Digital Commons Network^™

Finding Lost & Found: Designer’S Notes From The Process Of Creating A Jewish Game For Learning, Owen Gottlieb

Articles

This article provides context for and examines aspects of the design process of a game for learning. Lost & Found (2017a, 2017b) is a tabletop-to-mobile game series designed to teach medieval religious legal systems, beginning with Moses Maimonides’ Mishneh Torah (1180), a cornerstone work of Jewish legal rabbinic literature. Through design narratives, the article demonstrates the complex design decisions faced by the team as they balance the needs of player engagement with learning goals. In the process the designers confront challenges in developing winstates and in working with complex resource management. The article provides insight into the pathways the team …

A New Cryptic Species Of Aleochara Gravenhorst Associated With Marmota Monax (Linnaeus) Burrows And Caves In North America (Coleoptera: Staphylinidae: Aleocharinae), Jan Klimaszewski, Reginald P. Webster, Adam Brunke

Insecta Mundi

A new cryptic species, Aleochara (Xenochara) castaneimarmotae Klimaszewski, Webster, and Brunke, new species (Coleoptera: Staphylinidae: Aleocharinae), associated with Marmota monax (Linnaeus) burrows and caves in eastern North America, is described and illustrated. A key to Canadian species of subgenus Xenochara Mulsant and Rey and revised distributions of the taxonomically difficult fumata species group are provided. Aleochara quadrata Sharp is recorded from Washington and Oregon for the first time.

Redescripción Del Género Ogyges Kaup (Coleoptera: Passalidae) Con Una Lista Comentada De Los Tipos Primarios, Enio B. Cano

Insecta Mundi

Se redescribe el género Ogyges Kaup, 1871 (Coleoptera: Passalidae), incluyendo su historia taxonómica. Se presentan las imágenes, los datos registrados en las etiquetas, las coordenadas geográficas, mediciones, comentarios taxonómicos y las instituciones depositarias de 19 tipos primarios que fueron descritos o que están incluidos dentro del género Ogyges Kaup. El nombre infrasubespecífico Ogyges laevior ab. vinculotaenia Kuwert, 1897, está indisponible, de acuerdo al artículo 45.6.2 del ICZN.

The genus Ogyges Kaup, 1871 (Coleoptera: Passalidae) is redescribed, including the taxonomic history. Also, images, data registered in labels, geographic coordinates, measurements, taxonomic comments, and repository institutions of 19 primary types previously described …

High Fructose Corn Syrup Induces Metabolic Dysregulation And Altered Dopamine Signaling In The Absence Of Obesity, Allison M. Meyers, Devry Mourra, Jeff A. Beeler

Publications and Research

The contribution of high fructose corn syrup (HFCS) to metabolic disorder and obesity, independent of high fat, energy-rich diets, is controversial. While high-fat diets are widely accepted as a rodent model of diet-induced obesity (DIO) and metabolic disorder, the value of HFCS alone as a rodent model of DIO is unclear. Impaired dopamine function is associated with obesity and high fat diet, but the effect of HFCS on the dopamine system has not been investigated. The objective of this study was to test the effect of HFCS on weight gain, glucose regulation, and evoked dopamine release using fast-scan cyclic voltammetry. …

A New Species Of Trichopeltis Pocock, 1894 From Southern China, With A Checklist And A Distribution Map Of Trichopeltis Species (Diplopoda, Polydesmida, Cryptodesmidae), Natdanai Likhitrakarn, Sergei I. Golovatch, Ruttapon Srisonchai

KIP Articles

The millipede genus Trichopeltis Pocock, 1894 contains 12 described species including a new species from southern China described here. Trichopeltis sutchariti sp. n. can be distinguished from congeners by its gonopods that are strongly caudolaterally curved and have a prominent, high, curved, densely setose process on each coxa. An updated checklist and a distribution map are provided for all species of the genus.

