Digital Commons Network^™

The Zodiac Army., Keith Charles Marks

Electronic Theses and Dissertations

This thesis is the beginning of a book title The Zodiac Army. The book is the first in a trilogy and follows three different characters. The first, Ash, is a teenage boy who discovers he is a powerful magician who, along with another magician, can control the elements of nature. The two form a Twin pairing and will fight for each other and for the safety of the kingdom. Alora, the second character, is a young and faithful priestess in the Temple. Her faith, in both the gods and those in charge of the Temple, could bring the entire system …

Retinoic Acid Signaling Regulates Krt5 Independently Of Stem Cell Markers In Submandibular Salivary Gland Epithelium., Timur Maratovich Abashev

Electronic Theses and Dissertations

Vitamin A metabolism, which produces the signaling molecule Retinoic Acid (RA), has been demonstrated to be important for growth and branching morphogenesis of mammalian embryonic salivary gland epithelium. However, it is not known whether RA functions directly within epithelial cells or in associated tissues that influence morphogenesis of salivary epithelium. Moreover, downstream targets of RA transcriptional regulation have not been identified. Here we show that canonical RA signaling occurs in multiple tissues of embryonic mouse salivary glands, including epithelium, associated parasympathetic ganglion neurons, and non‑neuronal mesenchyme. By culturing epithelium explants in isolation from other tissues we demonstrate that RA influences …

Exploring The Relation Between School Pushout And Future Outlook For Black Youth., Kish Cumi

Electronic Theses and Dissertations

This dissertation study is an examination of the relation between school pushout and future outlook for Black youth. Theoretically, this dissertation study is framed by Bronfenbrenner’s Ecological Model (Bronfenbrenner, 1977) and Racial Encounter Coping Appraisal and Socialization Theory (RECAST). In light of the systemic racial disparities entrenched in school pushout phenomena among Black youth, the researcher sought to explore parental warmth as a protective factor for youth subjected to school pushout. School pushout as praxis was discussed in conjunction with the school-toprison pipeline (STPP), as school pushout is identified as an entry point within the STPP. This dissertation study explored …

Mechanism Of Interaction Of Peptide Modified Nanoparticles With Porphyromonas Gingivalis., Ankita Jain

Electronic Theses and Dissertations

Studies suggest that P. gingivalis functions as a keystone pathogen and interacts with primary colonizers in the supragingival biofilm such as S. gordonii. This interaction contributes to the initial colonization of the oral cavity by P. gingivalis and thus represents a potential target for therapeutic intervention. We have identified a peptide (BAR) derived from the streptococcal SspB protein that functions to inhibit P. gingivalis adherence to S. gordonii. In addition, we showed that nanoparticles (NPs) functionalized with BAR inhibit this interaction more potently than free soluble peptide, possibly by promoting interaction with P. gingivalis at higher valency than …

Professional School Counselors : Integral Stakeholders In The Recruitment, Retention, And Support Of African American, Latino, And Low-Income Students In Advanced Placement Programs., Damien Sweeney

Electronic Theses and Dissertations

Numerous studies have been conducted that show the importance of diversifying Advanced Placement Courses. However, Griffin and Steen (2011) state that: Despite a vast body of literature that stresses the importance of school counselors in addressing inequities that exists in schools, few articles provide concrete strategies that school counselors can infuse in their practice. More research is warranted because many school counselors face barriers when trying to implement systemic change in the schools. (p. 76) This qualitative research study is based on a collective phenomenological case study of six participants (five Professional School Counselors and one Director of School Counselors) …

The Role And Regulation Of Inhibitor Of Kappa B Kinase In The Impaired Monocyte Response., Norman James Galbraith

Electronic Theses and Dissertations

Trauma, major surgery and systemic infection can lead to a subsequent immunosuppressed state which can predispose patients to nosocomial infection and death. Approximately a sixth of patients will have impaired monocyte function, as determined by decreased HLA-DR expression or decreased TNF-α production in response to ex-vivo lipopolysaccharide (LPS) stimulation. This project aimed to develop an in-vitro model of impaired monocyte function using isolated monocytes from healthy volunteers, to study the effect of monocyte impairment on IκK signaling, and determine the role of IκK in the impaired monocyte response. These studies have provided the following results:

