Digital Commons Network^™

A Spatial Critique Of Intellectual Property Law And Policy, Peter K. Yu

Washington and Lee Law Review

No abstract provided.

The Klein Rule Of Decision Puzzle And The Self-Dealing Solution, Evan C. Zoldan

Washington and Lee Law Review

Scholars and courts have struggled to make sense of the Supreme Court’s decision in United States v. Klein, an intriguing but enigmatic opinion concerning the limits of Congress’s ability to interfere with cases pending before the federal courts. Klein is intriguing because its broad and emphatic language suggests significant limits on the power of Congress. Klein is enigmatic because the Court has never again struck down a statute because of Klein or even made clear what principle animates its result. In fact, despite reaffirming the existence of a principle based on Klein, the Court has repeatedly read it …

Amblyomma Maculatum Secis Binding Protein 2 And Putative Selenoprotein P Are Indispensable For Pathogen Replication And Tick Fecundity, Khemraj Budachetri, Gary Crispell, Shahid Karim

Faculty Publications

Selenium, a vital trace element, is incorporated into selenoproteins to produce selenocysteine. Our previous studies have revealed an adaptive co-evolutionary process that has enabled the spotted fever-causing tick-borne pathogen Rickettsia parkeri to survive by manipulating an antioxidant defense system associated with selenium, which includes a full set of selenoproteins and other antioxidants in ticks. Here, we conducted a systemic investigation of SECIS binding protein 2 (SBP2) and putative selenoprotein P (SELENOP) by transcript silencing in adult female Gulf-coast ticks (Amblyomma maculatum). Knockdown of the SBP2 and SELENOP genes depleted the respective transcript levels of these tick selenogenes, and …

Acquisitions Unit Annual Report 2016-2017, Andrée J. Rathemacher

Technical Services Reports and Statistics

Annual Report of the Acquisitions Unit, University Libraries, University of Rhode Island for FY17. Covers personnel, work flow, special projects, and serial, monograph, and e-resource acquisitions. Supplemental files include data on library materials expenditures by a number of variables as well as important working documents from the year.

Brain Injury-Induced Synaptic Reorganization In Hilar Inhibitory Neurons Is Differentially Suppressed By Rapamycin, Corwin R. Butler, Jeffery A. Boychuk, Bret N. Smith

Physiology Faculty Publications

Following traumatic brain injury (TBI), treatment with rapamycin suppresses mammalian (mechanistic) target of rapamycin (mTOR) activity and specific components of hippocampal synaptic reorganization associated with altered cortical excitability and seizure susceptibility. Reemergence of seizures after cessation of rapamycin treatment suggests, however, an incomplete suppression of epileptogenesis. Hilar inhibitory interneurons regulate dentate granule cell (DGC) activity, and de novo synaptic input from both DGCs and CA3 pyramidal cells after TBI increases their excitability but effects of rapamycin treatment on the injury-induced plasticity of interneurons is only partially described. Using transgenic mice in which enhanced green fluorescent protein (eGFP) is expressed in …

Collateral Damage: The Gun Debate Moves Into America's National Parks, Clare E.M. Mack

Colorado Environmental Law Journal

No abstract provided.

Bleached! The Catastrophe Management Of Corals, Irus Braverman

Journal Articles

Corals have recently emerged as both a sign and a measure of the imminent catastrophic future of life on earth and, as such, have become the focus of intense conservation management. Bleached! draws on in-depth interviews and participatory observations with coral scientists and managers to explore the management of the corals’ ecological catastrophe to come. The article starts by describing the unique life of corals, the importance of calculability in catastrophe management, and the coral scientists’ preoccupation with classifying, counting, and seeing in their attempt to comprehensibly monitor corals and anticipate their decline. Algorithmic models and elaborate temporal analyses are …

In Vivo Evaluation Of Antipyretic Effects Of Homoeopathic Ultrahigh Dilutions Of Typhoidinum On Baker's Yeast-Induced Fever In Comparison With Paracetamol, Saeed Ahmad, Tayyeba Rehman, Waheed Ababsi

