Digital Commons Network^™

Vamorolone, A Dissociative Steroidal Compound, Reduces Pro-Inflammatory Cytokine Expression In Glioma Cells And Increases Activity And Survival In A Murine Model Of Cortical Tumor., Elizabeth Wells, Madhuri Kambhampati, Jesse M Damsker, Heather Gordish-Dressman, Sridevi Yadavilli, Oren J Becher, Jamila Gittens, Mojca Stampar, Roger J. Packer, Javad Nazarian

Genomics and Precision Medicine Faculty Publications

Corticosteroids, such as dexamethasone, are routinely used as palliative care in neuro-oncology for their anti-inflammatory benefits, however many patients experience dose limiting side effects caused by glucocorticoid response element (GRE)-mediated transcription. The purpose of this study was to use a murine model to investigate a new steroid alternative, vamorolone, which promises to reduce side effects through dissociating GRE-mediated transcription and NF-κB -mediated anti-inflammatory actions. To compare vamorolone to dexamethasone in reducing pro-inflammatory signals in vitro, murine glioma cells were treated with dexamethasone, vamorolone or vehicle control. Changes in mRNA expression were assessed using the nanostring inflammatory platform. Furthermore, drug …

Provider Liability And Medical Identity Theft: Can I Get Your (Insurance) Number?, Thomas Clifford

Northwestern Journal of Law & Social Policy

No abstract provided.

Anthony Torres V. City Of Philadelphia

2016 Decisions

USDC for the Eastern District of Pennsylvania

Usa V. Michael Lewis

2016 Decisions

USDC for the District Court of the Virgin Islands

Abraham Unger V. Maureen Sogluizzo

2016 Decisions

USDC for the District of New Jersey

Patrick Gelin V. Attorney General United States

2016 Decisions

Agency

Comparative Genomic Analysis Of Two Serotype 1/2b Listeria Monocytogenes Isolates From Analogous Environmental Niches Demonstrates The Influence Of Hypervariable Hotspots In Defining Pathogenesis, Aidan Casey, Kieran Jordan, Aidan Coffey, Edward M. Fox, Olivia Mcauliffe

Department of Biological Sciences Publications

The vast majority of clinical human listeriosis cases are caused by serotype 1/2a, 1/2b, 1/2c, and 4b isolates of Listeria monocytogenes. The ability of L. monocytogenes to establish a systemic listeriosis infection within a host organism relies on a combination of genes that are involved in cell recognition, internalization, evasion of host defenses, and in vitro survival and growth. Recently, whole genome sequencing and comparative genomic analysis have proven to be powerful tools for the identification of these virulence-associated genes in L. monocytogenes. In this study, two serotype 1/2b strains of L. monocytogenes with analogous isolation sources, but …

A Town Wants Visitor Feedback? There’S An App For That, Sarah Schaier

UNH Today Archive

No abstract provided.

Relief Fund Proposed For New Hampshire’S Dairy Farms, Sarah Schaier

UNH Today Archive

No abstract provided.

Frank Named First Executive Vice Chair In Medicine, Uab Heersink School Of Medicine News

Browse All News

No abstract provided.

2016-December-21-Travis Graves, University Marketing And Commucications, East Tennessee State Univeristy

ETSU News

No abstract provided.

The Terrorist's Veto: Why The First Amendment Must Protect Provocative Portrayals Of The Prophet Muhammad, Daniel Ortner

Northwestern Journal of Law & Social Policy

No abstract provided.

When Religious Belief Becomes Scientific Opinion: Burwell V. Hobby Lobby And The Unraveling Of Federal Rule 702, Meredith Rachel Mandell

Northwestern Journal of Law & Social Policy

No abstract provided.

Integrated Strategy Improves The Prediction Accuracy Of Mirna In Large Dataset., Bin Xue, David Lipps, Sree Devineni

Molecular Biosciences Faculty Publications

MiRNAs are short non-coding RNAs of about 22 nucleotides, which play critical roles in gene expression regulation. The biogenesis of miRNAs is largely determined by the sequence and structural features of their parental RNA molecules. Based on these features, multiple computational tools have been developed to predict if RNA transcripts contain miRNAs or not. Although being very successful, these predictors started to face multiple challenges in recent years. Many predictors were optimized using datasets of hundreds of miRNA samples. The sizes of these datasets are much smaller than the number of known miRNAs. Consequently, the prediction accuracy of these predictors …

Abq Free Press, December 21, 2016, Abq Free Press

ABQ Free Press

No abstract provided.

Philibert Kongtcheu V. Richard Constable, Iii

2016 Decisions

USDC for the District of New Jersey

Erik Crooks-Richards V. Attorney General Usa

2016 Decisions

Agency

Re-Optimization Of Radiation Therapy Dose To The Prostate Using Cbct: Reducing Dose To Organs At Risk, R. Charles Keider Jr.

