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2017

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Jurisdiction Over Jihid: Islamic Law And The Duty To Fight, Adnan A. Zulfiqar Dec 2017

Jurisdiction Over Jihid: Islamic Law And The Duty To Fight, Adnan A. Zulfiqar

West Virginia Law Review

No abstract provided.


Utah V. Strieff: Lemonade Stands And Dragnet Policing, Guy Padula Dec 2017

Utah V. Strieff: Lemonade Stands And Dragnet Policing, Guy Padula

West Virginia Law Review

No abstract provided.


Ebolamania And Equal Protection Of Health Care Workers Under Rational Basis With Bite Review, Jennifer Jolly-Ryan Dec 2017

Ebolamania And Equal Protection Of Health Care Workers Under Rational Basis With Bite Review, Jennifer Jolly-Ryan

West Virginia Law Review

No abstract provided.


The Antitrusting Of Patentability, Saurabh Vishnubhakat Dec 2017

The Antitrusting Of Patentability, Saurabh Vishnubhakat

Seton Hall Law Review

No abstract provided.


Quantitative Foraging Ecology Of Terns At Great Gull Island, New York: Theory, Models, And Remote Sensing Of Collective Behavior In A Dynamic Habitat, Samuel Stetson Urmy Dec 2017

Quantitative Foraging Ecology Of Terns At Great Gull Island, New York: Theory, Models, And Remote Sensing Of Collective Behavior In A Dynamic Habitat, Samuel Stetson Urmy

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Most seabirds forage for prey whose distributions are patchy and unpredictable, and their strategies for locating food have long interested ecologists. Recent studies using individual telemetry have yielded many insights, but our understanding is still limited: simultaneous measurements of prey and predator distributions are rare, and tracking tags can be deployed on only small numbers of animals at once. I addressed these challenges using a marine radar deployed at a breeding colony of common and roseate terns (Sterna hirundo and S. dougallii) on Great Gull Island, New York, in 2014 and 2015. I calibrated the radar, enabling measurements of tern …


Regulation Of Fyn Phosphorylation By The Ptpn23 Tumor Suppressor Phosphatase In Breast Tumorigenesis, Siwei Zhang Dec 2017

Regulation Of Fyn Phosphorylation By The Ptpn23 Tumor Suppressor Phosphatase In Breast Tumorigenesis, Siwei Zhang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Disruption of the balanced modulation of reversible tyrosine phosphorylation has been implicated in the etiology of various human cancers. Breast cancer is the most prevalent invasive malignancy among women in the US. It features high heterogeneity, divisible into a variety of subtypes with different molecular profiles and clinical status. Protein Tyrosine Phosphatase Non-receptor 23 (PTPN23) gene resides on chromosomal region 3p21.3, which is hemizygously or homozygously lost in various cancers, including breast cancer of different subtypes. In a loss.of.function PTPome screen, our laboratory previously identified PTPN23 as a suppressor of cell motility and invasion in mammary epithelial and breast cancer …


The Role Of The Serotonin 1a Receptor In Mood Disorders, Rajapillai Laban Isaac Pillai Dec 2017

The Role Of The Serotonin 1a Receptor In Mood Disorders, Rajapillai Laban Isaac Pillai

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Major Depressive Disorder (MDD) is a heterogeneous and debilitating disorder. As of now, there is no reliable biomarker for this disorder, either for diagnosis or prediction of treatment response. The serotonin 1A (5-HT1A) receptor has been shown through animal, post-mortem, and in vivo human studies to be elevated in mood disorders such as MDD, and thus may be a promising biomarker. In my dissertation, I aim to explore this receptor and the serotonin system in order to better understand MDD pathophysiology and to establish tools for future research and clinical use. The raphe nucleus (RN) is the major source of …


Effect Of Treadmill Training On Recovery Of Lower Urinary Tract And Locomotor Function Following Incomplete Spinal Cord Injury In Adult Rats, Faiza Qureshi Dec 2017