1. Monocytes treated with low dose …

Dynamic Warehouse Optimization Using Predictive Analytics., Parvaneh Jahani

Electronic Theses and Dissertations

The forward area is a small area of a warehouse with a low picking cost. Two approaches that are investigated for selecting the SKUs of this area and the allocated space are the static and the dynamic approaches. In the case that decisions about the forward area are made periodically (e.g. yearly) and the products' demand patterns are completely ignored, the FRP is static. We developed two heuristics that solve the large discrete assignment, allocation, and sizing problem simultaneously. Replenishing the same product in the same place of the forward area brings about a ``Locked" layout of the fast picking …

Crime And Culture : A Thematic Reading Of Sherlock Holmes And His Adaptations., Britney Broyles

Electronic Theses and Dissertations

This dissertation focuses on the adaptation of Arthur Conan Doyle’s Sherlock Holmes character and stories into the television shows Sherlock and Elementary on air today. The project will consider three central questions: 1) Why is this Victorian detective hero still popular in the twenty-first century and what has remained constant and still resonates with modern audiences? 2) Both television shows transport Holmes in time by setting their narratives in the present day; therefore, what has been changed in this process of adaptation? 3) How do these changes represent shifts in our cultural thinking about important aspects of humanistic inquiry? The …

Secular But Not Superficial : An Overlooked Nonreligious/Nonspiritual Identity., Daniel G. Delaney

Electronic Theses and Dissertations

Since Durkheim’s characterization of the sacred and profane as “antagonistic rivals,” the strict dichotomy has been framed in such a way that “being religious” evokes images of a life filled with profound meaning and value, while “being secular” evokes images of a meaningless, self-centered, superficial life, often characterized by materialistic consumerism and the cold, heartless environment of corporate greed. Consequently, to identify as “neither religious nor spiritual” runs the risk of being stigmatized as superficial, untrustworthy, and immoral. Conflicts and confusions encountered in the process of negotiating a nonreligious/nonspiritual identity, caused by the ambiguous nature of religious language, were explored …

Approaches To Arthropod Conservation : Landscape Genetics, Community Assessment, And Prediction Of Extinction Risk., Victoria Annette Prescott

Electronic Theses and Dissertations

Although urbanization is a leading cause of species extinction throughout the world, the impact of urban development on arthropods is little studied and, as a result, poorly understood. I used three distinct approaches to studying arthropod conservation in North America. First, I used landscape genetics techniques to study the impact of urbanization on gene flow among populations of Rabidosa rabida, the rabid wolf spider. While gene flow was not detrimentally reduced, urban development correlated with a reduction in migration rates among populations, and to my knowledge, this is the first study to document isolation by resistance in spiders. Next, …

Reflectivity Of Light Emitting Diodes (Led) And Incandescent Lights On Concrete And Asphalt Pavements., Jeremy Elliott Rice

Electronic Theses and Dissertations

The purpose of this study is to investigate the reflectivity of light on concrete and asphalt pavement systems. In 1983, the Illuminating Engineering Society (IES) published the first recommended practice (RP-8) for the design of roadway and parking lot lighting. This design method implemented empirically tested factors which were defined as the “reduced luminance coefficients” or the R-Tables. The R-Tables are essential for proper design of light pole installation dimensions, required power, and the distribution of light. The originally tested pavements are not necessarily representative of modern pavement materials used today. Moreover, recent Light Emitting Diodes (LED) are a relatively …

Detecting Evidence Of Systemic Inflammation From Osteological Markers In The Indian Knoll Population Of Ohio County, Kentucky., Krysta Wilham

