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2016

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Articles 158431 - 158460 of 159446

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Modifying Hofstee Standard Setting For Assessments That Vary In Difficulty, And To Determine Boundaries For Different Levels Of Achievement, Sa Burr, J Whittle, Lc Fairclough, L Coombes, I Todd Jan 2016

Modifying Hofstee Standard Setting For Assessments That Vary In Difficulty, And To Determine Boundaries For Different Levels Of Achievement, Sa Burr, J Whittle, Lc Fairclough, L Coombes, I Todd

Peninsula Medical School

No abstract provided.


The Impact Of Large Scale Licensing Examinations In Highly Developed Countries: A Systematic Review, Julian Archer, Nick Lynn, Lee Coombes, Martin Roberts, Tom Gale, Tristan Price, De Bere S Regan Jan 2016

The Impact Of Large Scale Licensing Examinations In Highly Developed Countries: A Systematic Review, Julian Archer, Nick Lynn, Lee Coombes, Martin Roberts, Tom Gale, Tristan Price, De Bere S Regan

Peninsula Medical School

No abstract provided.


Dietary Administration Of A Commercial Mixed-Species Probiotic Improves Growth Performance And Modulates The Intestinal Immunity Of Tilapia, Oreochromis Niloticus, B. T. Standen, D. L. Peggs, M. D. Rawling, A. Foey, S. J. Davies, G. A. Santos, D. L. Merrifield Jan 2016

Dietary Administration Of A Commercial Mixed-Species Probiotic Improves Growth Performance And Modulates The Intestinal Immunity Of Tilapia, Oreochromis Niloticus, B. T. Standen, D. L. Peggs, M. D. Rawling, A. Foey, S. J. Davies, G. A. Santos, D. L. Merrifield

School of Biological and Marine Sciences

No abstract provided.


Anti-Envelope Antibody Responses In Individuals At High Risk Of Hepatitis C Virus Who Resist Infection, R. E. Swann, P. Mandalou, M. W. Robinson, M. M. Ow, S. K.H. Foung, J. Mclauchlan, A. H. Patel, M. E. Cramp Jan 2016

Anti-Envelope Antibody Responses In Individuals At High Risk Of Hepatitis C Virus Who Resist Infection, R. E. Swann, P. Mandalou, M. W. Robinson, M. M. Ow, S. K.H. Foung, J. Mclauchlan, A. H. Patel, M. E. Cramp

Peninsula Medical School

No abstract provided.


Changes In The Eeg Amplitude As A Biomarker For Early Detection Of Alzheimer's Disease., Ali H. Al-Nuaimi, Emmanuel Jammeh, Lingfen Sun, Emmanuel Ifeachor Jan 2016

Changes In The Eeg Amplitude As A Biomarker For Early Detection Of Alzheimer's Disease., Ali H. Al-Nuaimi, Emmanuel Jammeh, Lingfen Sun, Emmanuel Ifeachor

School of Engineering, Computing and Mathematics

The rapid increase in the number of older people with Alzheimer's disease (AD) and other forms of dementia represents one of the major challenges to the health and social care systems. Early detection of AD makes it possible for patients to access appropriate services and to benefit from new treatments and therapies, as and when they become available. The onset of AD starts many years before the clinical symptoms become clear. A biomarker that can measure the brain changes in this period would be useful for early diagnosis of AD. Potentially, the electroencephalogram (EEG) can play a valuable role in …


Functional Involvement Of Γ-Secretase In Signaling Of The Triggering Receptor Expressed On Myeloid Cells-2 (Trem2), K Glebov, P Wunderlich, I Karaca, J Walter Jan 2016

Functional Involvement Of Γ-Secretase In Signaling Of The Triggering Receptor Expressed On Myeloid Cells-2 (Trem2), K Glebov, P Wunderlich, I Karaca, J Walter

Peninsula Medical School

No abstract provided.


