Digital Commons Network^™

Whole Genome Sequencing In Psychiatric Disorders: The Wgspd Consortium, Stephan J. Sanders, Benjamin M. Neale, Hailiang Huang, Donna M. Werling, Joon-Yong An, Shan Dong, Goncalo Abecasis, P. Alexander Arguello, John Blangero, Michael Boehnke

School of Medicine Publications

As technology advances, whole genome sequencing (WGS) is likely to supersede other genotyping technologies. The rate of this change depends on its relative cost and utility. Variants identified uniquely through WGS may reveal novel biological pathways underlying complex disorders and provide high-resolution insight into when, where, and in which cell type these pathways are affected. Alternatively, cheaper and less computationally intensive approaches may yield equivalent insights. Understanding the role of rare variants in the noncoding gene-regulating genome, through pilot WGS projects, will be critical to determine which of these two extremes best represents reality. With large cohorts, well-defined risk loci, …

Opus Reflection: Mercy Beyond Borders In Haiti, Chris Lew

Jesuit Higher Education: A Journal

No abstract provided.

Philosophy In Our Core, Patrick Tully Ph.D.

Jesuit Higher Education: A Journal

The Jesuit (and Catholic) educational tradition is characterized by a number of identity-conferring basic positions that are incompatible with correlative positions on offer in the popular culture. Some of these fundamental differences between the tradition and the culture are philosophical in nature in that they bear on questions of moral truth and philosophical anthropology. Institutions of higher education committed to forming their students in light of these basic and counter-cultural beliefs must ensure that the incompatible cultural alternatives are carefully examined and the reasonableness of the Ignatian (Catholic) alternatives carefully explored. The discipline Philosophy plays an irreplaceable role in this …

Genetic Variation And Gene Expression Across Multiple Tissues And Developmental Stages In A Non-Human Primate, Anna J. Jasinska, Ivette Zelaya, Susan K. Service, Christine B. Peterson, Rita M. Cantor, Oi-Wa Choi, Joseph Deyoung, Eleazar Eskin, Lynn A. Fairbanks, John Blangero, Thomas D. Dyer

School of Medicine Publications

By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral …

Wap Four-Disulfide Core Domain Protein 2 Promotes Metastasis Of Human Ovarian Cancer By Regulation Of Metastasis-Associated Genes, Y Chen, L Huang, S Wang, T Liu, Et Al

Peninsula Medical School

BACKGROUND: WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. METHODS: In this study, we evaluated the role of WFCD2 in tumor mobility, invasion and metastasis of ovarian cancer in clinical tissue and in ovarian cancer cells, both in vitro and in vivo. RESULTS: Our results revealed WFCD2 was overexpressed in ovarian tissues, and the expression level of WFCD2 was associated with metastasis and lymph node metastasis. Higher expression of WFCD2 was also observed in aggressive HO8910-PM cells than in HO8910 cells, and WFCD2 knockdown halted cell migration, invasion, tumorigenicity and metastasis …

Fashion Law: More Than Wigs, Gowns, And Intellectual Property, Mark K. Brewer

San Diego Law Review

[T]his article frames the emerging field of fashion law and synthesizes its substance from an international perspective in order to raise the profile of fundamental areas in which the law and fashion intersect as well as identify key areas for future research. Part II examines the background on fashion law, initially focusing on its origins and then examining IP, traditionally the main area of the field. Additionally, the Article defines, frames, and justifies the emerging field of fashion law. Because an exhaustive analysis of the emerging trends in fashion law is beyond the scope of this Article, Part III only …

O'Erwhelmed By Noise: Soundhouses And Sonic Experiments In Ben Jonson's Epicene, Bs Frost

School of Law, Humanities and Social Sciences

No abstract provided.

The Legacy Of The Pharmacy Industry: Cleveland, Ohio, Richard Klein

MSL Academic Endeavors eBooks

This book recognizes the many business contributions made by the major Cleveland, Ohio-based drugstore chains over the past two hundred years and how their highly resourceful approaches towards marketing and retailing affected the national pharmacy industry over that same period of time.

