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Itraq-Based Proteomics Analysis And Network Integration For Kernel Tissue Development In Maize, Long Zhang, Yongbin Dong, Qilei Wang, Chunguang Du, Wenwei Xiong, Xinyu Li, Sailan Zhu, Yuling Li

Department of Biology Faculty Scholarship and Creative Works

Grain weight is one of the most important yield components and a developmentally complex structure comprised of two major compartments (endosperm and pericarp) in maize (Zea mays L.), however, very little is known concerning the coordinated accumulation of the numerous proteins involved. Herein, we used isobaric tags for relative and absolute quantitation (iTRAQ)-based comparative proteomic method to analyze the characteristics of dynamic proteomics for endosperm and pericarp during grain development. Totally, 9539 proteins were identified for both components at four development stages, among which 1401 proteins were non-redundant, 232 proteins were specific in pericarp and 153 proteins were specific in …

Smartscope2: Simultaneous Imaging And Reconstruction Of Neuronal Morphology., Brian Long, Zhi Zhou, Ali Cetin, Jonathan Ting, Ryder Gwinn, Bosiljka Tasic, Tanya Daigle, Ed Lein, Hongkui Zeng, Peter Saggau, Michael Hawrylycz, Hanchuan Peng

Articles, Abstracts, and Reports

Quantitative analysis of neuronal morphology is critical in cell type classification and for deciphering how structure gives rise to function in the brain. Most current approaches to imaging and tracing neuronal 3D morphology are data intensive. We introduce SmartScope2, the first open source, automated neuron reconstruction machine integrating online image analysis with automated multiphoton imaging. SmartScope2 takes advantage of a neuron's sparse morphology to improve imaging speed and reduce image data stored, transferred and analyzed. We show that SmartScope2 is able to produce the complex 3D morphology of human and mouse cortical neurons with six-fold reduction in image data requirements …

Northwest Passage, Beth Potier

UNH Today Archive

No abstract provided.

2017-08-24 Undergraduate Curriculum Meeting Minutes, Morehead State University. Faculty Senate., Undergraduate Curriculum Committee

Faculty Senate Records

Undergraduate Curriculum Committee meeting minutes for August 24, 2017.

Key Differences Between Hepatic And Intestinal Apoc3 Regulation And Expression, And Implications For Cardiovascular Disease Risk, Gabrielle West

Master's Theses

In the intestine, apoC-III delays chylomicron secretion, and causes a decrease in chylomicron size. Once apoC-III is in circulation, apoC-III delays triglyceride-rich remnants clearance by inhibiting lipoprotein lipase and liver low-density lipoprotein receptor. In humans, high levels of plasma apoC-III directly result in hypertriglyceridemia. ApoC-III is a critical cardiovascular risk factor, and humans expressing null mutations in apoC-III are robustly protected from cardiovascular disease. Because of its critical role in elevating plasma lipids and CVD risk, the factors that regulate apoC-III expression in the liver have been determined, and include glucose, insulin (through FoxO1), and dietary fat. Considerably less is …

Bfs News Online, Georgia Southern University

Art: News & Publications (2008-2023)

• Georgia Southern Art Students Exhibit Work at Savannah's Blick Gallery

Life Begins, Yuju Yen

Theses

My work reveals the world I see, the world I feel, and the world I imagine. The story I want to tell in my thesis is about every stunning moment when a life begins. While the sculptures and jewelry in my thesis body of work differ in scale, they are all singing the same theme: when a life starts to grow and when a flower blooms.

The forms of my thesis work are inspired from various natural lives, such as virus, fungi, jellyfish, bacteria, blooming flowers, and sea creatures. They are vividly waving, rotating, spinning their tentacles, antennas, and microfibers …

Oxidative Stress-Induced Jnk/Ap-1 Signaling Is A Major Pathway Involved In Selective Apoptosis Of Myelodysplastic Syndrome Cells By Withaferin-A, Karine Z. Oben, Sara S. Alhakeem, Mary Kathryn Mckenna, Jason A. Brandon, Rajeswaran Mani, Sunil K. Noothi, Jinpeng Liu, Shailaja Akunuru, Sanjit Kumar Dhar, Inder P. Singh, Ying Liang, Chi Wang, Ahmed Abdel-Latif, Harold F. Stills Jr., Daret K. St Clair, Hartmut Geiger, Natarajan Muthusamy, Kaoru Tohyama, Ramesh C. Gupta, Subbarao Bondada

