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Leading With All The Feels: Exploring The Perceptions Of Middle School Administrators' Implementation Of School-Wide Social-Emotional Learning Programming, Sabrina Smith Richardson Dec 2025

Leading With All The Feels: Exploring The Perceptions Of Middle School Administrators' Implementation Of School-Wide Social-Emotional Learning Programming, Sabrina Smith Richardson

Teaching & Learning Theses & Dissertations

Middle school administrators have multiple responsibilities that range from ensuring the safety and security of staff and students to overseeing the curriculum and instructional foci of their buildings. At the same time, middle school students are experiencing the early stages of adolescence. Because it is a complex time for students to navigate, it creates anxiety, a decline in academic achievement and motivation, and peer and academic pressures (London, 2022; Schlund, 2021). Middle school students have social-emotional needs that are not typically met in secondary schools, which means programming is not typically a part of the instructional day. This study examined …


Exploring The Impact Of Identity-Based Bullying On Suicidal Thoughts And Behaviors Among 6th-12th Grade Youth In Virginia, Camille N. Johnson Dec 2025

Exploring The Impact Of Identity-Based Bullying On Suicidal Thoughts And Behaviors Among 6th-12th Grade Youth In Virginia, Camille N. Johnson

Psychology Theses & Dissertations

Suicidal thoughts and behaviors (STBs) are a growing public health concern among youth. Bullying victimization is a robust risk factor for STBs and identity-based bullying (IBB) or bullying that occurs due to a person’s actual or perceived social-identity/identities that is ingrained in discrimination, prejudice, or bias, has been found to be more strongly associated with STBs compared to bullying that was unrelated to identity. The current study used data from the Virginia School Survey of Climate and Working Conditions (N=399,493) to examine associations between general bullying, adult-perpetrated bullying, and IBB with depression and STBs among 6th-12th grade youth. This study …


On The Scalability Of Anisotropic Mesh Adaptation On Distributed And Shared Memory Architectures For Numerical Approximations, Kevin Mark Garner Jr. Dec 2025

On The Scalability Of Anisotropic Mesh Adaptation On Distributed And Shared Memory Architectures For Numerical Approximations, Kevin Mark Garner Jr.

Computer Science Theses & Dissertations

Mesh generation is a critical component in numerical approximations of Partial Differential Equations (PDEs). One such example includes Computational Fluid Dynamics (CFD), as CFD simulations in turn are crucial for applications in many industries, such as personalized healthcare and the design of aerospace vehicles. Generating high quality meshes for large-scale CFD problems presents a significant bottleneck in the CFD workflow. This dissertation proposes “fast,” parallel 3D mesh generation methodologies that are designed to leverage the concurrency offered by emerging High-Performance Computing (HPC) architectures. First, a distributed memory method is presented that integrates a sequential state-of-the-art isotropic, advancing front local reconnection-based …


Unraveling The Links Between Substance Use And Academic Motivation In Higher Education, Melissa Lynn Goins Dec 2025

Unraveling The Links Between Substance Use And Academic Motivation In Higher Education, Melissa Lynn Goins

STEMPS Theses & Dissertations

Self-Determination Theory (SDT) posits that the quality of students’ motivation regulation (i.e., autonomous versus controlled) shapes both learning and health behavior, yet few studies have examined the relations among motivation regulation, alcohol and cannabis use, and achievement. In this study, I surveyed 459 undergraduates at a mid-sized public university in the southeastern United States. Participants completed the Academic Motivation Scale-College version 28 to assess autonomous and controlled motivation regulation, a typical-week alcohol grid, a seven-day cannabis grid, and self-reported grade point average (GPA). Results indicated that autonomous academic motivation was uniquely related to GPA; however, neither motivation variable related to …


Bridging The Gap Between Counselor Education And Trauma Treatment In Practice: A Phenomenology Of Trauma-Specialized Counselors, Ariel Hutcheon Dec 2025

Bridging The Gap Between Counselor Education And Trauma Treatment In Practice: A Phenomenology Of Trauma-Specialized Counselors, Ariel Hutcheon