Discovery Of Novel, Orally Bioavailable, Antileishmanial Compounds Using Phenotypic Screening, Diana Ortiz, W. Armand Guiguemde, Jared T. Hammill, Angela K. Carrillo, Yizhe Chen, Michele Connelly, Kayla Stalheim, Carolyn Elya, Alex Johnson, Jaeki Min, Anang Shelat, David C. Smithson, Lei Yang, Fangyi Zhu, R. Kiplin Guy, Scott M. Landfear

Pharmaceutical Sciences Faculty Publications

Leishmaniasis is a parasitic infection that afflicts approximately 12 million people worldwide. There are several limitations to the approved drug therapies for leishmaniasis, including moderate to severe toxicity, growing drug resistance, and the need for extended dosing. Moreover, miltefosine is currently the only orally available drug therapy for this infection. We addressed the pressing need for new therapies by pursuing a two-step phenotypic screen to discover novel, potent, and orally bioavailable antileishmanials. First, we conducted a high-throughput screen (HTS) of roughly 600,000 small molecules for growth inhibition against the promastigote form of the parasite life cycle using the nucleic acid …

Computer-Aided Drug Design Of Capuramycin Analogues As Anti-Tuberculosis Antibiotics By 3d-Qsar And Molecular Docking, Yuanyuan Jin, Shuai Fan, Guangxin Lv, Haoyi Meng, Zhengyang Sun, Wei Jiang, Steven G. Van Lanen, Zhaoyong Yang

Pharmaceutical Sciences Faculty Publications

Capuramycin and a few semisynthetic derivatives have shown potential as anti-tuberculosis antibiotics.To understand their mechanism of action and structureactivity relationships a 3D-QSAR and molecular docking studies were performed. A set of 52 capuramycin derivatives for the training set and 13 for the validation set was used. A highly predictive MFA model was obtained with crossvalidated q² of 0.398, and non-cross validated partial least-squares (PLS) analysis showed a conventional r² of 0.976 and r²_pred of 0.839. The model has an excellent predictive ability. Combining the 3D-QSAR and molecular docking studies, a number of new capuramycin analogs with …

Protected: Arsenic And Old Pelts: Deadly Pesticides In Museum Collections, Alice B. Kehoe, Marshall Joseph Becker

Anthropology & Sociology Faculty Publications

No abstract provided.

Simulations For Designing And Interpreting Intervention Trials In Infectious Diseases., M Elizabeth Halloran, Kari Auranen, Sarah Baird, Nicole E Basta, Steven E Bellan, +Several Additional Authors

Global Health Faculty Publications

BACKGROUND: Interventions in infectious diseases can have both direct effects on individuals who receive the intervention as well as indirect effects in the population. In addition, intervention combinations can have complex interactions at the population level, which are often difficult to adequately assess with standard study designs and analytical methods.

DISCUSSION: Herein, we urge the adoption of a new paradigm for the design and interpretation of intervention trials in infectious diseases, particularly with regard to emerging infectious diseases, one that more accurately reflects the dynamics of the transmission process. In an increasingly complex world, simulations can explicitly represent transmission dynamics, …

A Highly Stable Blood Meal Alternative For Rearing Aedes And Anopheles Mosquitoes, Ted Baughman, Chelsea Peterson, Corrie Ortega, Sarah R. Preston, Christopher Paton, Jessica Williams, Amy Guy, Gavin Omodei, Brian Johnson, Helen Williams, Scott L. O'Neill, Scott A. Ritchie, Stephen L. Dobson, Damian Madan

Entomology Faculty Publications

We investigated alternatives to whole blood for blood feeding of mosquitoes with a focus on improved stability and compatibility with mass rearing programs. In contrast to whole blood, an artificial blood diet of ATP-supplemented plasma was effective in maintaining mosquito populations and was compatible with storage for extended periods refrigerated, frozen, and as a lyophilized powder. The plasma ATP diet supported rearing of both Anopheles and Aedes mosquitoes. It was also effective in rearing Wolbachia-infected Aedes mosquitoes, suggesting compatibility with vector control efforts.

