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2016

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Morphological Assessment Of The Retina In Uveitis., Michael M. Altaweel, Sapna S. Gangaputra, Jennifer E. Thorne, James P. Dunn, Susan G. Elner, Glenn J. Jaffe, Rosa Y. Kim, P. Kumar Rao, Susan B. Reed, John H. Kempen Dec 2016

Morphological Assessment Of The Retina In Uveitis., Michael M. Altaweel, Sapna S. Gangaputra, Jennifer E. Thorne, James P. Dunn, Susan G. Elner, Glenn J. Jaffe, Rosa Y. Kim, P. Kumar Rao, Susan B. Reed, John H. Kempen

Wills Eye Hospital Papers

BACKGROUND: The objective of this study is to describe a system for color photograph evaluation in uveitis and report baseline morphologic findings for the Multicenter Uveitis Steroid Treatment (MUST) Trial. Four-hundred seventy-nine eyes of 255 subjects with intermediate, posterior, and panuveitis had stereoscopic color fundus photographs obtained by certified photographers and evaluated by certified graders using standardized procedures to evaluate morphologic characteristics of uveitis. The posterior pole was evaluated for macular edema, vitreoretinal interface abnormalities, and macular pigment disturbance/atrophy; the optic disk was assessed for edema, pallor, or glaucomatous changes. The presence of neovascularization, vascular occlusion, vascular sheathing, and tractional …

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Matthew's Least Brothers And It's Application In The Catholic Church, Runbao Zhang Dec 2016

Matthew's Least Brothers And It's Application In The Catholic Church, Runbao Zhang

School of Theology and Seminary Graduate Papers/Theses

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Songs From The Willow Tree: Staging Collective Inspiration For Creative Songwriting, Aubrey W. Carpenter Dec 2016

Songs From The Willow Tree: Staging Collective Inspiration For Creative Songwriting, Aubrey W. Carpenter

Undergraduate Honors Theses

The songwriting process, inspiration to song, can take many forms. This project explores a highly structured approach, using themes derived from reported individual experience to direct the creation of musical ends addressing common experience.

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Design, Construction, And Preliminary Testing Of A Square Cross-Sectional Mixing Chamber, Holly Holmes-Smith Dec 2016

Design, Construction, And Preliminary Testing Of A Square Cross-Sectional Mixing Chamber, Holly Holmes-Smith

Chemical Engineering Undergraduate Honors Theses

Throughout the US, large quantities of chlorine are produced and transported by rail. In the past, train accidents led to deadly accidental releases and the need for mass evacuation. However, moving people unnecessarily may cause pandemonium or danger to health for sensitive members of the public. In these past cases, the models used for evacuation distances did not accurately predict the impact of the chlorine release, but these models did not take into account the reactivity of chlorine. Because chlorine is a highly reactive gas, it is absorbed into the surrounding environment which reduced the amount of chlorine in the …

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Cryogenic Viscous Liquids On Icy Moons, Danielle Neighbour Dec 2016

Cryogenic Viscous Liquids On Icy Moons, Danielle Neighbour

Civil Engineering Undergraduate Honors Theses

The study of cryogenically viscous liquids such as methane and ethane offers critical insight into the behavior of fluids on icy moons such as Saturn’s moon Titan. Shrouded by a hazy hydrocarbon shield, Titan’s significant nitrogen atmosphere of 1.5 bar, methane-driven hydrological cycle, and lakes and rivers are vaguely similar to our Earthly home. The European-created Huygens probe, carried by the Cassini spacecraft, arrived on Titan’s surface in January 2005 [1]. Upon landing, Huygens photographed its landing site, as seen in Figure 1. The photo depicts rock like objects, thought to be comprised of water ice sitting in a dry …

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Galaxy And Mass Assembly (Gama) : Detection Of Low-Surface-Brightness Galaxies From Sdss Data., Richard P. Williams, I. K. Baldry, L. S. Kelvin, P. A. James, S. P. Driver, M. Prescott, S. Brough, M. J. I. Brown, L. J. M. Davies, Benne W. Holwerda, J. Liske, P. Norberg, A. J. Moffett, A. H. Wright Dec 2016

