hospital Conversions: A Question Of Social Capital?, Antionette Smith Epps Jan 2017

Publc Hospital Conversions: A Question Of Social Capital?, Antionette Smith Epps

All ETDs from UAB

ABSTRACT Between 1975 and 2015, the number of public hospitals decreased by 43%, from 1761 to 1003. Public hospitals have undergone changes in ownership status, structural and/or governance conversions and closures. Reasons for these changes are varied and numerous, however, many studies identify financial difficulties as a major reason that decision-makers consider an ownership change. Some public hospitals persist despite exhibiting financial issues. Therefore, there may be other factors contributing to the persistence of some public hospitals. This paper examines the potential role of social capital or community engagement and cohesion as a factor in determining if a public hospital …

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Home Healthcare And Performance: Development And Application Of A Typology For Home Health Agencies, Ronique Nechelle Evans Jan 2017

Home Healthcare And Performance: Development And Application Of A Typology For Home Health Agencies, Ronique Nechelle Evans

All ETDs from UAB

This three-paper dissertation sought to examine the existence of strategic groups in the home health industry, the application of Porter’s generic strategies (cost leader, differentiator, “stuck-in-the-middle” and both cost leader/differentiator) in identifying these groups, and the association of group membership with agency performance. The findings of this study will provide researchers and managers with a highlight of the current strategic makeup of the home health industry and its relationship with quality and financial performance. The results of this dissertation provide some evidence that strategic groups do exist in the home health industry and can be described along the basis of …

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The Effectiveness Of Clinical Integration: The Relationship Between Evidence-Based Clinical Processes, In-Network Utilization And Clinical, Service And Efficiency Outcomes, Patrick D. Falvey Jan 2017

The Effectiveness Of Clinical Integration: The Relationship Between Evidence-Based Clinical Processes, In-Network Utilization And Clinical, Service And Efficiency Outcomes, Patrick D. Falvey

All ETDs from UAB

THE EFFECTIVENESS OF CLINICAL INTEGRATION: THE RELATIONSHIP BETWEEN EVIDENCE-BASED CLINICAL PROCESSES, IN-NETWORK UTILIZATION AND CLINICAL, SERVICE AND EFFICIENCY OUTCOMES PATRICK D. FALVEY EXECUTIVE DOCTORAL PROGRAM – SCHOOL OF HEALTH PROFESSIONS ABSTRACT The evolving U.S. health care system continues to steer healthcare organizations and integrated healthcare delivery networks (IDNs) to function as population health networks and ACOs. Policymakers, payers, health care leaders and consumer groups are advocating that IDNs clinically integrate processes and structures under the assumption that they will improve the clinical outcomes for a population, reduce the health care spend, and enhance the patient experience. Relatively little research has …

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Identification And Exploration Of The Information Needs And Information-Seeking Behaviors Of Medical-Surgical Nurses During Patient Care, Carrie Lee Gardner Jan 2017

Identification And Exploration Of The Information Needs And Information-Seeking Behaviors Of Medical-Surgical Nurses During Patient Care, Carrie Lee Gardner

All ETDs from UAB

Errors during the course of clinical practice are common and can lead to adverse events in hospitalized patients. Insufficient information and lack of clinician knowledge can serve as major contributing factors to the incidence of errors that occur during patient care. Nurses at the bedside need immediate access to patient specific information, at the point of care, and in an easily accessible format. There is a need for better understanding of the information needs and information-seeking behaviors of medical-surgical nurses. The purpose of this mixed-methods study was to explore the information-seeking behaviors of nurses when delivering patient care on medical-surgical …

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Immunoregulation During Acute And Chronic Exposure To Aspergillus Fumigatus, Jaleesa M. Garth Jan 2017

Immunoregulation During Acute And Chronic Exposure To Aspergillus Fumigatus, Jaleesa M. Garth

All ETDs from UAB

A. fumigatus is one of the most common fungal isolates with clinical disorders ranging from mild to severe. The development of Aspergillus-induced allergic and invasive fungal infections is a major health concern in several patient populations. IL-1 family members have been shown to play critical roles in host defense against A. fumigatus. IL-33, an IL-1 family member widely study in allergic and inflammatory diseases, was induced upon acute exposure to A. fumigatus. IL-33 receptor knockout mice, (Il1rl1-/-), demonstrated lower lung fungal burden in the presence of enhanced IL-1α, IL-1β, IL-6, IL-17A, IL-22, and PGE2 production. Administration of IL-33 to normal …

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Reducing Acute Cardiovascular Hospitalizations With A Weight Management Program (Reach), Laura A. Graham Jan 2017