School-Based Oral Health Promotion And Intervention In Amiga (Alfonso, Mendez, Indang, General Emilio Aguinaldo, Amadeo) Cavite, Arlene Cecilia Alfaro

ASEAN Journal of Community Engagement

Dental caries affect 87.4% of Filipinos while 48.3% have periodontal disease. In most developing low-income countries like the Philippines, more than 90% of caries is untreated. Because of the evident disparities in health, high cost of healthcare, unaffordable and unavailable health service, there was a call for reorientation towards prevention on a mass scale by the World Health Organization. This pushed for oral health promotion in schools. Schools give an ideal setting for introducing preventive measures for health with the objective of developing sustainable health promoting behavior change and long-term health outcome improvements. The dental interns from the University of …

Improving Wayfinding And Signage Systems Of The Ragunan Zoo As A Way To Enhance Visitors’ Quality Time, Yulia Nurliani Lukito, Enira Arvanda

ASEAN Journal of Community Engagement

Ragunan zoo is the biggest zoo in Jakarta that becomes one of the most favorite recreation areas during holidays. Unfortunately, the existing signage in the zoo does not provide simple wayfinding and good signage systems that resulted in the confusion of visitors in exploring the zoo. Beside recreation, zoo also functions as, educational and conservational areas. Confusing wayfinding and signage make visitors have less time to enjoy the exhibits and reduce visitors’ motivation to fulfill the education and conservation goals. This paper analyzes existing wayfinding and signage systems at the Ragunan Zoo and proposes a more comprehensive system by using …

Estate Of Adams V. Fallini, 132 Nev. Adv. Op. 81 (December 29, 2016), Krystina Viernes

Nevada Supreme Court Summaries

The Court considered whether a party may appeal a district court’s order granting an NRCP 60(b) motion to set aside a final judgment for fraud upon the court. The Court held the district court’s order interlocutory and may not be appealed until a final judgment is entered.The Court held that the district court was not barred from considering the NRCP 60(b) motion and the district court did not abuse its discretion in granting relief based on fraud upon the court.

Kansas Trends And Changes In Temperature, Precipitation, Drought, And Frost-Free Days From The 1890s To 2015, X. Lin, J. Harrington, I. Ciampitti, P. Gowda, D. Brown, I. Kisekka

Journal of Contemporary Water Research and Education

Kansas extends 660 km from the moderate elevations and semi-humid conditions of the Lower Missouri Basin to the High Plains lying above the Ogallala Aquifer and along the Rockies’ eastern slope. Such characteristics result in significant climate variability across the state, making timely and accurate climate trend and change information valuable for water resources management and crop production. Here we used high-quality daily and monthly climate observations spanning a long-term period of 121 years (1895–2015) to assess trends and changes in air temperature, precipitation, drought, and frost-free days across Kansas. We show that a statewide average warming rate of 0.06°C …

Study Of Ozone And Electron Beam Irradiation On Degradation Of Zearalenone And Ochratoxin A, Luo Xiaohu, Li Ke, Wang Ren, Xing Jiali, Wang Li, Du Zhihong, Pan Lihong, Sun Dongling, Li Yanan, Chen Zhengxing

Food and Machinery

Mycotoxin contamination caused by Zearalenone (ZEN) and Ochratoxin A (OTA) is widespread for being prone to happen and hard to degrade. In this paper, the effects of ozone and electron beam irradiation (EBI) on the degradation of Zearalenone and Ochratoxin A were investigated. After 10 s of 2.0 mg/L ozone treatment, the ZEN content decreased from 50 μg/mL to concentration undetectable. After 12 kGy of EBI, the degradation rate of ZEN was up to 86% and concentration of ZEN within 0.5～5.0 μg/mL had no significant different (P＜0.05), with the degradation of ZEN being faster in acetonitrile than methanol. After 30 …

Expression Of Human Leukocyte Antigen-E And Natural Killer Cells In Intra Uterine Fetal Death, Sri Sulistyowati, Muhammad Anggit Nugroho, Supriyadi Hari Respati, Soetrisno Soetrisno