Galaxy And Mass Assembly (Gama) : Detection Of Low-Surface-Brightness Galaxies From Sdss Data., Richard P. Williams, I. K. Baldry, L. S. Kelvin, P. A. James, S. P. Driver, M. Prescott, S. Brough, M. J. I. Brown, L. J. M. Davies, Benne W. Holwerda, J. Liske, P. Norberg, A. J. Moffett, A. H. Wright

Faculty and Staff Scholarship

We report on a search for new low-surface-brightness galaxies (LSBGs) using Sloan Digital Sky Survey (SDSS) data within the Galaxy And Mass Assembly (GAMA) equatorial fields. The search method consisted of masking objects detected with SDSS photo, combining gri images weighted to maximize the expected signal-to-noise ratio, and smoothing the images. The processed images were then run through a detection algorithm that finds all pixels above a set threshold and groups them based on their proximity to one another. The list of detections was cleaned of contaminants such as diffraction spikes and the faint wings of masked objects. From these, …

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Associations Between Teacher-Reported School Climate And Depressive Symptoms In Australian Adolescents : A 5-Year Longitudinal Study., Patrick Pössel, Christopher Rakes, Kathleen Moritz Rudasill, Michael G. Sawyer, Susan H. Spence, Jeanie Sheffield Dec 2016

Associations Between Teacher-Reported School Climate And Depressive Symptoms In Australian Adolescents : A 5-Year Longitudinal Study., Patrick Pössel, Christopher Rakes, Kathleen Moritz Rudasill, Michael G. Sawyer, Susan H. Spence, Jeanie Sheffield

Faculty and Staff Scholarship

Adolescent depression is serious and common. As adolescents spend approximately 15,000 h in school, this setting is a logical place to seek etiological factors. Research suggests there are negative associations between school climate and adolescent depressive symptoms. However, such studies typically use student reports of both climate and depressive symptoms; this is problematic because common method variance results when the same individual provides information on all variables, contributing to overestimations of associations between depressive symptoms and school climate. Therefore, the purpose of this study is to examine the association between teacher-reported school climate and adolescent-reported depressive symptoms. Thus, 2545 Australian …

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The Role Of Biotic And Environmental Factors In Spatial And Temporal Variability Of Indian River Lagoon Copepod Communities, Hannah G. Kolb Dec 2016

The Role Of Biotic And Environmental Factors In Spatial And Temporal Variability Of Indian River Lagoon Copepod Communities, Hannah G. Kolb

Theses and Dissertations

The role of zooplankton communities as the link between phytoplankton and secondary consumers is dependent on the species make-up of the copepod community. Copepods often dominate zooplankton in numbers and biomass and are frequently the dominant grazers. Species variabilities in behavioral and morphological traits, and seasonal variances in species make-up, have the potential to alter trophic dynamics in planktonic communities. The goal of this study was to identify the driving forces behind copepod community composition and better understand the role of key species in the Northern Indian River Lagoon (N-IRL). Copepods made up 76% of the N-IRL zooplankton community and …

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Influence Of Ndbc Buoy Design On Sea Surface Temperature Trends In The Coastal United States, Alexander Keith Nickerson Dec 2016

Influence Of Ndbc Buoy Design On Sea Surface Temperature Trends In The Coastal United States, Alexander Keith Nickerson

Theses and Dissertations

The sea surface temperature (SST) record is the one of the oldest climate records, stretching back to 1662. Since that time, voluntary observing ships (VOSs) have been including these data in their ship‘s log. Due to the sparseness of VOS data, moored buoys were created to provide data at regular intervals in order to provide a more continuous record with data collection unaffected by human error. The SST sensor in National Data Buoy Center (NDBC) buoys is inside a hull and not in direct contact with the ocean. Thus, the design of the buoy may subject them to additional biases …

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Indonesian Women’S Health Determinants, Victoria A. Mcgrady Dec 2016

Indonesian Women’S Health Determinants, Victoria A. Mcgrady

Theses and Dissertations

This study utilized the Indonesian Family Life Survey 5 to investigate the relationships between broad health outcomes and selected biopsychosocial measures. The study population was comprised of 17,480 Indonesian women who ranged in age from 15 years to 103 years with a mean age of 38.27 years. The results of this study showed the biopsychosocial model of health is valid for Indonesian women. Results supported the assumption that the measures of physical health (acute morbidity and medically diagnosed chronic conditions) are significantly correlated with the measures of psychological health (depression, and subjective wellbeing). Results also supported the assumption that biopsychosocial …

