Digital Commons Network^™

Distinctive Roles For α7*- And α9*-Nicotinic Acetylcholine Receptors In Inflammatory And Autoimmune Responses In The Murine Experimental Autoimmune Encephalomyelitis Model Of Multiple Sclerosis, Qiang Liu, Paul Whiteaker, Barbara J. Morley, Fu Dong Shi, Ronald J. Lukas

Translational Neuroscience

Previous studies have demonstrated immunosuppressive and anti-inflammatory effects of nicotine, including in the experimental autoimmune encephalomyelitis (EAE) model in mice of some forms of multiple sclerosis (MS). Other studies using knock-out (KO) mice have implicated nicotinic acetylcholine (ACh) receptors containing α7, α9, or β2 subunits (α7*-, α9*- or β2*-nAChR) in different, disease exacerbating or disease-ameliorating processes. These outcomes are in harmony with gene expression analyses showing nAChR subunit mRNA in many classes of immune system cell types. Consistent with influences on disease status, predictable effects of nAChR subunit (and subtype) KO, or of nicotine exposure, are seen on immune cell …

The Chanticleer, 2017-09-22, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

1017-September-22-Renaissance Child, University Marketing And Communication, East Tennessee State University

ETSU News

No abstract provided.

Researchers Describe Mechanism That Underlies Age-Associated Bone Loss, Jeff Hansen

Browse All News

No abstract provided.

Phytochemicals: Extraction, Isolation, And Identification Of Bioactive Compounds From Plant Extracts, Ammar Altemimi, Naoufal Lakhssassi, Azam Baharlouei, Dennis G. Watson, David A. Lightfoot

Articles

There are concerns about using synthetic phenolic antioxidants such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) as food additives because of the reported negative effects on human health. Thus, a replacement of these synthetics by antioxidant extractions from various foods has been proposed. More than 8000 different phenolic compounds have been characterized; fruits and vegetables are the prime sources of natural antioxidants. In order to extract, measure, and identify bioactive compounds from a wide variety of fruits and vegetables, researchers use multiple techniques and methods. This review includes a brief description of a wide range of different assays. The …

Amino Acid Modulation Of Dopamine In The Nucleus Accumbens Mediates Sex Differences In Nicotine Withdrawal., Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

The Parthenon, September 22, 2017, Jared Casto

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2016 Fall semester, the newspaper is only published two days a week. Physical issues are printed on Tuesdays and Fridays. The editorial staff is responsible for the news and the editorial content.

Chimes: September 22, 2017, Calvin College

Chimes

Faculty join students in DACA debate by Peter Ford

Interfaith walk celebrates St. Francis' Legacy of Peace by Courtney Zonnefeld

Students get Ready for Life by Emily Joy Stroble

Sexuality Series to cover porn, dating by Katie Ulrich

Muntu Theater visits Calvin by Daniel Hickey

'It' rises above standard horror movie cliches by Brandon Schreur

What four years can teach you by Michelle Hofman

Nashville Statement sparks controversy among Christian by Juliana Knot & Courtney Zonnefeld

Molnar's star prediction featured in film by David Fitch

Cib1 Protects Against Mptp-Induced Neurotoxicity Through Inhibiting Ask1., Kyoung Wan Yoon, Hyun-Suk Yang, Young Mok Kim, Yeonsil Kim, Seongman Kang, Woong Sun, Ulhas P. Naik, Leslie V. Parise, Eui-Ju Choi

Department of Medicine Faculty Papers

Calcium and integrin binding protein 1 (CIB1) is a calcium-binding protein that was initially identified as a binding partner of platelet integrin αIIb. Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain remains unclear. Here, we show that CIB1 negatively regulates degeneration of dopaminergic neurons in a mouse model of Parkinson's disease using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Genetic deficiency of the CIB1 gene enhances MPTP-induced neurotoxicity in dopaminergic neurons in CIB1(-/-) mice. Furthermore, RNAi-mediated depletion of CIB1 in primary dopaminergic neurons potentiated 1-methyl-4-phenyl pyrinidium (MPP(+))-induced neuronal death. CIB1 physically associated with apoptosis signal-regulating kinase 1 …

Filtering Out Parasites: Sand Crabs (Lepidopa Benedicti) Are Infected By More Parasites Than Sympatric Mole Crabs (Emerita Benedicti), Zen Faulkes

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Two digging decapod crustaceans, the sand crab species Lepidopa benedicti and the mole crab species Emerita benedicti, both live in the swash zone of fine sand beaches. They were examined for two parasites that infect decapod crustaceans in the region, an unidentified nematode previously shown to infect L. benedicti, and cestode tapeworm larvae, Polypocephalus sp., previously shown to infect shrimp (Litopenaeus setiferus). Lepidopa benedicti were almost always infected with both parasite species, while E. benedicti were rarely infected with either parasite species. This difference in infection pattern suggests that tapeworms are ingested during sediment feeding in …

An Exploratory, Qualitative Study Of Perceptions Of A Hospital-Based Animal-Assisted Intervention Program, Elizabeth A. Richards, Kathleen Abrahamson, Yun Cai, Marguerite O'Haire, Krista Cline

Biennial Convention (CONV)

The purpose of this qualitative pilot study was to contribute to the body of knowledge surrounding the experiences and perceptions of hospital staff who have participated in a hospital-based animal assisted intervention program.