Counseling & Human Services Theses & Dissertations

Trauma impacts the life experiences of a sizable portion of the population. Given that so many clients bring trauma into counseling, even when not the presenting issue, knowledge of trauma’s impact and proficiency with trauma treatment are essential topics in counselor education. This study gave voice to counselors in the field to share what they have found effective from working with clients with trauma. The researcher used a phenomenological approach and interviewed six self-identified trauma-specialized counselors who have practiced for five years or longer. The data was explicated, and four major themes were identified. The first theme was Inadequate Training: …


A Psychometric Evaluation Of The Pbss-20 Among Sexual And Non-Sexual Minority College Students, Alex Melville Dec 2025

A Psychometric Evaluation Of The Pbss-20 Among Sexual And Non-Sexual Minority College Students, Alex Melville

Master's Theses

This study evaluated the psychometric properties of the Protective-Behavioral Strategies Scale-20 in a large national sample of college students containing sexual minority and non-sexual minority students. Specifically, confirmatory factor analysis was used to evaluate the model fit with this sample, invariance testing was used to compare the model among sexual and non-sexual minority students, and construct validity was evaluated. Participants included college students (N = 1,730; Mage = 19.41) from 12 universities across the United States, who were predominantly White non-Hispanic (63.6%), identified as female (70%), and as completely heterosexual (67.6%). Participants completed demographic information and measures of …


Weathering Of Black Doulas In Hospitals: Challenges And Opportunities, Denise Elaine Bolds Dec 2025

Weathering Of Black Doulas In Hospitals: Challenges And Opportunities, Denise Elaine Bolds

Education Doctoral

Black maternal health continues to face significant disparities in the United States, highlighting the crucial role of Black Doulas in promoting birth equity (Declercq & Zephyrin, 2020; K. Taylor et al., 2023). This qualitative, phenomenological study explored the lived experiences of 10 certified Black Doulas working in hospital settings nationwide. Guided by the weathering hypothesis (Geronimus, 1992, /2023), critical race feminist theory (Wing, 2020), Black feminist theory (Collins, 2000), Sojourner syndrome (Bailey, 2017), and the looking-glass self (Cooley, 1902), the study examined how systemic racism, occupational challenges, and advocacy fatigue intersect to shape their professional experiences.

Using semi-structured interviews, participants …


Exploring The Relationship Between Job Satisfaction And Servant Leadership In Community Corrections: A Probation Officer’S Perspective, Shamira B. Gambrell Dec 2025

Exploring The Relationship Between Job Satisfaction And Servant Leadership In Community Corrections: A Probation Officer’S Perspective, Shamira B. Gambrell

Education Doctoral

Probation officers work in demanding environments marked by high caseloads, role conflict, and organizational pressures that can negatively affect job satisfaction and workforce stability. Leadership practices at the frontline supervisory level play a critical role in shaping these experiences, yet limited empirical research has examined servant leadership within community corrections. The purpose of this quantitative correlational study was to examine the relationship between probation officers’ perceptions of servant leadership demonstrated by their direct supervisors and their level of job satisfaction.

Data were collected from probation officers affiliated with departments connected to the American Probation and Parole Association using an anonymous …


Coupled Machine Learning Models: Combining Observations And Numerical Analysis In A Physics-Regularized Approach, Austin B. Schmidt Dec 2025

Coupled Machine Learning Models: Combining Observations And Numerical Analysis In A Physics-Regularized Approach, Austin B. Schmidt

LSU New Orleans Theses and Dissertations

This dissertation investigates surrogate modeling for fixed-location environmental forecasting using novel data-combination techniques. The work surveys the landscape of observational measurements and numerically generated data, identifying similar research and gaps in current methodologies. The ratio-coupled training framework is introduced to combine two data sources per predicted feature through a tunable parameter that weights training signal strength. An optimization scheme is developed to simultaneously tune surrogate weights and the coupled signal ratio, allowing relative influence between signals to act as an explicit regularizer. Three case studies demonstrate the methodology and approach in a variety of contexts. The first study is based …


