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2017

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Magnesium Isotope Investigation Of Stromatolitic Knobs In Storr’S Lake, San Salvador, Bahamas: Implications For Organomineralization And Laminae Formation, Zijian Li Aug 2017

Magnesium Isotope Investigation Of Stromatolitic Knobs In Storr’S Lake, San Salvador, Bahamas: Implications For Organomineralization And Laminae Formation, Zijian Li

Earth & Environmental Sciences Theses - Archive

Storr’s Lake, a hypersaline lake located on San Salvador Island, Bahamas, contains modern, fine-grained stromatolites. This study focused on two morphological types of stromatolitic mounds in Storr’s Lake (pinnacle mound and plateau-mushroom) and systematically investigated their mineralogy, elemental abundance, carbon, oxygen and magnesium (Mg) isotopic signature to gain insights into the organomineralization process and laminae formation of stromatolites. In addition, the hydrochemistry of Storr’s Lake was characterized by in situ measurement of water parameters, elemental analysis, and Mg isotope investigation. Cations and anions analysis indicates the lake is spatially homogenous and shows little seasonal variation. Mg isotope analysis of the …

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Retrotransposons Are The Major Contributors To The Expansion Of The Drosophila Ananassae Muller F Element, Wilson Leung, Gerard Mcneil Aug 2017

Retrotransposons Are The Major Contributors To The Expansion Of The Drosophila Ananassae Muller F Element, Wilson Leung, Gerard Mcneil

Publications and Research

The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (5.2 Mb) is the smallest chromosome in Drosophila melanogaster, but it is substantially larger (.18.7 Mb) in D. ananassae. To identify the major contributors to the expansion of the F element and to assess their impact, we improved the genome sequence and annotated the genes in a 1.4-Mb region of the D. ananassae F element, and a 1.7-Mb region from the D element for comparison. We find that transposons (particularly LTR and LINE retrotransposons) are major contributors …

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Morphological Integration Between The Face And Dentition Throughout Ontogeny, Allison Nesbitt Aug 2017

Morphological Integration Between The Face And Dentition Throughout Ontogeny, Allison Nesbitt

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Modern humans have flatter faces, wider palates and smaller teeth compared to chimpanzees and our early human ancestors. Many hypotheses concerning the evolution of the human face assume a relationship between the face and the teeth. It is likely that the face and teeth develop in a coordinated manner throughout the growth and development of an organism due to similar developmental origins, and functions, and the teeth residing in the maxillae. What is not fully understood is whether the face and teeth are two separate units (modules) that can evolve independently or if they are tightly correlated (integrated) during evolution. …

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Essays On Patent Transfer Behavior In The Pharmaceutical Industry, Yupeng Li Aug 2017

Essays On Patent Transfer Behavior In The Pharmaceutical Industry, Yupeng Li

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

While large pharmaceutical companies continue to dominate drug development and patent acquisition, their timing of drug patent acquisition and subsequent payoffs remain poorly understood. In an effort to examine the patent acquisition timing in the U.S. pharmaceutical industry, both empirical and theoretical approaches are used to analyze the effects of firm characteristics on the timing of patent purchases. In Chapter 1, I construct a unique dataset using publicly-available data provided by the United States Patent and Trademark Office (USPTO), and examine the purchasing behavior of public firms within the U.S. pharmaceutical industry. I focus on the role of firm size …

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Advances In Developing Therapies To Combat Zika Virus: Current Knowledge And Future Perspectives, Ashok Munjal, Rekha Khandia, Kuldeep Dharma, Swati Sachan, Kumaragurubaran Karthik, Ruchi Tiwari, Yashpal S. Malik, Deepak Kumar, Raj K. Singh, Hafiz M. N. Iqbal, Sunil K. Joshi Aug 2017

Advances In Developing Therapies To Combat Zika Virus: Current Knowledge And Future Perspectives, Ashok Munjal, Rekha Khandia, Kuldeep Dharma, Swati Sachan, Kumaragurubaran Karthik, Ruchi Tiwari, Yashpal S. Malik, Deepak Kumar, Raj K. Singh, Hafiz M. N. Iqbal, Sunil K. Joshi