Spartan Daily, September 21, 2017, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2017

Volume 149, Issue 13

September 21, 2017, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Setonian, September 21, 2017, Seton Hall University

2017

No abstract provided.

Natural History Of Hpv Infection Across The Lifespan: Role Of Viral Latency., Patti E Gravitt, Rachel L Winer

Global Health Faculty Publications

Large-scale epidemiologic studies have been invaluable for elaboration of the causal relationship between persistent detection of genital human papillomavirus (HPV) infection and the development of invasive cervical cancer. However, these studies provide limited data to adequately inform models of the individual-level natural history of HPV infection over the course of a lifetime, and particularly ignore the biological distinction between HPV-negative tests and lack of infection (i.e., the possibility of latent, undetectable HPV infection). Using data from more recent epidemiological studies, this review proposes an alternative model of the natural history of genital HPV across the life span. We argue that …

Rabies Screen Reveals Gpe Control Of Cocaine-Triggered Plasticity., Kevin T. Beier, Christina K. Kim, Paul Hoerbelt, Lin Wai Hung, Boris D. Heifets, Katherine E. Deloach, Timothy J. Mosca, Sophie Neuner, Karl Deisseroth, Liqun Luo, Robert C. Malenka

Department of Neuroscience Faculty Papers

Identification of neural circuit changes that contribute to behavioural plasticity has routinely been conducted on candidate circuits that were preselected on the basis of previous results. Here we present an unbiased method for identifying experience-triggered circuit-level changes in neuronal ensembles in mice. Using rabies virus monosynaptic tracing, we mapped cocaine-induced global changes in inputs onto neurons in the ventral tegmental area. Cocaine increased rabies-labelled inputs from the globus pallidus externus (GPe), a basal ganglia nucleus not previously known to participate in behavioural plasticity triggered by drugs of abuse. We demonstrated that cocaine increased GPe neuron activity, which accounted for the …

Student Movement - Issue 3, Andrews University

Student Movement v. 102 (2017-2018)

Student Movement, Issue 3, 2017

Kenyon Collegian - September 21, 2017

The Kenyon Collegian

No abstract provided.

Delivery Of Antioxidant And Anti-Inflammatory Agents For Tissue Engineered Vascular Grafts, Kenyatta S. Washington, Chris A. Bashur

Biomedical Engineering and Sciences Faculty Publications

The treatment of patients with severe coronary and peripheral artery disease represents a significant clinical need, especially for those patients that require a bypass graft and do not have viable veins for autologous grafting. Tissue engineering is being investigated to generate an alternative graft. While tissue engineering requires surgical intervention, the release of pharmacological agents is also an important part of many tissue engineering strategies. Delivery of these agents offers the potential to overcome the major concerns for graft patency and viability. These concerns are related to an extended inflammatory response and its impact on vascular cells such as endothelial …

Suppression Of Chrn Endocytosis By Carbonic Anhydrase Car3 In The Pathogenesis Of Myasthenia Gravis, Ailian Du, Shiqian Huang, Xiaonan Zhao, Kuan Fang, Shuangyan Zhang, Jiefang Huang, Xiang Miao, Fulvio Baggi, Rennolds S. Ostrom, Yanyun Zhang, Xiangjun Chen, Congfeng Xu

Pharmacy Faculty Articles and Research

Myasthenia gravis is an autoimmune disorder of the neuromuscular junction manifested as fatigable muscle weakness, which is typically caused by pathogenic autoantibodies against postsynaptic CHRN/ AChR (cholinergic receptor nicotinic) in the endplate of skeletal muscle. Our previous studies have identified CA3 (carbonic anhydrase 3) as a specific protein insufficient in skeletal muscle from myasthenia gravis patients. In this study, we investigated the underlying mechanism of how CA3 insufficiency might contribute to myasthenia gravis. Using an experimental autoimmune myasthenia gravis animal model and the skeletal muscle cell C2C12, we find that inhibition of CAR3 (the mouse homolog of CA3) promotes CHRN …

Crashapp™ –Concurrent Multiple Stakeholder Evaluation Of A Dsr Artefact, Timothy M. Papp

USF Tampa Graduate Theses and Dissertations

The successful design, implementation, deployment, and use of mobile software applications is rare. While many mobile apps are developed, few succeed. This design science research project builds and evaluates CrashApp™, a mobile application that connects lawyers and clients before, during, and after car accidents. The effective, widespread use of this app depends on satisfying the needs of three groups of stakeholders – the end-users (clients), the owners (lawyers), and the software developers. The research objective is to investigate the key differences among the three stakeholder groups on evaluation criteria for mobile app success. Evaluation strategies and methods are selected to …

A Striking New Genus And Species Of Troglobitic Campodeidae (Diplura) From Central Asia

KIP Articles

No abstract provided.

Hawks' Herald -- Sep. 21, 2017, Roger Williams University

Hawk's Herald

No abstract provided.