Navigating Upstream: How Medical Educators Strategize The Unfamiliar During Their Transition Into A Leadership Role, Sarah Williams Dec 2025

Navigating Upstream: How Medical Educators Strategize The Unfamiliar During Their Transition Into A Leadership Role, Sarah Williams

LSU New Orleans Theses and Dissertations

As the medical field grows more complex, the need for medical educator leaders has increased, driving the integration of leadership training into medical education to help manage an increase in administrative challenges. In U.S. medical schools, the Liaison Committee on Medical Education (LCME) standards require faculty to fill high-ranking leadership roles who must balance academic and administrative duties. Medical educators in these leadership roles must manage the tensions between teaching, research, patient care, and administrative responsibilities. Although leadership programs designed for medical educators exist, as well as faculty development opportunities, educators consistently express a lack of training as they transitioned …


Recruitment And Retention Of Adult Learners In The State Of Louisiana: A Look Into The Adult Learner’S Decision-Making Process As A Consumer, Austin T. Rogers Dec 2025

Recruitment And Retention Of Adult Learners In The State Of Louisiana: A Look Into The Adult Learner’S Decision-Making Process As A Consumer, Austin T. Rogers

LSU New Orleans Theses and Dissertations

With the looming enrollment cliff and several institutions across the state and country already experiencing decreased enrollment, schools across the country have begun adjusting their current practices to maintain steady enrollment in the future. University administration and admissions offices are having to target new student groups in order to offset the traditional student populations they have historically worked with. However, in order for these new student groups to be successful on campus, these schools must also understand the needs of these new student populations. This narrative study aimed to better understand the experiences of adult learners currently enrolled at University …


Where's Waldo?: Finding The Missing Voice Of The College Counselor, Krystyn K. Dupree Dec 2025

Where's Waldo?: Finding The Missing Voice Of The College Counselor, Krystyn K. Dupree

LSU New Orleans Theses and Dissertations

College counseling has been integral to higher education for more than a century; however, the role of college counselors has become increasingly complex amid rising student mental health needs, growing symptom severity, and constrained institutional resources. Despite extensive research on college student mental health, little contemporary scholarship has examined the lived experiences of the professionals providing these services. The purpose of this qualitative study was to explore how college counselors who provide mental health services perceive their professional role within the context of higher education.

Guided by Bronfenbrenner’s ecological systems theory, this study conceptualized college counselors as embedded within interconnected …


A Quantitative Exploration Of Risk And Protective Factors Affecting The Mental Health Of Chitimacha Tribal Youth, Daphnie Vilcan-Tanner Dec 2025

A Quantitative Exploration Of Risk And Protective Factors Affecting The Mental Health Of Chitimacha Tribal Youth, Daphnie Vilcan-Tanner

LSU New Orleans Theses and Dissertations

This study examines the relationships between demographics, risk factors, and protective factors with mental distress among Chitimacha Tribal adolescents aged 12 to 18. Using a Positive Youth Development framework, the research aimed to identify the prevalence of mental distress, trauma, discrimination, and protective factors, as well as their collective and individual impacts on mental health. Data were collected through online surveys completed by 73 participants residing on or near the Chitimacha Tribal Reservation. Descriptive statistics and multiple linear regression analyses were conducted to analyze the data. Results revealed that while trauma and discrimination collectively predicted mental distress, family and community …


Large Language Models (Llms) For Clinical Note Generation: International Classification Of Disease (Icd) Code, Knowledge Graph (Kg) And Prompt Evaluation, Ivan P. Makohon Dec 2025

Large Language Models (Llms) For Clinical Note Generation: International Classification Of Disease (Icd) Code, Knowledge Graph (Kg) And Prompt Evaluation, Ivan P. Makohon