Indian Journal of Research in Homoeopathy

Introduction: Homoeopathy is a widely used, controversial alternative system of medicine. It is assumed that homoeopathic medicines are slower in action and does not work in acute conditions such as ‘fever’. The study aims to estimate the effectiveness of some homoeopathic remedies in fever and to compare their effects with Paracetamol. Materials and Methods: Baker's yeast fever model of rabbits was used in the study. Rabbits were divided into four different groups (n = 6). Rectal temperature was measured before and after fever induction hourly. After fever induction, medicines were administered orally. Paracetamol and Typhoidinum in 200C and 1M potencies …

Application Of An Advanced Maximum Likelihood Estimation Restoration Method For Enhanced-Resolution And Contrast In Second-Harmonic Generation Microscopy, Mayandi Sivaguru, Mohammad M. Kabir, Manas Ranjan Gartia, David S.C. Biggs, Barghav S. Sivaguru, Vignesh A. Sivaguru, Glenn A. Fried, Gang Logan Liu, Sakthivel Sadayappan, Kimani C. Toussaint

Faculty Publications

Second-harmonic generation (SHG) microscopy has gained popularity because of its ability to perform submicron, label-free imaging of noncentrosymmetric biological structures, such as fibrillar collagen in the extracellular matrix environment of various organs with high contrast and specificity. Because SHG is a two-photon coherent scattering process, it is difficult to define a point spread function (PSF) for this modality. Hence, compared to incoherent two-photon processes like two-photon fluorescence, it is challenging to apply the various PSF-engineering methods to improve the spatial resolution to be close to the diffraction limit. Using a synthetic PSF and application of an advanced maximum likelihood estimation …

From Railways To Radiators: How Support Teams Can Use Special Interests To Promote Success Among Individuals With Autism, Maggie Bredlau

Journal of Educational Leadership in Action

Autism Spectrum Disorder (ASD) is currently being diagnosed at a rate of 1 in 68 children (Katz, Malow, & Reynolds, 2016). According to the DSM-V a diagnosis of autism carries with it two identifying characteristics: 1. consistent deficits in social communication and social interaction across more than one context; 2. restricted, repetitive interests that are evident through highly fixated odd interests. Children with autism can have difficulty finding ways to incorporate these highly-fixated interests into their daily lives. Research indicated that when individuals on the spectrum can incorporate their fixations into daily interactions and routines their self-esteem, social connections, career …

Historical Practices And Modern Interpretations: Understanding The Wai Khru Ceremony As A Thai Educational And Cultural Tradition, Ryan V. Guffey, Anothai Kaewkaen

Journal of Educational Leadership in Action

While working in Thailand, education professionals from Western backgrounds often remark on a certain social eminence accorded to teachers by Thais, and many will also experience, especially in abridged form, the rituals of the Wai Khru, or Homage to Teachers, ceremony. However, it could be that few without direct cultural orientation can appreciate these traditions to the depth such long-standing cultural practices deserve. More detrimentally, they may not be aware of the social expectations these traditional views place on educators within Thai society. Drawing on primary sources from Thai literature and media and their own experiences as educators in Thailand, …

European Starlings, H. Jeffrey Homan, Ron J. Johnson, James R. Thiele, George M. Linz

Wildlife Damage Management Technical Series

European starlings (Sturnus vulgaris, Figure 1) are an invasive species in the United States. The first recorded release of the birds was in 1890 in New York City’s Central Park. Because starlings easily adapt to a variety of habitats, nest sites and food sources, the birds spread quickly across the country. Today, there are about 150 million starlings in North America. Conflicts between people and starlings occur mostly in agricultural settings. Conflicts can occur during winter in urban and suburban environments, especially in business districts.

