Digital Commons Network^™

Co-Activation Of Stat3 And Yes-Associated Protein 1 (Yap1) Pathway In Egfr-Mutant Nsclc, Imane Chaib, Niki Karachaliou, Sara Pilotto, Jordi Codony Servat, Xueting Cai, Xuefei Li, Ana Drozdowskyj, Carles Condony Servat, Jie Yang, Chunping Hu, Andres Felipe Cardona, Guillermo Lopez Vivanco, Alain Vergnenegre, Jose Miguel Sanchez, Mariano Provencio, Noemi Reguart, Caicun Zhou, Peng Cao, Patrick C. Ma, Trever G. Bivona, Rafael Rosell

Clinical and Translational Science Institute

Background: The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non–small cell lung cancer (NSCLC) is limited by adaptive activation of cell survival signals. We hypothesized that both signal transducer and activator of transcription 3 (STAT3) and Src-YES-associated protein 1 (YAP1) signaling are dually activated during EGFR TKI treatment to limit therapeutic response.

Methods: We used MTT and clonogenic assays, immunoblotting, and quantitative polymerase chain reaction to evaluate the efficacy of EGFR TKI alone and in combination with STAT3 and Src inhibition in three EGFR-mutant NSCLC cell lines. The Chou-Talalay method was used for the …

Novel Rat Tail Discitis Model Using Bioluminescent Staphylococcus Aureus, Phillip A. Bostian, Jonathan M. Karnes, Shari Cui, Lisa J. Robinson, Scott D. Daffner, Michelle R. Witt, Sanford E. Emery

Clinical and Translational Science Institute

Management of spondylodiscitis is a challenging clinical problem requiring medical and surgical treatment strategies. The purpose of this study was to establish a rat model of spondylodiscitis that utilizes bioluminescent Staphylococcus aureus, thus permitting in-vivo surveillance of infection intensity. Inocula of the bioluminescent S. aureus strain XEN36 were created in concentrations of 102 CFU/0.1 mL, 104 CFU/0.1 mL, and 106 CFU/0.1 mL. Three groups of rats were injected with the bacteria in the most proximal intervertebral tail segment. The third most proximal tail segment was injected with saline as a control. Bioluminescence was measured at baseline, 3 days, and weekly …

The Progestin Receptor Interactome In The Female Mouse Hypothalamus: Interactions With Synaptic Proteins Are Isoform Specific And Ligand Dependent, Kalpana D. Acharya, Sabin A. Nettles, Katherine J. Sellers, Dana D. Im, Moriah Harling, Cassandra Pattanayak, Didem Vardar-Ulu, Cheryl F. Lichti, Shixia Huang, Dean P. Edwards, Deepak P. Srivastava, Larry Denner, Marc J. Tetel

Faculty Research and Scholarship

Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study, proteins from female mouse hypothalamus that associate with PR were isolated using affinity pull-down assays with glutathione S-transferase–tagged mouse PR-A and PR-B. Using complementary proteomics approaches, reverse phase protein array (RPPA) and mass spectrometry, we identified hypothalamic proteins that interact with PR in a ligand-dependent and isoform-specific manner and were confirmed by Western blot. Synaptic proteins, including synapsin-I and synapsin-II, interacted with agonist-bound PR isoforms, …

Faculty Senate Report, September 2017, Faculty Senate

Faculty Senate Documents

No abstract provided.

Zombie Perennialism: An Intelligent Design For Psychology? A Further Response To Taylor's Soft Perennialism, Glenn Hartelius

International Journal of Transpersonal Studies

In a recent paper Taylor has suggested that perennialist models are or should be resurgent within transpersonal psychology. However, perennialist models such as those of Wilber and Taylor are metaphysical philosophies of spirituality typical of New Age religions; while such systems may be studied by a psychology that considers human spirituality, they are not and should not be proffered as psychology. Claims that Taylor's soft perennialism are partly evidence based are compared with invalid claims that the narrative of Noah's flood or the Christian-based idea of intelligent design are partly evidence based. Critiques of Wilber's integral perennialism and Taylor's soft …

End Matter

Religious Educator: Perspectives on the Restored Gospel

No abstract provided.

