Digital Commons Network^™

Preclinical Development Of Therapeutic Strategies Against Triple-Negative And Inflammatory Breast Cancer, Angie M. Torres-Adorno

Dissertations and Theses (Open Access)

Triple-negative (TNBC) and inflammatory (IBC) breast cancer are the most aggressive forms of breast cancer, accounting for 20% and 10% of cancer-related deaths, respectively. Among IBC cases, 30% are additionally classified with TNBC molecular pathology, a diagnosis that significantly worsens patient’s prognosis. The current lack of TNBC and IBC molecular understanding prevents the development of effective therapeutic strategies. To identify effective treatments, we explored aberrant apoptosis pathways and cell membrane fluidity as novel therapeutic targets.

We first identified an effective therapeutic strategy against TNBC and IBC by pro-apoptotic protein NOXA-mediated inhibition of the anti-apoptotic protein MCL1 following inhibition of histone …

Investigating The Role Of Prmt1 And Arginine Methylation Of Hsp70 In Human Pancreatic Cancer, Liang Wang

Dissertations and Theses (Open Access)

Protein arginine methyltransferase 1 (PRMT1) is the major arginine methyltransferase, which catalyzes the addition of one or two methyl groups to the arginine residues of its substrate proteins. The best-known substrate for PRMT1 is histone, while more and more non-histone proteins are now found to be methylated by PRMT1. Dysregulation of PRMT1 is reported in several human cancer types. However, its biological roles in human pancreatic cancer initiation and development are still unclear. In the first part of this study, I found that the expression level of PRMT1 was elevated in both human and mouse pancreatic cancer tissues in immunohistochemistry …

Improvements In Four-Dimensional And Dual Energy Computed To Mography, Rachael M. Martin

Dissertations and Theses (Open Access)

Dual energy and 4D computed tomography (CT) seek to address some of the limitations in traditional CT imaging. Dual energy CT, among other purposes, allows for the quantification and improved visualization of contrast materials, and 4D CT is often used in radiation therapy applications as it allows for the visualization and quantification of object motion. While much research has been done with these technologies, areas remain for potential improvement, both in preclinical and clinical settings, which will be explored in this dissertation. Preclinical dual energy cone-beam CT (CBCT) can benefit from wider separation between the peak energy of the two …

Modification Of Aplysia Feeding Network By L-Dopa And Dopamine-Dependent Learning, Curtis Neveu, Curtis L. Neveu

Dissertations and Theses (Open Access)

Dopamine (DA) is a ubiquitous neuromodulator of neuronal networks in the animal kingdom and has a well-established role in modulating motor behavior and encoding reward information. Although the effects of DA and DA-dependent learning at the behavioral and molecular levels are well-understood, many questions still remain concerning the effects of DA at the network level. DA-dependent learning effects on a neuronal circuit were examined by measuring the biophysical properties before and after in vitro operant conditioning (OC) of the feeding circuit of Aplysia. OC reduced the excitability of B4 and the B4-to-B51 synaptic connection, with a trend towards an …

Pharmacologic And Genetic Manipulations Of Angiotensin Signaling In Thoracic Aortic Disease Models, Andrew M. Peters

Dissertations and Theses (Open Access)

Thoracic aortic aneurysms and dissections (TAAD) are a major cause of morbidity and mortality in patients. Many different risk factors have been associated TAAD, but hypertension is the largest risk factor. Subsets of TAAD patients have identifiable syndromic genetic diseases, yet a number of genetic non-syndromic patients have been identified. Infusion of angiotensin II into mouse models causes aortic disease through inflammation and fibrosis. An angiotensin type I receptor (AT1R) blocker (ARB) or an angiotensin converting enzyme (ACE) inhibitor (ACEi) can reverse aortic pathology in some mouse models. I set out to better understand the relationship between angiotensin and TAAD …

Look Who's Talking: A Multi-Case Study Of In-Service English Language Arts Teachers' Conceptions And Uses Of Discussion In The Secondary Classroom, John D. Mcelroy

