Digital Commons Network^™

4-Nonylphenol Induces Neurodegeneration By Altering Cytoskeleton, Cynthia Carreon

Open Access Theses & Dissertations

4-nonylphenol (4-NP), an endocrine-disrupting compound (EDC), has been shown to affect brain development and may cause neurodegeneration. In the environment, 4-NP arises as a degradation product of alkylphenol polyethoxylates, compounds widely used as nonionic surfactants in commercial production, as well as in herbicides, pesticides, polystyrene plastics, and paints and has been shown to undergo a high level of accumulation in biological tissues. However, the mechanism by which 4-NP exerts its effect is not understood. Recent results from our laboratory indicate that Gβγ, an important component of the G protein-signaling pathway, induces neuronal outgrowth and differentiation by modulating microtubule (MT) assembly, …

Organic-Inorganic Graphite And Transition Metal Dichalcogenide Based Composites For 3d Printing, Jorge Alfredo Catalan Gonzalez

Open Access Theses & Dissertations

This project was multipronged to help fuse together topics of additive manufacturing and two-dimensional (2D) layered materials, and studying the mechanical and electrical properties of the composites produced. The composites are made from the thermoplastic polymer acting as a matrix and the graphite and 2D transition metal dichalcogenides (TMDs) serving as the filler or reinforcement. Different concentrations of TMD's were added to the matrix to study the effect of composition on the mechanical and electrical properties. To shed insights into the mechanical properties, test coupons were produced as "dog bone" structures for tensile testing using the ASTM D638 type 5 …

From The Fangs Of Monsters: Gender, Empire, And Civilization In The Pacific, 1800-1850, Michael David Chavez

Open Access Theses & Dissertations

As the nineteenth century commenced, contact between Pacific Islanders and Anglo-Americans increased as did the concern for what resulted from those interactions. In the United States, antebellum restrained men––those who upheld their Protestant faith, self-reliance, and familial values––used ideals of gender to combat the perceived “savagery” of Pacific Islanders and the corruption of American sailors among them. In the mission field, restrained men consciously sought after Anglo-American women’s influence often believing them to be the moral authority of a softer form of empire. This particular form of empire was not government led; nor did it entail the immediate conquest of …

Cultivating Social Capital In Undergraduate Research: Key Sources And Distinctions By Gender, Heather Ann Daniels

Open Access Theses & Dissertations

Women are outpacing men in overall educational attainment, however this is not the case in science, technology, engineering, and mathematics (STEM) fields when women fall behind men. Establishing strong social connections is important to retention in STEM fields and persistence in the STEM pipeline. This study qualitatively examines what serves as social capital in STEM-focused undergraduate research and how social capital is accrued and deployed differently by men and women in ways that could be contributing to the gender gap in STEM. 17 students participating in external summer research programs at 12 different universities were interviewed at 3 points in …

A Study Of Hippocampal Microglia Distribution In Pre-Adolescent Mice Chronically Exposed To Lead, Salvador Dominguez

Open Access Theses & Dissertations

Background: Lead is a major unresolved child health hazard. Children are uniquely vulnerable to the effects of lead exposure, which include disruption of brain development and brain function. How lead exposure alters brain development and brain function is not currently known. Our laboratory has been developing a mouse model to understand effects of low-level lead exposure in the developing brain. In previous studies, we have shown that early chronic low level lead exposure diminished the number of microglia in the dentate gyrus region of the hippocampus, an area responsible for learning and memory. Building on the results of the previous …

Predicting Individualized Treatment Effects Via Random Forests Of Interaction Trees, Annette Pena Franco

Open Access Theses & Dissertations

Abstract Not Available

A Behavioral And Neuroimmune System Model Of The Effects Of Chronic Low-Level Lead Exposure In Young Male C57bl/6j Mice, Mayra Gisel Flores-Montoya