Impacts Of Java Language Features On The Memory Performances Of Android Apps, Yoonsik Cheon, Adriana Escobar De La Torre

Departmental Technical Reports (CS)

Android apps are written in Java, but unlike Java applications they are resource-constrained in storage capacity and battery lifetime. In this document, we perform an experiment to measure quantitatively the impact of Java language and standard API features on the memory efficiency of Android apps. We focus on garbage collection because it is a critical process for performance affecting user experience. We learned that even Java language constructs and standard application programming interfaces (APIs) may be a source of a performance problem causing a significant memory overhead for Android apps. Any critical section of code needs to be scrutinized on …

Elman Neural Network Trained By Using Artificial Bee Colony For The Classification Of Learning Style Based On Students Preferences, Nor Liyana Mohd Shuib, Ahmad Shukri Mohd Noor, Haruna Chiroma, Tutut Herawan

Applied Mathematics & Information Sciences

Efforts have been made in recent times by educators and researchers to provide learners with appropriate learning objects (LO) based on their learning style (LS). Previous studies on the classification of LS, typically classifyLS based on the description of the LS preference itself without giving attention to the student preferences.This study presents a new knowledge in classifying learning material based on learning style. In this paper, we propose Elman Neural Network (ENN) trained by using Artificial Bee Colony (ABC) (ABCENN) to create a classifier for the classification of LS (Diverging, Accommodating, Converging, and Assimilating) based on student preference of teaching …

Studies Of Wolf X Coyote Hybridization Via Artificial Insemination, L. David Mech, Cheryl S. Asa, Margaret Callahan, Bruce W. Christensen, Fran Smith, Julie K. Young

Wildland Resources Faculty Publications

Following the production of western gray wolf (Canis lupus) x western coyote (Canis latrans) hybrids via artificial insemination (AI), the present article documents that the hybrids survived in captivity for at least 4 years and successfully bred with each other. It further reports that backcrossing one of the hybrids to a male gray wolf by AI also resulted in the birth of live pups that have survived for at least 10 months. All male hybrids (F1 and F2) produced sperm by about 10 months of age, and sperm quality of the F1 males fell within the …

Annual Report, 2016-2017, University Of Arkansas, Fayetteville. College Of Engineering

College of Engineering Annual Report

No abstract provided.

2017 Proceedings: Exercise Your Faith, Southern Adventist University School Of Education And Psychology, Mike Boyd, Rick Schwarz, Rodney Bussey, Robert Benge, Ruth Williams

Reynolds' Chair Symposium Proceedings

No abstract provided.

Circular Reasoning Is Not The Uroboros: Rejecting Perennialism As A Psychological Theory, Glenn Hartelius

International Journal of Transpersonal Studies

Efforts to present valid evidence for perennialist models do not withstand critical scrutiny. One strategy common to most versions of perennialism points to perceived patterns in reports of spiritual experiences, whether from traditional, clinical, or phenomenological accounts as evidence for such an approach; the shortcoming is that these same patterns are the basis for perennialist premises. Offering one’s premises as evidence for their conclusions is circular reasoning, and does not constitute valid support for an idea. Pointing to similarities between reports of spiritual or other transformative experiences is what inspires perennialist models, but is not evidence for their validity. Careful …

Moving Beyond Materialism: Can Transpersonal Psychology Contribute To Cultural Transformation?, Steve Taylor

International Journal of Transpersonal Studies

The issue of whether it is possible to separate science and metaphysics is discussed, with reference to William James and the writings of quantum physicists. The metaphysical framework of scientific materialism is analysed and some of its key assumptions are identified. It is suggested that these assumptions are becoming increasingly untenable, as is evident by the advocacy of post-materialist science by some contemporary scientists. The main appeal of transpersonal psychology to students and practitioners is arguably its lack of allegiance to a materialist metaphysics. Rather than allying itself to the metaphysical paradigm of naturalistic science or attempting to bracket out …

Self-Transformation Through The Experience And Resolution Of Mental Health Crises, Guy Albert

