Digital Commons Network^™

Muscarinic Acetylcholine Receptor M1’S Impact On Fear Extinction Learning, Joshua R. Mcelroy

Theses and Dissertations

Post-Traumatic Stress Disorder (PTSD) is a mental health disorder that can occur following a traumatic event like combat, assault, or disaster. Individuals with PTSD are unable to extinguish fear memories which can become chronic and disabling. However, it remains unclear why some individuals exposed to a traumatic event develop PTSD while others are resilient. Acetylcholine plays a critical role in fear learning, but its role in fear extinction is less well understood. In this investigation, we used a rat model of fear extinction to determine if individual differences in extinction learning are correlated with markers of cholinergic signaling. Cholinergic markers …

Atherosclerotic Plaque Adhesion Strength And Its Role In Plaque Rupture, Bilal Merei

Theses and Dissertations

Cardiovascular diseases are disorders affecting the blood vessels and the heart. According to the World Health Organization, cardiovascular diseases are one of the leading causes of death worldwide. They are responsible for over 17.1 million deaths per year worldwide, representing 31.5% of deaths 1, 2. Atherosclerosis, a chronic inflammatory disorder affecting large arteries, is the underlying cause of many cardiovascular diseases. Plaque rupture is a serious complication of advanced atherosclerosis, often leading to life-threatening clinical consequences such as myocardial infarction (heart attack) or stroke. 75% of newly developed myocardial infarction cases are caused by atherosclerotic plaque rupture. It affects approximately …

The Underside Of Power: Reading The Fantastic In The Works Of The Chilean Writer José Donoso, Andrew Mark Corley

Theses and Dissertations

This dissertation examines the fantastic in the work of the Chilean author José Donoso (1924-1996). My thesis is that Donoso’s invocation of the fantastic in these narratives, subverts social constructs and power structures, specifically those associated with identity and sexuality. Via textual analysis, I argue that narratives such as “Santelices” (1956), El obsceno pájaro de la noche (1970), El jardín de al lado (1981), Naturaleza muerta con cachimba (1990), El lugar sin límites (1971), and Lagartija sin cola (2007) invite us to rethink how we see ourselves as we interact with his characters, often portrayed as tormented souls in hellish …

The Role Of Lipocalin-2 In The Hepatic Microenvironment Of Colorectal Cancer Metastasis, Daniel Titus Hughes

Theses and Dissertations

Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States. The major cause of death is metastasis and the frequent target organ is the liver. When diagnosed early at a localized stage, the five year survival rate after resection is 90%. However, after metastasis has occurred, this drops to less than 12%. Metastasis is often asymptomatic and diagnosed at the final stage when therapeutic options are limited. Because of this, the genetic and cellular mechanisms regulating metastasis are still poorly understood. Recent studies have shown that prior to the arrival of cancer cells at the …

Determining The Population Dynamics And Reproductive Life History Of Commercially Important Tunas In The Gulf Of Mexico, Katrina C. Hounchell

Theses and Dissertations

The Gulf of Mexico (GOM) is an important spawning ground for many commercially important fish species including yellowfin, skipjack, and blackfin tunas. In particular, it is an essential spawning habitat for Atlantic bluefin tuna, whose stock status is of great international concern. It is vital to the appropriate conservation management of these species to determine both the location of their spawning grounds and the genetic diversity found within them. Fish eggs are a fisheries-independent source of spawning information that can provide more accurate estimates of spawning sites compared to larvae. This study describes population diversity and reproductive life histories in …

Utility Of The Modified Early Warning System Score In Early Sepsis Identification, Lisa E. Hart

Theses and Dissertations

The purpose of this quality improvement project is to improve outcomes for patients presenting to the emergency department with sepsis, realizing that time is a key factor. The appraised evidence indicates that early recognition and prompt treatment improve outcomes and decrease mortality. The evidence further highlights that use of an early warning system, like the Modified Early Warning Score, can assist nurses and providers with recognizing deterioration more quickly and lead to a reduction in time to interventions. Between January 2016 and March 2017, the author conducted a retrospective chart review to compare time to antibiotic administration and lactate measurement …

