Digital Commons Network^™

Tox Regulates Growth, Dna Repair, And Genomic Instability In T-Cell Acute Lymphoblastic Leukemia, Riadh Lobbardi, Jordan Pinder, Barbara Martinez-Pastor, Marina Theodorou, Jessica S. Blackburn, Brian J. Abraham, Yuka Namiki, Marc Mansour, Nouran S. Abdelfattah, Aleksey Molodtsov, Gabriela Alexe, Debra Toiber, Manon De Waard, Esha Jain, Myriam Boukhali, Mattia Lion, Deepak Bhere, Khalid Shah, Alejandro Gutierrez, Kimberly Stegmaier, Lewis B. Silverman, Ruslan I. Sadreyev, John M. Asara, Marjorie A. Oettinger, Wilhelm Haas, A. Thomas Look, Richard A. Young, Raul Mostoslavsky, Graham Dellaire, David M. Langenau

Molecular and Cellular Biochemistry Faculty Publications

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. Using a transgenic screen in zebrafish, thymocyte selection–associated high mobility group box protein (TOX) was uncovered as a collaborating oncogenic driver that accelerated T-ALL onset by expanding the initiating pool of transformed clones and elevating genomic instability. TOX is highly expressed in a majority of human T-ALL and is required for proliferation and continued xenograft growth in mice. Using a wide array of functional analyses, we uncovered that TOX binds directly to KU70/80 and suppresses recruitment of this complex to DNA breaks to inhibit nonhomologous end joining (NHEJ) repair. …

Regenerative Therapy By Replacement Of Stem Cells In Females, Saara Ahmad, Rehana Rehman, Fatima Ahmad

Department of Biological & Biomedical Sciences

No abstract provided.

A High Quality, Eulerian 3d Fluid Solver In C++, Lejon Anthony Mcgowan

Computer Science and Software Engineering

Fluids are a part of everyday life, yet are one of the hardest elements to properly render in computer graphics. Water is the most obvious entity when thinking of what a fluid simulation can achieve (and it is indeed the focus of this project), but many other aspects of nature, like fog, clouds, and particle effects. Real-time graphics like video games employ many heuristics to approximate these effects, but large-scale renderers aim to simulate these effects as closely as possible.

In this project, I wish to achieve effects of the latter nature. Using the Eulerian technique of discrete grids, I …

Reforming Our Visions Of City Nature, Lea F. Schweitz

Intersections

No abstract provided.

Disseminated Hydatid Cyst Of Liver And Lung, Nousheen Iqbal, Muhammad Hussain, Romana Idress, Muhammad Irfan

Section of Pulmonary & Critical Care

Hydatid cyst commonly affects liver followed by lung, but rarely affects both organs simultaneously. Here we presented a patient who presented with concurrent involvement of both lungs and liver. Patient presented with dyspnoea and generalised weakness with bilateral rounded opacities throughout the lung field of variable sizes. CT scan chest with contrast showed multiple rounded soft tissue density in both lungs and liver. Patient underwent mini thoracotomy which revealed multiple cystic lesions throughout lung. ELISA for anti-Echinococcusantibodies shows positive titres. Due to extensive involvement, patient was started on medical treatment albendazole. The patient showed significant improvement both clinically …

Wild Westworld: Section 230 Of The Cda And Social Networks’ Use Of Machine-Learning Algorithms, Catherine Tremble

Fordham Law Review

This Note argues that Facebook’s services—specifically the personalization of content through machine-learning algorithms—constitute the “development” of content and as such do not qualify for § 230 immunity. This Note analyzes the evolution of § 230 jurisprudence to help inform the development of a revised framework. This framework is guided by congressional and public policy goals and creates brighter lines for technological immunity. It tailors immunity to account for user data mined by ISPs and the pervasive effect that the use of that data has on users—two issues that courts have yet to confront. This Note concludes that under the revised …

Seeing The Place Makes It Real: Place-Based Teaching In The Environmental And Planning Law Classroom., Estair Van Wagner

Articles & Book Chapters

A model for place-based teaching in land use and environmental law subjects based on theoretical and experiential foundations - argues legal education should prepare legal graduates to understand and engage in the work of translation and transformation involved in land use disputes - the need for a critical approach to place-based law teaching in order to address calls for the Indigenisation and decolonization of legal education.

