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Board Of Trustees Meeting Minutes, December 15, 2017

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on December 15, 2017.

Health Starts In The Home: An Assessment Of Efforts To Improve Occupant Health Through Healthy Building Materials In San Francisco’S Affordable Housing, Staci Hoell

Master's Projects and Capstones

Americans spend 90% of their lives indoors, and much of this time is spent at home, surrounded by building materials that typically have added chemicals like flame retardants, highly fluorinated compounds, and antimicrobials. Recent research has linked these chemicals to adverse health outcomes such as asthma, endocrine disruption, cancer, neurodevelopmental issues, and reproductive problems (Bayer et al., n.d.; Green Science Policy Institute). Furthermore, these chronic health conditions disproportionately affect low-income populations. Fortunately, substantial efforts in research, practice, and policy are working to reduce the use of these potentially harmful chemicals in building materials, particularly in San Francisco’s affordable housing sector. …

Habitat Selection, Survival, And Movement Ecology Of The American Woodcock (Scolopax Minor) In Louisiana Usa, Elisa Constancia Elizondo

LSU Master's Theses

The American Woodcock (Scolopax minor) is a migratory upland game species occurring across much of eastern North America. Across its breeding range in the northern U.S. and southern Canada, this species has experienced significant, pervasive declines over the last half century. As woodcock populations continue to decline, active habitat management for this species has become increasingly important.

The state of Louisiana has substantial amounts of woodcock habitat and receives wintering birds from across the woodcock range. However, few data exist regarding survival rates, habitat utilization, and movement patterns across the state.

In order to better manage for woodcock …

Cpap-Mad Combination Therapy For Cpap Intolerant Patients With Moderate To Severe Osa, Jacob Stadiem

Theses & Dissertations

The treatment of obstructive sleep apnea (OSA) allows for a multidisciplinary approach between dentistry and medicine. Continuous positive airway pressure (CPAP) is the gold standard for OSA treatment, but the non-adherence rates are high. The mandibular advancement device (MAD) has a higher acceptance rate than the CPAP, however the efficacy is much lower in cases of moderate to severe OSA. This thesis attempted to evaluate if there was a change in compliance when a MAD was added as a combination therapy to moderate to severe OSA subjects that were currently non-compliant with their CPAP. In addition, the change in air …

Novel Therapeutic Approaches For Juvenile Neuronal Ceroid Lipofuscinosis (Cln3), Megan Elizabeth Bosch

Theses & Dissertations

Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) is a lysosomal storage disease caused by autosomal recessive mutations in CLN3. Neuronal loss is thought to occur via glutamate excitotoxicity; however, little is known about neuron-astrocyte glutamate regulation in JNCL. We discovered that Cln3^Δex7/8 astrocytes have significantly lower basal spontaneous Ca²⁺ oscillations and decreased responses to glutamate, indicating a disrupted signaling network. Cln3^Δex7/8 astrocytes also displayed significantly lower basal mitochondrial respiration and ATP production, suggesting impaired metabolic functions. Concurrent with diminished astrocyte metabolism and Ca²⁺ signaling, Cln3^Δex7/8 neurons were hyper-responsive to glutamate stimulation. These studies suggest that CLN3 …

Defining The Role Of Neuropilin-2 In Macrophages: Implications In Tumor Associated Macrophages In Pancreatic Cancer, Sohini Roy

Theses & Dissertations

Macrophages are extremely heterogeneous and highly plastic hematopoietic cells that reside in all tissues and act as a bridge between the innate and adaptive arms of the immune responses. Besides, they undertake a wide array of housekeeping functions like, clearance of cellular debris that arise due to regular turnover in tissues, iron homeostasis, immune surveillance as well as tissue repair processes post inflammation. They are also causally associated with several clinical conditions, including cancer where the infiltration of macrophages contribute to disease progression, metastasis and therapy resistance, and thereby poor clinical outcome.

Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins …

Organizational Effects Of Defeminizing Toxicants: Lessons Learned From An Environmental Sentinel Organism, The Fathead Minnow., Jonathan Ali

Theses & Dissertations

Endocrine disrupting compounds (EDCs) are chemicals that interfere with hormone function and are increasingly detected in aquatic environments, where they elicit adverse effects from exposed organisms. The toxicological effects of EDCs can be described as either activational (reversible) or organizational (irreversible), where the latter are associated with adverse outcomes in reproductive performance of adult fish. However, few studies have investigated the organizational impacts of anti-estrogenic or “defeminizing” EDCs, e.g. agrichemicals or pharmacological agents, in an environmentally-relevant or “sentinel” species. The objective of this study was to investigate the impacts of early-life EDC-initiated changes in estrogenic gene expression on organizational effects …