Reducing Acute Cardiovascular Hospitalizations With A Weight Management Program (Reach), Laura A. Graham

All ETDs from UAB

Reducing cardiovascular (CVD) risk factors such as obesity through lifestyle and behavioral interventions like weight management programs should result in better cardiovascular health. However, there is conflicting evidence on the effectiveness of these interventions in reducing long-term CVD outcomes such as acute myocardial infarction or stroke. This reflects an important gap in our understanding about factors affecting recruitment and engagement in these programs and how these factors relate to improvement in long-term cardiovascular health. To address this gap, we will use a retrospective study with up to 11 years of follow up data from the nation’s largest health care system-associated …

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The Effects Of 6 Weeks Of High Intensity Interval Training Vs. Moderate Intensity Training On Cardiometabolic Health Markers And Mitochondrial Function In Individuals With Spinal Cord Injury, Kyle Gary Graham Jan 2017

The Effects Of 6 Weeks Of High Intensity Interval Training Vs. Moderate Intensity Training On Cardiometabolic Health Markers And Mitochondrial Function In Individuals With Spinal Cord Injury, Kyle Gary Graham

All ETDs from UAB

Background: Individuals with SCI fail to meet the recommended exercise guidelines due to limited time, resources, and structural or architectural limitations (e.g., accessibility of facilities and knowledgeable instructors). Therefore, a time efficient and effective exercise program is needed to reverse chronic metabolic conditions and improve health quality in individuals with SCI. A growing body of evidence from our group and others has demonstrated the potential for low volume high-intensity interval training (HIIT) to provide comparable or superior improvements in cardiometabolic health outcomes in able-bodied individuals compared to continuous moderate intensity training (MIT) that requires 60-80% greater time commitment. Purpose: To …

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Evaluating The Genotype Phenotype Correlations In Cleidocranial Dysplasia, Stephen Lamar Greene Jan 2017

Evaluating The Genotype Phenotype Correlations In Cleidocranial Dysplasia, Stephen Lamar Greene

All ETDs from UAB

Cleidocranial dysplasia (CCD, OMIM 119600) is a rare (1 in 1,000,000) human autosomal dominant skeletal disorder with unique craniofacial and dental features caused by mutations the gene coding for transcription factor RUNX2. RUNX2 is a key master regulator of osteoblast differentiation, chondrocyte maturation and tooth formation. CCD is commonly diagnosed based on bone defects with ~90% of cases presenting with supernumerary teeth or a “third dentition”. Mouse Runx2 null models (Runx2+/-), although having similar CCD skeletal defects, do not mimic the human dental phenotype of supernumerary teeth. Instead, Runx2-/- mouse have arrested tooth formation at the cap stage. Furthermore, based …

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Transcriptional Dysregulation In Interneurons Causes Altered Modulation Of Hippocampal Synaptic Transmission And Circuit Function By The Dopamine System, Lillian J. Brady Jan 2017

Transcriptional Dysregulation In Interneurons Causes Altered Modulation Of Hippocampal Synaptic Transmission And Circuit Function By The Dopamine System, Lillian J. Brady

All ETDs from UAB

Genetic deletion of the transcriptional coactivator PGC-1α leads to transcriptional dysregulation in interneurons, and transcriptional dysregulation in interneurons lead to changes in hippocampal synaptic transmission and circuit function. Hippocampal circuit activity and synaptic transmission alterations have implications for symptoms of cognitive impairment in neurological disorders like schizophrenia. Modulation of dopamine receptor activity through pharmacologic application of haloperidol and the specific dopamine D4 receptor antagonist L-745,870 in PGC-1α-/- mice leads to altered effects on inhibitory/excitatory synaptic transmission balance, circuit function, and innate hippocampal dependent nesting behavior. These are key aspects underlying hippocampus dependent cognitive impairment. Specifically, bath application of haloperidol restores …

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Strategies Early Childhood Elementary Teachers Use In Order To Provide A Welcoming Environment For Student Who They Perceive To Be Lgbtq Or Exhibit Stereotypical Characteristics, Felecia Brooks-Jones Jan 2017

Strategies Early Childhood Elementary Teachers Use In Order To Provide A Welcoming Environment For Student Who They Perceive To Be Lgbtq Or Exhibit Stereotypical Characteristics, Felecia Brooks-Jones