Bioelectrics Publications

Zika virus (ZIKV) remained largely quiescent for nearly six decades after its first appearance in 1947. ZIKV reappeared after 2007, resulting in a declaration of an international “public health emergency” in 2016 by the World Health Organization (WHO). Until this time, ZIKV was considered to induce only mild illness, but it has now been established as the cause of severe clinical manifestations, including fetal anomalies, neurological problems, and autoimmune disorders. Infection during pregnancy can cause congenital brain abnormalities, including microcephaly and neurological degeneration, and in other cases, Guillain-Barré syndrome, making infections with ZIKV a substantial public health concern. Genomic and …

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A Functional Subnetwork Approach To Designing Synthetic Nervous Systems That Control Legged Robot Locomotion, Nicholas Szczecinski, Alexander J. Hunt, Roger Quinn Aug 2017

A Functional Subnetwork Approach To Designing Synthetic Nervous Systems That Control Legged Robot Locomotion, Nicholas Szczecinski, Alexander J. Hunt, Roger Quinn

Mechanical and Materials Engineering Faculty Publications and Presentations

A dynamical model of an animal’s nervous system, or synthetic nervous system (SNS), is a potentially transformational control method. Due to increasingly detailed data on the connectivity and dynamics of both mammalian and insect nervous systems, controlling a legged robot with an SNS is largely a problem of parameter tuning. Our approach to this problem is to design functional subnetworks that perform specific operations, and then assemble them into larger models of the nervous system. In this paper, we present networks that perform addition, subtraction, multiplication, division, differentiation, and integration of incoming signals. Parameters are set within each subnetwork to …

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Physiological Parameters, Isoenzymes And Hormonal Profiling In Different Varieties Of Date Palm In United Arab Emirates, Saeed Rashed Hamad Al Shamsi Aug 2017

Physiological Parameters, Isoenzymes And Hormonal Profiling In Different Varieties Of Date Palm In United Arab Emirates, Saeed Rashed Hamad Al Shamsi

Aridland Agriculture Theses

The present investigation was carried out to explore the physiological changes in early, mid and late varieties of date palms in United Arab Emirates. The concentrations of biochemicals and antioxidant compounds, activities of antioxidant enzymes with their isoenzyme profiles, endogenous phytohormone contents were studied from preflowering, flowering, and post-flowering stages. Two varieties each from early (Shaham, Khanezi), mid (Barhee, Nabthasaif) and late (Khasab, Fardh) flowering types were used in the study. The protein content was higher in early varieties in preflowering stage, but lower in other two varieties. The phenol showed an opposite trend to protein. Ascorbic acid, reduced glutathione …

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Uah Humanities Center, 2017, University Of Alabama In Huntsville Aug 2017

Uah Humanities Center, 2017, University Of Alabama In Huntsville

Newsletters

No abstract provided.

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3-Aryl-4h-Chromene-4-Ones As Antineoplastic Agents For The Treatment Of Cancer, Svitlana P. Bondarenko, Mykhaylo S. Frasinyuk, Chunming Liu, David S. Watt Aug 2017

3-Aryl-4h-Chromene-4-Ones As Antineoplastic Agents For The Treatment Of Cancer, Svitlana P. Bondarenko, Mykhaylo S. Frasinyuk, Chunming Liu, David S. Watt

Markey Cancer Center Faculty Patents

Isoflavonoids or pharmaceutically acceptable salts thereof or pharmaceutically acceptable compositions thereof for the treatment of prostate cancer or for the treatment or inhibition of prostate cancer metastasis in a patient in need thereof are disclosed.