Computer Science Theses & Dissertations

In the past decade, a surge in the amount of electronic health record (EHR) data in the United States occurred, driven by a favorable policy environment created by the Health Information Technology for Economic and Clinical Health (HITECH) Act of 2009 and the 21st Century Cures Act of 2016. Clinical notes for patients’ assessments, diagnoses, and treatments are captured in these EHRs in free-form text by physicians, who spend a considerable amount of time entering them. Manually writing these notes is time-consuming, increasing patient waiting times and potentially delaying diagnoses. Large language models (LLMs), such as GPT-4o, possess the ability …


Piezoelectric Energy Harvesting From Roadways: Challenges, Advances, And Future Directions, Heba Gaber, Mohamed Abdelraheem Dec 2025

Piezoelectric Energy Harvesting From Roadways: Challenges, Advances, And Future Directions, Heba Gaber, Mohamed Abdelraheem

Faculty Publications

As the global demand for renewable energy intensifies, piezoelectric energy harvesting from roadways has emerged as a promising avenue for sustainable power generation. This systematic literature review analyzes 61 peer-reviewed studies to assess the feasibility, performance, and potential of integrating piezoelectric systems into roadway infrastructure. While technology faces challenges, such as high installation costs, limited energy output, and a scarcity of thorough economic evaluations, findings suggest it holds considerable promise as a supplementary renewable energy source. The review analyzes the operational characteristics and efficiencies of various piezoelectric transducers, identifies key factors influencing system performance, and evaluates recent technological advances. It …


Association Of Area Deprivation Index With Perinatal And Covid-19 Outcomes During The Early Pandemic: A Secondary Analysis Of A Prospective Cohort Study, Abigail Bell, Megan Foeller, Candice Woolfolk, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony Carter, Indira U Mysorekar, Jeannie C Kelly Dec 2025

Association Of Area Deprivation Index With Perinatal And Covid-19 Outcomes During The Early Pandemic: A Secondary Analysis Of A Prospective Cohort Study, Abigail Bell, Megan Foeller, Candice Woolfolk, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony Carter, Indira U Mysorekar, Jeannie C Kelly

2020-Current year OA Pubs

OBJECTIVE: We sought to evaluate the relationship between neighborhood-level deprivation and perinatal outcomes, particularly preterm birth, as well as COVID-19 outcomes among pregnant patients during the early pandemic.

METHODS: We performed a secondary analysis of a prospective longitudinal cohort study that investigated the impact of prenatal COVID-19 exposure on perinatal outcomes. Pregnant patients were recruited 12/23/20-7/18/22 and serially assessed for COVID-19 exposure during pregnancy, with serum antibody testing, electronic medical record review, and patient report. For this secondary analysis, address at the time of delivery was used to categorize patients into low ADI (≤50

RESULTS: 306 patients were included: 124 …


Using An Adapted Ripple Effect Map To Evaluate The Community Impact Of A Mobile Harm Reduction Team In Allentown, Pa., Alexandra Bersani Do, Alex Benjamin Md, Nyann Biery Dhsc, Abby S. Letcher Md Dec 2025

Using An Adapted Ripple Effect Map To Evaluate The Community Impact Of A Mobile Harm Reduction Team In Allentown, Pa., Alexandra Bersani Do, Alex Benjamin Md, Nyann Biery Dhsc, Abby S. Letcher Md

Department of Family Medicine

No abstract provided.


Impact Of Silencing Automated Penicillin Cross-Reactivity Alerts On Perioperative Antibiotic Prescribing And Surgical Site Infection Rates, Michael J Durkin, Joshua Nordman, Alice Bewley, Andrew Atkinson, Jonas Marschall, Helen Newland, Kimberly G Blumenthal Dec 2025

Impact Of Silencing Automated Penicillin Cross-Reactivity Alerts On Perioperative Antibiotic Prescribing And Surgical Site Infection Rates, Michael J Durkin, Joshua Nordman, Alice Bewley, Andrew Atkinson, Jonas Marschall, Helen Newland, Kimberly G Blumenthal

2020-Current year OA Pubs

We evaluated the impact of silencing penicillin cross-reactivity alerts on perioperative antibiotic prescribing and surgical site infections (SSIs) in 6 hospitals using an interrupted time series analysis. Silencing the alerts minimally increased cefazolin prescribing among penicillin allergy labeled patients (sensitivity analysis only;


