Digital Commons Network^™

Mechanistic Studies In Heterogeneous Catalysis Via In Situ Ft-Ir Spectroscopy, Joseph William Magee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Dependence on a finite supply of fossil fuel-based energy sources has provided motivation for research in and development of alternative, renewable energy sources. A strong candidate as an alternative fuel is ethanol. Ethanol has a high energy density, low toxicity, and as a liquid, compatibility with the existing fuel delivery infrastructure. When considering the possibility of using ethanol as a fuel, both synthetic methods to produce ethanol and reactions that convert ethanol to energy should be optimized. One method to produce ethanol is through the conversion of synthesis gas, or syngas, (CO + H2). Currently, syngas conversion is used to …

Synthesis Of New Generation Taxoid Anticancer Agents And Dendrimer-Based Multifunctional Conjugates For Tumor-Targeting Drug Delivery, Yi Sun

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Cancer remains the second leading cause of death in the United States. Although tremendous efforts have been made in the area of cancer therapy, there is still no common cure for cancer. Paclitaxel, which is a microtubule stabilizer, is used as an antitumor agent against several cancers such as ovarian, lung, and breast cancer. However, paclitaxel shows poor antitumor activities against drug resistant cell lines, and may cause undesirable side effects. Over the past decades, significant achievements have been made in the development of new generation taxoids that exhibit increased cytotoxicity against resistant cancer cell lines. Additionally work has been …

Development Of Antitubercular Agents Targeting Ftsz And Antinociceptive Agents Targeting Fatty Acid Binding Proteins (Fabp), Simon Tong

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Tuberculosis, responsible for 1.5 million deaths worldwide in 2014, is treated using first and second line drugs. The repertoire of treatments has remained virtually static for decades, but the prevalence of drug resistance has increased. The rise of MDR- and XDR-TB has rendered current treatments ineffective, and new anti-tubercular agents with unique mechanisms of action are needed to overcome this hurdle. Filamenting temperature-sensitive mutant Z (FtsZ) is an essential bacterial cell division protein and a promising target. Inhibition of FtsZ will disrupt cell division, killing bacterial cells. Libraries of 2,5,6- and 2,5,7-trisubstituted benzimidazoles were previously synthesized and tested against Mtb …

Overcoming Element Quality Dependence Of Finite Element Methods, Rebecca Conley

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The finite element methods (FEM) are important techniques in engineering for solving partial differential equations, especially on complex geometries. One limitation of the classical FEM is its heavy dependence on element shape quality for stability and good performance. We introduce the Adaptive Extended Stencil Finite Element Method (AES-FEM) as a means to overcome this dependence on element shape quality. Our method replaces the traditional basis functions with a set of generalized Lagrange polynomial (GLP) basis functions, which we construct using local weighted least-squares approximations. The method preserves the theoretical framework of FEM, and allows imposing essential boundary conditions and integrating …

Estimation And Detection Of Network Variation In Intraday Stock Market, Shanshan Li

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The last few years have witnessed an exponential growth in the collection and analysis of financial market data. Investigating the interactions between the dynamics of the financial system and extracting useful information from these multivariate data streams can help us in improving our understanding of the underlying backbone in the financial market. These massive noisy data sets require the application of suitable and efficient dependency measurements for their analysis in a real-time environment. And that is why network analysis has emerged recently, which is a plausible representation helps interpret the hidden interconnection between the elements in large datasets. However, most …

The Music Of Romantic Poetry And The Mediation Of Romanticism, Matthew J. Gilbert

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In the poetry of British Romanticism, “music†has a significance that stretches across versification, figurative conceits, rapidly evolving generic modes, song lyrics, the cultural practice of music, impassioned recitation, the conspicuous silence of print, and the sale of printed books—in other words, an interrelated spectrum of issues that reaches through formalism to historicism and beyond. Music’s relevance to various romantic cultures, as well as its many tropes and topoi, mirrors a conceptual versatility that poets found abundantly instrumental when sitting down (or walking along) to contemplate the relation of self and craft, craft and culture, and, above all, sound and …

The Macro- And Micro-Anatomy Of Primate Volar Surfaces, Amanda Kathryn Kingston

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The soft tissues of the volar surfaces of primate hands and feet are the primary point of interaction between an individual animal and its environment and, as such, are likely to be under strong functional selection. These tissues serve three major functions: 1) force attenuation – the volar fat pads assist in attenuating reaction forces generated during grasping locomotion; 2) friction enhancement – the volar fat pads also act as viscoelastic surfaces that increase the coefficient of friction between the pads and substrate at low body weights; in addition, the ridged volar skin interlocks with and thus increases friction with …