Electronic Theses and Dissertations

Indian Knoll is an Archaic shell midden site located in the Green River region of west-central Kentucky, and was excavated twice in the first half of the 20^th century. While Indian Knoll has been the subject of frequent bioarchaeological studies, the present study presents an osteological analysis of the relationships between skeletal markers commonly associated with local inflammatory processes, and that have the potential to be used as proxies for systemic inflammation. The analysis revealed a significant positive association in the presence of periodontal disease (PD) and periosteal lesions (PL), suggesting a potential underlying hyper-inflammatory status or phenotype. These …

Cost Of Care For Hospitalized Patients With Pulmonary Mycobacterial Diseases In The United States., Mary Beth Wells Allen

Electronic Theses and Dissertations

Background: Pulmonary mycobacterial diseases describe both tuberculosis (TB) and nontuberculous mycobacteria (NTM). Few data are available measuring the cost burden of mycobacterial diseases on the national level. The purpose of this study was to evaluate the cost burden and measure emerging trends in hospitalization of pulmonary TB and NTM in the US from 2001 through 2012. Methods: This study was a retrospective community based cost analysis of hospitalized patients with a principal diagnosis of pulmonary mycobacterial diseases from 2001 through 2012. Data for pulmonary TB and NTM were retrieved from the Healthcare Cost and Utilization Project (HCUP), US Department of …

Strategies And Techniques For Fabricating Mems Bistable Thermal Actuators., Dilan Ratnayake

Electronic Theses and Dissertations

Bistable elements are beginning to appear in the field of MEMS as they allow engineers to design sensors and actuators which require no electrical power and possess mechanical memory. This research focuses on the development of novel strategies and techniques for fabricating MEMS bistable structures to serve as no electrical power thermal actuators. Two parallel strategies were explored for the design and fabrication of the critical bistable element. Both strategies involved an extensive material study on candidate thin film materials to determine their temperature coefficient of expansion and as-deposited internal stress properties. Materials investigated included titanium tungsten, Invar, silicon nitride …

Patchwork : A Southern Family Portrait., Rebekah Dement Farmer

Electronic Theses and Dissertations

This dissertation is a jointly scholarly and creative exploration of the potentials of autobiography. Specifically, this dissertation seeks to examine how the personal narrative may be utilized to undermine or challenge prevailing cultural myths and legends of the American South as they are manifested in master narratives propagated within an individual family’s narrative. As emblems of Southern culture, these master narratives have privileged the white male experience over other Southern voices. An interdisciplinary examination of selected historical and literary texts reveals certain external challenges to the resilient master narrative, but this dissertation suggests autobiography may prove a particularly potent force …

Identification Of Residual Descending Pathways After Human Spinal Cord Injury., Darryn A. Atkinson

Electronic Theses and Dissertations

Spinal Cord Injury (SCI) in humans is a heterogeneous diagnosis, resulting in variable paralysis and paresthesia based on the mechanism, rostro-caudal location, and severity of injury. Both neurophysiological and anatomical studies have suggested that subclinical residual supraspinal-spinal connectivity exists in a subset of individuals deemed to have motor and sensory complete injuries. Recent reports of volitional movement in chronic, motor complete individuals during epidural spinal stimulation have provided compelling evidence that these residual projections may be capable of mediating volitional movement when the functional state of spinal circuitry is electrically modulated. It was the goal of this project to identify …

An Integrated Economic Equilibrium Model For Electricity Markets., Swapna Pothabathula

Electronic Theses and Dissertations

The increasing energy challenges worldwide are forcing researchers to explore ways for energy systems that work more efficiently on their own and with each other. This thesis develops an integrated electricity market equilibrium model (EMEM) as a mixed complementarity problem (MCP). In particular, we first develop an equilibrium model to study an electricity market consisting of coal producers, electricity generation firms, natural gas producers, natural gas marketers, natural gas pipeline owners, natural gas consumers and electricity consumers. The equilibrium model not only captures a decentralized optimization for each player but considers the interaction amongst players. Second, we formulate the equilibrium …

Experimental Observation Of The Relationship Between The Pressure Drop And Flow Rate Of Radial Flow Through Porous Media., Matthew William Okruch