All Dissertations

Educational scholars and practitioners recognize that classroom discussion offers great promise for helping students develop content knowledge, critical thinking skills, and a variety of meta-cognitive and process skills associated with learning content knowledge and disciplinary processes. Despite this research-based and anecdotal consensus regarding the value of discussion, an equally extensive body of research shows that discussion is not used in U.S. classrooms as consistently or effectively as it might be. This study sought to examine this issue by exploring the relationship between in-service English language arts teachers' beliefs about discussion, their goals for the use of discussion, and their actual …

Application Of Glycoconjugate-Functionalized Magnetic Nanoparticles As Potent Anti-Adhesion And Anti-Bacterial Agents, Yash S. Raval

All Dissertations

Magnetic nanoparticles (MNPs) are currently being extensively in multitude of biomedical applications on account of their exceptional biocompatibility. By attaching different targeting ligands/molecules, MNPs have been broadly used in magnetic hyperthermia, cancer therapy, targeted drug delivery, MRI imaging, pathogen detection, and biological cell-separation. In this dissertation, MNPs coated with polyethylene oxide (PEO) based polymer (PEO-MNPs) and functionalized with bacterial adhesin-specific glycoconjugate molecule Neu5Ac(α2-3)Gal(β1-4)-Glcβ-sp (GM3-MNPs), are investigated for their interactions with enterotoxigenic Escherichia coli (E. coli). It also describes the feasibility of using alternating magnetic fields (AMF) for targeted killing of E. coli K99 (EC K99) strain using MNPs. Lastly, the …

Effective Visualizations Of The Uncertainty In Hurricane Forecasts, Le Liu

All Dissertations

The track forecast cone developed by the U.S. National Hurricane Center is the one most universally adopted by the general public, the news media, and governmental officials to enhance viewers' understanding of the forecasts and their underlying uncertainties. However, current research has experimentally shown that it has limitations that result in misconceptions of the uncertainty included. Most importantly, the area covered by the cone tends to be misinterpreted as the region affected by the hurricane. In addition, the cone summarizes forecasts for the next three days into a single representation and, thus, makes it difficult for viewers to accurately determine …

Evaluating The Effects Of Immersive Embodied Interaction On Cognition In Virtual Reality, Dhaval Parmar

All Dissertations

Virtual reality is on its advent of becoming mainstream household technology, as technologies such as head-mounted displays, trackers, and interaction devices are becoming affordable and easily available. Virtual reality (VR) has immense potential in enhancing the fields of education and training, and its power can be used to spark interest and enthusiasm among learners. It is, therefore, imperative to evaluate the risks and benefits that immersive virtual reality poses to the field of education. Research suggests that learning is an embodied process. Learning depends on grounded aspects of the body including action, perception, and interactions with the environment. This research …

Identification Of Genetic Variants Underlying Simple And Complex Canine Myopathies, Jacquelyn Marie Evans

All Dissertations

The unique population structure of dog breeds, arising from their domestication from gray wolves and subsequent breed formation, and the similarity of their inherited diseases to human disorders make them an ideal comparative genetics model. Herein the genetic basis of three canine muscle diseases, each a model for human disease, is investigated using genome-wide approaches. Nemaline rod myopathy (NM) is one of the most common congenital myopathies in people and is characterized by rod bodies in the muscle fibers, muscle weakness, and reduced muscle tone. We characterized the first large animal model of autosomal recessive NM in a family of …

Essays On Flood Disaster Relief Recovery Practices And Policy: Applying The Lens Of Service Operations Strategy, Niratcha Tungtisanont

All Dissertations

This dissertation uses a service operations lens to investigate flood disasters’ recovery phase, the least-studied area of Humanitarian Operations and Crisis Management (HOCM). Comprising three essays, my dissertation deepens our knowledge of disaster recovery by using two different units of analysis, including province (state) and household levels.

In Essay 1, entitled “The Influence of Industrialization and Internet Usage on Per-Capita Income: A Longitudinal Analysis of Flood Events in Thai Provinces,” we introduce a novel approach to research HOCM by using econometric analyses. We use panel data as a tool to guide decision makers in understanding the notion of flood recovery, …

The Bystander During The Holocaust, Robert A. Goldberg

Utah Law Review

The German people today have embraced their sense of collective responsibility. They have accepted the seamless case of genocide and its implications are part of the national soul. They have come to full reckoning, determined to remember a difficult past and not repeat it. The Austrians, the Dutch, and the Poles have yet to reach the point of confession or even an awareness of responsibility. Perhaps the most remarkable symbol of national responsibility is the grassroots Stolperstein or Stumble Stone project, which began in Germany in 1992 with the goal to remember the victims of the Holocaust individually. Cobblestone-size concrete …

Aug2017, Robert Kelly

Robert Kelly Manuscripts

From the August 2017 Robert Kelly archive.