Theme Park Demand, Theme Park Attractiveness, And Visitors’ Theme Park Choices, Yingsha Zhang

Theses and Dissertations

This dissertation examines the relationship among theme park demand, theme park attractiveness, and visitors’ theme park choices. It consists of three studies reported through five chapters. Key data were obtained from the website of an online travel agency, TripAdvisor, using web scraping techniques. The first study developed a new approach to measure tourist source markets’ theme park demand and theme park attractiveness by solving a reverse gravity model via particle swarm optimization. Findings from this study should help theme parks to evaluate more accurately the demand market and their own competitiveness compared to other theme parks. The second study explored …

Acculturative Stress And Depression Among Latinos/As: Investigating The Role Of Neighborhood Context, Rebeca Castellanos

Theses and Dissertations

Latinos/as are the fastest growing demographic in the United States (U.S. Census Bureau, 2015). As they encounter U.S. society, Latino/as may experience acculturative stress (Berry, 1997). Empirical evidence suggests that Latinos/as in the U.S. report high rates of depression symptoms (Wassertheil-Smoller et al 2014). Acculturative stress has been strongly associated with depression (Driscoll & Torres, 2013) and research suggests that Latino/as may experience acculturative stress differently depending on their generational status (i.e., how recently they or their parents immigrated to the U.S). There is evidence to suggest that contextual factors such as neighborhood context may influence both acculturative stress processes …

Identifying Associations Between Religious Commitment And Preventive Health Behaviors In A Southeastern Rural County, Nathan A. Peters

Theses and Dissertations

Health disparities within the United States (US) are continuing to impact ethnic minorities living in rural areas nationwide. In response, there is growing interest in using faith-based settings as vehicles to deliver much needed disease prevention interventions. However, few studies have identified the relationship between private and public religious commitment, individually, and the behaviors or risk factors associated with chronic disease. The purpose of this study was to observe the association between religious commitment, both private (i.e., time spent trying to grow in one’s religious understanding) and public (i.e., frequency of attendance, time spent in fellowship with others) individually, and …

The Relation Between Quantitative Eeg Coherence And Self-Report Adhd Behavior Scale Responses, Tayllor Vetter

Theses and Dissertations

Differences in brain wave activity during resting states between adults with and without Attention-Deficit/Hyperactivity Disorder (ADHD) have been detected with electroencephalography (EEG). However, the relation between these patterns of brain wave activity and a dimensional, self-report measure of ADHD symptoms in male and female college students has never been investigated. The present study aimed to determine whether coherence, a measure of brain wave activity, can predict self-report symptoms of inattentiveness and hyperactivity in male and female college students. The analyses consisted of 14 male and 28 female adults between 18 and 27 years of age. Regression analyses were utilized to …

Effectiveness Of Community-Based Eibi Treatment: A Longitudinal Analysis Of Adaptive Behavior And Language Outcomes, John Kuntz

Theses and Dissertations

Autism spectrum disorders (ASDs) are a group of lifelong, neurodevelopmental disorders characterized by deficits in social interaction, communication, relationship development and by the presence of repetitive or stereotypical behaviors including restricted interests. Continued advances in understanding treatment outcomes and broadening access to effective treatment is critical to improving the quality of life of children with autism and their families and minimizing the cost associated with care. The overall aim of this study is to assess the effectiveness of a community-based implementation of an Early Intensive Behavioral Intervention (EIBI) treatment program through a large-sample, longitudinal secondary analysis of administrative data. Additionally, …

Comparison Of Intimate Partner Violence And Sexual Assault Among Black And White College Women At Predominantly White Institutions (Pwis), Cynthia Nicole White

Theses and Dissertations

Objective: The current study sought to compare Black and White college women’s experiences following sexual assault or physical intimate partner violence (IPV) while attending a predominately White institution (PWI). Prevalence rates, depression, academic effects, binge drinking, and help-seeking among victims was compared by race.

Method: Black (N= 435) and White (N= 4,313) college women from 3 large PWIs in the United States completed online surveys. The survey included questions about race, sexual assault, physical IPV, depression, academic outcomes of victimization, binge drinking, and help-seeking.