Electronic Theses and Dissertations

This research experimentally observed the relationship between pressure drop and flow rate for high velocity, radial flow through porous media. The criterion for what represents high velocity is a function of the Reynold’s number of the flow. Pressure drop – flow rate curves were developed by flowing air and water through the porous carbon block samples. Each sample’s permeability was calculated from on the air test results. Each sample’s porosity was determined through digital microscope image analysis. Darcy’s Law, the Forchheimer equation, and the Ergun equation were converted to the radial flow domain and compared to the experimental data. The …

Spreading Speeds Along Shifting Resource Gradients In Reaction-Diffusion Models And Lattice Differential Equations., Jin Shang

Electronic Theses and Dissertations

A reaction-diffusion model and a lattice differential equation are introduced to describe the persistence and spread of a species along a shifting habitat gradient. The species is assumed to grow everywhere in space and its growth rate is assumed to be monotone and positive along the habitat region. We show that the persistence and spreading dynamics of a species are dependent on the speed of the shifting edge of the favorable habitat, c, as well as c^*(∞) and c^*(−∞), which are formulated in terms of the dispersal kernel and species growth rates in both directions. When …

Order Picking Strategies For Healthcare Warehouses., Ehsan Khodabandeh

Electronic Theses and Dissertations

Order picking is the process of collecting goods and items in specified quantities from storage locations, in response to customer orders. Since many labor resources are involved in this process, finding ways to make it more efficient have been a primary goal for researchers and practitioners. Determining a better allocation of products to the storage areas, finding the best route and sequence to pick multiple products, and choosing the best picking policies to minimize congestion in the aisles are just a few of many objectives regarding order picking process. Due to regulatory compliances and the chance of product spoilage, additional …

Optimization Models And Algorithms For Demand Response In Smart Grid., Guangyang Xu

Electronic Theses and Dissertations

For demand response in smart grid, a utility company wants to minimize total electricity cost and end users want to maximize their own utility. The latter is considered to consist of two parts in this research: electricity cost and convenience/comfort. We first develop a system optimal (SO) model and a user equilibrium (UE) model for the utility company and end users, respectively and compare the difference of the two. We consider users' possible preference on convenience over cost-saving under the real-time pricing in smart grid, and each user is assumed to have a preferred time window for using a particular …

Simulation Modeling For Energy Consumption Of Residential Consumers In Response To Demand Side Management., Prajwal Khadgi

Electronic Theses and Dissertations

Energy efficiency in the electricity distribution system continues to gain importance as demand for electricity keeps rising and resources keep diminishing. Achieving higher energy efficiency by implementing control strategies and demand response (DR) programs has always been a topic of interest in the electric utility industry. The advent of smart grids with enhanced data communication capabilities propels DR to be an essential part of the next generation power distribution system. Fundamentally, DR has the ability to charge a customer the true price of electricity at the time of use, and the general perception is that consumers would shift their load …

The Role Of Nicotine, A7 Nicotinic Acetylcholine Receptors And Extracellular Matrix Remodeling In Pulmonary Fibrosis., Glenn Ward Vicary

Electronic Theses and Dissertations

The median survival for idiopathic pulmonary fibrosis (IPF) patients from diagnosis is a dismal 3 years. This condition is characterized by pulmonary fibroproliferation and excess production and disordered deposition of extracellular matrix (ECM) proteins resulting in obliteration of the original tissue architecture, loss of lung function and eventual death due to respiratory failure. The main hindrance to the development of effective treatments against pulmonary fibrosis is the late detection of its progression and is often of unknown cause. Tobacco smoke represents the most important environmental factor linked to the development of pulmonary fibrosis, with over 60% of IPF patients current …

The Effects Of Direct Peritoneal Resuscitation On Leukocyte Infiltration After Acute Brain Death., Jessica Lee Weaver