Genetics Reveal The Identity And Origin Of The Lionfish Invasion In The Mediterranean Sea, M Bariche, P Kleitou, S Kalogirou, G Bernardi

School of Biological and Marine Sciences

Following aquarium releases, invasive lionfishes have colonized large areas of the Caribbean and western Atlantic, resulting in an immense ecological damage. The early stages of that invasion are poorly known. Indeed, a lag of time between the introduction and detection often preclude genetic characterization of that crucial phase. With elevated awareness, the recent invasion of Pterois miles was quickly detected in the Mediterranean Sea. We hereby show that the very first individuals establishing populations in the Mediterranean Sea display haplotypes that nest within the large genetic diversity of Red Sea individuals, thus indicating an invasion via the Suez Canal. We …

A Comparison Of Inferential Analysis Methods For Multilevel Studies: Implications For Drawing Conclusions In Animal Welfare Science, Kn Stevens, L Asher, K Griffin, M Friel, N O'Connell

Peninsula Medical School

Investigations comparing the behaviour and welfare of animals in different environments have led to mixed and often conflicting results. These could arise from genuine differences in welfare, poor validity of indicators, low statistical power, publication bias, or inappropriate statistical analysis. Our aim was to investigate the effects of using four approaches for inferential analysis of datasets of varying size on model outcomes and potential conclusions. We considered aggression in 864 growing pigs over six weeks as measured by ear and body injury score and relationships with: less and more enriched environments, pig's relative weight, and sex. Pigs were housed in …

"I Was Not Ready To Die Yet": William Stowell's Utah War Ordeal, Kenneth L. Alford Ph.D., R. Devan Jensen

Faculty Publications

In the fall of 1857, young wives Cynthia Jane Stowell and Sophronia Stowell bade fare­well to their husband, William R. R. Stowell, a lieutenant in the Utah militia working to hinder the US Army from entering Utah Territory. That winter they received word that William had been captured and was being held prisoner at Camp Scott, in present-day Wyoming. The Utah War arose from a complex web of causes and motivations: federal and Utah territorial authorities often clashed regarding Mormon authority and influence in the territorial court sys­tem, the mail service, policies regarding American-Indian relations, polygamy, and the moral character …

The Potential Of Raman Spectroscopy In The Diagnosis Of Premalignant Oral Lesions, Ola Ibrahim

Doctoral

Thesis submitted in partial fulfilment for the degree of Doctor of Philosophy (PhD) Technological University Dublin, School of Physics December 2017.

Legal Punishment As Civil Ritual: Making Cultural Sense Of Harsh Punishment, Professor Spearit

The Bridge: Interdisciplinary Perspectives on Legal & Social Policy

This article is an excerpt American Prisons: A Critical Primer on Culture and Conversion to Islam. The central aim of this chapter is to examine the post-civil rights push toward harsh punishment through the cultural lens of ritual. The United States is one of the most punitive countries on the planet--the country is the world leader in imprisonment and is one of the top five that executes capital defendants. However, determining the catalysts of this turn to harsh punishment has proved vexing. Scholars have adequately explained how the end of the welfare state, followed by a proliferation of drug laws, …

Enriching And Cutting: How To Visualize Networks Thanks To Linked Open Data Platforms., Lea Saint-Raymond, Antoine Courtin

Artl@s Bulletin

Networks are developing very quickly in the social sciences, and they are beginning to emerge in art history. This paper explores the making of network visualizations, from the building of the dataset to the analysis of results. Starting from an initial corpus regarding the Parisian auction sales for modern paintings, we developed a methodology to enrich it, thanks to linked open data platforms and technologies for realigning datasets. We then call into question the visualization of networks. Although it brings about an overview of the market and allows a very close reading, the best is the enemy of the good: …

Fifth Graders’ Creativity In Inventions With And Without Creative Articulation Instruction, Darcie K. Kress, Audrey C. Rule