Predicting Mental Conditions Based On "History Of Present Illness" In Psychiatric Notes With Deep Neural Networks, Tung Tran, Ramakanth Kavuluru

Computer Science Faculty Publications

Background—Applications of natural language processing to mental health notes are not common given the sensitive nature of the associated narratives. The CEGS N-GRID 2016 Shared Task in Clinical Natural Language Processing (NLP) changed this scenario by providing the first set of neuropsychiatric notes to participants. This study summarizes our efforts and results in proposing a novel data use case for this dataset as part of the third track in this shared task.

Objective—We explore the feasibility and effectiveness of predicting a set of common mental conditions a patient has based on the short textual description of patient’s history …

Forage News [2017-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Don't Let Potash Limit Your Forages
• Cyanide Poisoning in Ruminants
• Web Survey
• Summary of 2017 KY Grazing Conference
• Fall Pasture Evaluation
• Is My Alfalfa Safe to Graze?

Volkswagen's Bad Decisions & Harmful Emissions: How Poor Process Corrupted Codetermination In Germany's Dual Board Structure, Nicola Faith Sharpe

Michigan Business & Entrepreneurial Law Review

This Article directly challenges the often argued proposition that Ger-many’s two-tier board of directors is superior to America’s single-tier board structure. It argues that regardless of structure, any decision-making body that lacks effective decision-making processes is at signifcant risk of failure, scandal, and ineffectiveness. Legal scholars and policymakers have largely ignored the connection between decision-making processes and the efficacy of corporate leadership. The Article is the first to examine this underexplored relationship in the context of the German dual-board.

Volkswagen’s 2015 emissions scandal provides a vehcicle to critcally assess the relationship between Germany’s two-tiered board and an effec-tive decision-making process. …

Evaluating Financial Integration And Cooperation In The Asean, Brendan Harvey

Michigan Business & Entrepreneurial Law Review

Financial integration is less pronounced in the ASEAN than other mea-sures of economic integration. This is particularly apparent when com-pared against other regions that have undergone similar integrative efforts, such as the European Union. Cross-border trade flows, foreign-direct in-vestment, and investment in capital goods outstrip other investment flows. Regional institutional and legal structures governing these investment flows, while limited, present marked achievements towards creating an ASEAN financial community. The gap persists despite suggestions that the Asian Financial Crisis and the Global Financial Crisis (or the North Atlan-tic Financial Crisis from the Asian and Stiglitz perspective) would acceler-ate financial regionalism as …

Property Rights In Augmented Reality, Declan T. Conroy

Michigan Telecommunications & Technology Law Review

Increasingly, cities, towns, and even rural communities are being slowly reshaped by a dynamic yet initially imperceptible phenomenon: the elaboration of augmented reality. Through applications that place virtual features over specific, real-world locations, layers of augmented reality are proliferating, adding new elements to an increasingly wide range of places. However, while many welcome the sudden appearance of arenas for battling digital creatures in their neighborhood or the chance to write virtual messages on their neighbor’s wall, the areas being augmented oftentimes are privately owned, thereby implicating property rights. Many intrusions, of course, are de minimis: an isolated, invisible Pikachu unexpectedly …

The Fox And The Goose: The Pamphlet Wars And Volpone's Animal Metaphors, Julie Anne Anderson