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Environmental Signaling Through The Target Of Rapamycin Complex 1 (Torc1) And The Regulation Of Epigenetic Mechanisms, Jason J. Workman Dec 2016

Environmental Signaling Through The Target Of Rapamycin Complex 1 (Torc1) And The Regulation Of Epigenetic Mechanisms, Jason J. Workman

Theses and Dissertations (ETD)

The gene expression profile of a eukaryotic cell is responsive to a variety of extracellular stimuli, including nutrient availability, which allows cells to toggle between anabolism and catabolism based on the favorability of their environment. Much of this information is relayed through signaling complexes, such as the target of rapamycin complex 1 (TORC1), to downstream chromatin modifying enzymes. These enzymes impact the gene regulatory process through altered histone post-translation modifications, changes in chromatin structure, and docking of chromatin regulatory complexes. Yet, despite preliminary studies suggesting that TORC1 affects epigenetic mechanisms, including histone H3 lysine 56 acetylation (H3K56ac), almost nothing is …

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Role Of Occludin In The Regulation Of Epithelial Tight Junctions, Bhargavi Manda Dec 2016

Role Of Occludin In The Regulation Of Epithelial Tight Junctions, Bhargavi Manda

Theses and Dissertations (ETD)

Tight junctions (TJ) constitute the primary component of epithelial barrier function, a disruption of which is involved in the pathogenesis of many gastrointestinal, pulmonary and renal diseases. Occludin is the major transmembrane protein of TJ, a deletion of which leads to a complex phenotype including chronic inflammation in several epithelial tissues of occludin deficient mice and poor TJ integrity in epithelial cell lines. Its down regulation was seen in Crohn’s disease, tumors of the colon, brain, endometrium and breast cancer. Occludin is also known to be a target that enables Hepatitis C Virus infection and bacterial pathogenesis. But the specific …

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Regulation Of Cancer Metastasis By Protein Kinase D1: A Global Regulatory Cascade, Aditya Ganju Dec 2016

Regulation Of Cancer Metastasis By Protein Kinase D1: A Global Regulatory Cascade, Aditya Ganju

Theses and Dissertations (ETD)

Protein Kinase D1 (PKD1) is a serine threonine kinase which is downregulated in Prostate, Breast and Colon Cancer. It functions as a tumor suppressor in different cancer cells. Downregulation of PKD1 is known to be associated with aggressiveness of the cancer. PKD1 is known to regulate many key oncogenic signaling pathways such as E-cadherin, β-catenin and Androgen Receptor signaling pathways. Aberrant expression of these oncogenic pathways leads to transformation of cells from normal to malignant phenotype, thereby leading to increased proliferation, growth and metastasis to distant organs of these cancer cells. Literature evidence also points to the fact that E-cadherin …

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The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation With Arginine-Rich Nucleolar Proteins Through Weak, Multivalent Electrostatic Interactions, Jaclyn Alicia Cika Dec 2016

The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation With Arginine-Rich Nucleolar Proteins Through Weak, Multivalent Electrostatic Interactions, Jaclyn Alicia Cika

Theses and Dissertations (ETD)

Nucleoli are nuclear membrane-less organelles that are the sites for ribosome biogenesis and serve as sensors of cellular stress. Weak, multivalent protein-protein interactions and interactions between disordered, low complexity domains (LCDs) and rRNA have been shown to promote liquid-liquid phase separation (LLPS) in vitro, suggesting a basis for the liquid-like behavior of nucleoli. Nucleophosmin (NPM1), a multifunctional and highly abundant nucleolar protein, exhibits structural features associated with LLPS suggesting a role in nucleolar organization. Specifically, NPM1 forms a pentamer through its N-terminal oligomerization domain and can bind to rRNA through its C-terminal nucleic acid binding domain. Multiple acidic tracts throughout …

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Dissecting The Physiological Roles Of Ulk1/2 In The Mouse Brain, Bo Wang Dec 2016

Dissecting The Physiological Roles Of Ulk1/2 In The Mouse Brain, Bo Wang

Theses and Dissertations (ETD)

