Digital Commons Network^™

Differentiation And Protective Capacity Of Virus-Specific Cd8, Vesselin T. Tomov, Olesya Palko, Chi Wai Lau, Ajinkya Pattekar, Yuhang Sun, Ralitza Tacheva, Bertram Bengsch, Sasikanth Manne, Gabriela L. Cosma, Laurence C. Eisenlohr, Timothy J. Nice, Herbert W. Virgin, E. John Wherry

Department of Microbiology and Immunology Faculty Papers

Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown. We used genetically engineered strains of mouse norovirus (MNV) to investigate CD8⁺ T cell differentiation during chronic infection. We found that chronic infection drove MNV-specific tissue-resident memory (Trm) CD8⁺ T cells to a differentiation state resembling inflationary effector responses against latent cytomegalovirus with only limited evidence of exhaustion. These MNV-specific Trm cells remained highly functional yet appeared ignorant of ongoing viral replication. Pre-existing MNV-specific Trm cells provided partial protection against chronic infection but largely ceased …

A Latent Propriospinal Network Can Restore Diaphragm Function After High Cervical Spinal Cord Injury, Jared M. Cregg, Kevin A. Chu, Lydia E. Hager, Rachel S. J. Maggard, Daimen R. Stoltz, Michaela Edmond, Warren J. Alilain, Polyxeni Philippidou, Lynn T. Landmesser, Jerry Silver

Spinal Cord and Brain Injury Research Center Faculty Publications

Spinal cord injury (SCI) above cervical level 4 disrupts descending axons from the medulla that innervate phrenic motor neurons, causing permanent paralysis of the diaphragm. Using an ex vivo preparation in neonatal mice, we have identified an excitatory spinal network that can direct phrenic motor bursting in the absence of medullary input. After complete cervical SCI, blockade of fast inhibitory synaptic transmission caused spontaneous, bilaterally coordinated phrenic bursting. Here, spinal cord glutamatergic neurons were both sufficient and necessary for the induction of phrenic bursts. Direct stimulation of phrenic motor neurons was insufficient to evoke burst activity. Transection and pharmacological manipulations …

Nanoparticle Delivery Of Mir-34a Eradicates Long-Term-Cultured Breast Cancer Stem Cells Via Targeting C22orf28 Directly, Xiaoti Lin, Weiyu Chen, Fengqin Wei, Binhua P. Zhou, Mien-Chie Hung, Xiaoming Xie

Molecular and Cellular Biochemistry Faculty Publications

Rationale: Cancer stem cells (CSCs) have been implicated as the seeds of therapeutic resistance and metastasis, due to their unique abilities of self-renew, wide differentiation potentials and resistance to most conventional therapies. It is a proactive strategy for cancer therapy to eradicate CSCs. Methods: Tumor tissue-derived breast CSCs (BCSC), including XM322 and XM607, were isolated by fluorescence-activated cell sorting (FACS); while cell line-derived BCSC, including MDA-MB-231.SC and MCF-7.SC, were purified by magnetic-activated cell sorting (MACS). Analyses of microRNA and mRNA expression array profiles were performed in multiple breast cell lines. The mentioned nanoparticles were constructed following the standard molecular cloning …

Teachers' Perceptions Of Addressing Leisure In Curriculum For Students With Severe Disabilities, Kara Klepp

Theses and Dissertations

This qualitative study was designed to examine the perspectives of addressing leisure in curriculum for students with severe disabilities. Quality of life disucssions have shown the importance of considering skills to prepare them for adulthood which includes leisure outcomes. Research has examined many different aspects of transition including vocational education, but limited research has been conducted relating to leisure outcomes. Qualitative data obtained through semi-structured interviews indicated that more research is needed in leisure education including curriculum development and prioritization of skills taught. The participants reflected on their own definitions of leisure, current leisure outcomes, and the types of assessment …