Assessment Of Knowledge And Attitudes Of Undergraduate Students On Trichomoniasis In Ghana, Christopher Yaw Dumevi, Ezekiel Kofi Vicar, Lorie Christla Quansah, Rhoda Oklu, Smith Joshua, Joyce Junior Asiamah, James-Paul Kretchy, George Boateng Kyei, Patience B Tetteh-Quarcoo, Nicholas T K D Dayie, Irene Ayi, Patrick F Ayeh-Kumi Dec 2025

Assessment Of Knowledge And Attitudes Of Undergraduate Students On Trichomoniasis In Ghana, Christopher Yaw Dumevi, Ezekiel Kofi Vicar, Lorie Christla Quansah, Rhoda Oklu, Smith Joshua, Joyce Junior Asiamah, James-Paul Kretchy, George Boateng Kyei, Patience B Tetteh-Quarcoo, Nicholas T K D Dayie, Irene Ayi, Patrick F Ayeh-Kumi

2020-Current year OA Pubs

BACKGROUND: Trichomoniasis is a non-viral neglected sexually transmitted disease of public health importance. Undergraduate students, often experiencing newfound freedom from family oversight, may engage in risky sexual behaviors, predisposing them to trichomoniasis and other sexually transmitted infections (STIs). This study aimed to assess the knowledge, attitudes, and practices towards trichomoniasis and associated factors among the Central University students in the Greater Accra Region of Ghana.

METHODS: An institutional cross-sectional study was conducted between March and July 2024, involving 387 undergraduate students from Central University who were selected using a simple random sampling technique. Data were collected using a structured researcher-led …


Functional Connectivity Associations With Markers Of Disease Progression In Grn Pathogenic Variant Carriers, Taru M Flagan, Nupur Ghoshal, Et Al. Dec 2025

Functional Connectivity Associations With Markers Of Disease Progression In Grn Pathogenic Variant Carriers, Taru M Flagan, Nupur Ghoshal, Et Al.

2020-Current year OA Pubs

OBJECTIVE: Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN-related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression. We previously showed that asymptomatic GRN variant carriers exhibit thalamocortical hyperconnectivity that increases with age, presumably as they are approaching symptom onset. Whether hyperconnectivity arises concomitantly with markers of neurodegeneration remains unclear.

METHODS: Utilizing T1 and task-free functional magnetic resonance imaging from 49 asymptomatic and 26 symptomatic GRN variant carriers, we determined the relationships between functional connectivity, as measured by voxelwise …


A Guide For Initiating And Managing Chimeric Antigen Receptor T Cell Therapy Clinical Trials In Autoimmune Rheumatic Diseases, Roberto Caricchio, Stacie Bell, Sasha Bernatsky, Maria Dall'era, David Goddard, Kenneth Kalunian, Alfred H J Kim, Fotios Koumpouras, Jose Rubio, Amit Saxena, Saira Sheikh, Lupus Clinical Investigators Network Dec 2025

A Guide For Initiating And Managing Chimeric Antigen Receptor T Cell Therapy Clinical Trials In Autoimmune Rheumatic Diseases, Roberto Caricchio, Stacie Bell, Sasha Bernatsky, Maria Dall'era, David Goddard, Kenneth Kalunian, Alfred H J Kim, Fotios Koumpouras, Jose Rubio, Amit Saxena, Saira Sheikh, Lupus Clinical Investigators Network

2020-Current year OA Pubs

Chimeric antigen receptor (CAR) T-cell therapy, long transformative in oncology, is now rapidly emerging as a frontier in autoimmune rheumatic diseases, particularly systemic lupus erythematosus (SLE), driven by accumulating evidence of deep B-cell depletion, immune "resetting," and durable drug-free remission in early studies, yet its translation into rheumatology demands mastery of formidable logistical, regulatory, clinical, and ethical complexities that span institutional readiness, multidisciplinary team formation, stringent regulatory compliance, sophisticated operational workflows, comprehensive patient selection and education, meticulous clinical management of both classical toxicities (CRS, ICANS, ICAHT) and autoimmune-specific reactions such as LICATS, robust financial and resource planning, and long-term follow-up …