Journal of STEM Arts, Crafts, and Constructions

Industry and authors of 21^st Century Skill Frameworks are calling for student proficiency in creativity, problem-solving, innovation, collaboration, and communication skills. This project involved 13 fifth grade gifted students in inventing products for a specified audience with a set of given materials, time limit, and topic constraints. The complex, challenging project supports Next Generation Science Engineering Process Standard 3-5-ETS1-2 and applies concepts of plant and animal adaptations. The study had a counterbalanced, repeated measures design in which student made an initial invention during the pretest, then participated in two trials with one in the control condition and the other …

Reading Nonfiction Science Literature With And Without Arts Integration Activities, Elizabeth Mccartney, Catherine Mochal, Victoria Boyd, Audrey C. Rule, Sarah E. Montgomery

Journal of STEM Arts, Crafts, and Constructions

This study explores the integration of the arts into the teaching of science nonfiction texts during literacy instruction. Sixty-one elementary students (15 second graders, 25 third graders, and 21 fifth graders) attending schools of differing socio-economic levels participated in this study. The study examined the effects of artsintegration on student content knowledge, engagement level, and attitudes toward learning regarding science nonfiction texts. Throughout the eight-week study, students experienced both the traditional no-arts control condition and the experimental arts-integration condition in two-week segments for different science topics. Both conditions employed literacy strategies to teach comprehension of science nonfiction texts. The resulting …

Examining Natural Selection By Sketching And Making Models Of The Finches Of The Galapagos Islands, Phoebe J. Z. Pittman, Jolene K. Teske

Journal of STEM Arts, Crafts, and Constructions

This practical lesson describes how students in six eighth grade science classes participated in a lesson combining the National Core Arts Standards with the Next Generation Science Standards. The goal of the lesson was to provide visual representations of finch beak form and function so students could better understand genetic variation and how environmental pressures influence natural selection. Students sketched a finch with a large, medium, or small beak, corresponding to an experiment they had conducted with picking up different sizes of seeds with different sizes of binder clips. Using modeling with a variety of media, students created bird beaks …

Middle Level Preservice Teachers Experience A Natural History Arts-Integrated Interdisciplinary Thematic Unit, Carolyn A. Weber, Audrey C. Rule

Journal of STEM Arts, Crafts, and Constructions

Curricular demands and best practices for middle school require interdisciplinary units. Arts integration can provide motivation and a new pathway to learning. This unit focused on inquiry into the natural history of artifacts and rocks recovered from the exposed subsoil of an area near Cedar Falls, Iowa that had been bulldozed as part of subdivision development. The described unit involved preservice teachers in exploration of all subject areas (language arts, mathematics, science, and social studies) with arts-integrated projects (agate watercolor painting, stone tool graphing, acrylic polymer clay agate keyring making, and stone tool drawings). The content area activities for social …

How The Arts Standards Support Stem Concepts: A Journey From Stem To Steam, Ksenia S. Zhbanova

Journal of STEM Arts, Crafts, and Constructions

This issue of the Journal of STEM Arts, Crafts, and Constructions is focused on the effects of integrating arts with STEM areas, an important and widely-considered topic in education today. This editorial provides an overview of the current state of the arts and STEM areas integration paradigm, an analysis of the benefits of the arts integration with the STEM subjects, and an overview of the history of the arts anchor standards. Comparison and connections between the National Arts Core anchor arts standards, the scientific method, engineering design process, and the 5E learning cycle are also illuminated. Summaries of the practical …

Competing Narratives: Dordt Students Encounter The Land Of Israel, Sally Jongsma, Aleisa Dornbierer-Schat

The Voice

No abstract provided.