Starlings damage apples, blueberries, cherries, figs, grapes, peaches, and strawberries. Besides causing direct losses from …

Mice Lacking Gpr37 Exhibit Decreased Expression Of The Myelin-Associated Glycoprotein Mag And Increased Susceptibility To Demyelination, Brilee M. Smith, Michelle M. Giddens, Jessica Neil, Sharon Owino, Trang Kimberly T. Nguyen, Duc Duong, Fengqiao Li, Randy A. Hall

Neuroscience: Faculty Publications

GPR37 is an orphan G protein-coupled receptor that is predominantly expressed in the brain and found at particularly high levels in oligodendrocytes. GPR37 has been shown to exert effects on oligodendrocyte differentiation and myelination during development, but the molecular basis of these actions is incompletely understood and moreover nothing is known about the potential role(s) of this receptor under demyelinating conditions. To shed light on the fundamental biology of GPR37, we performed proteomic studies comparing protein expression levels in the brains of mice lacking GPR37 and its close relative GPR37-like 1 (GPR37L1). These studies revealed that one of the proteins …

“How Short Is A Piece Of String?”: An Investigation Into The Impact Of Text Length On Short-Text Classification Accuracy, Austin Mccartney

Dissertations

The recent increase in the widespread use of short messages, for example micro-blogs or SMS communications, has created an opportunity to harvest a vast amount of information through machine-based classification. However, traditional classification methods have failed to produce accuracies comparable to those obtained from similar classification of longer texts. Several approaches have been employed to extend traditional methods to overcome this problem, including the enhancement of the original texts through the construction of associations with external data enrichment sources, ranging from thesauri and semantic nets such as Wordnet, to pre-built online taxonomies such as Wikipedia. Other avenues of investigation have …

A Good Enough Heart: Kant And The Cultivation Of Emotions, Krista Karbowski Thomason

Philosophy Faculty Works

One way of understanding Kant’s views about moral emotions is the cultivation view. On this view, emotions play a role in Kantian morality provided they are properly cultivated. I evince a sceptical position about the cultivation view. First, I show that the textual evidence in support of cultivation is ambiguous. I then provide an account of emotions in Kant’s theory that explains both his positive and negative views about them. Emotions capture our attention such that they both disrupt the mind’s composure and serve as a surrogate for reason. As such, Kant cannot recommend that we cultivate our emotions.

2017 Bracke Library Retreat.Pdf, Marianne Stowell Bracke

Library Retreat

No abstract provided.

Extended-Spectrum Antiprotozoal Bumped Kinase Inhibitors: A Review, Wesley C. Van Voorhis, J. Stone Doggett, Marilyn Parsons, Matthew A. Hulverson, Ryan Choi, Samuel L. M. Arnold, Michael W. Riggs, Andrew Hemphill, Daniel K. Howe, Robert H. Mealey, Audrey O. T. Lau, Ethan A. Merritt, Dustin J. Maly, Erkang Fan, Kayode K. Ojo

Veterinary Science Faculty Publications

Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence, disruption of essential protein kinase function has been explored for therapy of parasitic diseases. However, the difficulty of inhibiting parasite protein kinases to the exclusion of host orthologues poses a practical challenge. A possible path around this difficulty is the use of bumped kinase inhibitors for targeting calcium dependent protein kinases that contain atypically small gatekeeper residues and are crucial for pathogenic apicomplexan parasites’ survival and proliferation. In this review, we review efficacy against the kinase target, the parasite growth in vitro, and in animal infection models, as well …

Connecting The Dots: Stopover Strategies Of An Intercontinental Migratory Songbird In The Context Of The Annual Cycle, Kristina Paxton, Frank R. Moore

Faculty Publications

The phases of the annual cycle for migratory species are inextricably linked. Yet, less than five percent of ecological studies examine seasonal interactions. In this study, we utilized stable hydrogen isotopes to geographically link individual black-and-white warblers (Mniotilta varia) captured during spring migration with breeding destinations to understand a migrant's stopover strategy in the context of other phases of the annual cycle. We found that stopover strategy is not only a function of a bird's current energetic state, but also the distance remaining to breeding destination and a bird's time-schedule, which has previously been linked to habitat conditions experienced …

Microbial Invasion Vs. Tick Immune Regulation, Daniel E. Sonenshine, Kevin R. Macaluso