Improved Accuracy For Myocardial Blood Flow Mapping With Deep Learning-Enabled Cmr Arterial Spin Labeling (Deepmasl): Validation By Microsphere In Vivo, Ran Li, Caleb Berberet, Qi Huang, Pamela K Woodard, Jie Zheng Dec 2025

Improved Accuracy For Myocardial Blood Flow Mapping With Deep Learning-Enabled Cmr Arterial Spin Labeling (Deepmasl): Validation By Microsphere In Vivo, Ran Li, Caleb Berberet, Qi Huang, Pamela K Woodard, Jie Zheng

2020-Current year OA Pubs

BACKGROUND: Current myocardial arterial spin labeling (ASL) methods are sensitive to noise (background and physiology), which limits the accuracy of myocardial blood flow (MBF) measurement. In this study, we demonstrated a new deep learning-enabled myocardial ASL approach (DeepMASL) and evaluated its accuracy to quantify MBF in a canine model of coronary arterial disease in vivo. The reference method was invasive microsphere measurements.

METHODS: Eighteen mongrel dogs were divided into two groups: healthy (n = 9) and coronary stenosis (n = 9). The latter was induced in an open-chest model with 3 types of stenosis: 50% (n= 3), 70% (n = …


Buprenorphine Treatment During The Extended Postpartum Period: A Survey Of Patient Experiences, Bridget Galati, Heather Jacobsen, Melissa Krauss, Melissa Mills, Brittaney Vaughn, Sam Williams, Michael Wenzinger, Cynthia Rogers, Nandini Raghuraman, Jeannie Kelly Dec 2025

Buprenorphine Treatment During The Extended Postpartum Period: A Survey Of Patient Experiences, Bridget Galati, Heather Jacobsen, Melissa Krauss, Melissa Mills, Brittaney Vaughn, Sam Williams, Michael Wenzinger, Cynthia Rogers, Nandini Raghuraman, Jeannie Kelly

2020-Current year OA Pubs

OBJECTIVE: The late postpartum period, defined as greater than 6 weeks to 12 months, is a high-risk time for individuals with opioid use disorder (OUD). Discontinuation rates of buprenorphine treatment for OUD during this period are high. Little is known about patients' subjective experience with buprenorphine treatment during this time. We sought to assess patient treatment experience, goals, facilitators and barriers to continued buprenorphine treatment throughout the extended postpartum period.

METHODS: We performed a cross-sectional survey of postpartum patients who received buprenorphine treatment, including sublingual and long-acting injectable formulations, in an interdisciplinary, wrap-around clinic for maternal OUD between February 2022 …


Does Health Insurance Coverage Improve Cardiometabolic Risk Factor Levels? Quasi-Experimental Evidence From India, Kavita Singh, Anubha Agarwal, Mark D Huffman, Et Al. Dec 2025

Does Health Insurance Coverage Improve Cardiometabolic Risk Factor Levels? Quasi-Experimental Evidence From India, Kavita Singh, Anubha Agarwal, Mark D Huffman, Et Al.

2020-Current year OA Pubs

BACKGROUND: Chronic conditions cause notable health and economic burdens. While health insurance enables access to healthcare, its effects on chronic care outcomes remain under-explored.

OBJECTIVE: To examine the association between health insurance coverage and cardiometabolic risk factors among people with chronic conditions in India.