Folia Medica Indonesiana

Intra Uterine Fetal Death (IUFD) is one contributor to infant mortality. Human Leukocyte Antigen-E (HLA-E) and Natural Killer Cells (NK cells) are believed to play an important role towards IUFD associated with immune maladaptation. This study aimed to determine the expression of HLA-E and NK cells on trophoblast on IUFD and normal pregnancy. The study used cross sectional approach undertaken at Department of Obstetrics and Gynecology, Dr. Moewardi Hospital, Surakarta, networking hospitals, and Anatomic Pathology Laboratory of Faculty of Medicine, Sebelas Maret University. The number of samples were 32 subjects consisting of 16 subjects with normal pregnancy and 16 subjects …

Ogallala Aquifer Program: A Catalyst For Research And Education To Sustain The Ogallala Aquifer On The Southern High Plains (2003-2017), David Brauer, Dan Devlin, Kevin Wagner, Mike Ballou, Dean Hawkins, Robert Lascano

Journal of Contemporary Water Research and Education

The Ogallala Aquifer Program (OAP) was created in 2003 with support from Congressmen from Kansas and Texas. The OAP is a research-education consortium seeking solutions from problems arising from declining water availability from the Ogallala Aquifer in western Kansas and the Texas High Plains. The consortium is led by the Agricultural Research Service (ARS) laboratories in Bushland and Lubbock, TX, and the university partners are Kansas State University, Texas A&M AgriLife Research and Extension Service, Texas Tech University, and West Texas A&M University. The OAP has provided over $40 million to support research and education activities. About half of these …

Calibration And Validation Of Csm-Cropgro-Cotton Model Using Lysimeter Data In The Texas High Plains, P. Adhikari, P.H. Gowda, G.W. Marek, D.K. Brauer, I. Kisekka, B. Northup, A. Rocateli

Journal of Contemporary Water Research and Education

Texas High Plains (THP), one of the most important food and fiber producing regions in the Ogallala Aquifer Region, currently faces rapid decline of groundwater levels. Predicted climate extremes and high temporal variability in growing season precipitation may require growers to pump more groundwater from the Ogallala Aquifer to meet higher crop water demand. The Decision Support System for Agrotechnology Transfer (DSSAT) Cropping System Model (CSM) is a widely used crop simulation tool for evaluating impacts of different water and crop management practices, including irrigation on crop yield and water use efficiency. In this study, CROPGRO-Cotton module of the DSSAT …

Aquifer Depletion In The Lower Mississippi River Basin: Challenges And Solutions, M.L. Reba, J.H. Massey, M.A. Adviento-Borbe, D. Leslie, M.A. Yaeger, M. Anders, J. Farris

Journal of Contemporary Water Research and Education

The Lower Mississippi River Basin (LMRB) is an internationally-important region of intensive agricultural crop production that relies heavily on the underlying Mississippi River Valley Alluvial Aquifer (MRVAA) for irrigation. Extensive irrigation coupled with the region's geology have led to significant aquifer decline. The response to the decline has been multi-faceted. Research related to three responses are highlighted: innovation in rice irrigation, on-farm reservoirs, and managed aquifer recharge. Irrigated rice grown in Arkansas, which is nearly 50% of annual U.S. rice production, accounts for a significant portion of aquifer withdrawal. As a result, strategies for using less water while maintaining rice …

The Downward Spiral: Postmodern Consciousness As Buddhist Metaphysics In The Dark Souls Video Game Series, Paolo Xavier Machado Menuez

Dissertations and Theses

This paper is about locating the meaning of a series of games known as the Dark Souls series in relation to contemporary social conditions in Japan. I argue that the game should be thought of as an emblem of the current cultural zeitgeist, in a similar way one might identify something like Jack Kerouac's The Dharma Bums as an emblem of the counter cultural 60s. I argue that the Dark Souls series expresses in allegorical form an anxiety about living in a time where the meaning of our everyday actions and even society itself has become significantly destabilized. It does …