Effect Of Treadmill Training On Recovery Of Lower Urinary Tract And Locomotor Function Following Incomplete Spinal Cord Injury In Adult Rats, Faiza Qureshi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Inability to walk and void efficiently after spinal cord injury (SCI) is associated with secondary health problems that affect quality of life. Individuals with paraplegia rate return of bladder function as one of their top priorities. Recently, studies have begun to investigate the recovery of bladder function after SCI. Additionally, several studies have shown improvements in locomotor function after SCI in human and animal models, however there is a gap of studying the correlation of temporal pattern of recovery of bladder and locomotor function after SCI. The aim of this research was to study the correlation of the temporal pattern …


Methylmercury Bioaccumulation, Transformation, And Trophic Transfer In Marine Food Chains, Cheng-Shiuan Lee Dec 2017

Methylmercury Bioaccumulation, Transformation, And Trophic Transfer In Marine Food Chains, Cheng-Shiuan Lee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Monomethylmercury (MeHg) is a neurotoxic compound that causes adverse health effects in exposed wildlife and humans. It is primarily accumulated through diet and is the only mercury species to build up in aquatic food chains. However, our understanding with respect to MeHg biogeochemical cycling in marine environments and its interactions with marine organisms is still limited. In order to better understand important processes in the MeHg biogeochemical cycling and factors governing its environmental fate, uptake, accumulation, transformation, and trophic transfer of MeHg in the marine chains, I conducted a series of experiments and measurements associated with marine bacterioplankton, phytoplankton, zooplankton, …


Role And Regulation Of Sphingolipids In Neuropathy, Nicholas Urban Schwartz Dec 2017

Role And Regulation Of Sphingolipids In Neuropathy, Nicholas Urban Schwartz

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Charcot-Marie-Tooth (CMT) disease is the most commonly inherited neurological disorder, but its molecular mechanisms remain unclear. One variant of CMT, Charcot-Marie-Tooth 2F (CMT2F), is characterized by mutations in heat shock protein 27 (Hsp27). Bioactive sphingolipids have been implicated in many neurodegenerative diseases, but it was unknown if they were dysregulated in CMT. Liquid chromatography/mass spectrometry was used to profile sphingolipids in CMT models. Hsp27 KO mice demonstrated decreases in ceramide in peripheral nerve tissue at an increased age, suggesting that sphingolipid metabolism may be involved in CMT2F. Indeed, the disease associated Hsp27 S135F mutant demonstrated decreases in mitochondrial ceramides. Given …


Quantitative Imaging Of 3d Cerebral Microvascular Network Dynamics By Ultrahigh -Resolution Optical Coherence Doppler Tomography (Μodt), Jiang You Dec 2017

Quantitative Imaging Of 3d Cerebral Microvascular Network Dynamics By Ultrahigh -Resolution Optical Coherence Doppler Tomography (Μodt), Jiang You

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Optical domain technologies can provide high spatiotemporal resolution for biomedical research and therefore attract tremendous interests in multiple disciplines including psychiatry, neurology, ophthalmology, oncology, urology and many more. Optical coherence tomography (OCT), after more than 20 years of development, has been becoming one of the most widely-used bio-optical modalities not only for laboratory-based research but also for clinical applications. For example, OCT becomes the standard of care for diagnosing glaucoma. Additionally, its derived velocimetry, optical coherence Doppler tomography (ODT), also demonstrates the unique capability of mapping cerebral blood flow velocity (CBFv) of vascular networks with capillary resolution (&phis;<6µm) and thus allows for the widespread utilization in numerous neurology studies. Although ODT has been widely used in biomedical research, there remain several technical limitations including the shallow penetration depth, low sensitivity for imaging slow flow in capillary and the measurement error due to Doppler angle. To address these challenges, viable solutions are proposed in this dissertation. Chapter 1 starts with a comprehensive review over basic principle of OCT and ODT. Chapter 2-4 explicitly address these OCT technical challenges, for instance, using a 1310nm super-luminescent Diode (SLD) laser source to extend optical penetration depth, utilizing optical contrast agent: intralipid to enhance ODT’s sensitivity for capillary flow detection, implementing numerical methods to extend ODT’s dynamic range and decouple Doppler angle. In addition to these technical improvements, Chapter 5-6 address two biomedical challenges in oncology and psychiatry. Specifically, Chapter 5 introduces a longitudinal optical access to rodent cerebral vasculature and a method of tumor boundary detection, which provides a powerful insight into the tumor progression. Chapter 6 reveals the close correlation between cocaine-elicited transient ischemic attack (TIA) and hypo-perfused cortex. Chapter 7 focuses on the development of multi-modality system and novel imaging scheme for the study of neurovascular coupling. Chapter 8 briefly concludes the contents presented in this dissertation and outlines the future development and potential applications of ODT. | 129 pages