A Role For Δ-Catenin In Synaptic Regulation, Li Yuan

Theses & Dissertations

The cadherin-catenin complex regulates cell-cell adhesion and signal transduction in epithelial cells. It is becoming increasingly evident that components of the complex regulate various aspects of neuronal architecture and function. δ-catenin is a cytosolic component of the cadherin-catenin complex and is predominantly expressed in the central nervous system. Loss of CTNND2, which encodes δ-catenin, is associated with intellectual disability and mutations in CTNND2 have been identified in autism, suggesting that δ-catenin is a critical component of the molecular machinery underlying neural circuit function. We have previously demonstrated that δ-catenin regulates multiple aspects of synaptic and dendritic development, including dendritic …

Evaluation Of Aminopyrazole Analogs As Cyclin-Dependent Kinase Inhibitors For Colorectal Cancer Therapy, Caroline Robb

Theses & Dissertations

Colorectal cancer (CRC) remains one of the leading causes of cancer related deaths in the United States. Currently, there are limited therapeutic options for CRC patients, none of which focus on the cell signaling mechanisms controlled by members of the cyclin dependent kinase (CDK) family. CDK5 has been implicated in a variety of cancers, and most recently as a tumor promoter in CRC.

As such, we evaluated a compound developed by Pfizer, CP-668863 (a.k.a. 20-223), that inhibits CDK5 in neurodegenerative disorders. In our CRC xenograft model, 20-223 reduced tumor growth and tumor weight, indicating its value as a potential anti-CRC …

Effects Of Gm-Csf On Dendritic Cells And Regulatory T Cells In Parkinson’S Disease Patients And Models Of Parkinson’S Disease, Charles Schutt

Theses & Dissertations

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder. Pathologically, loss of nigrostriatal neurons and dopamine released by these neurons are responsible for PD motor symptoms. During PD, activation of resident microglia and infiltrating lymphocytes leads to progressive neuroinflammation and reduction in the number and function of regulatory immune cells. Neuroinflammation contributes to progressive neurodegeneration and declining motor function. Reducing neuroinflammation is the target for novel PD therapeutics. Our goal is to increase the number and function of regulatory T cells (Tregs) in PD patients to decrease neuroinflammation and reduce PD symptoms. One potential therapy is granulocyte-macrophage colony stimulating …

Identifying The Role Of Janus Kinase 1 In Mammary Gland Development And Breast Cancer, Barbara Swenson

Theses & Dissertations

The development of the postnatal mammary gland is tightly controlled by peptide hormones and cytokines. The signaling of these extracellular ligands through their corresponding receptors rely on Janus Kinases (JAKs) that activate downstream Signal Transducers and Activators of Transcription (STATs). The JAK/STAT signaling pathway is crucial for processes such as growth, proliferation, and cell survival of the epithelial tissue, but also for the breakdown and remodeling of the mammary gland via IL-6 class inflammatory cytokines (e.g. LIF and OSM). JAK1 and JAK2, which are expressed in the mammary gland, are thought to have redundant functions. However, our previous studies demonstrated …

In-Vitro And In-Vivo Models Of Bile Acid Metabolism And Transport, Rhishikesh Thakare

Theses & Dissertations

All biomedical research is conducted in animal models first. In addition, the Food and Drug Administration requires extrapolation from animal data to predict human responses. There are ongoing scientific and regulatory challenges translating interspecies comparisons and predictions. Metabolic pathways are a cornerstone to understanding drug metabolism and toxicities and the liver is a key organ in this process. Bile acids (BAs) play a central role in the hepatobiliary toxicities of chemicals, toxins, and biological reagents. BAs have many physiological functions including regulation of genes involved in cholesterol and glucose metabolism and BA homeostasis. However, BAs also have several pathological effects …

Focus: A Graph Approach For Data-Mining And Domain-Specific Assembly Of Next Generation Sequencing Data, Julia Sommer

Theses & Dissertations

Next Generation Sequencing (NGS) has emerged as a key technology leading to revolutionary breakthroughs in numerous biomedical research areas. These technologies produce millions to billions of short DNA reads that represent a small fraction of the original target DNA sequence. These short reads contain little information individually but are produced at a high coverage of the original sequence such that many reads overlap. Overlap relationships allow for the reads to be linearly ordered and merged by computational programs called assemblers into long stretches of contiguous sequence called contigs that can be used for research applications. Although the assembly of the …

Metabolic Reprogramming Of Pancreatic Ductal Adenocarcinoma Cells In Response To Chronic Low Ph Stress, Jaime Abrego