Queen Victoria's Shadows, Anthony Teets

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation discusses how Victorian writers, artists, and critics represent historical queens as shadows of Queen Victoria throughout her long reign (1837-1901). Focusing on Victorian representations of four queens—Catherine de Medici, Mary Stuart, Queen Elizabeth I, and Marie-Antoinette—this project seeks to establish a literary genealogy by showing how British writers drew upon historical interpretations of dead French and English queens to express psychological ambivalence, political anxiety about female monarchy, national, confessional difference, and complex sexual and erotic dimensions. Rather than approach these queens as historical persons, this dissertation concentrates on the literary, figural, and spectral qualities that translate unevenly across …

Operating In A Fallen Vehicle: How The Corrupted Language Of Paradise Lost Serves Milton's God, Steven Telano

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This essay explores the significance of Milton’s use of poetic language, the cultural byproduct of what would be considered fallen language, in Paradise Lost as a means to highlight God’s uniqueness from the other beings of the poem, including the Speaker, and thus bolstering his goal to justify the ways of God to man. By looking at all of the different beings in this poem as existing in a hierarchical structure, it becomes apparent that the further a being exists away from God, who exists as the purest being of the hierarchy and is therefore placed at the top, the …

Indoor Inhalation Intake Fractions Of Fine Particulate Matter: Review Of Influencing Factors, Natasha Hodas, Miranda Loh, Hyeong-Moo Shin, Dingsheng Li, Deborah Bennett, Thomas E. Mckone, Olivier Jolliet, Charles J. Weschler, Matti J. Jantunen, Paul Lioy, Peter Fantke

Environmental Science and Management Faculty Publications and Presentations

Exposure to fine particulate matter ( PM2.5) is a major contributor to the global human disease burden. The indoor environment is of particular importance when considering the health effects associated with PM2.5 exposures because people spend the majority of their time indoors and PM2.5 exposures per unit mass emitted indoors are two to three orders of magnitude larger than exposures to outdoor emissions. Variability in indoor PM2.5 intake fraction ( iFin,total), which is defined as the integrated cumulative intake of PM2.5 per unit of emission, is driven by a combination of building-specific, human-specific, and pollutant-specific factors. Due to a limited …

Reduced Snow Cover Alters Root-Microbe Interactions And Decreases Nitrification Rates In A Northern Hardwood Forest, Patrick O. Sorensen, Pamela H. Templer, Lynn M. Christenson, Jorge Durán, Timothy J. Fahey, Melany C. Fisk, Peter M. Groffman, Jennifer L. Morse, Adrien C. Finzi

Environmental Science and Management Faculty Publications and Presentations

Snow cover is projected to decline during the next century in many ecosystems that currently experience a seasonal snowpack. Because snow insulates soils from frigid winter air temperatures, soils are expected to become colder and experience more winter soil freeze-thaw cycles as snow cover continues to decline. Tree roots are adversely affected by snowpack reduction, but whether loss of snow will affect root-microbe interactions remains largely unknown. The objective of this study was to distinguish and attribute direct (e.g., winter snow-and/ or soil frost-mediated) vs. indirect (e.g., root-mediated) effects of winter climate change on microbial biomass, the potential activity of …

The Business Of Defense: Defense-Side Litigation Financing, Emily Samra

University of Chicago Law Review

No abstract provided.

The Missouri Miner, December 1, 2016

The Missouri Miner Newspaper

No abstract provided.

The Irrelevance Of Nanotechnology Patents, Emily Michiko Morris

Faculty Scholarly Works

Although scientists have for decades now had the ability to manipulate matter at the atomic level, we have yet to see the nanotechnological revolution that these scientists predicted would follow. Despite the years of effort and billions of dollars that have been invested into research and development thus far, nanotechnology has yielded surprisingly few end-user applications. A number of commentators have blamed this lack of progress on the Bayh-Dole Act and other changes to patent law, arguing that, although these laws are supposed to stimulate technological development, they have in fact had the exact opposite effect when it comes to …

Regional Mapping Of Flow And Wall Characteristics Of Intracranial Aneurysms, Juan R. Cebral, Xinjie Duan, Piyusha S. Gade, Bong Jae Chung, Fernando Mut, Khaled Aziz, Anne M. Robertson

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

The evolution of intracranial aneurysms (IAs) is thought to be driven by progressive wall degradation in response to abnormal hemodynamics. Previous studies focused on the relationship between global hemodynamics and wall properties. However, hemodynamics, wall structure and mechanical properties of cerebral aneurysms can be non-uniform across the aneurysm wall. Therefore, the aim of this work is to introduce a methodology for mapping local hemodynamics to local wall structure in resected aneurysm specimens. This methodology combines image-based computational fluid dynamics, tissue resection, micro-CT imaging of resected specimens mounted on 3D-printed aneurysm models, alignment to 3D vascular models, multi-photon microscopy of the …