University Of Dayton Magazine. Winter 2017-18, University Of Dayton Magazine Dec 2017

University Of Dayton Magazine. Winter 2017-18, University Of Dayton Magazine

University of Dayton Alumni Publications

The University of Dayton Magazine is published quarterly by the Office of Communications for alumni, parents, students, faculty/staff, trustees and other friends of UD. Articles include "In Distinguished Company," "What Makes Us Human," and "Maybe Just Give Up and Go Home."


Functional Characterization Of Two Novel Myofiber Type-Specific Non-Histone Protein Methyltransferases, Chao Wang Dec 2017

Functional Characterization Of Two Novel Myofiber Type-Specific Non-Histone Protein Methyltransferases, Chao Wang

Open Access Dissertations

Skeletal muscles are composed of muscle cells or myofibers which are classified as four types (I, IIa, IIx/d, and IIb), with different physiological, biochemical, structural and metabolic characteristics. The molecular regulation of myofiber identify is not completely understood. I identified methyltransferase like 21 (Mettl21) e and Mettl21c as the type IIb and type I myofiber- specific protein, respectively. The aim of this dissertation was to determine the function of Mettl21e and Mettl21c in regulating myofiber identity. In the first part of the thesis, I used in silico approaches to identify Mettl21e as one of the top up-regulated genes in myostatin …


Effects Of Exercise Environments On Stress With Premedical And Predental College Students, Islam Hammad Dec 2017

Effects Of Exercise Environments On Stress With Premedical And Predental College Students, Islam Hammad

2017 Fall Honors Capstone Projects - Archive

The purpose of this study is to measure effects of exercise environments on stress in premedical and predental students, and how to provide a method that would strive to reduce stress levels in college students. To further understand the different ways stress levels can be reduced, a method was performed to see if exercise environments have an effect on stress in premedical and predental students. Participants took the Perceived Stress Survey Inventory (PSSI) and were then instructed to walk one mile every day for one week at the University of Texas Arlington (UTA) or a park. It was hypothesized by …


The Effect Of Pet Ownership On Esl Students’ U.S. Academic Success, Emily Benjumea Dec 2017

The Effect Of Pet Ownership On Esl Students’ U.S. Academic Success, Emily Benjumea

Animal Science Undergraduate Honors Theses

This study examines the academic success of English as a second language (ESL) students based on ownership of and/or relationship with a pet, due to pets’ ability to benefit and support their owners. A survey was compiled for middle school, ESL students in the Fayetteville, Arkansas school district. The goal of the study was to discover if pet ownership has an effect on ESL student academic success in terms of the academic, social, and emotional aspects of school. It was found that pets aid in some academic aspects of school but more so in the social and emotional aspects such …


Improving Cell Seeding Of Decellularized And Porated Porcine Arterial Scaffolds, Harrison Smallwood Dec 2017

Improving Cell Seeding Of Decellularized And Porated Porcine Arterial Scaffolds, Harrison Smallwood

All Theses

Coronary artery disease is one of the number one killers in the U.S. Current treatment of using CABG surgery has limitations from availability of autologous grafts, and low patency of artificial grafts. Tissue engineered grafts would ideally provide more availability, while also replicating the mechanical properties of the native grafts. Current issues in tissue engineering arteries lie in using an effective scaffold to get correct mechanical properties, and allowing for cell infiltration to assist in integrating with native tissue once implanted. This study shows the use of a decellularized and chemically and mechanically porated porcine carotid artery in mechanical characterization …


Enantioselective Synthesis Of An Anticancer Ruthenium Polypyridyl Complex (Rpc) And Influence Of Chiral Selectivity On Dna Photocleavage, Shomita Ferdous Dec 2017