Cellubrevin/Vesicle-Associated Membrane Protein-3–Mediated Endocytosis And Trafficking Regulate Platelet Functions, Meenakshi Banerjee, Smita Joshi, Jinchao Zhang, Carole L. Moncman, Shilpi Yadav, Beth A. Bouchard, Brian Storrie, Sidney W. Whiteheart

Molecular and Cellular Biochemistry Faculty Publications

Endocytosis is key to fibrinogen (Fg) uptake, trafficking of integrins (αIIbβ₃, α_vβ₃), and purinergic receptors (P2Y₁, P2Y₁₂), and thus normal platelet function. However, the molecular machinery required and possible trafficking routes are still ill-defined. To further identify elements of the platelet endocytic machinery, we examined the role of a vesicle-residing, soluble N-ethylmaleimide factor attachment protein receptor (v-SNARE) called cellubrevin/vesicle-associated membrane protein-3 (VAMP-3) in platelet function. Although not required for normal platelet exocytosis or hemostasis, VAMP-3^−/− mice had less platelet-associated Fg, indicating a defect in Fg uptake/storage. Other granule …

The German Plunder And Theft Of Jewish Property In The General Government, David M. Crowe

History Faculty Books and Book Chapters

"Th e German conquest of Poland in the fall of 1939 unleashed the full horror of Nazi racial ideals that saw the gradual evolution of policies that ultimately led to the mass murder of 90 percent of prewar Poland’s 3.3–3.5 million Jews. The geographical center for what the Germans would ultimately call the Final Solution—a plan that Alfred Rosenberg explained meant 'the biological eradication of the entire Jewish people'—was the Generalgouvernement für die besetzten polnischen Gebiete (General Government for the Occupied Areas of Poland). Over time, the General Government would become not only Nazi Germany’s principal racial laboratory but also …

Developmental Biology, The Stem Cell Of Biological Disciplines, Scott F. Gilbert

Biology Faculty Works

Developmental biology (including embryology) is proposed as "the stem cell of biological disciplines.” Genetics, cell biology, oncology, immunology, evolutionary mechanisms, neurobiology, and systems biology each has its ancestry in developmental biology. Moreover, developmental biology continues to roll on, budding off more disciplines, while retaining its own identity. While its descendant disciplines differentiate into sciences with a restricted set of paradigms, examples, and techniques, developmental biology remains vigorous, pluripotent, and relatively undifferentiated. In many disciplines, especially in evolutionary biology and oncology, the developmental perspective is being reasserted as an important research program.

An Investigation Of Factors Predicting The Type Of Bladder Antimuscarinics Initiated In Medicare Nursing Homes Residents, Daniela C. Moga, Qishan Wu, Pratik Doshi, Amie J. Goodin

Pharmacy Practice and Science Faculty Publications

Background: To examine factors predicting type of bladder antimuscarinics (BAM) initiated in nursing home (NH) residents.

Methods: Incident BAM initiators following NH admission were identified by constructing a retrospective cohort from Medicare files and Minimum Data Set (MDS). Participants included all residents 65 years and older admitted in Medicare-certified NH between January 1, 2007 and December 31, 2008 who were prescribed BAM and had continuous Medicare (Part A, B, and D) enrollment. Patient characteristics, medications, and comorbidities were derived from Medicare enrollment and claims. NH characteristics and health status were derived from MDS assessments. The outcome was defined as type …

Shoe Insole For Eccentric Activities On Daily Application Prevents Muscular Damage And Improves Fasting Blood Glucose, Ahmad Abdullah, Herdianty Kusuma, Elyana Asnar, Bambang Purwanto

Folia Medica Indonesiana

The eccentric contraction has been proven to improve Glut-1 expression in muscle and fasting glucose levels in mice. The same eccentric contraction occurs in human being when walking or running while wearing high heels. Innovation on the eccentric contraction with high heels can be done by using a specific shoe insole. The design of the rear insole is made thicker than the front. The purpose of this study was to determine the effects of insole use specified for eccentric activities on daily work shoes on the skeletal muscle damage after wearing the specified insole. Skeletal muscle damage was measured based …