Plain Language Review Of Volatile Substance Use Among Aboriginal And Torres Strait Islander People, Trish Amaranti Jan 2016

Plain Language Review Of Volatile Substance Use Among Aboriginal And Torres Strait Islander People, Trish Amaranti

Research outputs 2014 to 2021

This review is a plain language version of the Review of volatile substance use among Aboriginal and Torres Strait Islander people (2016). It provides key information on the use of volatile substances (petrol, paint, glue and other substances), among Aboriginal and Torres Strait Islander people in Australia. Technical terms are explained and information is provided in an easy to understand format, with additional graphs and images to illustrate data. This plain language review provides background information on volatile substance use in Australia as well as information that has specific relevance to the health and wellbeing of Aboriginal and Torres Strait …


Microbiological Quality Of Ready-To-Eat Fresh Vegetables And Their Link To Food Safety Environment And Handling Practices In Restaurants, Dima Faour-Klingbeil, Ewen C.D. Todd, Victor Kuri Jan 2016

Microbiological Quality Of Ready-To-Eat Fresh Vegetables And Their Link To Food Safety Environment And Handling Practices In Restaurants, Dima Faour-Klingbeil, Ewen C.D. Todd, Victor Kuri

School of Biological and Marine Sciences

he increased consumption of ready-to-eat salads outside homes as a result of a fast paced lifestyle, awareness on their nutritional attributes and enhanced processing technology is well documented. This study aimed to determine the microbiological quality of fresh-cut salads vegetables in small and medium sized foodservice establishments (SMEs) and to identify risk factors and handling practices through observational assessment in order to investigate if an association between microbiological quality and visual assessment (inspection) scores can be established. A total of 118 samples fresh-cut vegetable salads were collected from 50 inspected locations and analysed microbiologically, in addition to 49 swabs of …


Giving Over Taking/Receiving In Volunteer Tourism The Impact Of Motivation, Attitude, And Subjective Norm On Stage Of Readiness And Its Implication On Social Marketing, Usep Suhud, Greg Willson Jan 2016

Giving Over Taking/Receiving In Volunteer Tourism The Impact Of Motivation, Attitude, And Subjective Norm On Stage Of Readiness And Its Implication On Social Marketing, Usep Suhud, Greg Willson

Research outputs 2014 to 2021

The main objective of this study is to investigate the impact of motivation, attitude, and subjective norm on stage of readiness to be involved in volunteer tourism and its implication on social marketing. Volunteer tourism is a tourism product that combines volunteerism and tourism activities in a destination and commonly offered by an international volunteer organisation. In this study the author examine the influence of motivation, subjective norm, and attitude towards volunteer tourism concept on stage of readiness to be involved in volunteer tourism. Motivation is treated as two different variables - taking/receiving and giving motivations. Taking/receiving represents self-interest whereas …


Rehabilitation Goals Of People With Spinal Cord Injuries Can Be Classified Against The International Classification Of Functioning, Disability And Health Core Set For Spinal Cord Injuries, B. Haas, E. D. Playford, A. Q. Ahmad, T. Yildiran, A. J. Gibbon, J. A. Freeman Jan 2016

Rehabilitation Goals Of People With Spinal Cord Injuries Can Be Classified Against The International Classification Of Functioning, Disability And Health Core Set For Spinal Cord Injuries, B. Haas, E. D. Playford, A. Q. Ahmad, T. Yildiran, A. J. Gibbon, J. A. Freeman

School of Health Professions

No abstract provided.


The Use Of Dynamic Elastomeric Fabric Orthosis Suits As An Orthotic Intervention In The Management Of Children With Neuropathic Onset Scoliosis: A Retrospective Audit Of Routine Clinical Case Notes, Martin Matthews, Suzanne Blandford, Jonathan Marsden, Jennifer Freeman Jan 2016

The Use Of Dynamic Elastomeric Fabric Orthosis Suits As An Orthotic Intervention In The Management Of Children With Neuropathic Onset Scoliosis: A Retrospective Audit Of Routine Clinical Case Notes, Martin Matthews, Suzanne Blandford, Jonathan Marsden, Jennifer Freeman

School of Health Professions

No abstract provided.


Fall Risk In People With Ms: A Physiological Profile Assessment Study, Phu D. Hoang, Meryem Baysan, Hilary Gunn, Michelle Cameron, Jenny Freeman, Jennifer Nitz, Choy Nl Low, Stephen R. Lord Jan 2016

Fall Risk In People With Ms: A Physiological Profile Assessment Study, Phu D. Hoang, Meryem Baysan, Hilary Gunn, Michelle Cameron, Jenny Freeman, Jennifer Nitz, Choy Nl Low, Stephen R. Lord