Enantioselective Synthesis Of An Anticancer Ruthenium Polypyridyl Complex (Rpc) And Influence Of Chiral Selectivity On Dna Photocleavage, Shomita Ferdous

Chemistry & Biochemistry Theses - Archive

Ruthenium polypyridyl complexes (RPCs) represent a promising therapeiutic class of drugs for transition-metal based anticancer drug development. The complex [(phen)2Ru(tatpp)Ru(phen)2] (44+) is a RPC which has shown success in both cell free and cellular assay. Unlike many other RPCs, 44+ can selectively kill malignant cells without light irradiation from external sources. This binuclear complex 44+ is a DNA intercalator containing redox-active ligand tatpp (9,11,20,22-Tetraaza tetrapyrido[3,2-a:2'3'-c:3'',2''- 1:2''',3''']-pentacene) which cleaves DNA in presence of a mild reducing agent, i.e. glutathione (GSH).1,2,3 The cellular assay (MTT assay) with different types of malignant cells has also established this as an equally potent cytotoxic agent …


Diversification On Continents And Islands: A Herpetological Perspective, Kyle Anthony O'Connell Dec 2017

Diversification On Continents And Islands: A Herpetological Perspective, Kyle Anthony O'Connell

Biology Dissertations - Archive

This dissertation seeks to understand the geological and climatological processes that have promoted diversification on continental and island systems. Using molecular genetic data generated using Sanger sequencing and Next Generation Sequencing platforms, I conduct phylogenetic and biogeographic analyses, estimate gene flow, and conduct species delimitation. Using these analyses, I explore diversification processes on continents and islands using reptile and amphibian systems. In Chapter 2 I evaluate the role of geographical features to whipsnake diversification. Chapter 3 resolves the taxonomy of several poorly understood whipsnakes species and tests the effect of missing data on species delimitation. Chapter 4 investigates the biogeographical …


The Effects Of Palmitate On The Expression Of G-Protein Coupled Receptors And Glut Transporters In Neuro2a Cells, Brian Montoya Dec 2017

The Effects Of Palmitate On The Expression Of G-Protein Coupled Receptors And Glut Transporters In Neuro2a Cells, Brian Montoya

Seton Hall University Dissertations and Theses (ETDs)

Palmitate (PA) is a saturated fatty acid that has been reported to be elevated in individuals with metabolic syndromes. The effects of fatty acids on the expression of various fatty acid receptors on neuronal cells is unknown, as is the effects of fatty acids on GLUT transporters. In this study, Neuro-2a (N2a) cells were treated with either 300μM of bovine serum albumin (BSA) or 300μM of palmitate conjugated to BSA (PA) at various time points to determine the effect of palmitate on the expression of various fatty acid receptors and GLUT transporters. RNA isolation followed by RT-PCR with primers specific …


The Spatial Ecology And Microhabitat Selection Of The Pygmy Rattlesnake (Sistrurus Miliarius) In Southwestern Missouri, Dylan Wallace Maag Dec 2017

The Spatial Ecology And Microhabitat Selection Of The Pygmy Rattlesnake (Sistrurus Miliarius) In Southwestern Missouri, Dylan Wallace Maag

Graduate Theses/Dissertations

Despite a wide distribution throughout the southeastern United States, pygmy rattlesnakes (Sistrurus miliarius) have received less research attention than many other rattlesnake species. I captured a total of 33 S. miliarius at the Drury-Mincy Conservation Area (DMCA) and retained 14 large individuals (mostly gravid females) for a radio telemetry study. Snakes were primarily captured during evening road driving surveys and were encountered rarely with any other sampling technique. Sistrurus miliarius are widespread at DMCA where they were encountered in forest, savanna, and glade habitats. Snakes selected microhabitats with more vegetative cover and tree canopy closure than random sites …


Peppermint, Anthony Isaac Bradley Dec 2017

Peppermint, Anthony Isaac Bradley

Graduate Theses/Dissertations

This collection contains poetry introduced in a critical way via a theory-based creative nonfiction essay. The work included is a meditation on what identity means on both an intimate and a larger scale, and how the two might be affected by the choices we are faced with from a young age. Elements of pop culture are used alongside rural elements of the surrounding areas to illustrate changing or stagnant viewpoints on topics such as masculinity, gender norms, and queer expression. Peppermint is a document of my mind as it once was, and how it has been shaped up to this …