International Journal of Transpersonal Studies

This study investigated the spiritually positive self-transformation resulting from the experience and resolution of a mental health crisis. To participate in this study, a person’s experience needed to meet 4 criteria: The individual (a) experienced a crisis affecting self-concept and reality testing, which (b) resulted in a transformation that (c) was spiritually positive—that is, integrative and meaningful— and (d) they had no current acute mental health conditions. The study was conducted in 2 phases, the first of which used assessment instruments to evaluate participants’ (N = 35) appropriateness for this study relative to the above criteria. In the second phase, …

Safety & Risk Management New, Tara Chinn

Otterbein Police Department

No abstract provided.

Cross Country And Track Media Guide 2017-18, Wofford College. Department Of Athletics

Media Guides

No abstract provided.

Understanding The Transition From Benthic Egg To Dispersive Larvae: Observations On The Intra-Capsular Growth And Development Of A Marine Snail (Kelletia Kelletii), Megan N. Wilson

Biological Sciences

It has long been understood that the larval life stage is responsible for the dispersion of many marine organisms across their biogeographic range. Such organisms have a bipartite life cycle, existing in the water column and subject to oceanographic processes as planktonic larvae before settling to suitable habitat along the benthos where they grow and mature. Previous studies have demonstrated that larval growth rate and behavior in the water column can alter larval position in relation to ocean currents and affects their dispersal pathway. However, there is a paucity of information regarding the growth rate of the earliest larval stage …

Sep2017, Robert Kelly

Robert Kelly Manuscripts

From the September 2017 Robert Kelly archive.

Losac Agenda 2017-09, Library Operating Staff Advisory Committee

University Libraries Archives

No abstract provided.

Losac Minutes 2017-09, Library Operating Staff Advisory Committee

University Libraries Archives

No abstract provided.

Intimations Of A Spiritual New Age: I. The Spiritual Emergence And Personal Tragedy Of A Universalized Christian Mysticism In The Life And Work Of Simone Weil, Harry T. Hunt

International Journal of Transpersonal Studies

This is the first in a projected series on the envisionings during the crisis years of the 1930s of a future spiritual New Age consequent on the coming globalization of an individualist, capitalist, technologically driven world economy. In very different ways Jung, the philosophers Bergson and Heidegger, the historian Toynbee, and Wilhelm Reich, foresaw an emergent New Age consistent with a post-modern secular culture. Others such as Teilhard de Chardin, Krishnamurti, and Gurdjieff anticipated their own potential universalizing of more mystical aspects of the world religions. Simone Weil’s version of an essentialized mystical Christianity is part of the latter attempts, …

The Extreme Phronesis Of Percy Cerutty: A Narrativized Life History Of A Legendary Sports Coach, David Turner

International Journal of Transpersonal Studies

This paper presents and interprets a narrativized coaching life history of the Australian athletics coach Percy Cerutty (1895-1975). Through a relational process of self-improvement and practical wisdom sometimes called phronesis, Cerutty exemplifies an intimate interconnectedness with his own and others’ experiences, with the natural environment, and with the transformative capacities of such influences, as often highlighted in transpersonal literature. Three potential themes are offered from the resultant meaning-making: a feel for the game, phronesis, and the coach as a paradoxical figure. Those themes are also interwoven with a consideration of how Cerutty’s story and practices might link to aspects of …

Retrieving Realism: A Whiteheadian Wager, Matthew T. Segall

International Journal of Transpersonal Studies

This essay argues that the organic realism of Alfred North Whitehead (1861-1947) provides a viable alternative to anti-realist tendencies in modern and postmodern philosophy since Descartes. The metaphysical merits of Whitehead’s philosophy of organism are unpacked in conversation with Hubert Dreyfus and Charles Taylor’s recent book Retrieving Realism (2015). Like Dreyfus and Taylor, Whitehead’s philosophical project was motivated by a desire to heal the modern epistemic wound separating soul from world in order to put human consciousness back into meaningful contact with reality. While Dreyfus and Taylor’s book succeeds in articulating the problem cogently, its still too phenomenological answer remains …