Mri T2 Signal Changes Indicate Tau Pathophysiology In A Murine Alzheimer's Disease Model, Rajan Deep Adhikari

Theses and Dissertations

Pathogenesis, diagnosis and treatment, the essential domains in medical practice, seem helpless to address Alzheimer's disease (AD). With a huge mortality rate, it is looming and threatening the socioeconomic barrier. Despite many different studies, the pathogenesis of AD remains inconclusive. However, growing numbers of studies suggest oxidative stress to contribute to the initiation and progression of AD. We propose an iron hypothesis: iron mediated oxidative damage by reactive oxygen species (ROS), which induces protective roles of amyloid beta and hyper-phosphorylated tau (HP-tau) to sequester iron and limit the disease. We propose to study such mechanism using transgenic mice models for …

Nafta And Its Effect On Corn, Migration And Human Rights In Mexico, Thomas Nisivaco

College of Liberal Arts & Social Sciences Theses and Dissertations

This paper will attempt to show that U.S. corn subsidies that has led to the flooding of Mexican markets with corn, is the primary factor responsible for the internal displacement of rural farmers in Mexico. The NAFTA trade agreement has eliminated trade barriers and placed Mexico’s domestically produced corn in direct competition with U.S. highly subsidized corn that has led to Mexican corn farmers, who comprise the majority of the country’s agricultural sector, to experience a drastic decline in the price of their product causing them to have difficulties in sustaining a living in this market. Therefore, we can see …

Lemonade, Gin, And Juice: The Performance And Deconstruction Of Black Masculinity From N**Gers To Negus, Robert A. Barry

College of Liberal Arts & Social Sciences Theses and Dissertations

This project examines the effects of Black masculinity: its performance, the identity politics that materialize in the discovery of Black “maleness,” and its manifestation through male intrasexual competition to analyze how Black men learn and perform traditional patriarchal masculinity. Existing literature provides evidence regarding patriarchal masculinity as the “political-social system that insists that males are inherently dominating, superior to everything and everyone deemed weak, especially females, and endowed with the right to dominate and rule over the weak and to maintain that dominance through various forms of psychological terrorism and violence.” (hooks 2004, 1) Critical media literacy through a Black …

Dotphotozine Issue 7, August 2017, Students Of The Csusb Art Department, Thomas Mcgovern

Dotphotozine

No abstract provided.

Discovery Of Novel Tubulin Inhibitors And Selective Survivin Inhibitors For Advanced Melanoma And Total Synthesis Of Bioactive 20s-Hydroxyvitamin D3, Qinghui Wang

Theses and Dissertations (ETD)

According to the statistics from American Cancer Society, the 5-year survival rate for patients with advanced melanoma is as low as 5%. Treatment of advanced melanoma, therefore, represents an unmet medical need. In this dissertation, I will show the effort to develop new generations of bioavailable tubulin inhibitors targeting the colchicine binding site and selective small-molecule survivin inhibitors for treating advanced melanoma. Extensive structure-activity relationship (SAR) studies of lead molecules ABI-231 and UC-112 have been performed.

Chapter 1 will introduce the current situation of advanced or metastatic melanoma, its clinical drug treatments, as well as problems in current drug treatments. …

Do Eye Movements During Shape Discrimination Reveal An Underlying Geometric Structure?, Bradley R. Sturz, Ty W. Boyer, John F. Magnotti, Kent D. Bodily

Psychology: Faculty Publications

Using a psychophysical approach coupled with eye-tracking measures, we varied length and width of shape stimuli to determine the objective parameters that corresponded to subjective determination of square/rectangle judgments. Participants viewed a two-dimensional shape stimulus and made a two-alternative forced-choice whether it was a square or rectangle. Participants’ gaze was tracked throughout the task to explore directed visual attention to the vertical and horizontal axes of space. Behavioral results provide threshold values for two-dimensional square/rectangle perception, and eye-tracking data indicated that participants directed attention to the major and minor principal axes. Results are consistent with the use of the major …