The Effect Of Weight Carried And Time Ridden On Back Pain In Horses Ridden During Horse Shows As Determined By Pressure Algometry, Meghan Louise Mothershead Dec 2017

The Effect Of Weight Carried And Time Ridden On Back Pain In Horses Ridden During Horse Shows As Determined By Pressure Algometry, Meghan Louise Mothershead

Graduate Theses/Dissertations

The objective of this study was to determine the effects of weight carried (rider + tack) on back pain in horses used in riding classes and a series of intercollegiate horse shows. Sixteen school horses (431-649 kg) were ridden consistently over a semester. Cross sectional images were used to measure width and put in a mapping program to figure total area. Back pain scores were determined using a pressure algometer on predetermined points over the horses back. Pain scores were recorded over five periods, including 28 d into the semester (P1) and during the show period on three consecutive Fridays …


Synchronization Of Reproduction In Deertoe Mussel (Truncilla Truncata), Kendell R. Loyd Dec 2017

Synchronization Of Reproduction In Deertoe Mussel (Truncilla Truncata), Kendell R. Loyd

Graduate Theses/Dissertations

Freshwater mussels, Order Unionoida, are diverse and widespread in North America but have suffered general decline and many extinctions in recent decades. The reproductive biology of Unionoida is complex and may be vulnerable to human impacts. Male mussels release aggregates of sperm called spermatozeugmata that drift downstream. Females obtain spermatozeugmata from the water and brood the fertilized eggs internally during development. Many aspects of general reproductive biology are poorly understood, including the mechanisms that coordinate spawning and the route by which sperm meet eggs in the female. The present study focuses on reproduction in the Deertoe (Truncilla truncata), …


Effects Of Ocean Warming And Acidification On Fertilization Success And Early Larval Development In The Green Sea Urchin, Lytechinus Variegatus, Brittney L. Lenz Dec 2017

Effects Of Ocean Warming And Acidification On Fertilization Success And Early Larval Development In The Green Sea Urchin, Lytechinus Variegatus, Brittney L. Lenz

HCNSO Student Theses and Dissertations

Climate change is predicted to affect the larval stages of many marine organisms. Ocean warming can reduce larval survival and hasten larval development, whereas ocean acidification can delay larval development. Ocean acidification is especially concerning for marine organisms that develop and grow calcified shells or skeletons in an environment undersaturated with calcium carbonate minerals. This study assessed the effects of ocean warming and acidification on the fertilization and larval development of the green sea urchin, Lytechinus variegatus, a tropical species common in Florida and the Caribbean. After spawning, gametes were fertilized and embryos/larvae were reared at: 1) 28°C and …


Castor Canadensis Winter 2017-2018, Jedediah Smith Society Dec 2017

Castor Canadensis Winter 2017-2018, Jedediah Smith Society

Castor Canadensis - Jedediah Smith Society

Newsletter of the Jedediah Smith Society


Bibliography For Victorian England Holiday Display, Kristin Laughtin-Dunker Dec 2017

Bibliography For Victorian England Holiday Display, Kristin Laughtin-Dunker

Library Displays and Bibliographies

A bibliography of materials in the Leatherby Libraries related to the celebration of winter holidays in Victorian England, with a particular focus on the works of Charles Dickens.


Gastrointestinal Parasites In Captive And Free-Ranging Cebus Albifrons In The Western Amazon, Ecuador, Sarah Martin-Solano, Gabriel A. Carrillo-Bilbao, William Ramirez, Maritza Celi-Erazo, Marie-Claude Huynen, Bruno Levecke, Washington Benitez-Ortiz, Bertrand Losson Dec 2017

Gastrointestinal Parasites In Captive And Free-Ranging Cebus Albifrons In The Western Amazon, Ecuador, Sarah Martin-Solano, Gabriel A. Carrillo-Bilbao, William Ramirez, Maritza Celi-Erazo, Marie-Claude Huynen, Bruno Levecke, Washington Benitez-Ortiz, Bertrand Losson