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Boletín Espeleoar, Año 9, Número 16, August 2017, Gabriel Redonte Aug 2017

Boletín Espeleoar, Año 9, Número 16, August 2017, Gabriel Redonte

Boletin EspeleoAr

Contents: Staff y Editorial -- Curso de Espeleosocorro Nivel I de la ELE-FEALC y la CNAE en Las Lajas, Neuquén -- GEMA en Chile. Primera expedición internacional Cueva de La Quintrala - Pichidangui - Los Vilos -- Espeleología Bonaerense. Nuevas campañas del GEA en Tandilia y Ventania -- II Encuentro de la Comisión Nacional Argentina de Espeleosocorro en La Cumbrecita, Córdoba -- Giovanni Badino. Un amigo que se fue. Un ejemplo que quedará -- Introducción a la espeleología en Neuquén -- Nuevo sitio web del GEA -- XVII Congreso Internacional de Espeleología en Penrith, Australia 2017 -- Ciclo de conferencias …

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Repeated Evolution Of Vertebrate Pollination Syndromes In A Recently Diverged Andean Plant Clade, Laura P. Lagomarsino, Elisabeth J. Forrestel, Nathan Muchhala, Charles C. Davis Aug 2017

Repeated Evolution Of Vertebrate Pollination Syndromes In A Recently Diverged Andean Plant Clade, Laura P. Lagomarsino, Elisabeth J. Forrestel, Nathan Muchhala, Charles C. Davis

Faculty Publications

© 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution. Although specialized interactions, including those involving plants and their pollinators, are often invoked to explain high species diversity, they are rarely explored at macroevolutionary scales. We investigate the dynamic evolution of hummingbird and bat pollination syndromes in the centropogonid clade (Lobelioideae: Campanulaceae), an Andean-centered group of ∼550 angiosperm species. We demonstrate that flowers hypothesized to be adapted to different pollinators based on flower color fall into distinct regions of morphospace, and this is validated by morphology of species with known pollinators. This supports the existence of …

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Selection Of Breeding Stock By U.S. Meat Goat Producers, Narayan Nyaupane, Jeffrey Gillespie, Kenneth Mcmillin, Robert Harrison, Isaac Sitienei Aug 2017

Selection Of Breeding Stock By U.S. Meat Goat Producers, Narayan Nyaupane, Jeffrey Gillespie, Kenneth Mcmillin, Robert Harrison, Isaac Sitienei

Faculty Publications

© 2017 The Author(s). Using nationwide survey data, we investigate U.S. meat goat producer preferences and willingness to pay for meat goat breeding stock attributes. Discrete choice experiments were employed, and mixed logit and latent class models were used for analysis. Results showed that producers preferred animals that were highly masculine/feminine, had good structure and soundness, and were of the Boer breed, whereas they preferred fewer animals that were older, of Kiko and Spanish breeds, and priced higher. Significant preference heterogeneity was found among the respondents. Larger-scale producers had greater preference for high masculinity/femininity, good structure and soundness, and Boer …

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Retinoic Acid Inhibits White Adipogenesis By Disrupting Gadd45a-Mediated Zfp423 Dna Demethylation, Bo Wang, Xing Fu, Mei Jun Zhu, Min Du Aug 2017

Retinoic Acid Inhibits White Adipogenesis By Disrupting Gadd45a-Mediated Zfp423 Dna Demethylation, Bo Wang, Xing Fu, Mei Jun Zhu, Min Du

Faculty Publications

© The Author (2017). Retinoic acid (RA), a bioactive metabolite of Vitamin A, is a critical mediator of cell differentiation. RA blocks adipogenesis, but mechanisms remain to be established. ZFP423 is a key transcription factor maintaining white adipose identity. We found that RA inhibits Zfp423 expression and adipogenesis via blocking DNA demethylation in the promoter of Zfp423, a process mediated by growth arrest and DNA-damage-inducible protein alpha (GADD45A). RA induces the partnering between retinoic acid receptor (RAR) and tumor suppressor inhibitor of growth protein 1 (ING1), which prevents the formation of GADD45A and ING1 complex necessary for locus-specific Zfp423 DNA …

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Social Learning And Its Effect On Conservation Efforts In The Barrens Topminnow: An Evaluation Of Conditioning And Social Learning As A Viable Longterm Solution To Evolutionary Traps, Elijah Reyes Aug 2017

Social Learning And Its Effect On Conservation Efforts In The Barrens Topminnow: An Evaluation Of Conditioning And Social Learning As A Viable Longterm Solution To Evolutionary Traps, Elijah Reyes