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of all cancers with a 5-year survival rate of only 8.2%. This is because PDAC is diagnosed in its advanced stages and is characterized by radio and chemotherapy resistance. Aggressiveness of PDAC tumors is attributed to its high metabolic phenotype, which is characterized by increased glycolysis rate and lactate secretion, while oxidative metabolism is reduced. These metabolic features are required to fulfill the biosynthetic demands of proliferating PDAC cells. However, this increase in metabolic activity results in acidification of the extracellular space because the dense fibrotic stroma of PDAC tumors limits …

Mentalization In Counseling Processes, Matthew J. Swartzentruber

Educational Specialist, 2009-2019

The purpose of this literature review is to demonstrate the profound influences and numerous applications the concept of mentalization has within counseling processes. The skill of mentalizing extends across theoretical orientations within existing counseling frameworks and has been suggested to be a core factor within the counseling process (Allen, Fonagy, & Bateman, 2008). Mentalizing capacities have been linked to positive therapeutic alliances (Markowitz & Milrod, 2011), positive client outcomes (Bernbach, 2002; Bouchard et al., 2008; Fonagy & Target, 1996; Karlsson & Kermott, 2006; Levy et. al., 2006; Meehan, Levy, Reynoso, Hill, & Clarkin, 2009), and counselor effectiveness (Cologon, 2013); and …

Dreams: A Unified Theory Approach, Chance Mcdermott

Dissertations, 2014-2019

Henriques (2011) proposed a new unified theory of psychology (UT) which he argued could assimilate and integrate divergent lines of thought into a coherent whole. An implication of this claim is that the system can be applied to phenomena that was not addressed in the original work and the current work tests this proposition. Specifically, the current work utilized the UT and its components to examine the dream literature, especially psychodynamic, physiological and evolutionary approaches. Following a brief introduction, the project reviews the various lines of research and interpretations of why we dream and what they may mean for us. …

Color-Grapheme Synesthesia: A Study Of Population Prevalence, Christopher Hill

Dissertations, 2014-2019

Given the current state of the literature and weaknesses of many previous prevalence studies, the primary purpose of this research study was to gather base-rate data of color-grapheme synesthesia in a general population sample. Over a period of seven months, 502 participants enrolled in the study on Mechanical Turk and completed the online Synesthesia Battery. The primary data collected was the participant’s score on the synesthesia test, whereby a score of a one or below is deemed by the battery to be indicative of someone with a color-grapheme synesthetic ability. Of the 502 participants, eight percent (0.082) of the population …

Venous Thromboembolism Within Professional American Sport Leagues., Meghan Bishop, Matthew Astolfi, Eric M. Padegimas, Peter F. Deluca, Sommer Hammoud

Department of Orthopaedic Surgery Faculty Papers

Background: Numerous reports have described players in professional American sports leagues who have been sidelined with a deep vein thrombosis (DVT) or a pulmonary embolism (PE), but little is known about the clinical implications of these events in professional athletes.

Purpose: To conduct a retrospective review of injury reports from the National Hockey League (NHL), Major League Baseball (MLB), the National Basketball Association (NBA), and the National Football League (NFL) to take a closer look at the incidence of DVT/PE, current treatment approaches, and estimated time to return to play in professional athletes.

Study Design: Descriptive epidemiology study.

Methods: An …

Canela Shamanism: Shamans’ Accounts, “Journeying,” And Delimitation Of Shamanic Terms, William H. Crocker

Tipití: Journal of the Society for the Anthropology of Lowland South America

In this article I recount the stories of various shamans I have worked with throughout many decades of fieldwork among the Ramkokamekra-Canela (Eastern Timbira) of central Maranhão state, Brazil. Along with their narratives, I provide ethnographic context in order to address the following questions: (1) Who is a shaman? (2) What is shamanism? Is shamanism better understood (3) as a process or a method that is carried out to achieve certain ends, or is it better understood (4) as a particular set of beliefs associated with particular cultures? Additionally, (5) are altered or shamanic states of consciousness found in Canela …

The Crème De La Crème: Old Favourites, New-Fangled Works, And Other Fictions, Willy Maley

Studies in Scottish Literature

Introduces the SSL Debate, in which 18 contributors react to and add to the BBC Scotland poll on Scotland's Favourite Novel, discussing the purposes and limitations of various lists that have ranked recent Scottish fiction, and commenting briefly on the differences between this debate and the deliberations of a selection panel.

Fresh Air: Michel Faber, Under The Skin (2000) With A Comment On Trainspotting, Tony Jarrells

Studies in Scottish Literature

Comparing Faber's treatment of the Scottish Highlands (his only novel set in Scotland) with a Highland incident in Welsh's Trainspotting, arguing that in Faber the Highlands are "not merely some representation of a romanticized past," but also "represent this present moment,... marked by the class conflicts and near political hopelessness" seen in Welsh, but also "a strong sense of beauty and an appreciation for the environment."