Results: Black women were more likely to experience physical IPV than White women, …

Internet Speed And The Effect On Health Information Technology Adoption, Matthew W. Yuen

Theses and Dissertations

Background. The Internet has become pervasive in everyday life; the Pew Research Center reported over 84% of Americans use the Internet either on their phone or a computer. However, due to the methods by which the Internet was created, an Internet digital divide was created. The Internet digital divide is the disparity in access and speed of Internet of certain populations. This study looked into the disparity between urban and rural populations and their Internet access in two forms: e-prescriptions adoptions and Internet health information seeking behavior (HISB) through their mobile devices.

Methods. This study used 4 datasets, …

Racism Across The American South: The Association Between Racism On Twitter, Rurality, & Black Mortality, Jarrod Bullard

Theses and Dissertations

Racism can be understood as a system of dominance and power designed to uphold the racially privileged of society. One can be exposed to racism through various mechanisms including the Internet and social media. Evidence indicates that exposure to racism is associated with poor mental and physical health outcomes as well as unhealthy behaviors. Current literature studying the effects of racism focus primarily on experienced or perceived racism. Furthermore, the geographic influence of racism on health at the county level and across levels of rurality is currently unknown. The purpose of this study was twofold; 1.) To explore the geographic …

Multinational Foreign Affiliates In The Least Developed Countries: A Multilevel Approach, R. Scott Hibbs

Theses and Dissertations

Several studies have examined the country-level effects on multinational enterprises that go into the developing countries, including the least developed countries. Few studies have considered the firm-level effects. This study uses the multilevel modeling method as outlined by Klein and Kozlowski (2000), Raudenbush and Bryk (2002), and Bliese and Hanges (2004) to examine whether there are any systemic patterns of multinational enterprises across the least developed countries. This paper uses information on foreign affiliates in the least developed countries to examine the overall trends of multinational firms in the least developed countries. Using data from the United Nations’ most recent …

Effects Of A Mindfulness Based Intervention On Diurnal Cortisol In Cancer Survivors, Susannah Small

Theses and Dissertations

Background. There are approximately 15.5 million individuals alive today in the U.S. with a personal history of cancer. For this large and growing population, ill effects associated with cancer diagnosis and treatment include both physical and psychosocial symptoms adversely affecting quality of life. One low-risk alternative to conventional pharmaceutical use in treating these symptoms is mindfulness practice. Research on self-reported measures provides strong evidence that this type of intervention improves quality of life for cancer survivors, but evidence of impact on objective measures is limited. Cortisol, the body’s primary stress hormone, is one relatively easy to measure indicator that …

A Mechanistic Study Of Micro Rna 21 Induced Hepatic Fibrosis And Use Of Sparstolonin B In Remediation Of Environmental Nafld, Diptadip Dattaroy

Theses and Dissertations

Due to the increased prevalence of obesity, non-alcoholic fatty liver disease (NAFLD) has become a major public health problem in the Western world and Asian countries. Approximately a third of the general population in the US has NAFLD. NAFLD includes a spectrum of histological characteristics ranging from simple steatosis to steatohepatitis, fibrosis and cirrhosis and can be characterized into to two major phenotypes: nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Water disinfection byproducts like trihalomethanes can act as crucial risk factors for NAFLD progression. Here I have studied the molecular mechanisms of a water disinfection byproduct, Bromodichloromethane, in induction …

Assessing The Relationship Between Periodontal Disease And Subsequent Inflammatory Responses And Headache Disorders, Bryn E. Davis

Theses and Dissertations

Headaches are the sixth leading cause of disability worldwide, and the third leading cause of disability amongst those aged 50 and older. Several headache disorders, including migraines, have been associated with nitric oxide production. It is widely accepted that the pain associated with headache disorders is due to the ability of nitric oxide to function as a vasodilator. While nitric oxide is a known vasodilator and has been linked to headache disorder, it is also produced in response to bacterial infections. Periodontal disease is the result of long term bacterial infections occurring in the gum line and nitric oxide is …

Comparison Of Atypical Bacteriophages That Infect Caulobacter Crescentus, Doreen Nguyen