Open Access Theses & Dissertations

Chronic low-level lead exposure reduces memory in children however the brain mechanisms mediating these effects are not known. In previous studies we showed that early lead exposure reduced olfactory memory and exploratory behavior in young mice, and reduced microglia cell density in hippocampus/dentate gyrus. The present studies aimed to identify additional behavioral tests that were sensitive to early low-level lead exposure in young mice; and to examine whether microglia upregulated factors known to promote cell migration. Seventy-two C57BL/6J male mice were exposed to 0 ppm (controls), 30 ppm (low-dose), or 430 ppm (high-dose) of lead acetate via dams' milk from …

Evaluation Of Pertussis Knowledge Within The Child Daycare Staff And Management In The El Paso, Texas, Diana Jaqueline Gomez

Open Access Theses & Dissertations

BACKGROUND: Child daycare centers have an enormous influence on the children's health, which is important to maintain daycare staff and management informed on how to prevent communicable diseases, such as pertussis. Bordetella pertussis (Bp), the causative agent of whooping cough, is a small gram-negative bacterium that infects the nasopharynx of humans, which are the only reservoir. Bp is a highly contagious respiratory disease, which continues to be a severe disease in infants. The disease affects all ages and is easily transmitted from person to person, through respiratory droplets. Even though there is a vaccine available for all ages there are …

Evaluation Of A Gender-Relevant Physical Activity After-School Program, Vianay Lopez

Open Access Theses & Dissertations

Background: Physical activity rates have decreased in the past 30 years. Physical activity rates decline further among girls as they reach adolescence, yet studies suggest girls are more inclined to participate in moderate-to-vigorous physical activity (MVPA) while among peers. When in close social networks, girls who have more physically active friends report being more active themselves. Several mentor-based programs throughout the United States have increased physical activity among preadolescent girls, indicating that gender-relevant physical activity programs may reverse their declining rates of physical activity.

Purpose: To evaluate if participation in a gender-relevant physical activity after-school program influenced participants' aerobic fitness, …

Arak And Other Stories, Fatima Sausan Masoud

Open Access Theses & Dissertations

Set in the West Bank, Arak and Other Stories follows the lives of members of the Al-Hakim family. Through the stories, Palestinian-American, Layla Al-Hakim, uncovers long buried family secrets and discovers deep connections to her Palestinian cousins.

Integration Of Heterogeneous Traffic Data To Address Mobility Challenges In The City Of El Paso, Daniel Michael Mejia

Open Access Theses & Dissertations

Transportation performance measures are defined as quantitative and qualitative indicators that rely on data or information to explain mobility, traffic congestion, safety, environmental sustainability and other factors. Although performance measures have been used for freeways and other highways, not many have been specified and applied to the freight transportation system. Under the Fixing America's Surface Transportation Act (FAST Act), state transportation agencies and metropolitan planning organizations in the United States are implementing freight performance measurement systems for performance assessment. This research aims to expand the existing limited freight performance measures and organize them into a comprehensive framework that can be …

The Metabolically Sentient Arcuate Nucleus: A Functional, Chemoarchitectural And Connectional Study In The Adult Male Rat, Anais Martinez

Open Access Theses & Dissertations

As the obesity pandemic continues to increase, so does the incidence rate of related conditions including diabetes, cardiovascular disease, and neurodegenerative disorders (Yu and Kim 2012). At the level of the brain, the hypothalamus is a key structure for the integratration of autonomic, neuroendocrine and somatomotor functions for the control of metabolism and homeostasis. It has long been implicated as a critical player in the deregulation of an animal's energy status and in the onset of obesity, diabetes and metabolic syndrome (Elmquist et al., 1999). While many ongoing studies are aimed at preventing or treating these conditions, the underlying mechanisms …

Instilling Positive Beliefs About Organ Donation: An Information Processing Approach, Gerardo Jose Moreira

Open Access Theses & Dissertations

The number of those seeking a kidney donation in the United States continues to increase while the number of donors is not growing at the same rate (U.S. Department of Health and Human Services USDHHS, 2010). The lack of donations is more prevalent in low health literate communities which suffer from misinformation and ultimately negative beliefs toward organ donation. Thus, it is important to understand how marketing efforts can effectively change individuals' beliefs about organ donation.