The Ecowas Court, Activist Forces, And The Pursuit Of Environmental And Socioeconomic Justice In Nigeria, Okechukwu Emmanuel Effoduh

LLM Theses

The thesis has two objectives. The first (and central) objective is to examine the Community Court of Justice of the Economic Community of West African States, or ECOWAS Court (a sub-regional international court in West Africa), and its role within the West African region, especially how the Court has served as a resource for the Activist Forces that operate in the sub-region, in their pursuit of Environmental and Socioeconomic Justice in Nigeria. The second goal of this thesis, which is ancillary to the first, is to investigate the Courts jurisprudence in three landmark cases: SERAP v. Nigeria & Anor (2010); …

Hamill Honored For Her Leadership With The Association For The Advancement Of Health Education, Winthrop University

Winthrop News 2017

• Shelley Hamill, a professor of health and physical education, chaired the S.C. Health and Safety Education Standards Review/Writing Committee in updating the health education standards for K-12 public schools.
• Hamill provided leadership to guide the committee process and followed up with staff at the Department of Education to make sure the committee’s recommendations moved through the approval process.

Bio Buzz Newsletter, Issue 14, November 2017, Department Of Biology

Biology Buzz Newsletter

Denison University, Department of Biology newsletter for Fall 2017.

Chanticleer | November 30, 2017, Jacksonville State University

Chanticleer

No abstract provided.

November 30, 2017, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Mary In The News: Nov. 30, 2017, Michael Duricy

Marian Library Blog Archive

Read recent items about Mary in both Catholic and secular news. Also, see International Marian Research Institute news and updates.

Humanitarian Mine Action And Ieds, Craig Mcinally, Hans Risser

The Journal of Conventional Weapons Destruction

Norwegian People’s Aid (NPA) has been operational in improvised explosive device (IED) clearance in Hamdaniya, Iraq, since January 2017. Additionally, MAG (Mines Advisory Group) has operated in the same area clearing IEDs since September 2015 and has had operations in many parts of both Iraq and Syria. Other nongovernmental organizations (NGO) clearing IEDs include Handicap International and the Swiss Foundation for Mine Action (FSD). Without question, IED clearance is now an established part of humanitarian mine action (HMA). Yet this does not mean HMA should adopt the full spectrum of IED disposal (IEDD) operations. Rather, NGOs can provide invaluable capacity …

The Goat Ate The Butter, Nicole Pope

USU Student Folklore Fieldwork

Ok, so you know we had goats that were about you know we had some billy goats and I think we had at least one you know female goat and you know and we and they you know anyway one time my one of my brothers or maybe it was me you know we went out and did our chores and we didn't get the gate out in the field shut all the way and so well it didn't latch. the gate was shut but it didn't get latched so the goat was able to nudge the gate with its …

Ua12/2/1 College Heights Herald, Vol. 93, No. 26 [27], Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Alvey, Rebekah. Finding His Way – Timothy Caboni
• Coyle, Cameron. WKU Police Department Builds Trust with More Diverse Force
• Ziege, Nicole. Student Government Association Discusses Strategic Planning, Passes Two Bills
• Lee, David. College Heights Herald Reserve Fund
• King, Jennifer. Editorial Cartoon re: Responsibility
• Ho Ho Herald – Christmas Gifts
• Leonard, Nicole. Gender Disparities Impact Health Care Policy
• Semester Recap
• Fletcher, Griffin. Mr. Devastating: Male Pageant Aims to Defy Sexism – Delta Sigma Theta
• Mohr, Olivia. New Restaurant Hickory & Oak to Come to Town
• Moore, …

Effect Of Health Education On Community Participation To Eradicate Aedes Aegypti-Breeding Sites In Buahbatu And Cinambo Districts, Bandung, Zahratul Elsa, Uun Sumardi, Lia Faridah

Kesmas

Dengue hemorrhagic fever (DHF) is still a major public health problem in many regions in Indonesia including Bandung City. Community participation in implementing Eradication of Mosquito-Breeding Sites is still needed as it is considered the most effective method in controlling the dengue fever. This study aimed to determine the influence of health education towards community participation to eradicate mosquito-breeding sites, which was measured by knowledge level and larva index conducted in Bandung, specifically in two different locations with the highest and the lowest incidence rates of DHF. This study used quasi-experimental method. Samples were 100 people living in Cijawura and …