Digital Commons Network^™

Wagon Tracks. Volume 8, Issue 1 (November, 1993), Santa Fe Trail Association

Wagon Tracks

No abstract provided.

Wagon Tracks. Volume 7, Issue 1 (November, 1992), Santa Fe Trail Association

Wagon Tracks

No abstract provided.

Art Journal 2017 - Moving Forward

Art Journal

No abstract provided.

Wagon Tracks. Volume 9, Issue 3 (May, 1995), Santa Fe Trail Association

Wagon Tracks

No abstract provided.

Wagon Tracks. Volume 10, Issue 4 (August, 1996), Santa Fe Trail Association

Wagon Tracks

No abstract provided.

Wagon Tracks. Volume 10, Issue 3 (May, 1996), Santa Fe Trail Association

Wagon Tracks

No abstract provided.

Spatiotemporal Variation In Frugivore Assemblages And Population Dynamics Of An Invasive Shrub, Schinus Terebinthifolius, Kelley D. Erickson

Open Access Dissertations

Multiple introductions of an exotic species can facilitate invasion success by allowing for a wider range of expressed trait values in the adventive range. Schinus terebinthifolius Raddi (Brazilian Pepper) is an invasive shrub that was introduced into Florida in two separate introductions and has subsequently hybridized, resulting in three distinct lineages (eastern, western and hybrid). In the first chapter, to determine whether allocation of above ground biomass differed by introduction history we destructively sampled 257 stems from each of 6 populations with differing introduction histories. The proportion of aboveground biomass allocated to fruit, wood and leaves differed among the three …

George Yeo [Singapore, Minister Of Foreign Affairs], George Yeo

Digital Narratives of Asia

George Yeo, former Minister of Foreign Affairs who became a business leader, speaks to DNA about his philosophical Taoist worldview, the impact of the rise of China, and the challenges facing ASEAN at its 50th year. He talks on how the soft power of ASEAN's policy of non-interference has yield some successes.

Sexual Dimorphism In Glioma Glycolysis Underlies Sex Differences In Survival, Joseph E. Ippolito, Aldrin Kay-Yuen Yim, Jingqin Luo, Prakash Chinnaiyan, Joshua B. Rubin

Open Access Publications

The molecular bases for sex differences in cancer remain undefined and how to incorporate them into risk stratification remains undetermined. Given sex differences in metabolism and the inverse correlation between fluorodeoxyglucose (FDG) uptake and survival, we hypothesized that glycolytic phenotyping would improve glioma subtyping. Using retrospectively acquired lower-grade glioma (LGG) transcriptome data from The Cancer Genome Atlas (TCGA), we discovered male-specific decreased survival resulting from glycolytic gene overexpression. Patients within this high-glycolytic group showed significant differences in the presence of key genomic alterations (i.e., 1p/19q codeletion, CIC, EGFR, NF1, PTEN, FUBP1, and IDH mutations) compared with the low-glycolytic group. Although …

Unh Research Discovers Genetic Mechanism Preventing Kidney Injury After Severe Dehydration, Unh Today

Media Relations

No abstract provided.

Ages Of Grace, Leah Farish Esq.

College of Arts and Cultural Studies Faculty Research and Scholarship

Do you ever wonder about our sisters in Christ who lived in other ages–and about what we have in common with them? Our church decided to offer a women’s retreat with the title “Ages of Grace,” in which the teaching was by various characters who came to us with costume and music of their era.

The first talk began as the retreatants were settled on a Friday evening at a retreat lodge about 10 miles from our church. Candles were lit, and some recorded music suggesting the chants of the early church ushered in one of our members, wearing a …

Extrafollicular Activities: Perspectives On Hiv Infection, Germinal Centerindependent Maturation Pathways, And Kshv-Mediated Lymphoproliferation, Jennifer Totonchy

Pharmacy Faculty Articles and Research

Early events in the pathogenesis of KSHV-associated lymphoproliferations in the context of HIV disease remain poorly understood. Recent research indicates that latent HIV infection causes persistent immune dysfunction in B cell follicles. Simultaneously, lack of T cell immune surveillance in the lymph nodes dysregulates the biology of EBV. In sum, these defects bias B lymphocyte maturation away from traditional T cell-dependent germinal center-mediated pathways and towards extrafollicular pathways. Recent advances in B lymphocyte immunology suggest that extrafollicular maturation pathways for antibody secreting cells are more flexible and robust than previously believed. These responses are now understood to be both durable …

Lessons From The Cactus Mouse, Robbin Ray

UNH Today Archive

No abstract provided.