School of Health Professions

Introduction The Physiological Profile Assessment (PPA) is used in research and clinical practice for assessing fall risk. We compared PPA test performance between people with multiple sclerosis (MS) and healthy controls, determined the fall-risk profile for people with MS and developed a reference database for people with MS. Methods For this study, 416 ambulant people with MS (51.5 ± 12.0 years) and 352 controls (52.8 ± 12.2 years) underwent the PPA (tests of contrast sensitivity, proprioception, quadriceps strength, reaction time and sway) with composite fall-risk scores computed from these measures. MS participants were followed prospectively for falls for 3 months. …


Effects Of Pilates-Based Core Stability Training In Ambulant People With Multiple Sclerosis: Multicenter, Assessor-Blinded, Randomized Controlled Trial, Esther E. Fox, Alan D. Hough, Siobhan Creanor, Margaret Gear, Jennifer A. Freeman Jan 2016

Effects Of Pilates-Based Core Stability Training In Ambulant People With Multiple Sclerosis: Multicenter, Assessor-Blinded, Randomized Controlled Trial, Esther E. Fox, Alan D. Hough, Siobhan Creanor, Margaret Gear, Jennifer A. Freeman

School of Health Professions

Background Pilates exercise is often undertaken by people with multiple sclerosis (MS) who have balance and mobility difficulties. Objectives The primary aim of the study was to compare the effects of 12 weeks of Pilates exercises with relaxation on balance and mobility. Secondary aims were: (1) to compare standardized exercises with relaxation and (2) to compare Pilates exercises with standardized exercises. Methods A multicenter, assessor-blinded, randomized controlled trial was conducted. Participants with Expanded Disability Status Scale scores of 4.0 to 6.5 were randomly allocated to groups receiving 12 weeks of Pilates exercises, standardized exercises, or relaxation. Assessments were undertaken at …


Objectively Measured Physical Activity And Sedentary Behaviour Profiles Of People Moderately Affected By Multiple Sclerosis, Eh Coulter, J Freeman, L Miller, B Weller, A Mcconnachie, Pg Mattiosn, O Wu, L Paul Jan 2016

Objectively Measured Physical Activity And Sedentary Behaviour Profiles Of People Moderately Affected By Multiple Sclerosis, Eh Coulter, J Freeman, L Miller, B Weller, A Mcconnachie, Pg Mattiosn, O Wu, L Paul

School of Health Professions

No abstract provided.


Short Duration Small Sided Football And To A Lesser Extent Whole Body Vibration Exercise Induce Acute Changes In Markers Of Bone Turnover, J. L. Bowtell, S. R. Jackman, S. Scott, L. J. Connolly, M. Mohr, G. Ermidis, R. Julian, F. Yousefian, E. W. Helge, N. R. Jørgensen, J. Fulford, K. M. Knapp, P. Krustrup Jan 2016

Short Duration Small Sided Football And To A Lesser Extent Whole Body Vibration Exercise Induce Acute Changes In Markers Of Bone Turnover, J. L. Bowtell, S. R. Jackman, S. Scott, L. J. Connolly, M. Mohr, G. Ermidis, R. Julian, F. Yousefian, E. W. Helge, N. R. Jørgensen, J. Fulford, K. M. Knapp, P. Krustrup

School of Health Professions

We aimed to study whether short-duration vibration exercise or football sessions of two different durations acutely changed plasma markers of bone turnover and muscle strain. Inactive premenopausal women (n=56) were randomized to complete a single bout of short (FG15) or long duration (FG60) small sided football or low magnitude whole body vibration training (VIB). Procollagen type 1 amino-terminal propeptide (P1NP) was increased during exercise for FG15 (51.6±23.0 to 56.5±22.5 μg·L−1, mean ± SD, P<0.05) and FG60 (42.6±11.8 to 50.2±12.8 μg·L−1, P<0.05) but not for VIB (38.8±15.1 to 36.6±14.7 μg·L−1, P>0.05). An increase in osteocalcin was observed 48 h after exercise (P<0.05), which did not differ between exercise groups. C-terminal telopeptide of type 1 collagen was not affected by exercise. Blood lactate concentration increased during exercise for FG15 (0.6±0.2 to 3.4±1.2 mM) and FG60 (0.6±0.2 to 3.3±2.0 mM), but not for VIB (0.6±0.2 to 0.8±0.4 mM) (P<0.05). Plasma creatine kinase increased by 55±63% and 137±119% 48 h after FG15 and FG60 (P<0.05), but not after VIB (26±54%, NS). In contrast to the minor elevation in osteocalcin in response to a single session of vibration exercise, both short and longer durations of small sided football acutely increased plasma P1NP, osteocalcin, and creatine kinase. This may contribute to favorable effects of chronic training on musculoskeletal health.