Drawing on the Self-Determination Theory and Schema Theory, I proposed that the effectiveness of health education programs, which is to motivate individuals to be …

Sample Size Estimation For Linear Mixed Models With Dependent End Points, Michael Nsiah-Nimo

Open Access Theses & Dissertations

The primary objective is sample size estimation in linear mixed model settings. Sample size estimation is an important component of planning a well thought out scientific experiment. Whenever sample size estimation is performed, taking into account a priori model based inferences will provide a sample size estimate that will achieve the desired power without inflating the type I error rate of the study.

One common practice is a traditional approach cited in the literature that uses the largest sample size after you Bonferroni the type I error rate to estimate sample sizes as such. We are going to take into …

Airborne Lead In El Paso, Texas, Usa, Lisa Marie Paz

Open Access Theses & Dissertations

Despite significant strides to minimize lead in our air, water, soil, food, homes, workplaces, and consumer products, sporadic and systemic lead poisoning persists in industrial societies, e.g., the contemporary Flint (Michigan, USA) municipal water tragedy. Because lead exposure is cumulative, the sum of exposure from all sources, it is important to document and update potential community or neighborhood exposure levels from such environmental compartments as air, water, and housing. Here we present ambient airborne lead levels in El Paso, Texas, USA, parsed by particulate matter (PM) size fraction, geography, and season. Dichotomous samplers at 8 stations collected particulate matter continuously …

New Black Boxes: Technologically Mediated Intercultural Rhetorical Encounters On The U.S.-Mexico Border, Beau Scott Pihlaja

Open Access Theses & Dissertations

Activity theory (AT) and actor-network theory (ANT) as theoretical frameworks begin their analysis of the world with the concept of "actors" engaged in activity towards some objective and with other actors in the human and non-human world. In this project, I use AT and ANT to analyze the mediating effect of communication technologies in intercultural rhetorical contexts, in this case a binational small business, and address two questions: 1.) How do common communication technologies (email, phone, IM chat, texting applications) define and transform intercultural rhetorical encounters? And 2.) How do individuals rhetorically engage perceived cultural others using common communication technologies …

Dual Enrollment Participation In The United States: Findings From The High School Longitudinal Study Of 2009, Luis Eduardo Rivera

Open Access Theses & Dissertations

Today, dual enrollment programs are ubiquitous in the United States' secondary educational system. As a form of accelerated coursework, policy makers and school districts push dual enrollment as a means to improve college readiness and attainment. This paper studies the composition and characteristics of dual enrollment participants in the United States. Employing the High School Longitudinal Study of 2009 restricted dataset, three discrete logistic models are created to estimate the probability of a high school student participating in any dual enrollment coursework across the United States. The results from these models suggest that gender, prior academic achievement, and family socioeconomic …

Redesign Of A Volume Adjustable Transtibial Prosthetic Socket, Samuel Terrazas Quezada

Open Access Theses & Dissertations

Recent research and development in prosthetics have aimed at improving socket designs and components to mimic more efficiently the human body. One such innovation is the Aperture Socket, a low-cost volume adjustable prosthetic socket. During the validation stage of its development, the Aperture Socket successfully demonstrated that it could compensate for volume changes, but various improvements on use and comfort were identified. This project develops and tests a redesign of the Aperture Socket previously developed for amputees in developing countries and subsequently patented and licensed to LIMBS International, Inc.