Masters Theses and Doctoral Dissertations

The invasive Western Mosquitofish (WMF), Gambusia affinis, has facilitated the extinction and endangerment of multiple freshwater fish species, including the Barrens Topminnow (BTM), Fundulus julisia. In my study, I investigated if BTMs are capable of socially learning conditioned predator recognition, and I hypothesized that BTMs are capable of social learning and that such learning might improve survival of BTMs. To explore the role of conditioning and subsequent learning in the conservation of BTMs, I conducted a series of experiments in which I 1) attempted to condition BTMs to exhibit antipredator behavior when faced with WMF, and 2) created a situation …

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Habitat-Specific Fitness Benefits Of Sociality In Octodon Degus, Madeline Klees Strom Aug 2017

Habitat-Specific Fitness Benefits Of Sociality In Octodon Degus, Madeline Klees Strom

Masters Theses and Doctoral Dissertations

Recent debate has focused on how ecology shapes the evolution of group-living and cooperation in social vertebrates. Evidence suggests that group-living and cooperation enhance reproductive success under harsh local conditions in some species. Across two years, I studied two populations of Octodon degus, a plurally breeding rodent, to answer three questions: (1) Does living in large groups and having strong social network strength improve access to resources in harsh environments? (2) Does increased access to resources improve the reproductive success of group-living females? (3) Does living in large groups and having strong social network strength improve reproductive success of females …

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Techmatters: Browser Extensions And Add-Ons For Library Instructors, Krista Graham Aug 2017

Techmatters: Browser Extensions And Add-Ons For Library Instructors, Krista Graham

LOEX Quarterly

No abstract provided.

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Ion Channel Signaling Influences Cellular Proliferation And Phagocyte Activity During Axolotl Tail Regeneration, Brandon M. Franklin, S. Randal Voss, Jeffrey L. Osborn Aug 2017

Ion Channel Signaling Influences Cellular Proliferation And Phagocyte Activity During Axolotl Tail Regeneration, Brandon M. Franklin, S. Randal Voss, Jeffrey L. Osborn

Biology Faculty Publications

Little is known about the potential for ion channels to regulate cellular behaviors during tissue regeneration. Here, we utilized an amphibian tail regeneration assay coupled with a chemical genetic screen to identify ion channel antagonists that altered critical cellular processes during regeneration. Inhibition of multiple ion channels either partially (anoctamin1/Tmem16a, anoctamin2/Tmem16b, KV2.1, KV2.2, L-type CaV channels and H/K ATPases) or completely (GlyR, GABAAR, KV1.5 and SERCA pumps) inhibited tail regeneration. Partial inhibition of tail regeneration by blocking the calcium activated chloride channels, anoctamin1&2, was associated with a reduction of cellular proliferation in …

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Quantitative Assessment Of Water Security Using A Hydrological Modeling Framework, Anoop Valiyaveettil Aug 2017

Quantitative Assessment Of Water Security Using A Hydrological Modeling Framework, Anoop Valiyaveettil

All Dissertations

Water scarcity and drought are major threats to water security. Quantifying and defining boundaries between these threats are necessary to properly assess water security of a region. A comprehensive assessment of water security in terms of water scarcity, water vulnerability and drought can address water policy issues related to hydrological conditions and their interactions with societal and ecosystem functioning. Therefore, study of water security can provide useful information to multiple stakeholders. The overarching goal of this thesis is to improve water security in river basins around the world. To demonstrate our proposed methods, we selected Savannah River Basin (SRB) as …

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The Faithless Elector And 2016: Constitutional Uncertainty After The Election Of Donald Trump, Alexander Gouzoules Aug 2017

The Faithless Elector And 2016: Constitutional Uncertainty After The Election Of Donald Trump, Alexander Gouzoules

Faculty Publications

Presidential electors are generally expected to vote for the candidate who won their state's election, and those who do not are referred to as "faithless electors." A majority of states have laws of varying types that bind their electors to vote for the winning presidential candidate. The 2016 election, for the first time in modern history, produced a serious movement urging electors to cast faithless votes against Donald Trump. Although this movement was not successful, 2016 saw the most faithless electors in recent history by a large margin. Three separate, ultimately unsuccessful, lawsuits were filed by would-be faithless electors in …