Idarucizumab For Dabigatran Reversal - Full Cohort Analysis., Charles V. Pollack, Paul A. Reilly, Joanne Van Ryn, John W. Eikelboom, Stephan Glund, Richard A. Bernstein, Robert Dubiel, Menno V. Huisman, Elaine M. Hylek, Chak-Wah Kam, Pieter W. Kamphuisen, Jörg Kreuzer, Jerrold H. Levy, Gordon Royle, Frank W. Sellke, Joachim Stangier, Thorsten Steiner, Peter Verhamme, Bushi Wang, Laura Young, Jeffrey I. Weitz

Department of Emergency Medicine Faculty Papers

BACKGROUND: Idarucizumab, a monoclonal antibody fragment, was developed to reverse the anticoagulant effect of dabigatran.

METHODS: We performed a multicenter, prospective, open-label study to determine whether 5 g of intravenous idarucizumab would be able to reverse the anticoagulant effect of dabigatran in patients who had uncontrolled bleeding (group A) or were about to undergo an urgent procedure (group B). The primary end point was the maximum percentage reversal of the anticoagulant effect of dabigatran within 4 hours after the administration of idarucizumab, on the basis of the diluted thrombin time or ecarin clotting time. Secondary end points included the restoration …

Galen’S Analogy: Animal Experimentation And Anatomy In The Second Century C.E., Annastasia Conner

Anthós

Galen of Pergamum (129 – ca. 216 C.E.) is truly one of the most pivotal characters in the history of medicine, and particularly the field of anatomy. A physician in the ancient Roman Empire, he did not allow his work to be constrained by contemporary boundaries, instead delving further into the field of anatomy and physiology than any doctor had yet done. He built upon the existing work of his predecessors as well as making new discoveries through which he would shape contemporary and future understandings of anatomy, and of medicine as a whole. Although a luminary in his field, …

Ani-Bot: A Mixed-Reality Ready Modular Robotics System, Zhuangying Xu, Yuanzhi Cao

The Summer Undergraduate Research Fellowship (SURF) Symposium

DIY modular robotics has always had a strong appeal to makers and designers; being able to quickly design, build, and animate their own robots opens the possibility of bringing imaginations to life. However, current interfaces to control and program the DIY robot either lacks connection and consistency between the users and target (Graphical User Interface) or suffers from limited control capabilities due to the lack of versatility and functionality (Tangible User interface). We present Ani-Bot, a modular robotics system that allows users to construct Do-It-Yourself (DIY) robots and use mixed-reality approach to interact with them instantly. Ani-Bot enables novel user …

Low Power, Low Noise Circuit For Biological Signal Recording, Rachael A. Swenson, Daniel J. Pederson, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Implantable devices are ideal for recording biological signals in animal models as they have minimal effect on the animal’s normal behavior during observation. The creation of the circuitry for an implantable device has several restrictions including size, power consumption, and noise reduction. These factors compete against each other, making it necessary to carefully optimize circuit components for a given application. This study evaluates the design of a four-channel analog front end circuit board to record cardiac, neural, and respiratory biological signals. Through a critical analysis of component specifications for the circuit’s components and an evaluation of the circuits’ power and …

In Vivo Analysis Of Angiotensin Ii-Induced Hypertension And Vascular Disease In Rats, Hamna J. Qureshi, Evan H. Phillips, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Murine models of abdominal aortic aneurysms (AAA) are commonly used to study the pathogenesis of this disease. Rats are often used in laboratory studies because of their size and because they are more physiologically similar to humans than mice are. In this study, we subcutaneously implanted 9-week-old apolipoprotein E-deficient (apoE KO) rats with angiotensin II-filled pumps to study the effects of this vasoconstricting hormone on aneurysm development. Deletion of the apoE gene in mice causes excess lipid accumulation in the blood vessels, thereby increasing the likelihood of atherosclerotic lesions in the aorta. However, atherosclerotic plaque buildup was not evident when …

Ecological Responses Of Midwestern Snakes To Prescribed Fire, Zachary T. Truelock, Chelsea E. Clyde-Brockway, Elizabeth A. Flaherty