‘More Than Scaling-Up’: Sustainability Contexts, Competencies, And Consequences - A Critical Inquiry, Stephen Sterling, Paul Warwick, Wendy Miller, Harold Glasser, Marco Rieckmann Jan 2016

‘More Than Scaling-Up’: Sustainability Contexts, Competencies, And Consequences - A Critical Inquiry, Stephen Sterling, Paul Warwick, Wendy Miller, Harold Glasser, Marco Rieckmann

School of Health Professions

To identify and problematise the key issues characterising the relationship between global sustainability contexts and the limited response of HE to date - with the purpose of unlocking the potential for innovative, replicable efforts to develop sustainability competencies through innovation in curriculum policy and practice, through addressing these sub-aims:  How far does HE policy accommodate and reflect the need for sustainability competencies? How can capacity for teaching for competency be built and supported through new policies?  How can curricula and pedagogy be better aligned to facilitate the building of sustainability competency in learners and teachers?  What effect …


Lake Isotope Records Of The 8200-Year Cooling Event In Western Ireland: Comparison With Model Simulations, Jonathan A. Holmes, Julia Tindall, Neil Roberts, W Marshall, Jd Marshall, Ann Bingham, Ingo Feeser, Michael O'Connell, Tim Atkinson, Anne Lise Jourdan, Anna March, Elizabeth H. Fisher Jan 2016

Lake Isotope Records Of The 8200-Year Cooling Event In Western Ireland: Comparison With Model Simulations, Jonathan A. Holmes, Julia Tindall, Neil Roberts, W Marshall, Jd Marshall, Ann Bingham, Ingo Feeser, Michael O'Connell, Tim Atkinson, Anne Lise Jourdan, Anna March, Elizabeth H. Fisher

More Faculty of Science and Engineering Research

The early Holocene cooling, which occurred around 8200 calendar years before present, was a prominent abrupt event around the north Atlantic region. Here, we investigate the timing, duration, magnitude and regional coherence of the event as expressed in carbonate oxygen-isotope records from three lakes on northwest Europe's Atlantic margin in western Ireland, namely Loch Avolla, Loch Gealáin and Lough Corrib. An abrupt negative oxygen-isotope excursion lasted about 200 years. Comparison of records from three sites suggests that the excursion was primarily the result of a reduction of the oxygen-isotope values of precipitation, which was likely caused by lowered air temperatures, …


Review Of Harald Meller , Helge Wolfgang Arz , Reinhard Jung & Roberto Risch (Ed.). 2200 Bc—Ein Klimasturz Als Ursache Für Den Zerfall Der Alten Welt? 2200 Bc—A Climatic Breakdown As A Cause For The Collapse Of The Old World? 7. Mitteldeutscher Archäologentag Vom 23. Bis 26. Oktober 2014 In Halle (Saale). 7th Archaeological Conference Of Central Germany October 23–26, 2014 In Halle (Saale) (2 Volumes). 2015. 861 Pages, Numerous Colour And B&W Illustrations, And Tables. Halle (Saale): Landesamt Für Denkmalpflege Und Archäologie Sachsen-Anhalt, Landesmuseum Für Vorgeschichte. 978-3-944507-29-3 Hardback €109., N Roberts Jan 2016

Review Of Harald Meller , Helge Wolfgang Arz , Reinhard Jung & Roberto Risch (Ed.). 2200 Bc—Ein Klimasturz Als Ursache Für Den Zerfall Der Alten Welt? 2200 Bc—A Climatic Breakdown As A Cause For The Collapse Of The Old World? 7. Mitteldeutscher Archäologentag Vom 23. Bis 26. Oktober 2014 In Halle (Saale). 7th Archaeological Conference Of Central Germany October 23–26, 2014 In Halle (Saale) (2 Volumes). 2015. 861 Pages, Numerous Colour And B&W Illustrations, And Tables. Halle (Saale): Landesamt Für Denkmalpflege Und Archäologie Sachsen-Anhalt, Landesmuseum Für Vorgeschichte. 978-3-944507-29-3 Hardback €109., N Roberts

More Faculty of Science and Engineering Research

No abstract provided.