Biological Sciences Faculty Publications

Ticks transmit a greater variety of pathogenic agents that cause disease in humans and animals than any other haematophagous arthropod, including Lyme disease, Rocky Mountain spotted fever, human granulocytic anaplasmosis, babesiosis, tick-borne encephalitis, Crimean Congo haemorhagic fever, and many others (Gulia-Nuss et al., 2016). Although diverse explanations have been proposed to explain their remarkable vectorial capacity, among the most important are their blood feeding habit, their long term off-host survival, the diverse array of bioactive molecules that disrupt the host's natural hemostatic mechanisms, facilitate blood flow, pain inhibitors, and minimize inflammation to prevent immune rejection (Hajdušek et al., 2013). Moreover, …

X Chromosome Evolution In Cetartiodactyla, Anastasiya A. Proskuryakova, Anastasia I. Kulemzina, Polina L. Perelman, Alexey I. Makunin, Denis M. Larkin, Marta Farre, Anna V. Kukekova, Jennifer Lynn Johnson, Natalya A. Lemskaya, Violetta R. Beklemisheva, M. Roelke-Parker, June Bellizzi, Oliver A. Ryder, Stephen James O'Brien, Alexander S. Graphodatsky

Biology Faculty Articles

The phenomenon of a remarkable conservation of the X chromosome in eutherian mammals has been first described by Susumu Ohno in 1964. A notable exception is the cetartiodactyl X chromosome, which varies widely in morphology and G-banding pattern between species. It is hypothesized that this sex chromosome has undergone multiple rearrangements that changed the centromere position and the order of syntenic segments over the last 80 million years of Cetartiodactyla speciation. To investigate its evolution we have selected 26 evolutionarily conserved bacterial artificial chromosome (BAC) clones from the cattle CHORI-240 library evenly distributed along the cattle X chromosome. High-resolution BAC …

Address At The Lincoln Charter Of The Forest Conference, Bishop Grosseteste University: The Charter Of The Forest: Evolving Human Rights In Nature, Nicholas A. Robinson

Elisabeth Haub School of Law Faculty Publications

This conference is a singular event, long over due. It has been 258 years since William Blackstone celebrated “these two sacred charters,”1 Carta de Foresta and Magna Carta, with his celebrated publication of their authentic texts. In 2015, the Great Charter of Liberties enjoyed scholarly, political and popular focus. The companion Forest Charter was and is too much neglected.2 I salute the American Bar Association, and Dan Magraw, for the ABA’s educational focus of the Forest Charter, as well as Magna Carta. Today we restore some balance with this conference’s searching and insightful examination of the Forest Charter’s significance.

Differential Response To Mosquito Host Sex And Parasite Dosage Suggest Mixed Dispersal Strategies In The Parasite Ascogregarina Taiwanensis, John Soghigian, Todd Livdahl

Biology

Mixed dispersal strategies are a form of bet hedging in which a species or population utilizes different dispersal strategies dependent upon biotic or abiotic conditions. Here we provide an example of a mixed dispersal strategy in the Aedes albopictus / Ascogregarina taiwanensis host/parasite system, wherein upon host emergence, the gregarine parasite is either carried with an adult mosquito leaving the larval habitat, or released back into the larval habitat. We show that the parasite invests a larger proportion of its dispersing (oocyst) life stage into adult female mosquitoes as opposed to adult male mosquitoes at low parasite exposure levels. However, …

Timing Of Decompression In Patients With Acute Spinal Cord Injury: A Systematic Review, Jefferson R. Wilson, Lindsay A. Tetreault, Brian Kwon, Paul M. Arnold, Thomas E. Mroz, Christopher I. Shaffrey, James S. Harrop, Jens R. Chapman, Steven Casha, Andrea C. Skelly, Haley K. Holmer, Erika D. Brodt, Michael G. Fehlings