The Summer Undergraduate Research Fellowship (SURF) Symposium

Prescribed burning is a commonly used land management tool to reduce the risk of hazardous wildfires and improve wildlife habitat, especially for grassland ecosystems. However, prescribed fire has widely varying effects on differing wildlife taxa. The effects of prescribed fire on herpetofaunal biodiversity have been examined, but the responses of a common and wide-ranging species, the common garter snake (Thamnophis sirtalis), to fire and subsequent effects on its ecology have not been closely studied. The primary goal of this research was to evaluate differing resource use or movement patterns of common garter snakes in burned and unburned habitats. …

Mobility Characteristics Of Azithromycin In Soil, Ryan Minter, Jihyun Kim, Linda Lee

The Summer Undergraduate Research Fellowship (SURF) Symposium

The presence of pharmaceutical and personal care products (PPCPs) in the environment has become a widespread problem in recent decades. Azithromycin, a macrolide antibiotic commonly prescribed for infections in humans, has been detected in waste treatment plant discharge and surface waters across the world. Data on the mobility characteristics of azithromycin in soil is scarce, and further studies must be performed to explore the potential for azithromycin leaching to groundwater or becoming available for plant uptake. In this study, azithromycin sorption isotherms were measured on eight soils varying in pH, organic carbon content, and clay content. Soil was equilibrated with …

Co-Modulation Masking Release Begins In The Auditory Periphery, Kareem R. Hussein, Agudemu Borjigan, Mark Sayles

The Summer Undergraduate Research Fellowship (SURF) Symposium

Understanding speech in noisy environments can be difficult, especially for people with hearing loss. The background noise can cover up the sounds of interest. Normally, the auditory system works to alleviate this problem by tagging and then cancelling the noise. Our experiments are aimed at understanding the mechanism of this noise cancellation process. We hypothesize that non-linear signal processing in the mammalian cochlea (the most peripheral part of the auditory system) is the basis of noise cancellation. To test this hypothesis, we measured the responses of auditory-nerve fibers (ANFs) to sounds embedded in background noise with different statistical properties. ANFs …

Ergonomic Analysis Of Veterinary Surgical Tasks, Samantha M. Browne, Denny Yu, Hamed Asadi, Frank Peng, Micha C. Simons, Gert J. Breur, Kris A. Kazmierczak

The Summer Undergraduate Research Fellowship (SURF) Symposium

Studies have observed injuries and musculoskeletal discomforts among surgeons in human medicine. It is likely that veterinary surgeons endure similar discomfort; however, limited work has been done in this domain. Therefore, this research aims to identify occupational risk factors affecting the upper extremities of leading and assisting surgeons in orthopedic and soft tissue small animal surgeries. As a result, we aim to reduce surgeon injuries by assessing the surgical environment in veterinary care. To collect objective metrics, inertial measurement units (IMUs), heart rate monitors, and Electromyography (EMG) sensors are used. In addition, surveys are used to evaluate perceived pain before …

Another Route For Amino Acid Production?: Reverse Genetic Probing For A Functional Cytosolic Shikimate Pathway In Plants, Gabrielle C. Buck, Joseph Lynch, Natalia Dudareva

The Summer Undergraduate Research Fellowship (SURF) Symposium

The shikimate pathway is a metabolic pathway that produces the three aromatic amino acids—phenylalanine, tryptophan, and tyrosine—which are essential to human diets and necessary for many plant functions. Consequently, the shikimate pathway is commonly targeted for antibiotic and herbicide strategies as well as genetic engineering in several fields. This pathway is known to be localized in the plastids, or double membrane-bound organelles, of plant cells; however, there is enzymatic evidence of another shikimate pathway in the cell fluid, or cytosol. To determine whether a complete cytosolic shikimate pathway exists, we used a modified gene for the first enzyme of the …

Analysis Of The Flow Behaviors Of Corn Meal During Extrusion, Daniel N. Hauersperger, Martin R. Okos, Troy Tonner

The Summer Undergraduate Research Fellowship (SURF) Symposium

Food extrusion can be used to make many products we consume today, including pasta, cereals and more. The ability to predict the characteristics of the final product from an extruder using raw material characteristics and operating conditions is vital to the extrusion process. In order to answer this need, the flow behavior of corn meal was measured in a lab viscometer (off-line) and compared to the flow behaviors from an extruder (in-line) at three different moisture contents (32.5%, 35%, 37.5% wet basis). The extruder and product are heated through the friction of the corn meal passing through the barrel not …

Glutaraldehyde Crosslinked Zein Solutions Make Better Biodegradable Films, Fifi Sutanto, Morgan Meiser, Jozef L. Kokini