Theses and Dissertations

Ben Jonson wrote Volpone when England's pamphlet wars and the rule of Queen Elizabeth I contributed to an environment in which the "woman question" was forefront in many minds. These social concerns echo in Volpone, resulting in a play that not only deals with vices and greed, but that also, to a limited degree, contributes to the querelle de femmes. The play's numerous animal metaphors create distinctions between characters; among other things, animalistic surnames represent the vices and complexities of humanity, and, more specifically, reverberate with judgments that seem to underscore the injustices of misogynistic pamphleteers. Moreover, Jonson's …

The Fox And The Goose: The Pamphlet Wars And Volpone's Animal Metaphors, Julie Anne Anderson

Theses and Dissertations

Ben Jonson wrote Volpone when England's pamphlet wars and the rule of Queen Elizabeth I contributed to an environment in which the woman question was forefront in many minds. These social concerns echo in Volpone, resulting in a play that not only deals with vices and greed, but that also, to a limited degree, contributes to the querelle de femmes. The play's numerous animal metaphors create distinctions between characters; among other things, animalistic surnames represent the vices and complexities of humanity, and, more specifically, reverberate with judgments that seem to underscore the injustices of misogynistic pamphleteers. Moreover, Jonson's characters Bonario …

A Refuge For Jae-In Doe: Fugues In The Key Of English Major, Seo-Young J. Chu

Publications and Research

"A Refuge for Jae-in Doe: Fugues in the Key of English Major"

Author(s):

Seo-Young Chu (see profile)

Date:

2017

Subject(s):

Feminism, Creative nonfiction, Asian American literature, Sonnets, Social justice, Trauma

Item Type:

Essay

Tag(s):

#MeToo, Stanford, women in academia, early american

Permanent URL:

http://dx.doi.org/10.17613/cp82-8f39

Improving Access To Transit Thru Crowd Sourced Info, Cutr

Research Reports

No abstract provided.

Deseables E Indeseables: El Doble Discurso De Género En Las Representaciones De Conversos En Las Cantigas De Santa María, Robert Michael Philips

Modern Languages Theses - Archive

Con la victoria de los reinos cristianos ibéricos sobre las fuerzas almohades en las Navas de Tolosa en 1212, los cristianos tomaron control de la mayor parte de la Península Ibérica. Para consolidar su control sobre el territorio, los reinos cristianos tuvieron que instalar familias cristianas y lidiar con las poblaciones musulmanas y judías que quedaron. La política acerca de estas poblaciones no-cristianas vacilaba entre tres opciones: la tolerancia, la expulsión y la conversión. Alfonso X, El Sabio nació diez años después de la victoria en las Navas de Tolosa y fue coronado en 1252. Heredó no solo los terrenos, …

Pavarësia Editoriale E Lajmeve Në Rtk, Endrita Peqani

Theses and Dissertations

Ndikimi i televizionit në jetën tonë të përditshme është shumë i madh. Përveç ndikimit në rritje, ky punim analizon kulturën dhe sfidat e televizionit në aspektin kulturor të zhvillimit të shoqërisë në Kosovë. Duke pasur parasysh këtë dhe duke u bazuar në disa analiza studimore është kuptuar se televizioni është medium më me ndikim në Kosovë, por ka një tendencë në rritje të ndikimit të televizioni ndaj mediave sociale. Televizioni është mjet më i fuqishëm i komunikimit masiv dhe mjet më i fuqishëm i informimit. Televizioni ka rol shumë të rëndësishëm në edukimin dhe argëtimin e njeriut. Mjet të shprehjes, …

Full Issue, Indiana Audubon Quarterly

Indiana Audubon Quarterly

No abstract provided.

A Tattler Wandering Indiana: A New State Species, John Kendall, Eric Michael, Brad Bumgardner

Indiana Audubon Quarterly

No abstract provided.

November 2017 Student Handbook, Nova Southeastern University

NSU Student Handbooks

No abstract provided.