Morphological Awareness And Advanced Efl Learners’ Listening Comprehension, Xu Bian

Education Dissertations

This study explored the relationship between morphological awareness and advanced EFL learners’ listening comprehension by deconstructing three multi-dimension constructs, morphological awareness, vocabulary knowledge and listening comprehension. The variables under morphological awareness were compounding and derivational morphology; vocabulary knowledge included both reading and listening vocabulary; listening comprehension was assessed by two different listening tasks whose aural texts and response formats were interviews and multiple choices, and one mini lecture and the gap-filling. Participants were 152 third-year English-majors in two universities in China. The main findings were (1) morphological awareness was a significant predictor of listening comprehension when the latter was measured …

Volume 115, Number 7 - Tuesday, October 17, 2017, Saint Mary's College Of California

The Collegian

No abstract provided.

The Role Of B Cell Targeting In Chronic Graft-Versus-Host Disease., Ruben Rhoades, Md, Sameh Gaballa, Md

Department of Medical Oncology Faculty Papers

Chronic graft-versus-host disease (cGVHD) is a leading cause of late morbidity and mortality following allogeneic stem cell transplantation. Current therapies, including corticosteroids and calcineurin inhibitors, are only effective in roughly 50% of cases; therefore, new treatment strategies are under investigation. What was previously felt to be a T cell disease has more recently been shown to involve activation of both T and B cells, as well as a number of cytokines. With a better understanding of its pathophysiology have come more expansive preclinical and clinical trials, many focused on B cell signaling. This report briefly reviews our current understanding of …

Spartan Daily, October 17, 2017, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2017

Volume 149, Issue 23

Protecting Cows In Small Holder Farms In East Africa From Tsetse Flies By Mimicking The Odor Profile Of A Non-Host Bovid, Rajinder K. Saini, Benedict O. Orindi, Norber Mbahin, John A. Andoke, Peter N. Muasa, David M. Mbuvi, Caroline M. Muya, John A. Pickett, Christian W. Borgemeister

All Peer-Reviewed Publications

Background: For the first time, differential attraction of pathogen vectors to vertebrate animals is investigated for novel repellents which when applied to preferred host animals turn them into non-hosts thereby providing a new paradigm for innovative vector control. For effectively controlling tsetse flies (Glossina spp.), vectors of African trypanosomosis, causing nagana, repellents more powerful than plant derived, from a non-host animal the waterbuck, Kobus ellipsiprymnus defassa, have recently been identified. Here we investigate these repellents in the field to protect cattle from nagana by making cattle as unattractive as the buck. Methodology/Principal findings: To dispense the waterbuck repellents comprising guaiacol, …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Armstrong state University Professor Kurt Knoerl featured speaker at R.Frank Saunders, Jr. Fall History Lecture
• Department of Biology researchers bring fish hatchery back to life
• National Youth-at-Risk West conference set for Oct. 26-28 in San Antonio

Cosm Biology News, Georgia Southern University

Biology: News & Publications (2012-2017)

• Department of Biology researchers bring fish hatchery back to life

Eagle Baseball Launches Crowdfunding Campaign In Support Of The Team Trip To The Dominican Republic, Georgia Southern University

Athletics: News & Publications

• Eagle Baseball Launches Crowdfunding Campaign in Support of the Team Trip to the Dominican Republic
• The crowdfunding campaign will help cover the cost of airfare, ground transportation, meals, hotel accommodations, baseball activities and tours

Optimizing Fresh Specimen Staining For Rapid Identification Of Tumor Biomarkers During Surgery., Connor W. Barth, Jasmin M. Schaefer, Vincent M. Rossi, Scott C. Davis, Summer L. Gibbs