Heterodimers As The Structural Unit Of The T=1 Capsid Of The Fungal Double-Stranded Rna Rosellinia Necatrix Quadrivirus 1, Daniel Luque, Carlos P. Mata, Fernando González-Camacho, José M. González, Josué Gómez-Blanco, Carlos Alfonso, Germán Rivas, Wendy M. Havens, Satoko Kanematsu, Nobuhiro Suzuki, Said A. Ghabrial, Benes L. Trus, José R Castón

Plant Pathology Faculty Publications

Most double-stranded RNA (dsRNA) viruses are transcribed and replicated in a specialized icosahedral capsid with a T=1 lattice consisting of 60 asymmetric capsid protein (CP) dimers. These capsids help to organize the viral genome and replicative complex(es). They also act as molecular sieves that isolate the virus genome from host defense mechanisms and allow the passage of nucleotides and viral transcripts. Rosellinia necatrix quadrivirus 1 (RnQV1), the type species of the family Quadriviridae, is a dsRNA fungal virus with a multipartite genome consisting of four monocistronic segments (segments 1 to 4). dsRNA-2 and dsRNA-4 encode two CPs (P2 and …

Uchunguzi (Journal Watch/Montre De Journal) December 2016, Benjamin Wachira

Emergency Medicine, East Africa

Uchunguzi means investigation in Swahili and provides a summary of some of the most recent international literature as presented in other leading journals, but with an emphasis on what is relevant to our continent

Are Colleges And Universities Failing To Meet The Needs Of The Transgender And Gender Non-Conforming Community By Failing To Meet The Needs Of Social Work Students?, Constance D. Siegel

Social Work Theses - Archive

With the notable trend for recognition of the transgender and gender non-conforming (TGNC) Community, as well as their having issues that are separate and distinct from the lesbian, gay, and bisexual (LGB) community, the need for social workers specifically trained to meet the needs of this population has become apparent. An absence of qualified social workers in both macro and micro fields has necessitated a review of all Council on Social Work Education (CSWE) accredited programs to ascertain if education on TGNC individuals is being included in curriculum as is outlined in the CSWE diversity and accreditation standards. Currently, both …

Sustainable Gender Equality Framework: A Justice Perspective, Bonita Bhattarai Sharma

Social Work Dissertations - Archive

The current study emphasizes gender equality discourse within the frame of overarching sustainable development goals and proposes a shift in attention to the sustainability of components of a larger holistic social system that is built on moral imperatives of intra and intergenerational justice. The continued and building importance of the holistic and transferability of a just and inclusive system is indicative of the new global policy shift in addressing the lessons learned from past developmental approaches and the urgent need to protect the earth system. There are three key related issues that stand out within the broad context of Our …

Member Background: Implications For Incivility In The U.S. Congress, Aimee C. Arvayo

Honors Capstones

Politicians often receive criticism regarding their uncivil conduct as elected officials. There is no exception for members of the U.S. Congress. Instances in which elected officials act inappropriately while performing the official duties of their elected offices constitute acts of incivility, the phenomenon this research aims to study. This research investigates whether certain background qualities, specifically the procurement of a law degree, state legislative experience and gender, influence U.S. Congress members’ likelihood of being implicated in uncivil acts. Upon reviewing the historical databases for both the New York Times and the Washington Post using keywords relating to incivility, the researcher …

How Intermediate Capacity Modes Provide Accessibility And Resilience In Metropolitan Transit Networks: Insights From A Global Study Of 19 Cities, Jan Scheurer

Journal of Public Transportation

Drawing on the Spatial Network Analysis of Multimodal Urban Transport Systems (SNAMUTS) accessibility tool, this paper introduces comparative results of public transport network performance measures in 19 metropolitan regions in developed countries. These results are assessed typologically and functionally to highlight the contribution of each common public transport mode to maximize (or not) the integration of transport networks with the urban structure to optimize accessibility outcomes. It is shown that the capacity and performance spectrum embodied by each mode represents a gradual scale that allocates a specific niche to intermediate modes, particularly trams that are present in half the cities …

Investigating The Effect Of Gasoline Prices On Transit Ridership And Unobserved Heterogeneity, Hojin Jung, Gun Jea Yu, Kyoung-Min Kwon