Mammalian UNC-51–like kinases 1 and 2 (ULK1 and ULK2), Caenorhabditis elegans UNC-51 and Drosophila melanogaster Atg1 are redundant serine/threonine kinases that regulate flux through the autophagy pathway in response to various types of cellular stress. C. elegans UNC-51 and D. melanogaster Atg1 also promote axonal growth and defasciculation, and disruption of these genes results in defects in axon guidance in invertebrates. Germline Ulk1/2-deficient mice die perinatally. Therefore, we used a conditional-knockout approach to investigate the roles of ULK1/2 in the brain. Mice lacking Ulk1 and Ulk2 in their central nervous systems (CNS) showed defects in axonal pathfinding and defasciculation affecting …

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Endosomal Trafficking As A Determinant Of Antifungal Tolerance In The Pathogenic Fungus Candida Albicans, Arturo Luis Luna Dec 2016

Endosomal Trafficking As A Determinant Of Antifungal Tolerance In The Pathogenic Fungus Candida Albicans, Arturo Luis Luna

Theses and Dissertations (ETD)

Several important antifungal drugs inhibit the synthesis of ergosterol, a lipid that modulates the thickness, fluidity and permeability of fungal cell membranes. These include the azole antifungals, which block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of ‘toxic’ sterol intermediates are both thought to cause plasma membrane dysfunction and ultimately growth arrest. However, the effects of ergosterol depletion upon the function of intracellular membranes and organelles are not well described. The purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole, …

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Examining The Associations Between Depressive Symptoms, Body Mass Index, And Physical Activity Self-Efficacy In African American Mother-Child Dyads, Y'Esha Vonyae Williams Dec 2016

Examining The Associations Between Depressive Symptoms, Body Mass Index, And Physical Activity Self-Efficacy In African American Mother-Child Dyads, Y'Esha Vonyae Williams

Theses and Dissertations (ETD)

In recent decades the prevalence of childhood and adult depression and obesity has increased worldwide. Multiple factors influence the onset of both depression and obesity. Individual manifestations of depressive symptomatology and health-related problems associated with obesity vary; however, genetics and environmental and psychological factors have been implicated as correlates. Consequently, both disorders can ultimately interfere with individuals’ activities of daily living and decrease their quality of life. African American women are known to have a higher prevalence of obesity and more severe depressive symptoms in comparison to Caucasian women. Likewise, African American children are more obese and experience many factors …

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Understanding The Historical Diversification Of Valerianacea, Taylor Lebourgeois Dec 2016

Understanding The Historical Diversification Of Valerianacea, Taylor Lebourgeois

Senior Honors Theses

Ecologists and evolutionary biologists have long recognized that species diversity is unequally distributed among angiosperm lineages. For example, various plant clades found in the Andes have been proposed as examples of rapid radiations, and the Andes are recognized as one of the Earth’s biodiversity “hotspots”. Species within Valerianaceae, found in the South American Andes, appear to be an example of such a rapid radiation. Although much attention has been paid to the phylogeny of the South American species of Valerianaceae, there is still a great deal of uncertainty regarding species relationships. Several subgroups within the Andean Valerians have, either not …

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Research Based Recommendation: Effective Parent Advocacy For Students Who Are Twice-Exceptional, Academically Gifted With Autism, Tara Kennedy Dec 2016

Research Based Recommendation: Effective Parent Advocacy For Students Who Are Twice-Exceptional, Academically Gifted With Autism, Tara Kennedy

Senior Honors Theses

This thesis’s purpose is twofold. The first purpose is to present both information about what twice-exceptionality is and to make recommendations based on the existing research as to how parents or guardians can become more effective advocates and advocate for effective programming and services for their children who are twice-exceptional. While this thesis focuses on a specific subset of twice-exceptional students, those who are both gifted and have autism, a good deal of the material presented will be applicable to children who are gifted with learning disabilities. Effective parent advocacy looks the same across exceptionalities: producing the best educational experience …

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Effects Of Negative Online Word-Of-Mouth On Consumer Evaluations Of An Underdog Brand, Anja P. Luethi Dec 2016

Effects Of Negative Online Word-Of-Mouth On Consumer Evaluations Of An Underdog Brand, Anja P. Luethi