Creating Sustainable Supply Chains: Influencing Sustainable Practices In The Supply Chain, Saif Mir

Graduate Theses and Dissertations

Organizations worldwide are reporting their commitment to create sustainable supply chains. Ultimately, supply chain professionals are the drivers of change within their respective organizations, so this dissertation examines the role of communication as a tool to persuade supply chain professionals to create sustainable supply chains. The three studies within this dissertation employ different methodologies to examine the role of communication in the development and implementation of sustainability initiatives. The first study, a grounded theory investigation, highlights the network, communication, and structural factors that provide a strong business case for the development of sustainability initiatives. A strong business case influences the …

Cultivar, Season Extension, Fertilizer Trials Of Swiss Chard And Pedagogy Of Assessing Cultivars Using Technology, Chanelle Angeny

Electronic Theses and Dissertations

Abstract. Diversity of species is a cornerstone of horticulture, and the constant stream of new plant cultivars broadens the palette of options available to the industry. Fifteen Swiss chard (Beta vulgaris var. cicla) cultivars were evaluated during the fall/winter of 2014-2015 season (season 1) and 27 cultivars during the fall/winter of 2015-2016 season (season 2) to determine the best performing cultivars for production and landscape use for east Texas and the southeast by assessing survivability and yield. There was an increase in production of 3.0 ± 0.5 g per plant per harvest under the low tunnel. The cultivar …

Three Essays On Likability Factors, Crowdfunding, And Entrepreneurial Performance, Yuanqing Li

Theses and Dissertations

In this dissertation, I conduct three empirical studies exploring the relation between likability factors, crowdfunding characteristics and entrepreneurial performance. Together these studies integrate aspects of major entrepreneurial likability factors including liking of the entrepreneur (source attractiveness, credibility, personal traits) and liking of the message (verbal content and expression), and components of nonverbal and verbal cues. I apply computer-mediated communication (CMC) and persuasion theories, political and marketing literature to provide a more fine-grained understanding of likability on crowdfunding success. In the first essay, I study how the non-verbal cues of a crowdfunding video influence the crowdfunding success. By employing social presence …

The Effects Of Supplemental Rup In Corn Silage Growing Diets And Rup Digestibility Of Corn Silage, The Utilization Of Aggressive Implant Protocols, And The Effect Of Inoculate On Corn Silage And High Moisture Corn, Colton Ray Oney

Department of Animal Science: Dissertations, Theses, and Student Research

Three experiments evaluated the effect of implant strategies on feedlot performance and carcass characteristics of crossbred steers and Holstein steers. Final BW, ADG, and G:F were not different between implant strategies in Exp. 1 and 2. The utilization of more aggressive implant strategies has minimal impact on both feedlot and carcass performance of cross breed steers.

Four experiments evaluated the effects of supplemental RUP in corn silage growing diets and RUP content and RUP digestibility of corn silage. Exp. 1, supplemented five concentrations of RUP to growing calves consuming a corn silage diet. As supplemental RUP increased ADG and ending …

Effect Of Fat And Fiber On Methane Production And Energy Utilization In Lactating Dairy Cows, Olivia Rose Drehmel

Department of Animal Science: Dissertations, Theses, and Student Research

Due to rising concerns of greenhouse gases and that ruminants are the largest livestock methane producers, an emphasis has been put on developing methane mitigation strategies to reduce methane emissions in ruminants. Other than reducing methane, maximizing the energy utilization of cattle is also important for producer’s overall productivity and profitability.