Theses and Dissertations

Several Caulobacter bacterial genomes have been recently sequenced, and all of the genomes contained one or more clusters of genes with phage origins. This observation indicates that bacteriophages contribute to the Caulobacter gene pool, so in order to understand bacteria genomes we will need to understand phage genomes as well. As part of understanding the phage genomes, we want to isolate novel bacteriophages and study their genomics. This study resulted in the isolation of 12 new phages, including four that differ from the well-studied CbKlike phages. Two of these novel phages are Podoviruses with icosahedral heads and small tails, and …

Early Economic Hardship, Maternal Support, And Depressive Symptoms Among Black Young Adults, Mia Brantley

Theses and Dissertations

Substantial associations between childhood economic hardship and adult mental health have been acknowledged within social science research. However, there is a scarcity of research examining this relationship among Black Americans, as well as the sociocultural factors that may assist Black Americans in dealing with the effects of childhood economic hardship. This study suggests that family structure, specifically maternal support, may be a significant resource for Black Americans in the face of early economic adversity and mental health outcomes. Using data from the National Longitudinal Study of Adolescent to Adult Health, a nationally representative sample of Black Americans, this study outlines …

Characterization Of Subgrade Resilient Modulus For Mepdg And The Effects On Pavement Rutting, Md Mostaqur Rahman

Theses and Dissertations

In 2008, the American Association of State Highway and Transportation Officials (AASHTO) released a modified pavement design method (i.e., the Mechanistic Empirical Pavement Design Guide (MEPDG)) based on Long Term Pavement Performance (LTPP) data from all over the United States. The MEPDG default design parameters developed from the LTPP database are expected to be significantly different than those for South Carolina material, traffic and weather conditions, thus the default design parameters may not be accurate for South Carolina. Therefore, the new pavement design method should be calibrated for South Carolina conditions by performing MEPDG local calibration.

Different input variables should …

Marginal Structural Cox Model For Survival Data With Treatment-Confounder Feedback, Yanan Zhang

Theses and Dissertations

In an observational longitudinal study, there can be time-varying exposure/treatment and time-varying confounders. When the confounders affect the exposure and prior exposure also has an impact on levels of confounders, there is treatment confounder feedback. To admit estimation of unbiased causal effects, these conditions need to be hold, exchangeability, positivity, consistency. The traditional method of conditioning on potential confounders does not meet these 3 conditions. Therefore, parameter estimates from traditional Cox model are biased casual effect estimates when the treatment confounder feedback exists. The marginal structural Cox model can be used to address this issue. By calculating and including inverse …

Inflammatory Potential Of Diet And Pancreatic Cancer Risk: Interaction And Mediation Analysis In Two Prospective Cohorts, Jiali Zheng

Theses and Dissertations

Background: Inflammation plays a pivotal role in pancreatic cancer etiology and can be modulated by diet. We aimed to examine the association between inflammatory potential of diet, assessed with the Dietary Inflammatory Index (DIITM), and pancreatic cancer risk in two prospective cohorts, the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the National Institutes of Health American Association of Retired Persons (NIH-AARP) Diet and Health Study. We explored effect modification by important inflammation-related lifestyle factors, and investigated whether type-2 diabetes mediated the association in a pooled analysis of both studies.

Methods: A total of 101,449 and …

The Impact Of Autoimmune Disease On Breast Cancer Survival, Samantha Truman

Theses and Dissertations

Background Breast cancer is the second leading cause of cancer death for women in developed countries, while autoimmune disease effects approximately 10 million people in the United States, of which approximately 80% are female. Both diseases are associated with hormonal risk factors and are related to the divergent effects of the cellular and humoral immunity that is associated with the T-helper 1 and T-helper 2 immune response. To investigate the potential implications that autoimmune disease may have on breast cancer-specific mortality, we have conducted a population-based retrospective cohort study of women who were diagnosed with breast cancer between January 1, …

Trends In Gestational Weight Gain In South Carolina, 2004 - 2015, Marilyn Elizabeth Wende

Theses and Dissertations

Objective: Excessive and inadequate gestational weight gain (GWG) are associated with a myriad of adverse pregnancy outcomes. The objective of this study was to examine secular trends in GWG in South Carolina (SC) from 2004 to 2015. We hypothesized that there was a trend of higher GWG z scores (GWGZ) over this 11-year time period after adjusting for changes in population characteristics. We also hypothesize that a trend of higher mean GWGZ at higher percentiles is more apparent for African Americans, rural women, and women who are overweight or obese before pregnancy.