Markey Cancer Center Faculty Publications

Myelodysplastic syndromes (MDS) are a diverse group of malignant clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, dysplastic cell morphology in one or more hematopoietic lineages, and a risk of progression to acute myeloid leukemia (AML). Approximately 50% of MDS patients respond to current FDA-approved drug therapies but a majority of responders relapse within 2-3 years. There is therefore a compelling need to identify potential new therapies for MDS treatment. We utilized the MDS-L cell line to investigate the anticancer potential and mechanisms of action of a plant-derived compound, Withaferin A (WFA), in MDS. WFA was potently cytotoxic to …

Conventionalization And Reduction In Natural Language Emergence: An Experimental And Computational Model Investigation, Russell Richie

Doctoral Dissertations

In the emergence of natural languages, two processes typically co-occur: new form-meaning mappings are being conventionalized, and these forms reduce, i.e., shorten, in various ways. Despite this oft-noted co-occurrence, and the existence of theories of conventionalization and reduction separately, there are no explicit, mechanistic, and empirically-motivated theories of the connection between the two processes. To fill this gap, the present dissertation aims to better understand this relationship both empirically and theoretically, with experimental semiotics and agent-based modeling.

In the experiment, eight groups of four hearing, non-signing English-speaking participants were brought into the lab. Quads split into rotating dyads which …

Variability In Pragmatic Abilities In Children With Autism Spectrum Disorder, Iris Chin

Doctoral Dissertations

Communication involves information beyond what is coded in the linguistic stimuli produced by a speaker. How individuals are able to extract additional, pragmatic meaning from a speaker’s utterance (i.e., what kind of skills/knowledge might be involved) is relatively understudied. To address this question, the current study examined 7- to 10-year-old typically developing (TD) children and children with autism spectrum disorder (ASD)’s ability to interpret four different pragmatic devices: conventional implicatures, scalar implicatures, relevance implicatures, and metaphors. We were interested in determining whether variability in children with ASD’s ability to process such devices would be found and if so, whether their …

The Bg News August 24, 2017, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. August 24, 2017. Volume 97-Issue 3.

Ventilation And Neurochemical Changes During Μ-Opioid Receptor Activation Or Blockade Of Excitatory Receptors In The Hypoglossal Motor Nucleus Of Goats, Thomas M. Langer, Suzanne E. Neumueller, Emma Crumley, Nicholas J. Burgraff, Sawan Talwar, Matthew R. Hodges, Lawrence Pan, Hubert V. Forster

Physical Therapy Faculty Research and Publications

Neuromodulator interdependence posits that changes in one or more neuromodulators are compensated by changes in other modulators to maintain stability in the respiratory control network. Herein, we studied compensatory neuromodulation in the hypoglossal motor nucleus (HMN) after chronic implantation of microtubules unilaterally (n = 5) or bilaterally (n = 5) into the HMN. After recovery, receptor agonists or antagonists in mock cerebrospinal fluid (mCSF) were dialyzed during the awake and non-rapid eye movement (NREM) sleep states. During day studies, dialysis of the µ-opioid inhibitory receptor agonist [d-Ala², N-MePhe⁴, Gly-ol]enkephalin (DAMGO; 100 µM) decreased …

2017-08-24, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

Investigating The Physiological And Behavioral Responses To Fear In A Virtual Reality Fear Conditioning Paradigm, Emily Errante

Master's Theses

No abstract provided.

The Life Cycle Relative To Temperature Of Protaphorura Armatus (Tullberg) (Collembola: Onychiuridae), A Parathenogenetic Species, Renate M. Snider

The Great Lakes Entomologist

Apparent parthenogenetic reproduction in Collembola has sometimes been attributed to accidental transfer of spermatophores with the food material from one culture to another (Schaller, 1953; Mayer, 1957). Conclusive evidence of parthenogenesis has only in recent years been accumulated for a number of species of Collembola, of which some were found in field populations consisting entirely of females (Choudhuri, 1958; Huther, 1961; Marshall and Kevan, 1962; Petersen, 1965; 1971 ; Snider, 1973). In Onychiuridae, parthenogenesis is apparently quite common. Onychiurus parthenogeneticus Choudhuri and Tullbergia krausbaueri (Bomer) undoubtedly reproduce in the absence of males (Choudhuri, 1958; Hale, 1966; Petersen, 1971); so does …