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The Antidiabetic Activity Of Curry Leaves “Murraya Koenigii” On The Glucose Levels, Kidneys, And Islets Of Langerhans Of Rats With Streptozotocin Induced Diabetes, Imad M. Al-Ani, Rahajoe I. Santosa, Muhammad H. Yankuzo, Anil K. Saxena, Khalid S. Alazzawi Aug 2017

The Antidiabetic Activity Of Curry Leaves “Murraya Koenigii” On The Glucose Levels, Kidneys, And Islets Of Langerhans Of Rats With Streptozotocin Induced Diabetes, Imad M. Al-Ani, Rahajoe I. Santosa, Muhammad H. Yankuzo, Anil K. Saxena, Khalid S. Alazzawi

Makara Journal of Health Research

Background: The aims of this study were to explore the antihyperglycemic effect of curry leaves, Murraya koenigii "MK" aqueous extract, and to examine its possible protective effects on the islets of Langerhans and kidneys of streptozotocin (STZ) diabetic rats. Methods: Thirty healthy adult male Sprague Dawley rats were randomized into five groups (n=6); normal control, normal treated with "MK" control, diabetic control (non-treated with "MK"), diabetic treated with 200 mg/kg MK aqueous leaf extract and diabetic treated with 400 mg/kg MK aqueous leaf extract. Blood glucose levels and body weight were monitored gravimetrically. The animals were sacrificed on the 30th …

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Methodological Irregularities In Programming-Language Research, Andreas Stefik, Stefan Hanenberg Aug 2017

Methodological Irregularities In Programming-Language Research, Andreas Stefik, Stefan Hanenberg

Computer Science Faculty Research

Substantial industry and government investments in software are at risk due to changes in the underlying programming languages, despite the fact that such changes have no empirically verified benefits. One way to address this problem is to establish rigorous evidence standards like those in medicine and other sciences. © 1970-2012 IEEE.

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Structural And Mutational Analyses Of The Leptospira Interrogans Virulence-Related Heme Oxygenase Provide Insights Into Its Catalytic Mechanism, Anabel Soldano, Sebastián Klinke, Lisandro H. Otero, Mario Rivera, Daniela L. Catalano-Dupuy, Eduardo A. Ceccarelli Aug 2017

Structural And Mutational Analyses Of The Leptospira Interrogans Virulence-Related Heme Oxygenase Provide Insights Into Its Catalytic Mechanism, Anabel Soldano, Sebastián Klinke, Lisandro H. Otero, Mario Rivera, Daniela L. Catalano-Dupuy, Eduardo A. Ceccarelli

Faculty Publications

© 2017 Soldano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Heme oxygenase from Leptospira interrogans is an important virulence factor. During catalysis, redox equivalents are provided to this enzyme by the plastidic-type ferredoxin-NADP+ reductase also found in L. interrogans. This process may have evolved to aid this bacterial pathogen to obtain heme-iron from their host and enable successful colonization. Herein we report the crystal structure of the heme oxygenase-heme complex at …

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Estradiol Modulates Neural Response To Conspecific And Heterospecific Song In Female House Sparrows: An In Vivo Positron Emission Tomography Study, Christine R. Lattin, Frank A. Stabile, Richard E. Carson Aug 2017

Estradiol Modulates Neural Response To Conspecific And Heterospecific Song In Female House Sparrows: An In Vivo Positron Emission Tomography Study, Christine R. Lattin, Frank A. Stabile, Richard E. Carson

Faculty Publications

© 2017 Lattin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Although there is growing evidence that estradiol modulates female perception of male sexual signals, relatively little research has focused on female auditory processing. We used in vivo 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imaging to examine the neuronal effects of estradiol and conspecific song in female house sparrows (Passer domesticus). We assessed brain glucose metabolism, a measure of neuronal activity, in …

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Economic Growth And Mortality: Do Social Protection Policies Matter?, Usama Bilal, Richard Cooper, Francis Abreu, Claudia Nau, Manuel Franco, Thomas A. Glass Aug 2017

Economic Growth And Mortality: Do Social Protection Policies Matter?, Usama Bilal, Richard Cooper, Francis Abreu, Claudia Nau, Manuel Franco, Thomas A. Glass