METHODS: Data from the Centre for Cardiometabolic Risk Reduction in South Asia (CARRS) and Solan studies, including 2,926 adults with chronic conditions were analyzed using propensity score weighting to evaluate the associations between health insurance and cardiometabolic risk factors (HbA1c, low-density lipoprotein cholesterol [LDLc], and blood pressure [BP]) and self-reported health status (measured using European Quality …


Cholinergic Dysfunction In Occupational Manganese Exposure, T Noah Hutson, Susan Searles Nielsen, Natalie Senini, John O'Donnell, Hubert P Flores, Tamara Hershey, Joel S Perlmutter, Anil Kumar Soda, Stephen M Moerlein, Zhude Tu, Michael Kasper, Lianne Sheppard, Brad A Racette, Susan R Criswell Dec 2025

Cholinergic Dysfunction In Occupational Manganese Exposure, T Noah Hutson, Susan Searles Nielsen, Natalie Senini, John O'Donnell, Hubert P Flores, Tamara Hershey, Joel S Perlmutter, Anil Kumar Soda, Stephen M Moerlein, Zhude Tu, Michael Kasper, Lianne Sheppard, Brad A Racette, Susan R Criswell

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVE: Excessive exposure to manganese (Mn) produces a clinical syndrome of parkinsonism and cognitive impairment. However, our understanding of the mechanisms of Mn neurotoxicity remains limited. This study aimed to evaluate the relationships between Mn exposure, cholinergic function, and cognitive impairment in exposed workers.

METHODS: We assessed brain cholinergic function using vesicular acetylcholine transporter (VAChT) radiotracer (-)-(1-(8-(2-[(18)F]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone (VAT) with positron emission tomography (PET) in 21 Mn-exposed workers. We estimated occupational Mn exposure from work histories and the MRI pallidal index. A cognitive control battery consisting of the Verbal Fluency (VF), Letter Number Sequencing (LNS), Two-Back Letter Task (2B), …


Muc15 Ectodomain Architecture Regulates Integrin Clustering To Control Cancer Metastasis, Simei Zhang, Guy M Genin, Et Al. Dec 2025

Muc15 Ectodomain Architecture Regulates Integrin Clustering To Control Cancer Metastasis, Simei Zhang, Guy M Genin, Et Al.

2020-Current year OA Pubs

Cancer metastasis is governed by physical cues at the cell-matrix interface, with matrix stiffness, ligand density, and topography established as key determinants. Here, a fourth critical factor in cancer metastasis, the architecture of the cell-surface glycocalyx is identified. Using MUC15 as a representative small glycoprotein, mathematical modeling and domain truncation experiments are combined to show that glycoprotein size distribution governs integrin adhesion states and metastatic outcomes. MUC15 localizes to focal adhesions and interact with integrins, while larger glycoproteins such as MUC1 are sterically excluded. These physical effects, rather than intracellular signaling, dictate adhesion state transitions: removing MUC15's ectodomain eliminated its …


Renal Replacement Therapy In Lupus Nephritis-Related End-Stage Kidney Disease: A Systematic Review And Meta-Analysis, Hassan Kawtharany, Jessica N Williams, Et Al. Dec 2025

Renal Replacement Therapy In Lupus Nephritis-Related End-Stage Kidney Disease: A Systematic Review And Meta-Analysis, Hassan Kawtharany, Jessica N Williams, Et Al.

2020-Current year OA Pubs

OBJECTIVE: To assess the impact of renal replacement therapy in people with lupus nephritis (LN)-associated end-stage kidney disease (ESKD) and support the development of the 2024 American College of Rheumatology LN treatment guidelines.

METHODS: We conducted a systematic literature review and meta-analysis to address three Population, Intervention, Comparison, and Outcome (PICO) questions related to renal replacement therapy for ESKD due to LN, including comparisons of kidney transplant versus dialysis, hemodialysis versus peritoneal dialysis, and preemptive kidney transplant versus no preemptive kidney transplant. Outcomes of interest included mortality, cardiovascular (CV) events, infections, lupus flares, disease-related damage, graft failure, and quality of …


Introducing The Outpace Framework For Health Care Quality Improvement, Michele Bolles, Heather M. Alger, Mitchell S. V. Elkind, Howard Haft, Sabra C. Lewsey, Mariell Jessup, Karen E. Joynt Maddox, Chiadi E. Ndumele, Clyde W. Yancy, Christine Rutan, Michelle Congdon, Katherine Overton, Lynn Serdynski, Kathie Thomas, Gregg C. Fonarow Dec 2025