Species-Specific Metabolism Of Naphthalene And Phenanthrene In 3 Species Of Marine Teleosts Exposed To Deepwater Horizon Crude Oil, Erin Pulster, Kevan Main, Dana Wetzel, Steven Murawski

C-IMAGE Publications

The 2 most abundant polycyclic aromatic hydrocarbons (PAHs) measured in Deepwater Horizon crude oil, naphthalene and phenanthrene, and their associated homologs have both been shown to be acutely toxic in fish. Although fish have a relatively high metabolic capacity for PAHs, hydroxylated PAH (OH-PAH) derivatives formed during the initial metabolic response can negatively impact the health of fish. Species-specific metabolism of naphthalene and phenanthrene was evaluated in 3 marine teleosts, red drum (Scianops ocellatus), Florida pompano (Trachinotus carolinus), and southern flounder (Paralichthys lethostigma). Fish were exposed to Deepwater Horizon crude oil by intraperitoneal injections at time 0 and 48 h, …

2017 Nonprofit Sector Employment Trends And Career Opportunities, San Diego Workforce Partnership In Partnership With The Nonprofit Institute

Nonprofit Sector Issues and Trends

The Nonprofit sector plays a critical, but often unseen role in supporting and promoting activities that improve the lives of county residents, filling gaps in critical social services when needed. This study aims to inform the workforce development system—educational training institutions, Workforce Development Boards and community workforce development organizations—on how to best prepare the future workforce for this sector. The full report analyzes data on job growth, training gaps, hiring challenges and in-demand skills from firms in the Nonprofit sector.

Sailing Through Greek With Hanno Of Carthage, Michael L. Koneiczny

New England Classical Journal

No abstract provided.

Books Received

New England Classical Journal

No abstract provided.

Scientific Writing Class Grad Students Present Research, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Campus Chronicle, Victoria Story, Beth Lee, Barbara Fisher, Bailey Perkins, Hilary Hamilton, Anthony Arroyo, Brady Mooers, Taylor Burns, Josiah Sutton, Hannah Rothamel, Andy Langager

Campus Chronicle

No abstract provided.

November 1, 2017 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Effects Of Habitat Fragmentation On Genetic Diversity In Cycas Balansae (Cycadaceae), Tam Nguyen Minh, Trang Nguyen T. Phuong, Giang Vu T. Ha, Triest L. Triest

ASEAN Journal on Science and Technology for Development

Habitat fragmentation is a serious threat to species survival. In Vietnam, Cycas balansae has been considered as threatened species because of the reduction and fragmentation of its habitats and over-exploitation. We assessed genetic variability and the pattern of population structure among six populations sampled in four provinces: Hoa Binh, Ha Nam, Ninh Binh and Quang Ninh. Polyacrylamide gel electrophoresis was performed on leaf tissues from 152 individuals representing 6 populations of C. balansae. Six of twelve enzyme systems were used to estimate genetic diversity at population and species levels. Eleven loci were examined. The allozyme data showed high levels of …

Cysteines And N-Glycosylation Sites Conserved Among All Alphaherpesviruses Regulate Membrane Fusion In Herpes Simplex Virus 1 Infection, Paul J.F. Rider, Misagh Naderi, Scott Bergeron, Vladimir N. Chouljenko, Michal Brylinski, Konstantin G. Kousoulas

Faculty Publications

© 2017 American Society for Microbiology. Neurotropism is a defining characteristic of alphaherpesvirus pathogenicity. Glycoprotein K (gK) is a conserved virion glycoprotein of all alphaherpesviruses that is not found in other herpesvirus subfamilies. The extracellular amino terminus of gK has been shown to be important to the ability of the prototypic alphaherpesvirus herpes simplex virus 1 (HSV-1) to enter neurons via axonal termini. Here, we determined the role of the two conserved N-linked glycosylation (N48 and N58) sites of gK in virus-induced cell fusion and replication. We found that N-linked glycosylation is important to the regulation of HSV-1-induced membrane fusion …