Fungal Community Homogenization, Shift In Dominant Trophic Guild, And Appearance Of Novel Taxa With Biotic Invasion, Mark A. Anthony, Serita D. Frey, Kristina A. Stinson

Faculty Publications

Invasion by non-native plants may fundamentally restructure the soil fungal community. The invasive plant, Alliaria petiolata, produces secondary compounds suppressive to mycorrhizal fungi and may therefore be expected to have generally negative effects on other components of the fungal community. Here, we compared fungal biomass, diversity, community composition, and the relative abundance of fungal trophic guilds, along with edaphic properties of soils collected from uninvaded and invaded plots across six temperate forests. Invaded plots were differentiated from uninvaded plots by lower variation in fungal community composition (beta diversity) and soil properties, higher fungal richness and community evenness (alpha diversity), and …

Björkman, Brent Alan, B. 1964 (Fa 1098), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid for Folklife Archives Project 1098. Collection contains transcripts of video interviews conducted by Brent Björkman in 2013 and 2014 with park rangers from Mammoth Cave National Park. Topics of note within the interviews include the growth of women in the ranks of the ranger service, fiscal challenges faced by the park system, generational traditions, and the virtues of raising a family within the park community. Transcripts are part of a larger project titled "Rangerlore: The Occupational Folklife of Parks," which was created by Björkman after receiving the Archie Green Fellowship from the Library of Congress.

Kenyon Collegiate - September 21, 2017

Kenyon Collegiate

No abstract provided.

Integrating Art Into The Classroom: A Necessary Component Of A Well-Rounded Education, Kate Latham

Mahurin Honors College Capstone Experience/Thesis Projects

This thesis includes a combination of research and visual arts integration lesson plans. Research covers the benefits of exposure to the visual. Lesson plans were specifically designed for the core content area subjects: English/language arts, mathematics, science, and social studies. Each of these lessons was designed to meet local and national standards for the core content area and for visual arts. Additionally, each lesson plan includes a component of art production. This thesis can be utilized by a variety of individuals, including educators who strive to incorporate art into their classrooms. The research aspect can be utilized by those struggling …

The Grizzly, September 21, 2017, Valerie Osborne, Johnny Myers, Courtney A. Duchene, Emily Shue, Skyler L. Gailing, Kevin Leon, Paige Szmodis, Sophia Dibattista, David Mendelsohn

Ursinus College Grizzly Newspaper, 1978 to Present

CSCG Brings Biologist and Policy Maker Nina Federoff to Campus • Students Surprised by New Student Senate Requirements • International Film Festival Kicks Off • Q&A with Dean Mark Schneider • Beekeeping Society Creates Some Buzz • Final Member of Pi Omega Delta • Opinions: First-year Perspective: Challenge Yourself with New Experiences; How to be Involved but not Over-committed on Campus • Electric Start for UC Men's Cross Country • Party of Five: Women's Golf Wins First Match

Efficacy And Safety Comparison Between Suberoylanilide Hydroxamic Acid And Mitomycin C In Reducing The Risk Of Corneal Haze After Prk Treatment In Vivo, Govindaraj Anumanthan, Ajay Sharma, Michael R. Waggoner, Chuck W. Hamm, Suneel Gupta, Nathan P. Hesemann, Rajiv R. Mohan

Pharmacy Faculty Articles and Research

PURPOSE:

This study compared the efficacy and safety of suberoylanilide hydroxamic acid (SAHA) and mitomycin C (MMC) up to 4 months in the prevention of corneal haze induced by photorefractive keratectomy (PRK) in rabbits in vivo.

METHODS:

Corneal haze in rabbits was produced with −9.00 diopter PRK. A single application of SAHA (25 μM) or MMC (0.02%) was applied topically immediately after PRK. Effects of the two drugs were analyzed by slit-lamp microscope, specular microscope, TUNEL assay, and immunofluorescence.

RESULTS:

Single topical adjunct use of SAHA (25 μM) or MMC (0.02%) after PRK attenuated more than 95% corneal …

The Parasite Extinction Assessment & Red List: An Open-Source, Online Biodiversity Database For Neglected Symbionts, Colin J. Carlson, Oliver C. Muellerklein, Anna J. Phillips, Kevin R. Burgio, Giovanni Castaldo, Carrie A. Cizauskas, Graeme S. Cumming, Tad Dallas, Jorge Doña, Nyeema Harris, Roger Jovani, Zhongqi Miao, Heather Proctor, Hyun Seok Yoon, Wayne M. Getz

Faculty Publications

Parasite conservation is a rapidly growing field at the intersection of ecology, epidemiology, parasitology, and public health. The overwhelming diversity of parasitic life on earth, and recent work showing that parasites and other symbionts face severe extinction risk, necessitates infrastructure for parasite conservation assessments. Here, we describe the release of the Parasite Extinction Assessment & Red List (PEARL) version 1.0, an open-access database of conservation assessments and distributional data for almost 500 macroparasitic invertebrates. The current approach to vulnerability assessment is based on range shifts and loss from climate change, and will be expanded as additional data (e.g., host-parasite associations …