Journal of Public Transportation

Based on a unique scanner panel data set on debit and credit card transactions, we examined the effect of gasoline prices on individual choices between private vehicle use and public transit ridership. The unique feature of our data allowed us to address possible heterogeneity in the effect of gasoline prices and to explicitly incorporate the link between private vehicle use and public transit ridership. A series of empirical analyses reveal that there is significant heterogeneity in the effect of gasoline prices on fuel consumption and that financial constraints and commitment to vehicle use determine individual sensitivities to the price of …

Optimal Limited-Stop Bus Routes Selection Using A Genetic Algorithm And Smart Card Data, Yongju Yi, Keechoo Choi, Young-Jae Lee

Journal of Public Transportation

In recent years, express bus service has come into the spotlight by overcoming slow bus operating speeds while maintaining its accessibility when it operates with local bus services. This study developed an optimal limited-stop bus routes selection (LSBRS) guideline as a scenario-based analysis and compared it with case study results. Smart card data and a genetic algorithm (GA) were used to develop the model with different scenarios. Then, total travel time savings as a result of implementing limited-stop bus service generated by the GA model were computed. The effectiveness of each factor was verified by multiple regression analysis, and the …

Medication Adherence In Patients With Myotonic Dystrophy And Facioscapulohumeral Muscular Dystrophy, Bryan Fitzgerald, Kelly Conn, Joanne Smith, Andrew Walker, Amy L. Parkhill, James E. Hilbert, Elizabeth A. Luebbe, Richard T. Moxley Iii

Doctoral External Publications

Myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) are the two most common adult muscular dystrophies and have progressive and often disabling manifestations. Higher levels of medication adherence lead to better health outcomes, especially important to patients with DM and FSHD because of their multisystem manifestations and complexity of care. However, medication adherence has not previously been studied in a large cohort of DM type 1 (DM1), DM type 2 (DM2), and FSHD patients. The purpose of our study was to survey medication adherence and disease manifestations in patients enrolled in the NIH-supported National DM and FSHD Registry. The study …

Innovative Approach To Estimating Demand For Intercity Bus Services In A Rural Environment, Cutr

Research Reports

No abstract provided.

Public Transit Equity Analysis At Metropolitan And Local Scales: A Focus On Nine Large Cities In The Us, Greg P. Griffin, Ipek N. Sener

Journal of Public Transportation

Recent studies on transit service through an equity lens have captured broad trends from the literature and national-level data or analyzed disaggregate data at the local level. This study integrates these methods by employing a geostatistical analysis of new transit access and income data compilations from the Environmental Protection Agency. By using a national data set, this study demonstrates a method for income-based transit equity analysis and provides results spanning nine large auto-oriented cities in the US. Results demonstrate variability among cities’ transit services to low-income populations, with differing results when viewed at the regional and local levels. Regional-level analysis …

Passenger Satisfaction And Mental Adaptation Under Adverse Conditions: Case Study In Manila, Andra Charis Mijares, Mio Suzuki, Tetsuo Yai

Journal of Public Transportation

Public transportation systems in several developing cities face congestion, air pollution, and safety problems, yet many passengers use them regularly. This study examines the structure of passenger satisfaction and the role of mental adaptation under such conditions. Metro Manila MRT-3 was analyzed as a case study.

The actual and perceived conditions at the MRT-3 were assessed using surveys. Results of the waiting time and PM_2.5 monitoring surveys revealed that passengers queue for 30 minutes, on average, while being exposed to unsafe levels of PM_2.5. The questionnaire survey results show some discrepancies between actual and perceived values, suggesting …

Regularity Of Public Transport Usage: A Case Study Of Bus Rides In Lisbon, Portugal, Stefan Foell, Santi Phithakkitnukoon, Marco Veloso, Gerd Kortuem, Carlos Bento

Journal of Public Transportation

This paper presents an analysis of regularity in public transport usage based on a large-scale bus transportation data of Lisbon, Portugal. By exploring the combined information from the bus boarding history of riders and bus arrivals at each bus stop, an analysis of individual bus usage was performed. Daily and weekly patterns were extracted, from which it was observed that a rider takes, on average, 2 trips, visits 1.93 distinct stops, and uses 1.55 distinct bus lines daily. Inter-trip time analysis revealed a daily cycle, and a study of the interaction between riders and bus infrastructure explored how usage was …

Is Applied Behavioral Analysis Education, Medicine, Or Both?: A Study Of The Funding Challenges That Accompany An Autism Diagnosis, Yaakov Pollak

Seton Hall Law Review

No abstract provided.

A Standard Of Review For Gun Rights: The Second Amendment Question Hot As A Two-Dollar Pistol, Adam P. Soloperto

Seton Hall Law Review

No abstract provided.