Department of Neurosurgery Faculty Papers

Study Design: Systematic review. Objective: To conduct a systematic review and synthesis of the literature to assess the comparative effectiveness, safety, and cost-effectiveness of early (≤24 hours) versus late decompression (>24 hours) in adults with acute spinal cord injury (SCI). Methods: A systematic search was conducted of Medline, EMBASE, the Cochrane Collaboration Library, and Google Scholar to identify studies published through November 6, 2014. Studies published in any language, in humans, and with an abstract were considered for inclusion. Included studies were critically appraised and the overall strength of evidence was determined using methods proposed by the Grading of …

Prozac In The Water: Chronic Fluoxetine Exposure And Predation Risk Interact To Shape Behaviors In An Estuarine Crab, Joseph R. Peters, Elise F. Granek, Catherine E. De Rivera, Matthew Rollins

Environmental Science and Management Faculty Publications and Presentations

Predators exert considerable top-down pressure on ecosystems by directly consuming prey or indirectly influencing their foraging behaviors and habitat use. Prey is, therefore, forced to balance predation risk with resource reward. A growing list of anthropogenic stressors such as rising temperatures and ocean acidification has been shown to influence prey risk behaviors and subsequently alter important ecosystem processes. Yet, limited attention has been paid to the effects of chronic pharmaceutical exposure on risk behavior or as an ecological stressor, despite widespread detection and persistence of these contaminants in aquatic environments. In the laboratory, we simulated estuarine conditions of the shore …

Novel Spectral And Spatial Process Analytical Tools For Meat Quality And Safety Assessment, Yash Dixit

Doctoral

Meat and meat products are highly nutritious, containing important levels of protein, vitamins, minerals and micronutrients, which are important for human growth and development. Beef has emerged as an important protein source in human diets. Minced beef is the primary ingredient for a variety of products such as burgers, meat balls, meat pastes, sausages and so on. Authenticity of the meat is a major requirement to meet the demands of consumers and assuring compliance with the government regulations and safety standards. Near-Infrared (NIR) spectroscopy and Hyperspectral Imaging (HSI) are sensing solutions which provide real time quality control and assurance. Laser …

Cross-Reactive Immunity To Porcine Reproductive And Respiratory Syndrome Virus And Its Contribution To Protection, Ignacio Correas

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Due to the vast geographical distribution and significant economic losses generated, porcine reproductive and respiratory syndrome virus (PRRSV) can be considered the most important swine pathogen of contemporary times. Current control and eradication strategies against PRRSV have difficulty succeeding because of their complex nature and the absence of an effective vaccine. A major obstacle for PRRSV vaccine development is the broad heterogeneity of the virus, both at the genetic and antigenic level, its rapid evolution, and an incomplete knowledge of the immune responses responsible for clearing the virus from the host. Specifically, how known correlates of protection against PRRSV—neutralizing antibodies …

Fall 2017

In The Loop

Changing with the Times; A Triple Win; A Ticket to Sundance; Sports Stats; Technology for Tomorrow; City Lights; Combination Artist

Estimating Pasture Forage Mass From Pasture Height, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

The Rna-Binding Protein Hur Contributes To Neuroinflammation By Promoting C-C Chemokine Receptor 6 (Ccr6) Expression On Th17 Cells., Jing Chen, Jennifer L. Martindale, Carole Cramer, Myriam Gorospe, Ulus Atasoy, Paul D. Drew, Shiguang Yu

Department of Neurology Faculty Papers

In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS). Whereas many cytokines and their receptors are potently regulated via post-transcriptional mechanisms in response to various stimuli, how CCR6 expression is post-transcriptionally regulated in Th17 cells is unknown. Here, using RNA-binding protein HuR conditional knock-out (KO) and wild-type (WT) mice, we present evidence that HuR post-transcriptionally regulates CCR6 expression by binding to and stabilizing Ccr6 mRNA and by promoting CCR6 translation. We also found that HuR down-regulates several microRNA …

Section 1: Moot Court: Masterpiece Cakeshop, Ltd., Institute Of Bill Of Rights Law, William & Mary Law School

Supreme Court Preview

No abstract provided.