All Faculty Scholarship for the College of the Sciences

Currently, there is a lack of surveys that report the occurrence of gastrointestinal parasites in the whiteheaded capuchin monkey (Cebus albifrons). We therefore assessed the presence and richness (= number of different parasite genera) of parasites in C. albifrons in wildlife refuges (n = 11) and in a free-ranging group near a human village (n = 15) in the Ecuadorian Amazon. In the 78 samples collected (median of 3 samples per animal), we identified a total of 6 genera of gastrointestinal parasites, representing protozoa, nematodes, acanthocephalans and cestodes. We observed a high prevalence (84%) across the 26 individuals, with the …


The Human Journey As Work In Progress, Kymberly Day Dec 2017

The Human Journey As Work In Progress, Kymberly Day

All Theses

Sampling gesture, form, and monumentality from Classical figure sculpture, art history becomes an avenue for exploring tropes of the parallels between man and animal. Raw construction and shipping materials comprise these figures, interrupting conventions of display, archive, transport, and institution. Species are spliced and integrated into the human figure in each of the compositions. Traditionally, the animal is used as metaphor for different human conditions, emotions, and behaviors; our relationships to animals is one that stands the test of time in art. The animal becomes an extension of the figure's human-ness, while also acting as mere prop for the figure. …


Nadph Oxidase 5 (Nox5)-Induced Reactive Oxygen Signaling Modulates Normoxic Hif-1Α And P27, Smitha Antony, Guojian Jiang, Yongzhong Wu, Jennifer L Meitzler, Hala R Makhlouf, Diana C Haines, Donna Butcher, Dave S B Hoon, Jiuping Ji, Yiping Zhang, Agnes Juhasz, Jiamo Lu, Han Liu, Iris Dahan, Mariam Konate, Krishnendu K Roy, James H Doroshow Dec 2017

Nadph Oxidase 5 (Nox5)-Induced Reactive Oxygen Signaling Modulates Normoxic Hif-1Α And P27, Smitha Antony, Guojian Jiang, Yongzhong Wu, Jennifer L Meitzler, Hala R Makhlouf, Diana C Haines, Donna Butcher, Dave S B Hoon, Jiuping Ji, Yiping Zhang, Agnes Juhasz, Jiamo Lu, Han Liu, Iris Dahan, Mariam Konate, Krishnendu K Roy, James H Doroshow

Articles, Abstracts, and Reports

NADPH oxidase 5 (NOX5) generated reactive oxygen species (ROS) have been implicated in signaling cascades that regulate cancer cell proliferation. To evaluate and validate NOX5 expression in human tumors, we screened a broad range of tissue microarrays (TMAs), and report substantial overexpression of NOX5 in malignant melanoma and cancers of the prostate, breast, and ovary. In human UACC-257 melanoma cells that possesses high levels of functional endogenous NOX5, overexpression of NOX5 resulted in enhanced cell growth, increased numbers of BrdU positive cells, and increased γ-H2AX levels. Additionally, NOX5-overexpressing (stable and inducible) UACC-257 cells demonstrated increased normoxic HIF-1α expression and decreased …


The Effect Of Superparamagnetic Iron Oxide Nanoparticle Surface Charge On Antigen Cross-Presentation., Yongbin Mou, Yun Xing, Hongyan Ren, Zhihua Cui, Yu Zhang, Guangjie Yu, Walter J Urba, Qingang Hu, Hongming Hu Dec 2017

The Effect Of Superparamagnetic Iron Oxide Nanoparticle Surface Charge On Antigen Cross-Presentation., Yongbin Mou, Yun Xing, Hongyan Ren, Zhihua Cui, Yu Zhang, Guangjie Yu, Walter J Urba, Qingang Hu, Hongming Hu

Articles, Abstracts, and Reports

Magnetic nanoparticles (NPs) of superparamagnetic iron oxide (SPIO) have been explored for different kinds of applications in biomedicine, mechanics, and information. Here, we explored the synthetic SPIO NPs as an adjuvant on antigen cross-presentation ability by enhancing the intracellular delivery of antigens into antigen presenting cells (APCs). Particles with different chemical modifications and surface charges were used to study the mechanism of action of antigen delivery. Specifically, two types of magnetic NPs, γFe