Introducing The Outpace Framework For Health Care Quality Improvement, Michele Bolles, Heather M. Alger, Mitchell S. V. Elkind, Howard Haft, Sabra C. Lewsey, Mariell Jessup, Karen E. Joynt Maddox, Chiadi E. Ndumele, Clyde W. Yancy, Christine Rutan, Michelle Congdon, Katherine Overton, Lynn Serdynski, Kathie Thomas, Gregg C. Fonarow

2020-Current year OA Pubs

Equitable, timely, and evidence-based care remains a central goal across health care ecosystems, yet significant quality gaps, care variability, and health disparities persist. Professional societies, including the American Heart Association, have long developed clinical practice guidelines to provide standardized, evidence-based recommendations across the cardiovascular care continuum. These guidelines are operationalized into quality measures to monitor care, identify gaps, and guide improvement. Professional societies, agencies, and health systems have applied implementation science strategies, such as education, data sharing, and evaluation, to improve care quality and achieve quality measures defined in the clinical practice guidelines. American Heart Association's Get With The Guidelines …


Premature Ventricular Contraction Location And Incident Heart Failure, Thomas A Dewland, David G Rosenthal, Edward P Gerstenfeld, Melvin M Scheinman, Alvaro Alonso, Elsayed Z Soliman, Lin Yee Chen, David S Siscovick, Nona Sotoodehnia, John S Gottdiener, Bruce M Psaty, Susan R Heckbert, Phyllis K Stein, Gregory M Marcus Dec 2025

Premature Ventricular Contraction Location And Incident Heart Failure, Thomas A Dewland, David G Rosenthal, Edward P Gerstenfeld, Melvin M Scheinman, Alvaro Alonso, Elsayed Z Soliman, Lin Yee Chen, David S Siscovick, Nona Sotoodehnia, John S Gottdiener, Bruce M Psaty, Susan R Heckbert, Phyllis K Stein, Gregory M Marcus

2020-Current year OA Pubs

BACKGROUND: The anatomical distribution of spontaneous ventricular ectopy and the risk of heart failure associated with premature ventricular contraction (PVC) location has not been studied outside the narrow group of individuals presenting for arrhythmia-related clinical care.

OBJECTIVES: This study sought to describe the epidemiology of PVC site of origin and to determine whether PVC anatomical location is independently associated with incident heart failure risk.

METHODS: Ambulatory adults without prevalent heart failure were identified from the CHS (Cardiovascular Health Study) and the ARIC (Atherosclerosis Risk in Communities Study) cohorts. Anatomical PVC location was assessed by 2 expert reviewers using baseline 12-lead …


Adverse Experiences, Protective Factors, And Obesity In Latinx And Hispanic Youths, Victoria Goldman, Sevan Esaian, Miguel Ángel Rivas Fernández, Jonatan Ottino Gonzalez, Nicole Karcher, Jeffrey I Gold, Alaina P Vidmar, Shana Adise Dec 2025

Adverse Experiences, Protective Factors, And Obesity In Latinx And Hispanic Youths, Victoria Goldman, Sevan Esaian, Miguel Ángel Rivas Fernández, Jonatan Ottino Gonzalez, Nicole Karcher, Jeffrey I Gold, Alaina P Vidmar, Shana Adise

2020-Current year OA Pubs

IMPORTANCE: Pediatric obesity rates are rising, and adverse childhood experiences (ACEs) may contribute by promoting stress-induced weight gain. Few studies have examined the association of ACEs with body mass index (BMI) and youth-reported protective factors, particularly among Latinx and Hispanic youths, who face higher rates of ACEs and obesity.

OBJECTIVE: To evaluate the association of ACEs with BMI in a population-based cohort and determine whether youth-reported protective factors (eg, self-coping skills, caregiver or friend support, or overall support) moderate this association, with a focus on Latinx and Hispanic youths.

DESIGN, SETTING, AND PARTICIPANTS: This large, cross-sectional study of youths aged …