The Summer Undergraduate Research Fellowship (SURF) Symposium

The corn protein, zein, is a byproduct of the ethanol production industry. Recently, zein has been used in the production of films and food packaging due to its biodegradability, low production cost, and abundance of corn in the United States. To improve overall quality of zein films, the mechanical properties and surface properties should be enhanced. Therefore, in this study, our aim is to improve the properties of zein films with glutaraldehyde (GDA) as a crosslinker. Zein was solubilized and mixed with 70% ethanol and GDA, then sonicated. Solutions were poured onto different surface materials, including polydimethylsiloxane (PDMS), polystyrene (PS), …

Investigation Of Low Cost Solar Drying Of Apricots For Tajikistan, Huimin Wang, Richard L. Stroshine Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Dried apricots are one of Tajikistan’s major export products. The country wants to expand its production in the southern region. However, the producers don’t have the expertise needed to produce dried apricots that meet the quality requirements of the European Union and other potential export markets. Local producers in southern Tajikistan would benefit from improvements in methods of applying sulfur and drying the apricots. This would allow them to gain a share of global markets. Methods that were studied include sulfur treatment prior to drying and approaches for rapidly drying the apricots while preventing contamination. Because the project has just …

The Effects Of Compaction On Reconstitution Characteristics Of Dairy Powder, Michelle P. Dixon, Rose Prabin Kingsly Ambrose, Dhananjay Ashok Pai

The Summer Undergraduate Research Fellowship (SURF) Symposium

Milk powders are becoming more ubiquitous within the food industry, and they offer consumers a convenient form for direct intake of dairy. The costs associated with dairy are reduced when products are converted to powder, which markedly increases shelf life at ambient temperatures. Creating compacts from powders further improves cost efficiency by reducing volume. However, milk powders typically possess poor rehydration properties, such as a slow dispersion rate and low solubility, and powder compaction additionally prolongs rehydration time, reducing consumer acceptability. Previous studies have shown that modifying dairy products before or during the drying process can improve rehydration properties, but …

Supplemental Effects Of Ruminal Bypass Arginine And Lysine For Improving Meat Quality And Oxidative Stability Of Aged Beef Loins, Jacob Tuell, Hyun-Wook Kim, Juliana Guedes, Derico Setyabrata, Jin-Kyu Seo, Jon Schoonmaker, Yuan H. Brad Kim

The Summer Undergraduate Research Fellowship (SURF) Symposium

Postmortem aging is widely practiced in the beef industry to improve eating quality characteristics. However, the oxidative stability of aged beef muscle could be negatively affected by extending aging period. The use of ruminal bypass amino acids allows levels of crude protein in the diet to be lowered and may also positively impact oxidative stability of aged beef muscle. This study was conducted to evaluate the effects of ruminal bypass arginine (Arg) and lysine (Lys) supplementation on meat quality and oxidative stability of beef loins (M. longissimus lumborum, LL) under two durations of postmortem aging (14 and 28 days). …

Acoustic Signatures Of Habitat Types In The Miombo Woodlands Of Western Tanzania, Sheryl Vanessa Amorocho, Dante Francomano, Kristen M. Bellisario, Ben Gottesman, Bryan C. Pijanowski

The Summer Undergraduate Research Fellowship (SURF) Symposium

The Miombo Woodlands of Tanzania comprise several habitat types that are home to a great number of flora and fauna. Understanding their responses to increasing human disturbance is important for conservation, especially in places where people depend so directly on their local ecosystem services to survive. Soundscapes are a powerful approach to study complex biomes undergoing change. The sounds emitted by soniferous fauna characterize the acoustic profile of the landscapes they inhabit such that habitats with the highest acoustic abundance are considered as the most diverse and possibly more ecologically resilient. However, acoustic variability within similar habitat types may pose …

Comparative Analysis Of Nanoscale Ultrasound Contrast Agents, Elly Y. Lambert, Luis Solorio

The Summer Undergraduate Research Fellowship (SURF) Symposium

Current ultrasound contrast agents utilize microbubbles as a blood pooling agent, but the size inhibits access to small capillaries. The development of nanoscale ultrasound contrast agents can enter small capillaries of tissues and aid in the detection of diseased states. However, current nano-formulations are flushed from the body over a short period of time. We developed a nanoscale ultrasound contrast agent with increased circulation time to allow for better detection of diseased states in the microvasculature of the body. Characterization (zeta potential, size, echogenicity and stability) and pharmacokinetic analysis were conducted on three nanoscale formulations: 1) Liquid based Bovine Serum …