Senior Honors Theses

Research on underdogs has suggested that consumers feel sympathy for and a desire to support the underdog. However, it is unclear how their evaluations of the underdog will change if they receive negative information about it. The current research aims to explore the role of negative word-of-mouth of the underdog, compared to the top dog, in consumers’ brand attitude, brand value, and purchase intention. Specifically, drawing on two streams of research, two competing hypotheses are proposed and tested. An experiment was conducted with online consumer panel members. Consistent with confirmation bias and familiarity principle, the results supported a hypothesis that …

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The Great Radical Dualism: Locating Margaret Fuller’S Feminism In Nathaniel Hawthorne’S Fiction, Renee Michele Vincent Dec 2016

The Great Radical Dualism: Locating Margaret Fuller’S Feminism In Nathaniel Hawthorne’S Fiction, Renee Michele Vincent

Senior Honors Theses

The purpose of this thesis is to establish a foundation built on the congruencies between Margaret Fuller’s feminist theory and Nathaniel Hawthorne’s fiction, with the aim of addressing two major points: first, the implications of universalizing gender in the context of identity politics; and second, to show how gender universality is challenged within Hawthorne’s fiction and Fuller’s prose. Given that Nathaniel Hawthorne’s characters depict a range of personal variability, the act of synthesizing Margaret Fuller’s feminist theory with Hawthorne’s fiction functions to link the personal with the political. The overall goal of this study is to substantiate both writers within …

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The Color Of Dreams, Claudia N. Smith Dec 2016

The Color Of Dreams, Claudia N. Smith

Senior Honors Theses

No abstract provided.

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Multi-Axial Fiber Optic Reference Strain Sensor For Flexible Dynamics Of Structures, Gabriel Lapilli Dec 2016

Multi-Axial Fiber Optic Reference Strain Sensor For Flexible Dynamics Of Structures, Gabriel Lapilli

Theses and Dissertations

Launch vehicles are in an ever-decreasing weight trend, with bodies becoming more slender to reduce aerodynamic loading. Mass and stiffness tend to be opposing concepts when designing launch vehicles: a stiffer structure means it is usually heavier. Lower stiffness on launch vehicles may produce excessive vibrations during flight, reducing the performance, operating characteristics and safety margins of the vehicle. It also impacts flight dynamics: as the vehicle flies, the orientation of its thrusters and actuators are impacted by the vibrations, creating potential instabilities in the control schemes. This is currently accounted for by using single-point inertial measurements and feeding the …

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Maintenance And Improvement Of The Florida Public Hurricane Loss Model, Nicholas Wayne Miller Dec 2016

Maintenance And Improvement Of The Florida Public Hurricane Loss Model, Nicholas Wayne Miller

Theses and Dissertations

The Florida Public Hurricane Loss Model (FPHLM) predicts insurance losses due to hurricane events. This thesis describes maintenance tasks of the vulnerability component of the FPHLM. First, it explores the applicability of recent experimental research to the FPHLM opening protection, water intrusion, and roof pressure modeling features of the Personal Residential (PR) and Commercial Residential Low-Rise (CR-LR.) models. These changes were not implemented because either more experimental data is needed or they had no impact on the losses. Next, it discusses an additional update to the CR-LR model that changed the soffit area calculations, sampling bounds within the rain model, …

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A Study To Develop An Electronics Chassis Compound Cylinder Pressure Vessel Using Finite Element Modeling, Gordon Randall Straley Dec 2016

A Study To Develop An Electronics Chassis Compound Cylinder Pressure Vessel Using Finite Element Modeling, Gordon Randall Straley

Theses and Dissertations

This thesis develops a process to design and analyze a two-layer compound cylinder pressure vessel utilizing an inner insert to house electronic circuit card assemblies. The process begins with sizing and analysis of a compound cylinder based on analytical formulas and progresses in complexity to a 2-Dimensional plane stress finite element model of the chassis assembly and ends with a computationally expensive 3-Dimensional finite element analysis of the pressure vessel. Comparing the results from the compound cylinder to the electronics chassis, it is observed that the inner insert geometry has a strong influence on the interfacial pressure at the upper …