Data and Methods: Data came from SC …

The Association Of Changes In Cardiorespiratory Fitness With Changes In Cardiometabolic Risk Factors, Leanna Marie Ross

Theses and Dissertations

Cardiorespiratory fitness (CRF) is well established as having a strong inverse association with numerous cardiovascular disease (CVD) risk factors and mortality. As CVD remains the number one cause of death in America, the detrimental effects of low CRF present a substantial health threat. The studies presented in this dissertation syndicate both epidemiologic and clinical data that will enrich the knowledge base regarding the magnitude of change in CRF in relation to CVD risk factors.

Recently, the American Heart Association established a new construct termed ideal cardiovascular health (CVH), which is characterized by seven metrics known as Life’s Simple 7. The …

A Possible Mechanism For Leptin’S Role In Lung Function Independent Of Body Mass Index: Investigating Leptin’S Genotype, Dna, Methylation, And Serum Protein Levels, Mitra Yousefi

Theses and Dissertations

Background: Leptin, initially believed to simply be a satiety hormone responsible for obesity, is now recognized as a pleiotropic cytokine that is involved in many biological processes; including the body’s host inflammatory response. Clinically, leptin may affect lung function although research in this area is limited. It is also known that the leptin receptor is necessary for the activation of the leptin protein, making it an important protein to consider. Furthermore, single nucleotide polymorphisms (SNPs) and DNA methylations of the leptin and leptin receptor genes (LEP and LEPR respectively) may provide important insight on the relationship that leptin has …

Still Runnin’ The Underground: A Critical Case Study Of An Adolescent African American Male Reflecting On School, Dalisha Shante Williams

Theses and Dissertations

Despite the vast amount of research on effectively educating African American students, there are few studies capturing the educational narratives of African American students, and specifically Black males, in their own words. Much of the literature focuses on dismal statistics and outcomes concerning African American male students. Drawing upon Woodson’s (1933) timeless critique of the miseducation of the Negro, Afrocentricity in education (Asante, 1987; King & Swartz, 2014,2016) emancipatory pedagogies, and Ladson-Billings’ (1994) theory of culturally relevant pedagogy, this study explores one adolescent African American male’s reflections on school. Using a critical case study methodology, one participant, Merrick, participated in …

International Twitter Comments About 2016 U.S. Presidential Candidates Trump And Clinton: Agenda-Building Analysis In The U.S., U.K., Brazil, Russia, India And China, Jane O’Boyle

Theses and Dissertations

Based on agenda-building theory, this study performs content analysis on 6,019 international Twitter comments about Trump and Clinton in the 10 days prior to the 2016 U.S. presidential election. Even excluding bots and trolls, the preponderance of Twitter comments were positive about Trump and negative about Clinton, in the U.S., Russia, India and China. In the U.K. and Brazil, Twitter comments were largely negative about both candidates. Twitter sources and topics were also identified and explored to expand knowledge about the evolving role and effect of agenda-building in six nations, and around the world.

Non-Destructive Evaluation Of Composites: Predictive Ultrasonic Guided-Waves Modeling, Non-Destructive Material Characterization, And The Application To Aerospace Structures, Darun Barazanchy

Theses and Dissertations

To predict guided wave dispersion curves, it is common to use different solution approaches depending on the material type (isotropic or anisotropic) of the medium in which the wave propagates. The two different solution methods are defined in different domains, frequency-phase velocity domain for isotropic materials and wavenumber-phase velocity domain for anisotropic materials. This may lead to difficulties and unsatisfying results when predicting the dispersion curves for hybrid laminates which contain both isotropic and anisotropic materials. Therefore, a unified formulation defined in the wavenumber-phase velocity domain to accomodate both isotropic and anisotropic materials, as well as hybrid combinations, is desired. …