Some Observations On The Nature Of Insect Names, B. Elwood Montgomery

The Great Lakes Entomologist

A recent study of dragonfly names (Montgomery, 1973) has led to a consideration of insect names, especially ancient and early English names. This interest was aroused, chiefly by the statement in Sarot's study of the folklore of the dragonfly from "A Linguistic Approach" that no recognizable name for dragonflies has been found in Anglo-Saxon, classical Latin or ancient Greek. Any language is capable of supplying names for all objects, including insects, which are recognized by its community of speakers. As so many names for dragonflies have been found in modern languages, (95 in English, over 60 in German, about 40 …

The Life History Of Folsomia Candida (Willem) (Collembola: Isotomidae) Relative To Temperature, Renate M. Snider, James W. Butcher

The Great Lakes Entomologist

The parthenogenetic mode of reproduction in Collembola, although frequently questioned in the past (Schaller, 1953; Mayer, 1957; Falkenhan, 1932), has only recently been recorded and confirmed for several species; Onychiutus parthenogeneticus Choudhuri (Choudhuri, 1958), Folsomia candida (Willem) (Goto, 1960; Marshall and Kevan, 1962; Green, 1964; Husson and Paldvody, 1967), Folsomia cavicola Cassagnau and Delamare (Goto, 1960), Tullbergia krausbaueri (Bomer) (Hale, 1966; Petersen, 1971), and Isotoma notabilis Schaffer (Petersen, 1971).

Sex-ratios in populations of the above cited species are often unknown. Existing data indicate that the composition of a population may vary with the geographical distribution of the species. Populations of …

A Milliped New To Michigan (Pselaphognatha: Polyxenus), James R. Brice, Michael T. Barbour

The Great Lakes Entomologist

The authors wish to report the finding of representatives of the genus Polyxenus for the first time in Michigan (Fig. 1). In Bert M. Johnson's survey (1954) of the millipedes of Michigan, no members of the subclass Pselaphognatha were reported.

During the period of September through October 1970, the authors collected over 40 specimens of Polyxenus and observed over 100 in the field. All of the specimens were found in a mature pine stand in Ypsilanti Township.

George Starkey, An Early Seventeenth-Century American Entomologist, Ronald S. Wilkinson

The Great Lakes Entomologist

Between the earliest known North American entomological observations made by John White (Wilkinson, 1973a) and Thomas Hariot, and the beginning of more systematic investigations by John Banister (Ewan and Ewan, 1970) and other collectors in the late seventeenth and eighteenth centuries, especially those promoted by the London apothecary and naturalist James Petiver (Stearns, 1952; Wilkinson, 1966), a number of persons wrote about insects observed in British America. However, their remarks were usually very brief, and confined to notices of one or two species. Only a few seventeenth-century investigators actually studied North American insects and related forms in situ with any …

Cover Illustration: The Well-Dressed Entomologist, Ronald S. Wilkinson

The Great Lakes Entomologist

This issue's cover illustration is the frontispiece to a classic work of eighteenth-century entomology, Moses Harris' The Aurelian, which began to appear in parts in 1758 and was published entire in 1766 (Lisney, 1960). Harris, who was the illustrator as well as the author, pictures the contemporary entomologist with part of his array of collecting equipment. (By tradition, the frontispiece is supposed to be a self-portrait.)

Differential Preservation Of Vertebrates In Southeast Asian Caves, Julien Louys, Shimona Kealy, Sue O'Connor, Gilbert J. Price, Stuart Hawkins, Ken Aplin, Yan Rizal, Jahdi Zaim, Mahirta, Daud A. Tanudirjo, Wahyu Dwijo Santoso, Ati Rati Hidayah, Agus Trihascaryo, Rachel Wood, Joseph Bevitt, Tara Clark

International Journal of Speleology

Caves have been an important source of vertebrate fossils for much of Southeast Asia, particularly for the Quaternary. Despite this importance, the mechanisms by which vertebrate remains accumulate and preserve in Southeast Asian caves has never been systematically reviewed or examined. Here, we present the results of three years of cave surveys in Indonesia and Timor-Leste, describing cave systems and their attendant vertebrate accumulations in diverse geological, biogeographical, and environmental settings. While each cave system is unique, we find that the accumulation and preservation of vertebrate remains are highly dependent on local geology and environment. These factors notwithstanding, we find …

Academic Affairs Division Allocations For 2016-17, Csusb Faculty Senate

CSUSB Faculty Senate records

No abstract provided.