The first phase of this study was the creation of various …

Corporate Sponsorship And The Consumer Socialization Of African American Women Athletes: A Qualitative Study, Tahla Monique Wade

Open Access Theses & Dissertations

African-American consumption is a unique feature of the American consumer market. A characteristic of African American consumers is their participation in conspicuous consumption. A look into the sociological concept of consumer socialization can drive insight to what initiates purchases of this group. However, this is not studied as an evolving process. Over time, individuals may encounter several new influences that affect their consumer socialization and purchase behavior, including the possibility of corporate sponsorship. To explore this evolution, I examine if corporate sponsorships affect the consumer socialization of African-American women collegiate athletes. Fifteen NCAA Division I African-American women athletes from a …

¡Grito!: Cultural Nationalism And The Chicana/O Insurgency In New Mexico, 1968-1978, Dennis Aguirre Aguirre

Open Access Theses & Dissertations

"¡Grito!: Cultural Nationalism and the Chicana/o Insurgency in New Mexico, 1968-1978,” is one of the first to examine the development of Chicana/o movement practices in the “Land of Enchantment.” While others have cast the Chicana/o movement’s criticisms and actions against federal, state, and local governments as a struggle to gain greater rights for Mexican Americans, I argue that the insurgency was not exclusively a strategy of resistance to subjugation. Instead, I believe the Chicana/o movement was a conversation that activists attempted to have with their own communities to convince ethnic Mexicans to think about themselves in profoundly new ways. Focusing …

Image Data Mining For Quality Control Of Nanofiber Reinforced Piezoelectric Nanocomposites Based On Sem Images, Zhonghua Hu

Open Access Theses & Dissertations

Recently, portable and wireless nano-scaled devices have been widely used in environmental monitoring, medical implants, defense technology, industrial safety, and personal electronics, such as the nanowire-based gas and chemical sensors and programmable nanowire circuit for nano-processors. There has been an increasing demand for high energy density capacitors that can be engineered for various applications in advanced devices. In it, piezoelectric nanofiber materials play critical role in producing new products. A piezo-ceramic polymer composite contains a polymer of high dielectric strength and high permittivity ceramic inclusions, making it well suited as a high energy density capacitor. Furthermore, the research shows that …

Do Coaches Practice What They Preach? An Evaluation Of The Usage Of Evidence-Based Practices Among Probation Officer Coaches, Tamara Kang

Open Access Theses & Dissertations

Probation supervision has the potential to serve a rehabilitative function through the use of evidence-based practices (EBPs; practices supported by empirical research). Often, when administrators adopt EBPs in their agency, these programs may not be implemented with fidelity by probation officers who interact with offenders. Thus, there is a critical need to examine methods of increasing the effectiveness of implementing EBPs among officers. One method, peer mentoring (i.e., coaches), is gaining popularity; however, little is known about the highly-motivated officers who volunteer to be coaches. Consequently, this Dissertation investigates compliance with EBPs among officers who have volunteered to become coaches …

An Environmental Scan Of Diagnostic Practices For Children With Disabilities In El Paso, Alezandra Martinez

Open Access Theses & Dissertations

With the prevalence of developmental disabilities in the rise in the United States, it is important that these children are identified and diagnosed as soon as possible so that they may receive appropriate medical treatment and intervention. However, research suggests that there are several factors that influence screening, referral, and diagnostic practices. This study aimed to analyze key themes that arose when parents of children with disabilities and pediatric healthcare providers discussed screening, referral, and diagnostic practices for children in El Paso, a medically underserved community. Researchers conducted a 2- phase study that employed both quantitative and qualitative methodology. Results …

Renewable Energy Systems Optimization Using Monte Carlo Simulation And Evolutionary Algorithms, Nicolas Lopez

Open Access Theses & Dissertations

This Dissertation explores the Renewable Energy Integration Problem, and proposes a Genetic Algorithm embedded with a Monte Carlo simulation to solve large instances of the problem that are impractical to solve via full enumeration. The Renewable Energy Integration Problem is defined as finding the optimum set of components to supply the electric demand to a hybrid

microgrid. The components considered are solar panels, wind turbines, diesel generators, electric batteries, connections to the power grid and converters, which can be inverters and/or rectifiers. The methodology developed is explained as well as the combinatorial formulation. In addition, 2 case studies of a …