Late Holocene Climate: Natural Or Anthropogenic?, W. F. Ruddiman, D. Q. Fuller, J. E. Kutzbach, P. C. Tzedakis, J. O. Kaplan, E. C. Ellis, S. J. Vavrus, C. N. Roberts, R. Fyfe, F. He, C. Lemmen, J. Woodbridge Jan 2016

Late Holocene Climate: Natural Or Anthropogenic?, W. F. Ruddiman, D. Q. Fuller, J. E. Kutzbach, P. C. Tzedakis, J. O. Kaplan, E. C. Ellis, S. J. Vavrus, C. N. Roberts, R. Fyfe, F. He, C. Lemmen, J. Woodbridge

More Faculty of Science and Engineering Research

AbstractFor more than a decade, scientists have argued about the warmth of the current interglaciation. Was the warmth of the preindustrial late Holocene natural in origin, the result of orbital changes that had not yet driven the system into a new glacial state? Or was it in considerable degree the result of humans intervening in the climate system through greenhouse gas emissions from early agriculture? Here we summarize new evidence that moves this debate forward by testing both hypotheses. By comparing late Holocene responses to those that occurred during previous interglaciations (in section 2), we assess whether the late Holocene …


Corporate Governance And Risk Management In Gcc Banks, Ahmed A. El-Masry, Tarek Abdelfattah, Ehab Elbahar Jan 2016

Corporate Governance And Risk Management In Gcc Banks, Ahmed A. El-Masry, Tarek Abdelfattah, Ehab Elbahar

Plymouth Business School

The current study examines the relationship between corporate governance and risk management in GCC banks. It aims to contribute to the literature by providing empirical evidence from the GCC’s banking industry of the association between risk management and corporate governance characteristics such as role duality, board size and percentage of nonexecutives. Using sample of 900 observations from banks in the Gulf countries, non-parametric regression, Quantile and panel data analysis have been used to test the hypotheses and the proposed model. The study uses data from financial institutions in the Gulf countries over the period from 2003 till 2012. Findings suggest …


Palmitate-Induced Changes In Energy Demand Cause Reallocation Of Atp Supply In Rat And Human Skeletal Muscle Cells., Raid B. Nisr, Charles Affourtit Jan 2016

Palmitate-Induced Changes In Energy Demand Cause Reallocation Of Atp Supply In Rat And Human Skeletal Muscle Cells., Raid B. Nisr, Charles Affourtit

School of Biomedical Sciences

Mitochondrial dysfunction has been associated with obesity-related muscle insulin resistance, but the causality of this association is controversial. The notion that mitochondrial oxidative capacity may be insufficient to deal appropriately with excessive nutrient loads is for example disputed. Effective mitochondrial capacity is indirectly, but largely determined by ATP-consuming processes because skeletal muscle energy metabolism is mostly controlled by ATP demand. Probing the bioenergetics of rat and human myoblasts in real time we show here that the saturated fatty acid palmitate lowers the rate and coupling efficiency of oxidative phosphorylation under conditions it causes insulin resistance. Stearate affects the bioenergetic parameters …


The Effect Of A Health Intervention Scheme On The Mobility Of Dairy Cows In The Southwest Of England, Faye Shepherd Jan 2016

The Effect Of A Health Intervention Scheme On The Mobility Of Dairy Cows In The Southwest Of England, Faye Shepherd

School of Biological and Marine Sciences Theses

Health intervention schemes have previously been used in order to improve animal welfare and to reduce and sometimes eradicate disease (Bell et al., 2009). This investigation looks at the success of one such scheme upon the incidence of cattle lameness. Farmers participating in the Healthy Livestock Scheme, which took place in the South West of England from November 2010- January 2014, had their cattle mobility scored before commencing any mentored training, to determine pre-intervention lameness prevalence and again after intervention. The results confirm there was a significant reduction in lameness, from an average 26.7% lame before any intervention to 20.4% …


Improving Access For Community Health And Sub-Acute Outpatient Services: Protocol For A Stepped Wedge Cluster Randomised Controlled Trial, Katherine E. Harding, Jennifer J. Watts, Leila Karimi, M O’Reilly, Bridie Kent, Michelle Kotis, Sandra G. Leggat, Jackie Kearney, Nicholas F. Taylor Jan 2016

Improving Access For Community Health And Sub-Acute Outpatient Services: Protocol For A Stepped Wedge Cluster Randomised Controlled Trial, Katherine E. Harding, Jennifer J. Watts, Leila Karimi, M O’Reilly, Bridie Kent, Michelle Kotis, Sandra G. Leggat, Jackie Kearney, Nicholas F. Taylor

School of Nursing and Midwifery

No abstract provided.