Dartmouth Scholarship

Rationale: Positive margin status due to incomplete removal of tumor tissue during breast conserving surgery (BCS) is a prevalent diagnosis usually requiring a second surgical procedure. These follow-up procedures increase the risk of morbidity and delay the use of adjuvant therapy; thus, significant efforts are underway to develop new intraoperative strategies for margin assessment to eliminate re-excision procedures. One strategy under development uses topical application of dual probe staining and a fluorescence imaging strategy termed dual probe difference specimen imaging (DDSI). DDSI uses a receptor-targeted fluorescent probe and an untargeted, spectrally-distinct fluorescent companion imaging agent topically applied to fresh resected …

Número 141: 2.º Después De Navidad-4.º Después De Epifanía

Estudios Exégeticos Homiléticos

Domingo Primero de Enero de 2012 (2º después de Navidad)

Sal 147:13-21; Jeremías 31:7-14, Ef 1:3-14; Jn 1:1-18

Domingo 8 de Enero de 2012 (Bautismo de nuestro Señor - 1º después de Epifanía)

Sal 29; Gn 1:1‑5; Hch 19:1‑7; Mc 1:4‑11

Domingo 15 de Enero de 2012 (2º después de Epifanía)

Sal 139:1‑5, 12‑17; 1 Sam 3:1‑20; 1 Co 6:12‑20; Jn 1:43‑51

Domingo 22 de Enero de 2012 (3º después de Epifanía)

Sal 62:5-12 (6‑13); Jon 3:1‑5,10; 1 Co 7:29‑31; Mc 1:14‑20

Domingo 29 de Enero de 2012 (4º después de Epifanía)

Sal 111; Deut …

Survival And Food Detection By First-Instar Melanoplus Femurrubrum (Orthoptera: Acrididae), R. G. Bland

The Great Lakes Entomologist

Newly hatched Melanoplus femurrubrum (DeGeer) were evaluated for survival without food under various moisture, temperature, and light conditions. Although nymphs survived up to 113 h without food, they required food 48-W h after hatching to ensure continued survival and growth. Olfactory food detection was very limited and feeding tended to occur on the first suitable food encountered. Food covered with a ftlm of water and held within several millimetres of the palpi evoked palpal vibrations followed by antennal movements. The evidence suggests that hygroreceptors occur on the pa\pi and pa\pa\ stimulation is necessary before antennal olfaction occurs.

Indigenous Rights Education (Ire): Indigenous Knowledge Systems And Transformative Human Rights In The Peruvian Andes, Elizabeth Sumida Huaman

International Journal of Human Rights Education

This article focuses on the relationship between Indigenous places, rights, and education. In the context of the Peruvian Andes, historical ideological impositions reveal the trajectory of environmental exploitation, which have contributed to major ecological threats that collectively contribute to the aggressive re-making of the Andean world as sacrificed lands. With a focus on Quechua peoples, the link between Indigenous knowledge systems and human rights education is explored. Drawing from discourses of Indigenous rights, place, rights, and transformative human rights education, Indigenous rights education (IRE) is proposed.

Cultivating Critical Sentimental Education In Human Rights Education, Michalinos Zembylas

International Journal of Human Rights Education

No abstract provided.

An Investigation On The Larval Habitat Of Five Species Of Tree-Hole Breeding Mosquitoes (Diptera: Culicidae), Lee Mitchell, C. Lee Rockett

The Great Lakes Entomologist

A two-year study on the larval habitat of five species of tree-hole breeding mosquitoes was conducted in the vicinity of Bowling Green, Wood County, Ohio. Ninety-eight tree holes containing mosquito larvae were studied. Larval collections (27,741 specimens) were comprised of Aedes rriseriarus (90.8%), Orrhopodomyia signifera (3.3%), Aedes hendersoni (3.2%), Anopheles barberi (2.7%) and Orrhopodomyia alba (< 0.1%). Chemical parameters (BOD, tannin-lignin, pH, and conductivity) of different tree holes were evaluated. Although different tree-hole species were commonly found in association with one another at breeding sites, ecological differences between species were found in spatial, trophic, and temporal niche dimensions.