Development And Verification Of A Lab-Scale Green Propellant Hybrid Motor System, Shyamal Patel

Open Access Theses & Dissertations

Hybrid rocket propulsion offers the potential to combine advantages of both solid and liquid propellant systems, but low regression rates hinder their practicality. The suggested use of hydroxylammonium nitrate (HAN) based propellants in hybrids offers the potential for developing high impulse motors with low development and production costs. In this paper, I present the development of a small-scale system used to measure the regression rate of a hybrid motor. The system can accommodate fuel grains 5 cm long with an outer diameter of 6 cm and can implement the various decomposition gases needed for HAN. The motor firings of hydroxyl …

Developing Dual Diagnosis Care Curriculum For Nurses In Acute Psychiatric Inpatient Settings, Kofi Ahumkah Bonnie

Yale School of Nursing Digital Theses

Patients with co-existing substance use and mental disorder (dual diagnosis) have complex and challenging care needs especially in acute psychiatric inpatient settings. Acute psychiatric care plays a vital role in mental health service delivery and there is evidence that nurses working in these settings often have unmet learning needs regarding dual diagnosis care, posing a challenge to nursing practice. The purpose of this project was to develop an educational module which will equip nurses with the skills and knowledge required to deliver evidence-based dual diagnosis care in acute psychiatric settings. A survey of 74 acute psychiatric nurses was initially completed …

The Ebola Experience: Media Lessons For Nurse Leaders, Elizabeth Leary

Yale School of Nursing Digital Theses

Background: In October, 2014 the nursing profession gained unprecedented media attention when two nurses became infected with the Ebola virus, and another nurse who cared for Ebola patients defied two gubernatorial quarantine orders. Nurses have traditionally received little media attention, and the nursing profession was largely unprepared for the intense media scrutiny which occurred during the Ebola crisis.

Purpose: For decades nursing scholars have called for a new media image for the nursing profession, yet most of the nursing literature has focused on the profession’s poor media image rather than effective media communication techniques. The purpose of this paper is …

Adapting An Evidence-Based Pediatric Acute Asthma Exacerbation Severity Assessment Tool For Pediatric Primary Care, Anne Tipay Magpuri

Yale School of Nursing Digital Theses

Abstract

Introduction: The purpose of this project was to examine criteria derived from evidence-based pediatric acute asthma exacerbation assessment tools, asthma scores, and the acute asthma prediction rule validated and utilized in the emergency department and to adapt these criteria for pediatric primary care.

Method: Three stages of the project included: (1) identification of criteria in a literature review, (2) validation of the criteria by an expert panel, and (3) adaptation of the criteria in the design of an assessment tool.

Results: The criteria were validated and adapted in the design of “The Pediatric Acute Asthma Exacerbation Severity Assessment and …

Mental Health In The Primary Care Of Trans Patients, Ronica Mukerjee

Yale School of Nursing Digital Theses

Primary care clinicians working with trans patients may not realize the impact of systemic inequality on the mental health of their patients. Although clinical guidelines for care exist, most do not explicitly address this context of inequality. Placing guidelines in a framework of cultural safety will increase the likelihood that patient narrative, needs and culture are respected and taken into consideration when providing care and developing treatment plans for trans patients, thereby decreasing the impact of systemic inequality and improving the quality of the healthcare provided. Considering the positive impact that primary care clinicians can have on the health of …

The Development And Validation Of An Acuity Tool In A Pediatric Outpatient Burn Clinic, Arlene Swan-Mahony

Yale School of Nursing Digital Theses

In outpatient settings, the role of nurses has shifted from episodic, reactive care to management of patients with higher acuity. In a pediatric outpatient clinic specializing in burn injuries, it became apparent that the lack of an acuity tool to measure patient complexity challenged efficient nurse staffing and patient satisfaction. In this improvement project we developed a patient acuity tool that would help to determine nurse staffing, improve workload efficiencies, and improve the delivery of care.