Masters Theses

Cancer of the prostate is the second most common cancer among American males. The prostate is small gland, located in the pelvis, posterior to the bladder and anterior/inferior to the rectum. Due to this location when irradiating the prostate the normal tissue organs at risk are the bladder and rectum. Negative effects seen when these structures are irradiated can include; bladder stricture, dysuria, hematuria, diarrhea, rectal bleeding, and proctitis.

In order to eliminate or reduce these negative effects more precise and accurate treatment techniques have been employed. Intensity Modulated Radiation Therapy (IMRT) has been successful in achieving greater precision when …

Differential Protein Adsorption And Cellular Uptake Of Silica Nanoparticles Based On Size And Porosity, Jiban Saikia, Mostafa Yazdimamaghani, Seyyed Pouya Hadipour Moghaddam, Hamidreza Ghandehari

Chemical and Biochemical Engineering Faculty Research & Creative Works

Slight alterations in nanoparticles' surface properties can significantly influence the corona composition which may alter their interaction with the biological milieu. Size and porosity of silica nanoparticles (SNPs) are known to be predominant factors influencing their dose-dependent toxicity. Little is known however about the extent and type of protein adsorption on SNPs as a function of physicochemical properties and the role this might play on mechanisms of cellular uptake and toxicity. In this work we investigated the influence of size and porosity of SNPs on protein adsorption, cellular uptake, and toxicity in RAW 264.7 macrophages. Toxicity of the SNPs was …

Best Of 2016, Staff

Browse All News

No abstract provided.

Sonpavde Receives Award At European Multidisciplinary Meeting On Urological Cancer For Prostate Cancer Research, Staff

Browse All News

No abstract provided.

Uab's Alys Stephens Center Presents Jazz At Lincoln Center Orchestra With Wynton Marsalis On Jan. 18, Shannon Thomason

Browse All News

No abstract provided.

Italy To Bail Out Monte Dei Paschi Di Siena Bank, James Politi, Martin Arnold, Rachel Sanderson

Documents

No abstract provided.

Short-Term Retention Of Location-Identity Bindings For Complex Objects, Alexander Nalbandian

Theses

Knowing what is where is an essential and complex component of human perception. This ability refers to the concept of Situation Awareness (SA). The underlying mechanisms for this ability show parallels to the tracking of a set of identical objects moving on a screen, a theory known as Multiple Object Tracking (MOT) (Pylyshyn & Storm, 1988). This theory was useful for investigating the fundamental factors of visual tracking, but lacked a connection to real-world scenarios. In an attempt to bridge that gap, Oksama and Hyönä (2008) created the Model of Multiple Identity Tracking (MOMIT), which includes unique identities for each …

December 2016 (Issue 2) : Human Microbiome-The Hidden World, Aga Khan University Hospital, Karachi

Nutrition and Food Services Department (NFSD) Archives

• Effect of microbiome on various diseases
• Impact on immune system
• Impact on nutrition
• Impact on human behaviour
• What can clinicians do

Do In-State Tuition Benefits Affect The Academic Performance Of Non-Citizens? Data From Texas Public Universities, Terry K. Shaw

Theses and Dissertations

This paper investigates whether receiving in-state tuition benefits effects the academic performance of non-citizen students attending Texas public state-universities. Using data from the Texas Higher Education Opportunity Project, it examines the effect of the HB-1403 policy on contributing factors affecting academic performance of non-citizen students.

The Effect Of Health Insurance On Young Adults' Labor Market Outcomes: Evidence From The Affordable Care Act's Dependent Coverage Expansion, Quazi Hassan

Theses and Dissertations

The Affordable Care Act’s dependent coverage mandate extended young adults’ parental coverage to age 26. I study the expansion’s impact on young adults’ labor market outcomes using a control function method. Following the expansion, I find dependent coverage lowered labor force participation, lowered incomes, and mixed evidence regarding labor supply.

The Impact Of The Federally Qualified Health Center Advanced Primary Care Practice Demonstration On The Poor And Elderly, Jaison R. Moreno

Theses and Dissertations

Implementing a difference-in-differences, I quantify the effects of the Federally Qualified Health Centers Advanced Primary Care Practice demonstration on the self-reported general health of 367 U.S. counties across 47 states. I find small positive statistically significant effects of the demonstration on the elderly and residents of high poverty communities.

The Effects Of The Implementation Of Green Carts On New Yorkers' Bmi, Ana L. Pacheco

Theses and Dissertations

This study focuses on the Green Cart Initiative implemented by the New York City Mayor’s Office of Food Policy. The Initiative was implemented to bring fresh fruits and vegetables in a fast, cheap, and efficient way to neighborhoods considered food deserts and areas with high rates of obesity.

Fresh Air: The Impact Of Reformulated Gasoline On Infant Health, Mohammed Husain

Theses and Dissertations

This paper considers a 1996 Reformulated Gasoline program, where gasoline emissions were regulated in California, to observe the effects on infant health indicators. I use a cross-county analysis to find significant effects from the policy that suggests an improvement in birth weight, gestational length, and infant mortality.