All ETDs from UAB

STRATEGIES EARLY CHILDHOOD TEACHERS USE IN ORDER TO PROVIDE A WELCOMING CLASSROOM ENVIRONMENT FOR STUDENTS WHO THEY PERCEIVE TO BE LGBTQ OR EXHIBIT STEREOTYPICAL CHARACTERISTICS FELECIA BROOKS-JONES EARLY CHILDHOOD EDUCATION ABSTRACT People who identify as Lesbian, gay, bisexual, transgender, and queer/questioning are becoming more socially accepted today than they were before. Laws have been passed to give same-sex couples equal rights as heterosexual couples. However, they are not always treated the same, especially here in the southeast, which is known as the Bible Belt. There is minimal research or literature in the field of education concerning early elementary LGBTQ students, …

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Autism Spectrum Disorders And Social-Ecological Models: Understanding How Context Drives Prevalence, Anne Elizabeth Brisendine Jan 2017

Autism Spectrum Disorders And Social-Ecological Models: Understanding How Context Drives Prevalence, Anne Elizabeth Brisendine

All ETDs from UAB

Background: While there has been significant work done to explore disparities in autism spectrum disorder (ASD) diagnoses with respect to individual characteristics, little work has been done to examine the overall system and structure of the environment in which ASD identification is made and how it is related to diagnosis and services. The purpose of this study is to better understand the social-ecological factors that impact ASD diagnoses at the population level. Methods: In the first aim of this dissertation, a tailored social ecological model was developed and examined across variables in the 2011/12 National Survey of Children’s Health. In …

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Immunobiology Of The Mucosal Response To Helicobacter Pylori In Children, Kyle Brawner Jan 2017

Immunobiology Of The Mucosal Response To Helicobacter Pylori In Children, Kyle Brawner

All ETDs from UAB

Helicobacter pylori colonizes the stomach of approximately one half of the world’s population. However, the vast majority of infected persons remain asymptomatic. The degree of H. pylori-induced gastric inflammation depends on a complex interaction of several factors. In this dissertation, we focus on age as a determinant of gastritis severity. Children are known to respond to H. pylori infection with a stronger T regulatory cell profile compared with infected adults, yet the reason remains unknown. The influence of the microbiota on, and the communication among, cells of the innate immune system shape the nature of the adaptive immune response to …

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Nadph Oxidase-Derived Superoxide Production During Coxsackie B Virus Infection Fuels Macrophage Activation To Accelerate Type 1 Diabetes, Ashley R. Burg Jan 2017

Nadph Oxidase-Derived Superoxide Production During Coxsackie B Virus Infection Fuels Macrophage Activation To Accelerate Type 1 Diabetes, Ashley R. Burg

All ETDs from UAB

Type 1 diabetes (T1D) is a chronic inflammatory autoimmune disease in which autoreactive T cells selectively destroy insulin-producing pancreatic β-cells. While genetic predisposition underlies susceptibility, environmental factors are proposed to play the important role of triggering the activation of autoimmunity in T1D individuals. Viral infections, particularly by Coxsackie B viruses, are highly suspected as a precipitating event. However, the exact molecular mechanism for how viral infections elicit β-cell-specific autoimmunity remains unclear. Rodent models of virus-induced T1D suggest it is through bystander activation, during which innate antiviral responses to pancreas-tropic viral infections create an inflammatory milieu that breaks the peripheral tolerance …

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A Comparison Between Number And Letter Acuities Among Patients, Sarah Berry Jan 2017

A Comparison Between Number And Letter Acuities Among Patients, Sarah Berry

All ETDs from UAB

ABSTRACT Purpose: Previous studies have shown that there is an association between visual acuity and Alzheimers’ disease. Untreated visual problems may contribute to cognitive impairment and more progressive cognitive decline. This study investigates the association of chart design, specifically comparing charts using letters versus numbers, to accuracy and repeatability among patients with dementia. Methods: 23 English-speaking subjects diagnosed with moderate to advanced levels of dementia were recruited from two local Birmingham nursing homes. Visual acuities were measured in a randomly selected eye and timed from six different charts: Back-illuminated ETDRS chart with letters, Back-illuminated ETDRS chart with numbers, HOTV cards …

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Interplay Of The Circadian Clock And Growth Hormone Signaling In The Heart, Ryan Darrell Berry Jan 2017

Interplay Of The Circadian Clock And Growth Hormone Signaling In The Heart, Ryan Darrell Berry

All ETDs from UAB

Growth hormone (GH) signaling plays a critical role in postnatal development and the details of its release, regulation, and influence on the development of a number of organs has been well studied. GH is released from the anterior pituitary in a pulsatile fashion with pulse amplitude being greater at night than during the day in a number of species, including humans. Once in circulation, GH binds to the GH receptor (GHR) on target tissues throughout the body altering gene expression and stimulating the local production of insulin-like growth factor 1 (IGF-1). IGF-1 primarily acts in an autocrine and paracrine fashion. …

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