Electronic Theses and Dissertations

Background: Brain death triggers an inflammatory response that is associated with worse outcomes for recipients of transplanted organs procured from brain dead donors. The intestine has been shown to release inflammatory mediators in other types of shock, but its role is brain death is not well described. Direct peritoneal resuscitation (DPR) improves visceral organ blood flow and has been shown to reduce inflammation after hemorrhagic shock. Better understanding of this inflammatory process within the peripheral organs, the effects of DPR, and the role of the intestine could aid in better resuscitation of potential organ donors. Methods: Male Sprague-Dawley rats were …

Assessing Moral Injury And Existential Well-Being In Returning Servicemembers Using The Spiritual Attitudes Inventory - Revised (2010)., Leann E. Armes-Bruce

Electronic Theses and Dissertations

Military personnel returning from deployment often report a variety of distressing symptoms stemming from exposure to prolonged, extreme deployment stress, and traumatic experiences. In addition to reporting symptoms consistent with the diagnosis of Post-Traumatic Stress Disorder, they are also known to report struggling with existential angst often leading to great despair and a sense of profound changes in the core of their being. While this phenomenon, referred to herein as Moral Injury, has traditionally received little attention, it is beginning to emerge as a potentially viable construct in practice and research and may assist in explaining the effects of war …

Study Of Spatiotemporal Rainfall Structure And Optimized Local Radar Rainfall Application To Urban Watershed, Louisville, Kentucky, 2010-2014., Jin-Young Hyun

Electronic Theses and Dissertations

In urban areas, a prevalence of combined sewer systems (CSS) exist that carry both storm water runoff and sanitary sewer flows in a single pipe, these system are considered combined sewers. In the absence of rainfall-runoff most of these systems function adequately, however CSS capacity is typically inadequate to carry peak stormwater runoff volume. In order to minimize sewage flooding into streets and backups into homes and businesses, most CSSs (as well as separate sanitary sewer systems) are designed to overflow into surface waters such as streams and rivers, lakes and seas. This occurrence is considered a combined sewer overflow …

Challenging Conventional Wisdom : Section 8 Housing And The Real Impact On Neighborhood Values In Louisville, Kentucky., Paul Francis Dries

Electronic Theses and Dissertations

Section 8 Housing was designed to de-concentrate poverty and spread affordable housing across communities. There are many studies that have evaluated the successes associated with the policy of dispersing the urban poor to the surrounding suburban areas in various cities. The positive impacts of dispersing the urban poor, in terms of education, self-esteem, and jobs, is well documented. There are fewer studies related to the potential externalities associated with these programs. This study uses advanced multiple regression techniques to study 170 Louisville neighborhoods to look at whether large concentrations of Section 8 housing have a negative impact on neighborhood housing …

A Reduced Labeled Samples (Rls) Framework For Classification Of Imbalanced Concept-Drifting Streaming Data., Elaheh Arabmakki

Electronic Theses and Dissertations

Stream processing frameworks are designed to process the streaming data that arrives in time. An example of such data is stream of emails that a user receives every day. Most of the real world data streams are also imbalanced as is in the stream of emails, which contains few spam emails compared to a lot of legitimate emails. The classification of the imbalanced data stream is challenging due to the several reasons: First of all, data streams are huge and they can not be stored in the memory for one time processing. Second, if the data is imbalanced, the accuracy …

Dietary Resource Utilization Patterns And Head Morphology Among Three Sympatric Watersnake Species., Micah Warren Perkins

Electronic Theses and Dissertations

The coexistence of similar species may be related to a variety of resource utilization differences. Dietary resource utilization variation may be the most important difference allowing for the coexistence of sympatric snake species. Many watersnakes (Nerodia spp.) live in sympatry and use similar aquatic habitats feeding on similar prey. While these sympatric watersnakes may have different general foraging patterns, snake diet may be affected by a variety of factors. Therefore, I initiated an investigation to understand the coexistence of sympatric plain-bellied (N. erythrogaster), diamondback (N. rhombifer) and northern (N. sipedon) watersnakes by addressing …

Portfolio Review: Guidelines For Participants (Spanish), Diana Hernandez, Jessica Agustin

Critique and Reflection Tips

No abstract provided.