Land Surface Phenology And Seasonality Using Cool Earthlight In Croplands Of Eastern Africa And The Linkages To Crop Production, Woubet G. Alemu, Geoffrey M. Henebry

GSCE Faculty Publications

Across Eastern Africa, croplands cover 45 million ha. The regional economy is heavily dependent on small holder traditional rain-fed peasant agriculture (up to 90%), which is vulnerable to extreme weather events such as drought and floods that leads to food insecurity. Agricultural production in the region is moisture limited. Weather station data are scarce and access is limited, while optical satellite data are obscured by heavy clouds limiting their value to study cropland dynamics. Here, we characterized cropland dynamics in Eastern Africa for 2003–2015 using precipitation data from Tropical Rainfall Measuring Mission (TRMM) and a passive microwave dataset of land …

September 2017 News Items, Office Of Vice President For Research

Research and Discovery News

• Undergraduates Discover Discovery
• WMU researcher awarded $2.1 million to study evidence-based registers
• Leading scientists and treatment practitioners slated for Michigan Autism Conference

A Study Of The Pokot Cultural Worldview: Missiological Implications For Seventh-Day Adventist Witness Among The Pastoral Nomads Of Kenya, Haron Nyamweya Matwetwe

Journal of Adventist Mission Studies

"Seventh-day Adventist witness among the nomadic peoples of the East Africa region is faced with a number of challenges. Although the Church enjoys relative success in reaching most communities, its growth and development appears restricted to locations occupied by the settled communities. Unfamiliarity with nomads’ cultural structures and values is a partial explanation for why missionaries have failed to effectively connect with the nomads thereby hampering the establishment of a more vibrant mission work in pastoral nomadic regions. This qualitative research sought to describe the Pokot cultural worldview as a step toward understanding their socio-cultural context and identify barriers to …

Spiritual Emergency: The Understanding And Treatment Of Transpersonal Crises, Christina Grof, Stanislav Grof

International Journal of Transpersonal Studies

There exists increasing evidence that many individuals experiencing episodes of nonordinary states of consciousness accompanied by various emotional, perceptual, and psychosomatic manifestations are undergoing an evolutionary crisis rather than suffering from a mental disease (Grof, 1985). The recognition of this fact has important practical and theoretical consequences. If properly understood and treated as difficult stages in a natural developmental process, these experiences—spiritual emergencies or transpersonal crises—can result in emotional and psychosomatic healing, creative problem-solving, personality transformation, and consciousness evolution. is fact is reflected in the term “spiritual emergency,” which suggests a crisis, but also suggests the potential for rising to …

College Of Health Sciences Newsletter, September 2017, Irvin B. Harrell (Editor)

Ellmer College of Health Sciences Newsletters

September 2017 issue of Old Dominion University's College of Health Sciences Newsletter.

Letter, Jarrod Bailey

Opposition to Animal Research Collection

In a recent publication in Lab Animal,1 a nonhuman primate (NHP) researcher at the California National Primate Research Center, USA, argued for the continued importance of experiments on macaques for better understanding HIV and AIDS, and for tackling the virus and the disease with therapies and vaccines. Though the stance of the author is far from surprising, given his background and current employer (an organisation which houses around 5000 monkeys for research), the paper, even as comprehensive as it is, is not sufficiently critical of NHP experiments and overlooks a number of their deficiencies and established problems with them. Given …

Report On Owned Dog Population Survey In Cebu City, Philippines, Kazami Joanne Amano, Tamara Kartal

Demography and Statistics for Companion Animal Populations Collection

Many Southeast Asian countries like the Philippines have been dealing with rabies for a long time. In the Philippines alone, there are about 200 human deaths reported annually. The vast majority of which are caused by dog bites (Deray, 2015). Domestic dogs have been reported as the source of infection of more than 95% of human rabies cases worldwide (Cleaveland, et al., 2006). It is therefore a good strategy to focus on the source in order to eliminate rabies. The recommendation of the World Health Organization is to reach at least 70% vaccination coverage of the existing domestic dog population …