Writing On The Margins: Luke Sutherland, Venus As A Boy (2004), Manfred Malzahn

Studies in Scottish Literature

Recommends Sutherland's "epiphanic" short novel, which received rave reviews on publication, as a novel that should have been "an almost mandatory selection" for the BBC poll ballot, suggesting that it was excluded, not only because of length, explicit language, and violence, but because its island setting and depiction of "the fuzzy margins of sexual and racial identity" made it wrongly seem peripheral to the Scottish "mainland and mainstream."

Gavin Douglas's Aeneados: Caxton's English And 'Our Scottis Langage', Jacquelyn Hendricks

Studies in Scottish Literature

Discusses the Scots poet Gavin Douglas's translation of Virgil's Aeneid into Scots, and Douglas's treatment of his predecessor William Caxton's translation of Virgil into English, arguing that Douglas associates Caxton's English with a barbaric world of monsters and beasts, in contrast to Scots which is seen as expressing civilized classical values, and that Douglas's translation, by enhancing and showcasing the literary power of Scots for a wider audience, successfully resisted for at least forty years the linguistic standardization initiated by the burgeoning print industry.

Beattie's The Minstrel: A Missing Link In Scottish Poetry, Ian C. Robertson

Studies in Scottish Literature

Discusses the Scottish poet James Beattie's poetry, especially his major work The Minstrel, and his shorter poem in Scots, "To Mr Alexander Ross," in terms of his connections, role and influence within the Scottish poetry and culture of the mid- to late 18th century, arguing that without taking into account Beattie's complex relationship to Scottish, and specifically Aberdonian, culture, the development of 18th century Scottish poetry between Ramsay and Burns cannot be adequately understood.

The Scotch Bard And 'The Planting Line': New Documents On Burns And Jamaica, Clark Mcginn

Studies in Scottish Literature

Based on newly-identified documents, reexamines Burns's plan in 1786 to emigrate to Jamaica to take a job on a Scottish-owned slave plantation, and the timing and circumstances of his eventual decision to stay in Scotland, concluding that Burns "kept his options open to the last moment," and that the new documents might mean Burns "sought to prosper from chattel slavery," and "only dropped the opportunity because a better offer came along, not because of any moral scruples."

Contributors To Ssl 43:2

Studies in Scottish Literature

No abstract provided.

A Novel Model Of “Remedy And Elimination Of Tuberculosis”, Akanksha Mishra

Master's Theses

Tuberculosis (TB), is one of the top ten causes of death worldwide. TB is commonly linked to poverty and creates poverty as it is the single largest cause of death in the 15-49-year-old age group in South-East Asia (WHO, 2017). It is also linked to the HIV population, and its leading cause of death. TB is effected by socio-economic factors, cultural factors, and health policy. My goal of this dissertation is to identify systematic approaches that shall support the mission set by World Health Organization (WHO): to eliminate TB globally by the year 2050. Measures might include addressing social barriers …

Tastes Of Faith: Jewish Eating In The United States, Leah Hochman

The Jewish Role in American Life: An Annual Review

"Tell me what you eat, and I will tell you what you are," wrote the 18th Century French politician and musician Jean Brillat-Savarin, giving expression to long held assumptions about the role of food, taste, and eating in the construction of cultural identities.

Foodways—the cultural, religious, social, economic, and political practices related to food consumption and production—unpack and reveal the meaning of what we eat, our tastes. They explain not just our flavor profiles, but our senses of refinement and judgment. They also reveal quite a bit about the history and culture of how food operates and performs in society. …

The Law Code Of Hammurabi: Transliterated And Literally Translated From Its Early Classical Arabic Language, Saad D. Abulhab

Publications and Research

This book, which includes new translations of the old Babylonian laws of Hammurabi, is the second book by the author examining, from a historical Arabic linguistic perspective, a major Akkadian document. The first book offered new translations of three tablets from a literary work, the Epic of Gilgamesh, written in a late Babylonian language. The pioneering methodology used by the author to decipher the ancient Mesopotamian texts in both documents involves the primary utilization of old etymological Arabic manuscripts written by hundreds of accomplished scholars more than a thousand years ago. Using this methodology does not only provide more accurate, …

Teaching Efl/Esl College-Level Learners Through Current Global Topics: Integrated Lessons For Efl/Esl Teachers, Chaiyeon Sylvia Lee

Master's Projects and Capstones

The importance of educating effective English users competent in communicating and interacting in a variety of social settings is highlighted in today’s highly globalized world. Being able to understand and discuss complex global topics related to current cultural, social, and business issues and events has become an integral skill of English learners to achieve greater international connectivity. Unfortunately, many EFL/ESL college-level students, specifically Korean EFL students, do not seem to have sufficient preparation to build English communicative competence and cultural awareness necessary to cope with various situations in which they need to communicate meaningfully and purposefully as effective English users. …