Effects Of Red Dragon Fruit (Hylocereus Polyrhizus) Skin Extract On Lead Acetate Toxicity In The Morphology Of Balb/C Mice (Mus Musculus) Spermatozoa, Rahmawati Raharjo, Sri Agus Sudjarwo, Reny I'Tishom

Folia Medica Indonesiana

Red dragon fruit skin extract is used as an antioxidant to lead acetate toxicity. This study aimed to prove the difference in morphology of mice testicular spermatozoa exposed to lead acetate. Twenty-five mice were divided into 5 groups (5 mice per group). K- group was the control group without lead acetate and dragon fruit skin extract administration, K + group was treated with 8 mg/KgBW lead acetate administration for 14 days, P1 group was treated with the administration of 8 mg/KgBW lead acetate for 14 days + 250 mg/kgBW red dragon fruit skin extract for 21 days, P2 group was …

Effects Of Methyldopa On Vegf Levels As Proangiogenic Factor In Severe Pre-Eclampsia At Haji Hospital, Surabaya, Dina Ratna Juwita, Yulistiani Yulistiani, Eddy Zarkaty M

Folia Medica Indonesiana

Methyldopa is the main antihypertensive drug widely used in pregnant women with hypertensive disorder. It lowers blood pressure in pre-eclampsia by affecting a2-adrenoreceptors in central nervous system. However, it also decreases the production of proangio-genic factors that involved in the pathophysiology of hypertension in pre-eclampsia. Vascular Endothelial Growth Factor (VEGF) is one of proangiogenic and mitogenic factor that important for vasodilatation. VEGF is produced by the placenta and affected after treatment with methyldopa. The aim of this study was to analyze the effects of methyldopa on VEGF maternal circulating level as a proangiogenic factor in severe pre-eclampsia patients who were …

Così Fan Tutte: A Better Approach Than The Right To Be Forgotten, Martha Garcia-Murillo, Ian Macinnes

School of Information Studies - Faculty Scholarship

In this article, we argue in favor of a macro-societal approach to protect people from the potential harms of personal information online. In the tension between information and privacy, “the right to be forgotten” is not an appropriate solution. Such a micro, individual-based answer puts the burden of protection on each person instead of on external entities that can abuse such knowledge. The personal responsibility to delete personal data is challenging because of the leakage of data that happens through the connections we have with others, many of whom do not share the same privacy preferences. We show that effective …

Provitamin A Biofortification Of Cassava Enhances Shelf Life But Reduces Dry Matter Content Of Storage Roots Due To Altered Carbon Partitioning Into Starch, Getu Beyene, Felix R. Solomon, Raj D. Chauhan, Eliana Gaitán-Solis, Narayanan Narayanan, Jackson Gehan, Dimuth Siritunga, Robin L. Stevens, John Jifon, Joyce Van Eck, Edward Linsler, Malia Gehan, Muhammad Ilyas, Martin Fregene, Richard T. Sayre, Paul Anderson, Nigel Taylor, Edgar B. Cahoon

Center for Plant Science Innovation: Faculty Publications

Storage roots of cassava (Manihot esculenta Crantz), a major subsistence crop of sub-Saharan Africa, are calorie rich but deficient in essential micronutrients, including provitamin A β-carotene. In this study, β-carotene concentrations in cassava storage roots were enhanced by coexpression of transgenes for deoxy-d-xylulose-5-phosphate synthase (DXS) and bacterial phytoene synthase (crtB), mediated by the patatin-type 1 promoter. Storage roots harvested from field-grown plants accumulated carotenoids to ≤50 lg/g DW, 15- to 20-fold increases relative to roots from nontransgenic plants. Approximately 85%–90% of these carotenoids accumulated as all-trans-β-carotene, the most nutritionally efficacious carotenoid. β-Carotene-accumulating storage roots displayed delayed onset of postharvest …

Materialism Without Matter: Deleuze, Steven Swarbrick

Publications and Research

No abstract provided.