Transition To Specialty Practice Program Characteristics And Professional Development Outcomes, Julia Morphet, Bridie Kent, Virginia Plummer, Julie Considine Jan 2016

Transition To Specialty Practice Program Characteristics And Professional Development Outcomes, Julia Morphet, Bridie Kent, Virginia Plummer, Julie Considine

School of Nursing and Midwifery

No abstract provided.


P190bcr-Abl1 Signaling Modulates The Function Of Tumour Suppressor Protein Ikzf1, R Marke, M Demkes, E Lasonder, Et Al Jan 2016

P190bcr-Abl1 Signaling Modulates The Function Of Tumour Suppressor Protein Ikzf1, R Marke, M Demkes, E Lasonder, Et Al

School of Biomedical Sciences

No abstract provided.


Marine Renewable Energy Seascape, Alistair G.L. Borthwick Jan 2016

Marine Renewable Energy Seascape, Alistair G.L. Borthwick

School of Engineering, Computing and Mathematics

No abstract provided.


Simultaneous Removal Of Cr(Vi) And 4-Chlorophenol Through Photocatalysis By A Novel Anatase/Titanate Nanosheet Composite: Synergetic Promotion Effect And Autosynchronous Doping, Wen Liu, Weiling Sun, Alistair G.L. Borthwick, Ting Wang, Fan Li, Yidong Guan Jan 2016

Simultaneous Removal Of Cr(Vi) And 4-Chlorophenol Through Photocatalysis By A Novel Anatase/Titanate Nanosheet Composite: Synergetic Promotion Effect And Autosynchronous Doping, Wen Liu, Weiling Sun, Alistair G.L. Borthwick, Ting Wang, Fan Li, Yidong Guan

School of Engineering, Computing and Mathematics

No abstract provided.


An Advanced Micro-Bio-Loop To Produce Biogas, Qiang Jin, Alistair G.L. Borthwick Jan 2016

An Advanced Micro-Bio-Loop To Produce Biogas, Qiang Jin, Alistair G.L. Borthwick

School of Engineering, Computing and Mathematics

No abstract provided.


Efficient Electrochemical Oxidation Of Thallium (I) In Groundwater Using Boron-Doped Diamond Anode, Yunlong Li, Baogang Zhang, Alistair G.L. Borthwick, Yujiao Long Jan 2016

Efficient Electrochemical Oxidation Of Thallium (I) In Groundwater Using Boron-Doped Diamond Anode, Yunlong Li, Baogang Zhang, Alistair G.L. Borthwick, Yujiao Long

School of Engineering, Computing and Mathematics

No abstract provided.


Copy Number Variation In Bipolar Disorder, Ek Green, E Rees, Jtr Walters, K-G Smith, Et Al Jan 2016

Copy Number Variation In Bipolar Disorder, Ek Green, E Rees, Jtr Walters, K-G Smith, Et Al

School of Biomedical Sciences

Large (>100 kb), rare (<1% in the population) copy number variants (CNVs) have been shown to confer risk for schizophrenia (SZ), but the findings for bipolar disorder (BD) are less clear. In a new BD sample from the United Kingdom (n=2591), we have examined the occurrence of CNVs and compared this with previously reported samples of 6882 SZ and 8842 control subjects. When combined with previous data, we find evidence for a contribution to BD for three SZ-associated CNV loci: duplications at 1q21.1 (P=0.022), deletions at 3q29 (P=0.03) and duplications at 16p11.2 (P=2.3 × 10(-4)). The latter survives multiple-testing correction for the number of recurrent large CNV loci in the genome. Genes in 20 regions (total of 55 genes) were enriched for rare exonic CNVs among BD cases, but none of these survives correction for multiple testing. Finally, our data provide strong support for the hypothesis of a lesser contribution of very large (>500 kb) CNVs in BD compared with SZ, most notably for deletions >1 Mb (P=9 × 10(-4)).