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An Improved Fuel Spray Breakup Model For Advanced Internal Combustion Engine Configurations, Chitra Sadanandan Dec 2016

An Improved Fuel Spray Breakup Model For Advanced Internal Combustion Engine Configurations, Chitra Sadanandan

Theses and Dissertations

Lack of oil resources and increasing effects of global warming have emphasized and led to stricter regulation standards. To meet the current demands, the engines need to be highly efficient in terms of fuel efficiency and performance. One of the fundamental ways to achieve this goal is by studying the fuel atomization and the combustion process. However, there are several challenges involved in studying the process of atomization and combustion only through experimental approaches as they involve numerous parameters. A suitable supplement or alternative to the experimental approach is the numerical approach. Advances in high performance computing, have led to …

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The Design Of An Articulating Five-Headed In-Water Grooming Tool To Maintain Ships Free Of Fouling, Caglar Erdogan Dec 2016

The Design Of An Articulating Five-Headed In-Water Grooming Tool To Maintain Ships Free Of Fouling, Caglar Erdogan

Theses and Dissertations

Biofouling is a major concern to ship owners. Biofouling increases hull roughness, increasing the frictional resistance and fuel consumption while decreasing maximum speed. Finding a way to maintain hulls free from fouling has, therefore, become a research challenge for scientists and engineers. Grooming has been proposed as a novel method for controlling fouling (Tribou and Swain 2010). It refers to the regular proactive light cleaning to maintain the hull free of fouling with minimal impact to ship coatings. The purpose of this thesis is to design, build, and deploy a compliant multiheaded grooming tool which utilized five polypropylene vertically rotating …

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Making Sense Of Sound: Fourth Graders Use Physical And Technological Models To Illustrate And Explain The Nature And Characteristics Of Sound, Deepika Menon, Deanna Lankford Dec 2016

Making Sense Of Sound: Fourth Graders Use Physical And Technological Models To Illustrate And Explain The Nature And Characteristics Of Sound, Deepika Menon, Deanna Lankford

Department of Teaching, Learning, and Teacher Education: Faculty Publications

From the earliest days of their lives, children are exposed to all kinds of sound, from soft, comforting voices to the frightening rumble of thunder. Consequently, children develop their own naïve explanations largely based upon their experiences with phenomena encountered every day (Driver et al. 1994). When new information does not support existing conceptions, explanations are refashioned to agree with prior experiences, often resulting in misconceptions (Wesson 2001). Science education literature identifies multiple misconceptions related to sound commonly held by elementary students, including: Sound can only travel through air and not through solids and liquids; sound can travel through a …

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The Impact Of Sports Participation On The Academic Achievement Of African American Girls, Sarita Singleton Dec 2016

The Impact Of Sports Participation On The Academic Achievement Of African American Girls, Sarita Singleton

Doctoral Dissertations and Projects

Although there are several educational benefits resulting from participation in high school sports, African American students do not always experience the positive outcomes that other populations share. The purpose of this causal comparative study was to investigate the effect of athletic participation on the academic achievement of African American high school female students. The sample consisted of 100 female African American 12th-grade students. Descriptive statistics were collected and analyzed. Analysis involved archival data to determine the grade point averages and graduation rates of student athletes and non-athletes in two urban high schools in Georgia. The study sought to determine if …

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Life Satisfaction: A Study Of Engagement And The Academic Progress Of High School Students With Specific Learning Disabilities, Rebecca Dilling Dec 2016

Life Satisfaction: A Study Of Engagement And The Academic Progress Of High School Students With Specific Learning Disabilities, Rebecca Dilling

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand how high school students with specific learning disabilities describe life satisfaction and its impact on student motivation, academic engagement, and academic progress. Bruner’s constructivist theory guided this research. Other theories included: Piaget’s cognitive development theory, Bronfenbrenner’s ecological theory, Vygotsky’s social learning theory, Erikson’s psychosocial development theory, Maslow’s hierarchy of needs theory, Bowlby’s attachment theory, Dewey’s brain-based learning theory, Glasser’s control theory of motivation, Bandura’s social cognitive theory, Deci and Ryan’s self-determination theory, and Bandura’s self-efficacy theory. Data collection tools included the researcher’s journal, classroom observations, student interviews, two student focus …

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