Final Report Of The Afit Quality Initiative External Discovery Committee, Air Force Institute Of Technology, Jason M. Bindewald, Alice E. Grimes, Jason K. Freels, Andrew J. Geyer, Laurence D. Merkle, Amy J. High, Michael T. Hill, Richard Kappel

AFIT Documents

This report summarizes the findings of the Air Force Institute of Technology’s (AFIT’s) Quality Initiative - External Discovery Team. The overarching purpose of the Quality Initiative is to create a detailed, executable investment strategy for modernizing AFIT’s instructional capabilities across five thrust areas. These activities were completed over the course of one year, beginning in June of 2016 and concluding in June of 2017. The data gathered were evaluated and several recommendations for further review were decided upon by the External Discovery Team. The following report briefly covers those recommendations and provides sources from which the recommendations were gleaned. These …

The Collegian: August 23, 2017, The Collegian Staff, South Dakota State University

The Collegian, 2017-2018

Volume 133

Issue 1

Computational Design Of Multifunctional Nanodielectrics, John Mangeri

Doctoral Dissertations

In this dissertation, a mesoscale modeling approach is developed aimed at simulating the properties of dielectric nano/microstructures with coupled polar, elastic, and thermal degrees of freedom, as well as the dependence of these properties on the structure size, shape, morphology and applied conditions. The versatility of this computational method to predict functional behavior is exemplified in the following systems: (i) Semiconducting core-shell nanoparticles and the influence of their size, anisotropy, microstructure and applied pressure on their optical properties; (ii) Ferroelectric nanoparticles embedded in a dielectric medium, and the dependence on their polarization-field topology and transitions on particle shape and size, …

Prospectus, August 23, 2017, Parkand College, Evyjo M. Compton, Greg Gancarz, Emma Gray

Prospectus 2017

New state budget means reprieve from Parkland's funding woes; Parkland Theater hosts open auditions for upcoming plays;

Should Universities Abandon Placement Exams?, Rachel Robinson-Greene

Languages, Philosophy, and Communication Studies Faculty Publications

At most universities in the United States, students are required to take placement exams to determine their developmental level in math and English. Students are placed in classes that are appropriate for a student at that developmental level in each of those disciplines. Students who are placed in non-college ready, remedial classes are required to take up to three such classes before they can enroll in courses that actually count toward their degree. Last week, the Chancellor of the California State University educational system issued an executive order doing away with placement exams. Instead, students can try their hands at …

Calcium-Mediated Control Of S100 Proteins: Allosteric Communication Via An Agitator/Signal Blocking Mechanism., Yiming Xiao, Gary S Shaw, Lars Konermann

Chemistry Publications

Allosteric proteins possess dynamically coupled residues for the propagation of input signals to distant target binding sites. The input signals usually correspond to "effector is present" or "effector is not present". Many aspects of allosteric regulation remain incompletely understood. This work focused on S100A11, a dimeric EF-hand protein with two hydrophobic target binding sites. An annexin peptide (Ax) served as the target. Target binding is allosterically controlled by Ca²⁺ over a distance of ∼26 Å. Ca²⁺ promotes formation of a [Ca₄ S100 Ax₂] complex, where the Ax peptides are accommodated between helices III/IV and III'/IV'. …

Text In The Natural World: Topics Of Evolutionary Theory Of Literature, Laurence A. Gregorio

Gettysburg College Faculty Books

The study of literature has expanded to include an evolutionary perspective. Its premise is that the literary text and literature as an overarching institution came into existence as a product of the same evolutionary process that gave rise to the human species. In this view, literature is an evolutionary adaptation that functions as any other adaptation does, as a means of enhancing survivability and also promoting benefits for the individual and society. Text in the Natural World is an introduction to the theory and a survey of topics pertinent to the evolutionary view of literature. After a polemical, prefatory chapter …

Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K(+) Channel Dysfunction In Drg Neurons., Benjamin M. Zemel, Tanziyah Muqeem, Eric V. Brown, Miguel Goulão, Mark W Urban, Stephen R. Tymanskyj, Angelo C. Lepore, Manuel Covarrubias

Department of Neuroscience Faculty Papers

Dysfunction of the fast-inactivating Kv3.4 potassium current in dorsal root ganglion (DRG) neurons contributes to the hyperexcitability associated with persistent pain induced by spinal cord injury (SCI). However, the underlying mechanism is not known. In light of our previous work demonstrating modulation of the Kv3.4 channel by phosphorylation, we investigated the role of the phosphatase calcineurin (CaN) using electrophysiological, molecular, and imaging approaches in adult female Sprague Dawley rats. Pharmacological inhibition of CaN in small-diameter DRG neurons slowed repolarization of the somatic action potential (AP) and attenuated the Kv3.4 current. Attenuated Kv3.4 currents also exhibited slowed inactivation. We observed similar …