Faculty Publications

Background: In the 20th century, periods of macroeconomic growth have been associated with increases in population mortality. Factors that cause or mitigate this association are not well understood. Evidence suggests that social policy may buffer the deleterious impact of economic growth. We sought to explore associations between changing unemployment (as a proxy for economic change) and trends in mortality over 30 years in the context of varying social protection expenditures. Methods: We model change in all-cause mortality in 21 OECD (Organization for Economic Cooperation and Development) countries from 1980 to 2010. Data from the Comparative Welfare States Data Set and …

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Genistein Crosses The Bioartificial Oviduct And Alters Secretion Composition, Constantine A. Simintiras, Roger G. Sturmey Aug 2017

Genistein Crosses The Bioartificial Oviduct And Alters Secretion Composition, Constantine A. Simintiras, Roger G. Sturmey

Faculty Publications

The dietary derived isoflavone and oestrogen analogue, genistein, is known to perturb fundamental reproductive events such as implantation and embryo cleavage. However the question of whether genistein is able to traverse the oviduct epithelial monolayer and impact oviduct fluid secretion remains unclear. This study tests these research questions using a bioartificial oviduct to show that genistein permeates the oviduct lumen in vitro with a biphasic (burst and plateau) kinetic profile, faster than spontaneous diffusion, and alters the amino acid composition of in vitro derived oviduct fluid (ivDOF) but not as an oestrogen analogue. In addition to offering insights into the …

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2017-2018 Undergraduate And Graduate Catalog, The University Of Alabama In Huntsville Aug 2017

2017-2018 Undergraduate And Graduate Catalog, The University Of Alabama In Huntsville

Course Catalogs

No abstract provided.

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Leading For Good In The Impulse Society, Kimberly Townsend Aug 2017

Leading For Good In The Impulse Society, Kimberly Townsend

Education Doctoral

The purpose of this study is to explore the leadership dispositions and practices of executive leaders who are leading for good in the Impulse Society, which is described by Tazioli (2014) as, A world where business shamelessly seeks the fastest reward, regardless of the long-term social consequences; where political leaders reflexively choose shortterm fixes over broad, sustainable social progress; where individuals feel increasingly exploited by a marketplace obsessed with our private cravings, yet oblivious to our spiritual well-being or the larger needs of our families and communities (“Book of the Week,” para. 1). To accomplish this work, the research uses …

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First Choice, August 2017, Wusf Public Media Aug 2017

First Choice, August 2017, Wusf Public Media

First Choice Monthly Newsletter

The August 2017 issue of WUSF's newsletter "First Choice."

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Situating The Corporation Within The Vulnerability Paradigm: What Impact Does Corporate Personhood Have On Vulnerability, Dependency, And Resilience, Heather Kolinsky Aug 2017

Situating The Corporation Within The Vulnerability Paradigm: What Impact Does Corporate Personhood Have On Vulnerability, Dependency, And Resilience, Heather Kolinsky

UF Law Faculty Publications

As a result of Hobby Lobby, and the seemingly expanding notion of the corporation as a person within the traditional autonomous rights paradigm, a tension has developed between corporation as subject and corporation as institution. This evolution of corporation as person also highlights the problem of providing resilience to vulnerable subjects whose competing vulnerabilities are situated in the same corporate environment. Addressing this issue is of critical importance where employment has become the conduit for the responsive state to provide resilience to so many subjects, as well as the site of social institution building because the nature of our workplace …

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Ethnographic And Archaeological Perspectives On The Use Life Of Northwest Alaskan Pottery (Chapter 7), Shelby Anderson Aug 2017

Ethnographic And Archaeological Perspectives On The Use Life Of Northwest Alaskan Pottery (Chapter 7), Shelby Anderson

Anthropology Faculty Publications and Presentations

Chapter 7. The role of pottery in Arctic hunter-gatherer lifeways is analyzed through this investigation of how pottery procurement, production, use, and discard was incorporated into past hunter-gatherer seasonal activities. This case study highlights the complexity of making pottery at northern latitudes and the time investment, technological skill, and resources required of northern potters to resolve these challenges; mobility and environmental constraints unique to northern Alaska shape the character, production, and use of ceramic vessels.

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