In the first experiment, fat or cellulose was added to fiber isolated from dried distiller’s grains and solubles. Isolated NDF residue from an in vitro setting was fermented 1) alone (control); 2) with feed grade corn oil at 20%; or 3) with cellulose powder microcrystalline at 20% using the …

Branding India: Constructing A Reputation For Responsibility In The Nuclear Order, Karthika Sasikumar

Faculty Publications

Nation-branding professionals have the same goal as diplomats and politicians – the goal of endowing the nation with specific qualities in the minds of the target audience, so that it is identified with those qualities. In other words, they are constructing an identity for the country. Insights from the commercial practice of nation branding can illuminate the process of identity construction by states. As an illustration, the paper investigates the case of India’s branding/self-presentation as a responsible holder of nuclear weapons. In 1998, India declared itself a Nuclear Weapon State (NWS). Since India has not been granted NWS status under …

Simulation Modeling Approach For Evaluating A Solution Designed To Alleviate The Congestion Of Passenger Flow At The Composure Area Of Security Checkpoints, Maria Luisa Janer Rubio

Graduate Theses and Dissertations

In a previous study, we found that replacing the exit roller of a security checkpoint lane for a continuously circulating conveyor could potentially increase the throughput of passengers by over 28% while maintaining the TSA security-waiting time limit (Janer and Rossetti 2016). This study intends to expand this previous effort by investigating the impact of this circulating conveyor on the secondary screening related processes. Leone and Liu (2011) found that imposing a limit on the x-ray screening time, and diverting any item exceeding this limit to secondary screening, could decrease the waiting time by 43%. Our objective is to verify …

The Structural And Functional Properties Of A Double Mutant Of Human Acidic Fibroblast Growth Factor (Hfgf-1), Arwa Mohammed Alghanmi

Graduate Theses and Dissertations

Human acidic Fibroblast Growth Factor 1 (FGF-1), a member of the FGF superfamily, is a potent mitogen and heparin-binding protein involved in a broad spectrum of biological processes, including angiogenesis, cell proliferation, and wound healing. Design of hFGF-1 with an increased thermal stability and an enhanced cell proliferation activity is highly desired for wound healing applications. Herein, we have designed the variant of FGF-1 by substituting two important amino residues in the heparin-binding pocket. The variant was overexpressed in Escherichia coli and was successfully purified to homogeneity using an affinity chromatographic procedure. Far-UV circular dichroism spectroscopic analysis showed that the …

How Muslims Help : An Ethnography Of Muslim Voluntary Assistance For Syrian Refugees In Louisville, Ky., Irene Levy Yates

Electronic Theses and Dissertations

This thesis examines Islamic faith-based organizations’ involvement in Syrian refugee resettlement in Louisville, KY with special attention to the impact of an Islamic Relief USA community engagement grant awarded to Kentucky Refugee Ministries in 2014. A description of local Muslim community support for newly arrived refugees was constructed via participant observation and semi-structured interviews with former and current resettlement agency employees, a diverse set of Muslim community volunteers, and refugees who participate in and/or are supported by Islamic faith-based organizations. Muslim communities in Louisville approach refugee resettlement in ways that are significantly different from both resettlement agency staff and past …

Former Students Discuss Middle School Science Journalism : A Qualitative Study Of Personally Meaningful Disciplinary Writing., Marsha R. Buerger

Electronic Theses and Dissertations

This qualitative research study explores the experiences of six middle school students with science news writing (SciJourn) after they have transitioned to high school. The qualitative method of case study was used with the data analyzed through the method of constructivist grounded theory. SciJourn is a disciplinary approach to science literacy that allows students to choose and research their own topic, interact with experts in the field, construct their own knowledge, and have the opportunity to publish in an on-line science newspaper (Scijourner.org). Theoretically, this research draws on science as social practice where literacy learning is cognitively complex, is situated …

Mitochondrial Transcription Factor A'S Role In Heart Failure., George H. Kunkel

Electronic Theses and Dissertations

Background: An essential mitochondrial component, Mitochondrial Transcription Factor A (TFAM) is reduced within the failing heart. TFAM maintains regulatory functions of cardiomyocyte physiology and stability. Mitochondrial Transcription Factor A forms a mitochondrial nucleoid anti-oxidant structure and reduces pathophysiological abnormalities to structural and contractile proteins. Overall, this functions to physically stabilize mtDNA. Significant molecular changes such as a loss of TFAM drive pathophysiological concentrations of cytoplasmic Ca2+ and reactive oxygen species. Both of these factors induce proteolytic enzymes to degrade the physiological cardiomyocyte. In TFAMs absence, heart function deteriorates and hypertrophic expansion ensues: thereby changing the physiological myocardium to a pathological …